Cited by 264Pain Mechanisms and TreatmentsIon Channels and ReceptorsDermatology and Skin Diseases

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Circuit dissection of the role of somatostatin in itch and pain

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Huang, Jing, Polgár, Erika, Solinski, Hans Jürgen, Mishra, Santosh K., Tseng, Pang-Yen, Iwagaki, Noboru, Boyle, Kieran A., Dickie, Allen C., Kriegbaum, Mette C., Wildner, Hendrik, Zeilhofer, Hanns Ulrich, Watanabe, Masahiko, Riddell, John S., Todd, Andrew J., Hoon, Mark A.·2018·Nature Neuroscience

DOI 10.1038/s41593-018-0119-zPMC PMC5923877

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Abstract

Stimuli that elicit itch are detected by sensory neurons that innervate the skin. This information is processed by the spinal cord; however, the way in which this occurs is still poorly understood. Here we investigated the neuronal pathways for itch neurotransmission, particularly the contribution of the neuropeptide somatostatin. We find that in the periphery, somatostatin is exclusively expressed in Nppb+ neurons, and we demonstrate that Nppb+somatostatin+ cells function as pruriceptors. Employing chemogenetics, pharmacology and cell-specific ablation methods, we demonstrate that somatostatin potentiates itch by inhibiting inhibitory dynorphin neurons, which results in disinhibition of GRPR+ neurons. Furthermore, elimination of somatostatin from primary afferents and/or from spinal interneurons demonstrates differential involvement of the peptide released from these sources in itch and pain. Our results define the neural circuit underlying somatostatin-induced itch and characterize a contrasting antinociceptive role for the peptide.

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Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,652
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Intrathecal morphine in mice: A new technique
Hylden, J. L. K., & Wilcox, G. L. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90515-4 · Cited by 1,930
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
DREADDs for neuroscientists
Roth, B. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.040 · Cited by 1,742
A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing
Madisen, L., Mao, T., Koch, H., Zhuo, J.-M., Berenyi, A., Fujisawa, S., Hsu, Y.-W. A., Garcia, A. J., Gu, X., Zanella, S., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3078 · Cited by 1,398

Show all 70 references

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Bodnar, R. J. (2020) · Peptides · doi:10.1016/j.peptides.2020.170348 · Cited by 22
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Qi, L., Iskols, M., Shi, D., Reddy, P., Walker, C. J., Lezgiyeva, K., Voisin, T., Pawlak, M., Kuchroo, V. K., Chiu, I. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.22.537932 · Cited by 22
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Komiya, E., Tominaga, M., Hatano, R., Kamikubo, Y., Toyama, S., Sakairi, H., Honda, K., Itoh, T., Kamata, Y., Tsurumachi, M., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.08.003 · Cited by 18
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Zhang, D., Chen, Y., Wei, Y., Chen, H., Wu, Y., Wu, L., Li, J., Ren, Q., Miao, C., Zhu, T., et al. (2023) · eLife · doi:10.7554/elife.92046 · Cited by 38
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Filaković, P., Erić, A. P., & Radanović-Grgurić, L. (2012) · PubMed · Cited by 13
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Hui, S. E., & Westlund, K. N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136889 · Cited by 1

Authors: Huang, J., Polgár, E., Solinski, H. J., Mishra, S. K., Tseng, P.-Y., Iwagaki, N., Boyle, K. A., Dickie, A. C., Kriegbaum, M. C., Wildner, H., Zeilhofer, H. U., Watanabe, M., Riddell, J. S., Todd, A. J., & Hoon, M. A.
Affiliations: National Institutes of Health (US)
University of Glasgow (GB)
University of Zurich (CH)
Hokkaido University (JP)
Corresponding author: Todd, Andrew J.
Hoon, Mark A.
ORCID: Huang, Jing
Solinski, Hans Jürgen
Mishra, Santosh K.
Tseng, Pang-Yen
Iwagaki, Noboru
Boyle, Kieran A.
Dickie, Allen C.
Wildner, Hendrik
Zeilhofer, Hanns Ulrich
Watanabe, Masahiko
Riddell, John S.
Todd, Andrew J.
Hoon, Mark A.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-03-19
Volume: 21
Issue: 5
Pages: 707-716
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-018-0119-z
PMC: PMC5923877
OpenAlex: W2796422959
Cited by: 257
References: 70
Citations by year: 2026: 23 · 2025: 22 · 2024: 27 · 2023: 28 · 2022: 31 · 2021: 33 · 2020: 45 · 2019: 35 · 2018: 12
FWCI: 21.43
Type: journal article
Language: en
Update notices: correction (2018-04-19)
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Wellcome Trust (102645, 156393, 102645/Z/13/Z)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (156393)
Medical Research Council (MR/L003430/1, MR/N003403/1)
Biotechnology and Biological Sciences Research Council (BB/N006119/1)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: somatostatin, pruritus, pruriception, pruriceptors, dynorphin, disinhibition, spinal interneurons, primary afferents, antinociception, pain, neuropeptides, spinal cord circuitry
MeSH terms: Atrial Natriuretic Factor Receptor B, Animals, Dynorphins, Female, Ganglia, Spinal, Male, Mice, Inbred C57BL, Neural Pathways, Pain, Pruritus, Receptors, Purinergic, Sensory Receptor Cells, Somatostatin, Spinal Cord, Receptors, Atrial Natriuretic Factor, Receptors, Somatostatin, Mice, Optogenetics

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Circuit dissection of the role of somatostatin in itch and pain

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