The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks
Open accessAbstract
Understanding the organization of the hippocampus is fundamental to understanding brain function related to learning, memory, emotions, and diseases such as Alzheimer's disease. Physiological studies in humans and rodents have suggested that there is both structural and functional heterogeneity along the longitudinal axis of the hippocampus. However, the recent discovery of discrete gene expression domains in the mouse hippocampus has provided the opportunity to re-evaluate hippocampal connectivity. To integrate mouse hippocampal gene expression and connectivity, we mapped the distribution of distinct gene expression patterns in mouse hippocampus and subiculum to create the Hippocampus Gene Expression Atlas (HGEA). Notably, previously unknown subiculum gene expression patterns revealed a hidden laminar organization. Guided by the HGEA, we constructed the most detailed hippocampal connectome available using Mouse Connectome Project ( http://www.mouseconnectome.org ) tract tracing data. Our results define the hippocampus' multiscale network organization and elucidate each subnetwork's unique brain-wide connectivity patterns.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In rodents, DG and CA3 contribute primarily to intrahippocampal connectivity (working to integrate information within the hippocampus), while CA1/CA2 and subiculum are organized into global networks tasked with extrahippocampal communication12.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [12]
In the citing paper
“This prediction is highly consistent with the currently known interareal connections of HPF, providing a level of validation to the transcriptomic cell type framework”
From A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation (2021) · cites this paper as Bienkowski et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Fast unfolding of communities in large networks
Blondel, V. D., Guillaume, J.-L., Lambiotte, R., & Lefebvre, E. (2008) · Journal of Statistical Mechanics: Theory and Experiment · doi:10.1088/1742-5468/2008/10/p10008 · Cited by 21,424
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Self-citationMicrostructure of a spatial map in the entorhinal cortex
Hafting, T., Fyhn, M., Molden, S., Moser, M.-B., & Moser, E. I. (2005) · Nature · doi:10.1038/nature03721 · Cited by 4,068
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Self-citationCell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124
A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612
de Nó, R. L. (1934) · Cited by 1,974
Neuronal circuits for fear and anxiety
Tovote, P., Fadok, J. P., & Lüthi, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3945 · Cited by 1,786
Functional organization of the hippocampal longitudinal axis
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738
Cited by
Sorted by citations
Items 201–224 of 224
Li, X., Li, N., He, Y., Zhong, Q., & Zhong, Z. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.25.640033
Sex differences in context fear neural circuitry and behavior across development
Colón, L. M. (2021) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/3azw-h042
Brain Atlases: An Updated View
Pappas, I., & Toga, A. W. (2025) · Neuromethods · doi:10.1007/978-1-0716-4438-6_9 · Cited by 1
Ran, Q., Chen, Z., Yan, M., Liu, Y., Li, W., Duan, X., Wei, X., Yang, X., Hu, Z., & Peng, W. (2025) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2025.112033
Tseng, C.-S., Zhuang, Z.-H., Hsing, H.-W., Lee, C.-M., Hsu, T., Pan, Y., Hsueh, Y., Chen, B., & Chou, S. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003355
Kempermann, G. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197519233.003.0010
Essential function of Nr4a2 in subicular development and social novelty
Liu, X.-Y., Tao, Y., Zhang, Q., Liu, W., Zhao, L., Hu, Z., Zhou, B.-Y., Li, Z.-X., Qi, C., Zhang, L., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.12.014
