The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
Open accessAbstract
Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished all motor cortex projections below injury. However, the motor cortex immediately regained adaptive control over the paralyzed legs during electrochemical neuromodulation of lumbar circuits. Glutamatergic reticulospinal neurons with residual projections below the injury relayed the cortical command downstream. Gravity-assisted rehabilitation enabled by the neuromodulation therapy reinforced these reticulospinal projections, rerouting cortical information through this pathway. This circuit reorganization mediated a motor cortex-dependent recovery of natural walking and swimming without requiring neuromodulation. Cortico-reticulo-spinal circuit reorganization may also improve recovery in humans.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“We also know that reticulospinal neurons from the vGi mediate the volitional modulation of walking during EES28.”
From The neurons that restore walking after paralysis (2022) · cites this paper as [28]
Citations
Cites
Structural and molecular interrogation of intact biological systems
Chung, K., Wallace, J., Kim, S.-Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., et al. (2013) · Nature · doi:10.1038/nature12107 · Cited by 2,008
Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742
Basso, D. M., Beattie, M. S., & Bresnahan, J. C. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0098 · Cited by 1,470
A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons
Tervo, D. G. R., Hwang, B., Viswanathan, S., Gaj, T., Lavzin, M., Ritola, K., Lindo, S. E., Michael, S. C., Кулешова, Е. П., Ojala, D. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.021 · Cited by 1,220
The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
Bareyre, F. M., Kerschensteiner, M., Raineteau, O., Mettenleiter, T. C., Weinmann, O., & Schwab, M. E. (2004) · Nature Neuroscience · doi:10.1038/nn1195 · Cited by 1,088
Chemogenetics revealed: DREADD occupancy and activation via converted clozapine
Gomez, J. L., Bonaventura, J., Lesniak, W., Mathews, W. B., Sysa-Shah, P., Rodriguez, L. A., Ellis, R. J., Richie, C. T., Harvey, B. K., Dannals, R. F., et al. (2017) · Science · doi:10.1126/science.aan2475 · Cited by 980
Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
Lu, P., Wang, Y., Graham, L., McHale, K., Gao, M., Wu, D., Brock, J., Blesch, A., Rosenzweig, E. S., Havton, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.020 · Cited by 908
LOCOMOTOR CIRCUITS IN THE MAMMALIAN SPINAL CORD
Kiehn, O. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112910 · Cited by 868
Advanced CLARITY for rapid and high-resolution imaging of intact tissues
Tomer, R., Ye, L., Hsueh, B., & Deisseroth, K. (2014) · Nature Protocols · doi:10.1038/nprot.2014.123 · Cited by 842
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Self-citation
Cited by
Sorted by citations
Targeted neurotechnology restores walking in humans with spinal cord injury
Wagner, F. B., Mignardot, J.-B., Le Goff-Mignardot, C. G., Demesmaeker, R., Komi, S., Capogrosso, M., Rowald, A., Seáñez, I., Caban, M., Pirondini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0649-2 · Cited by 1,087
Self-citationConfronting false discoveries in single-cell differential expression
Squair, J. W., Gautier, M., Kathe, C., Anderson, M. A., James, N. D., Hutson, T. H., Hudelle, R., Qaiser, T., Matson, K. J. E., Barraud, Q., et al. (2021) · doi:10.1101/2021.03.12.435024 · Cited by 1,086
Self-citationRequired growth facilitators propel axon regeneration across complete spinal cord injury
Anderson, M. A., O’Shea, T. M., Burda, J. E., Ao, Y., Barlatey, S. L., Bernstein, A. M., Kim, J. H., James, N. D., Rogers, A. D., Kato, B., et al. (2018) · Nature · doi:10.1038/s41586-018-0467-6 · Cited by 528
Self-citationSpinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Self-citationRowald, A., Komi, S., Demesmaeker, R., Baaklini, E., Hernandez-Charpak, S. D., Paoles, E., Montanaro, H., Cassara, A., Becce, F., Lloyd, B., et al. (2022) · Nature Medicine · doi:10.1038/s41591-021-01663-5 · Cited by 455
Self-citation
Metadata
- Authors
- Asboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., Batti, L., Pagès, S., Kreider, J., Schneider, B. L., Barraud, Q., & Courtine, G.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Pavlov Institute of Physiology of the Russian Academy of Sciences (RU)
- Wyss Center for Bio and Neuroengineering (CH)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2018-03-19
- Volume
- 21
- Issue
- 4
- Pages
- 576-588
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2791494966
- Cited by
- 324
- References
- 56
- Citations by year
- 2026: 22 · 2025: 52 · 2024: 41 · 2023: 37 · 2022: 38 · 2021: 51 · 2020: 28 · 2019: 37 · 2018: 16
- FWCI
- 25.22
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Kissei
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- spinal cord contusion, circuit reorganization, functional recovery, reticulospinal neurons, motor cortex, locomotor recovery, paralysis, spinal cord injury
- MeSH terms
- Channelrhodopsins, Animals, Brain, Vestibular Nucleus, Lateral, Disease Models, Animal, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Cortex, Psychomotor Performance, Quipazine, Rats, Inbred Lew, Spinal Cord, Spinal Cord Injuries, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Thy-1 Antigens, Recovery of Function, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
