Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability

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Lateral habenula IL-10 controls GABAA receptor trafficking and modulates depression susceptibility after maternal separation

Ding, R., Tang, Y., Cao, G., Mai, Y., Fu, Y., Ren, Z., Li, W., Hou, J., Sun, S., Chen, B., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.009 · Cited by 9 · see citing works

Disrupted circadian rhythms and opioid‐mediated adverse effects: Bidirectional relationship and putative mechanisms

Mehranfard, N., Ghasemi, M., & Saboory, E. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70065 · Cited by 7 · see citing works

Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats

Chen, R.-S., Liu, J., Wang, Y., Ning, K., Liu, J., & Liu, Z. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01229-4 · Cited by 7 · see citing works

Functional Adaptation in the Brain Habenulo–Mesencephalic Pathway During Cannabinoid Withdrawal

Aroni, S., Sagheddu, C., Pistis, M., & Muntoni, A. L. (2024) · Cells · doi:10.3390/cells13211809 · Cited by 7 · see citing works

Role of Neuroglia in the Habenular Connection Hub of the Dorsal Diencephalic Conduction System

LOONEN, A. J. M. (2023) · Neuroglia · doi:10.3390/neuroglia4010004 · Cited by 7 · see citing works

Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms

Huang, W., Zuo, W., Chen, L., Wang, L., Tewfik, G., Fu, R., Zheng, J., Li, D., & Ye, J.-H. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2913-20.2021 · Cited by 6 · see citing works

Recent Advances in Habenula Imaging Technology: A Comprehensive Review

Bian, B., Zhang, B., Wong, C., Dou, L., Pan, X., Wang, H., Guo, S., Zhang, H., & Zhang, L. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28830 · Cited by 4 · see citing works

VTA µ-Opioidergic Neurons Facilitate Low Sociability in Protracted Opioid Abstinence

Jo, A. Y., Xie, Y., Wooldridge, L. M., Rogers, S. A., Kimmey, B. A., Rodrigues, A., Ortega, R. A. S., Creasy, K. T., Beier, K. T., Blendy, J. A., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1154-24.2025 · Cited by 8 · see citing works

The Missing Link: TNF-α as a Unifying Mechanism in Methamphetamine-Induced Neuronal Dysfunction and Blood-Brain Barrier Compromise

da Silva, M. C. M., de Oliveira, A. C. P., Candelario-Jalil, E., & Khoshbouei, H. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578736 · Cited by 3 · see citing works

VTA μ–opioidergic neurons facilitate low sociability in protracted opioid withdrawalPreprint

Jo, A. Y., Xie, Y., Rodrigues, A., Ortega, R. A. S., Creasy, K. T., Beier, K. T., Blendy, J. A., & Corder, G. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.602522 · Cited by 4 · see citing works

The lateral habenula as a master regulator of innate and learned social behaviors

Dodis, G. E., Choi, S., & Flanigan, M. E. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06911-x · Cited by 3 · see citing works

The Clinical Impact of Habenular Dysfunction on Depression and Suicidality: A Literature Review and Discussion on the Implications for Psychiatric Practice

Thippaiah, S. M., Wang, M., Ransdell, M., & Dwivedi, Y. (2025) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-024-00295-6 · Cited by 3 · see citing works

The actions of morphine on microglia and the underlying effects on associated adverse effects

Wu, W., Li, Q., & Yang, F. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06956-y · Cited by 2 · see citing works

Transcriptional Response to Chronic Long‐Access Fentanyl Self‐Administration in Rat Habenula and Amygdala

Magnard, R., González‐Padilla, D., Yalcinbas, E. A., Chaloux-Pinette, E., Eagles, N. J., Totty, M. S., Janak, P. H., Collado‐Torres, L., & Maynard, K. R. (2026) · Addiction Biology · doi:10.1111/adb.70179 · Cited by 2 · see citing works

Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula

Popat, A., Simon, R. C., Aoyama, B. B., Wokhlu, A., Ehrlich, A. T., Harwell, C. C., & Margolis, E. B. (2026) · The Journal of Comparative Neurology · doi:10.1002/cne.70175 · Cited by 3 · see citing works

Substance Use and Addiction

Newton, K. A., & Biase, L. M. D. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_19 · Cited by 3 · see citing works

