The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Animal models of neurodegenerative diseases
Open accessAbstract
Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease. Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. We discuss the limitations and utility of current models, issues regarding translatability, and future directions for developing animal models of these human disorders.
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“It typically requires additional expression of human tau harboring mutations associated with primary tauopathy (94–96) or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau (97) to develop the tau pathology.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [94]
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1 retracted
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RetractedAmyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo
Hasselmann, J., Coburn, M. A., England, W., Figueroa Velez, D. X., Kiani Shabestari, S., Tu, C. H., McQuade, A., Kolahdouzan, M., Echeverria, K., Claes, C., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.002 · Cited by 380
Microglia: Agents of the CNS Pro-Inflammatory Response
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Immune Signaling in Neurodegeneration
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Metadata
- Authors
- Dawson, T. M., Golde, T. E., & Lagier-Tourenne, C.
- Affiliations
- Johns Hopkins University (US)
- University of Florida (US)
- Corresponding author
- Dawson, Ted M.
- Golde, Todd E.
- Venue
- Nature Neuroscience
- Published
- 2018-09-24
- Volume
- 21
- Issue
- 10
- Pages
- 1370-1379
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC6615039
- OpenAlex
- W2891411797
- Cited by
- 576
- References
- 151
- Citations by year
- 2026: 59 · 2025: 73 · 2024: 89 · 2023: 72 · 2022: 88 · 2021: 79 · 2020: 70 · 2019: 41 · 2018: 4
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG018454, U01AG046139, P50AG047266)
- National Cancer Institute (P01CA166009)
- National Institute of Neurological Disorders and Stroke (R21NS098006, R01NS087227, R01NS082205, P50NS038377)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- animal models, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, rodent models, translatability, disease modeling
- MeSH terms
- Animals, Disease Models, Animal, Humans, Neurodegenerative Diseases
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