Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Gu, Hongjing; Chen, Qi; Yang, Guan; He, Lei; Fan, Hang; Deng, Yong-Qiang; Wang, Yanxiao; Teng, Yue; Zhao, Zhongpeng; Cui, Yujun; Li, Yuchang; Li, Xiao-Feng; Li, Jiangfan; Zhang, Na-Na; Yang, Xiaolan; Chen, Shaolong; Guo, Yan; Zhao, Guangyu; Wang, Xiliang; Luo, De-Yan; Wang, Hui; Yang, Xiao; Li, Yan; Han, Gencheng; He, Yuxian; Zhou, Xiaojun; Geng, Shusheng; Sheng, Xiaoli; Jiang, Shibo; Sun, Shihui; Qin, Cheng-Feng; Zhou, Yusen

doi:10.1126/science.abc4730

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Modeling SARS-CoV-2 in mice Among the research tools necessary to develop medical interventions to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, high on the list are informative animal models with which to study viral pathogenesis. Gu et al. developed a mouse mode…