Tachykinin 1 neurons in the lateral habenula signal negative reward prediction error

Suzuki, K. E., Seagoe, T. A., Holcomb, B., Kuyat, J. R., & Sylwestrak, E. (2026) · Current Biology · doi:10.1016/j.cub.2026.04.032 · Cited by 2 · see citing works

Tachykinin 1-expressing neurons in the lateral habenula signal negative reward prediction errorPreprint

Suzuki, K. E., Seagoe, T. A., Holcomb, B., Kuyat, J. R., & Sylwestrak, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.11.680558 · Cited by 1 · see citing works

Mechanical acupuncture stimulation of HT7 attenuates alcohol intake in alcohol self- administration rats via the medial prefrontal cortex-habenula-ventral tegmental area pathwayPreprint

Seo, S. Y., Bang, S. K., Kang, S.-Y., Cho, S. J., Choi, K., & Ryu, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1544888/v1

Spatiotemporal remodeling in habenula marks the onset of depression-related phenotypes

Molina, P., Osypenko, D., Garnica, J., Amossé, Q., Bouteldja, F., Camelot, L., Mondoloni, S., Congiu, M., Kathe, C., & Mameli, M. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02488-6

Opioid withdrawal engages a habenular subpopulation responsive to aversive statesPreprint

Blankenship, L. G., Moore, V., Holcomb, B., Salinas, I., & Sylwestrak, E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.721196

Targeting Mu Opioid Receptor Neurons of the Habenula to Limit Naloxone Aversion

Ozdemir, D., Ebner, C., Meyer, J., Pons, F., Liberti, C. C.-D., Guimaraes-Olmo, I., Rahman, M. T., Decker, A. M., Wendling, O., Schwartz, E., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.05.014

eIF4E-Dependent Translation Potentially Regulates Apoptosis and BDNF/TrkB Signaling in the Medial Prefrontal Cortex During Morphine-Induced CPP

Gao, F., Yang, X., Zhang, Y., Yu, D., Chen, J., Hou, B., Yang, Z., Li, L., Wang, D., Xie, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27115097

A habenula-enriched GPCR, GPR151, regulates behavioral sensitivity to inflammationPreprint

Rios, L., Lin, Y., Yuan, L., Sharma, Y., Arias, H., Jeddy, F., Thotakura, S., Geleta, A., Rajesh, R., & Shabel, S. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.02.742327

TNF-dependent regulation of synaptic plasticity and neuronal activity: implications for psychiatric disorders

Moschou, D., Adaïdi, H., & Stellwagen, D. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03861-4

Translational evidence for habenula’s role in human addiction: A scoping review

Parisien, C., Abidi, N. H.-E., Khalaf, E., Fortin, J., Pat, N., & Hétu, S. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107021

The role of TNFα in the periaqueductal gray during naloxone-precipitated morphine withdrawal in rats

Hao, S., Liu, S., Zheng, X., Zheng, W., Ouyang, H., Mata, M., & Fink, D. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.197 · Cited by 74 · see citing works

Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal

Clerke, J. A., Preston‐Ferrer, P., Zouridis, I. S., Tissot, A., Batti, L., Voigt, F. F., Pagès, S., Burgalossi, A., & Mameli, M. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.643138 · Cited by 19 · see citing works

Neural circuit adaptations during drug withdrawal — Spotlight on the lateral habenula

Meye, F. J., Trusel, M., Soiza‐Reilly, M., & Mameli, M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.08.007 · Cited by 35 · see citing works

Implication of habenular neurons expressing mu opioid receptors in negative affect associated with naloxone precipitated morphine withdrawal

Ozdemir, D., Liberti, C. C.-D., Meyer, J., Guimaraes-Olmo, I., Kieffer, B. L., & Darcq, E. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104112

Opioid-driven disruption of the septal complex reveals a role for neurotensin-expressing neurons in withdrawal

Simon, R. C., Fleming, W., Briones, B. A., Trzeciak, M., Senthilkumar, P., Ishii, K. K., Hjort, M. M., Martin, M. M., Hashikawa, K., Sanders, A. D., et al. (2024) · Neuron · doi:10.1016/j.neuron.2025.04.024 · Cited by 24 · see citing works