Fozoonmayeh, D., Sankaran, M., Yu, J., Walsh, M., Tyrtyshnaia, A. A., & Kleschevnikov, A. M. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111721
Sun, L., Zheng, H., Huang, Y., Huang, X., Yan, K., Wang, Z., Yang, L., Yue, Y., Gou, X., Du, G., et al. (2026) · National Science Review · doi:10.1093/nsr/nwag004 · Cited by 3
Li, J., Xiao, Y., Lyu, S., Wang, K., Zhang, H., Zheng, Y., Zhang, X., Yang, H., & Shu, Y. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03453-2
Yang, X., Shi, Y., Li, M., Li, T., Yang, J., Lei, J., Cui, C., Peng, X., Zha, H.-C., Luo, G.-G., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2516904123
Study of the Neuron-Astrocyte Relationship in a Rodent Model of Tauopathy
de Gérando, A. M. (2019) · theses.fr (ABES) · doi:10.70675/04658671zaca3z4fefza24dz2f5a011bebfe
Hétérogénéité de la réactivité astrocytaire dans la maladie d'Alzheimer
Guillemaud, O. (2020) · theses.fr (ABES) · doi:10.70675/038d98c5z55ccz4754z9af9z417e3826d282
Paredes, D., & Drew, M. R. (2026) · Hippocampus · doi:10.1002/hipo.70092
Kawamura, T., Nair, R. R., Tsutsui, K., & Ohara, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.13.724828
Homologous cell type markers highlight subdivisions of the domestic chick hippocampal formation
Fujita, T., Aoki, N., Mori, C., Homma, K. J., & Yamaguchi, S. (2026) · Scientific Reports · doi:10.1038/s41598-026-55962-3
GABAergic projection from the subiculum to the medial entorhinal cortex in mice and ratsPreprint
Aimi, T., Shibuya, T., Umeno, H., Karasawa, K., Tsutsui, K., Ohara, S., & Kitanishi, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.06.730551
Zhang, W., Zhao, M., Dai, J., Zhuo, L., Ye, H., Wang, J., & Wang, W. (2026) · Communications Biology · doi:10.1038/s42003-026-10457-9 · Cited by 3
Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems
Klug, M. E., Shanmugam, M. V., Huang, H., Arnold, D., Hahn, J. D., & Kanoski, S. E. (2026) · Brain Structure and Function · doi:10.1007/s00429-026-03164-y
The ventral hippocampus: computations, circuits and functions
Biane, J. S., Wagner-Carena, J., & Kheirbek, M. A. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01078-6 · Cited by 2
Vitamin D binding protein in ventral CA3 of the hippocampus drives stress-induced depression
Kong, Y., Huang, Z., Zeng, C., Xu, Y., & Zhang, Z. (2026) · Science Advances · doi:10.1126/sciadv.aeh9563
GABAergic subiculum–medial entorhinal projection in mice and rats
Aimi, T., Shibuya, T., Umeno, H., Karasawa, K., TSUTSUI, K.-I., Ohara, S., & Kitanishi, T. (2026) · Cerebral Cortex · doi:10.1093/cercor/bhag177
Metadata
- Authors
- Bienkowski, M. S., Bowman, I., Song, M. Y., Gou, L., Ard, T., Cotter, K., Zhu, M., Benavidez, N. L., Yamashita, S., Abu-Jaber, J., Azam, S., Lo, D., Foster, N. N., Hintiryan, H., & Dong, H.-W.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Bienkowski, Michael S.
- Dong, Hong-Wei
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2018-10-08
- Volume
- 21
- Issue
- 11
- Pages
- 1628-1643
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC6398347
- OpenAlex
- W2895709954
- Cited by
- 224
- References
- 58
- Citations by year
- 2026: 17 · 2025: 35 · 2024: 33 · 2023: 25 · 2022: 29 · 2021: 31 · 2020: 36 · 2019: 16 · 2018: 1
- FWCI
- 12.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005142)
- National Institute of Mental Health (U19MH114821, F32MH107071, R01MH094360, U01MH114829, RF1MH114112)
- National Cancer Institute (U01CA198932)
- National Institute on Deafness and Other Communication Disorders (R01DC008983)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, hippocampal subiculum, gene expression domains, laminar organization, neural tracing, mouse brain atlas
- MeSH terms
- Animals, Brain, Hippocampus, Nerve Net, Neural Pathways, Neurons, Gene Expression, Mice, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
