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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
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Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n control = 13; n AD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA-AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD. It was also observed that AD-associated circRNAs co-expressed with known AD genes. Finally, potential microRNA-binding sites were identified in AD-associated circRNAs for miRNAs predicted to target AD genes. Together, these results highlight the importance of analyzing non-linear RNAs and support future studies exploring the potential roles of circRNAs in AD pathogenesis.
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“A very recent study has established an association between circRNA expression and AD [620].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [620]
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Items 201–300 of 346
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Are Ischemic Stroke and Alzheimer’s Disease Genetically Consecutive Pathologies?
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InfluentialComprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains
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“…functions of most circRNAs are still not fully understood, an increasing body of evidence supports their critical roles in various disease processes, including neuro-degenerative disorders (Dube et al. 2019), metabolic diseases (Xu et al. 2015), and several types of cancer (Qian et al. 2018).”
BackgroundNovel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling
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BackgroundHigher Intron Retention Levels in Female Alzheimer's Brains May Be Linked to Disease Prevalence
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“Circular RNA made from back-splicing can act as an miRNA sponge that regulates AD pathology (Dube et al. 2019) while sex-specific decline of cholinergic-targeting tRNA fragments drove cholinergic dysfunction in female AD (Shulman et al. 2023).”
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“Next, promoter sequences of myo-3 ( ∼ 2.5 kb) were cloned at the 5 -end of the circ-crh-1 sequence using the multi cloning site (MCS) of pMC10.”
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“The role of circRNAs is gaining rapid attention in a great deal of illnesses, such as cancer [7], neurodegenerative illness [8], diabetes [9], obesity [10,11], etc.”
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“Besides, circRNA and miRNA are also found to be related to the pathogenesis of AD (Dube et al., 2019; Iranifar et al., 2019).”
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“Deregulated levels of various circRNAs such as CircPUM1 [56], CircPTK2 [55], Circ-0000831 [53], Circ-0007290 [103], Circ-Memo1 [52], Circ-0006459 [104], Circ-0000566 [47], Circ-0000647 [45, 46], Circ-0101874[46], and Circ-CTNNB1 [105] are found in neurological diseases (Table 3).”
Zimmann, F., Banik, P., Kubovčiak, J., Delattre, M., Thakur, P. K., Čapek, M., Kolář, M., Hrubá, E., Dobrovolný, R., Cvačková, Z., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40376-y · Cited by 5
Research progress on the relationship between epilepsy and circRNA
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“Furthermore, Ravanidis et al. (2021) investigated four additional targets, CORO1C_circ_0000437, WDR78_circ_0006677, PHC3_circ_0001359, SLAIN2_ circ_0126525, that have been shown to be deregulated in Alzheimer's disease as described in a prior study (Dube et al. 2019).”
Regulatory mechanism of circular RNAs in brain and neurodegenerative diseases
AmeliMojarad, M., & Amelimojarad, M. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1507575 · Cited by 6
CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury
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Utility of oligonucleotide in upregulating circular RNA production in a cellular model
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Recent progress in study of circRNAs and its role in leukemia
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“CircRNA has been implicated in affecting numerous disease progressions, especially cancers [58] and neurological diseases [59], and it often shows tissue-specific and cell-specific expressions, which makes it candidate for effective therapeutic targets [55].”
Non-coding RNAs: Circular RNAs (circRNAs)
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“To explore this, we prioritized three Notably, previous studies have demonstrated the involvement of brain-enriched circRNAs in Alzheimer’s disease (AD) pathology, providing the mechanistic link between cir-cRNAs and neurodegenerative processes [73].”
CircTarget: a comprehensive database of circRNA–target RNA interactions across multiple cell types
zhang, H., Zhang, Y., Li, P., Yuan, Z., Liu, W. Q., Zhang, J., Li, R., Chen, L., Zhu, P., & Xue, Y. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1280 · Cited by 4
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cirCodAn: A GHMM-based tool for accurate prediction of coding regions in circRNA
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BackgroundDiverse Roles and Therapeutic Potentials of Circular RNAs in Urological Cancers
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“Meanwhile, plentiful researches elucidated that the circRNAs are extensively involved in cancer cell growth and innate immunity, and their dysregulation is closely correlated with disease occurrence and progression (Dube et al., 2019; Huang et al., 2019; Vo et al., 2019; Wilusz, 2019), especially the initiation and de…”
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“For instance, several circRNAs were related with agerelated diseases, including neurodegenerative diseases [16], cardiovascular diseases [17], type 2 diabetes [18] and, even, cancers [19].”
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“Dysregulation of circRNAs contributes to the pathogenesis of autoimmune diseases (9), and may serve as potential biomarkers and immune regulators, offering potential opportunities for the identification of new therapies (10).”
BackgroundSelf-citationYang, D., Sun, K., Huang, F., Fan, H., Shi, T., Chen, X., & Lu, G. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2022e12347 · Cited by 4
“circRNAs exert ubiquitous biological functions in various tissues and cells (13,14,28).”
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“A growing body of research has confirmed that circRNAs play a critical role in the occurrence and development of various diseases [142–144].”
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Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension
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Self-citationCircular RNAs from the MAPT and TARDBP genes: Novel players in neurodegeneration?
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“This, in turn, may result in reduced activity of the γ-secretase complex, which is essential for amyloid beta processing [48, 48, 83, 84].”
InfluentialBlood-based circular RNAs for early diagnosis of Alzheimer’s disease
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“Although these studies have spanned multiple AD-relevant brain regions, including the parietal cortex 11 and hippocampus 12 , the brain is not readily accessible.”
InfluentialSelf-citationCircRTTN upregulates EPHA2 to aggravate the malignant process of melanoma via sponging miR-890.
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“Although individual circRNA analyses have been conducted in the MSBB dataset 9 , our development of circMeta2 enhances understanding of how the dysregulation of circRNAs at the cluster level contributes to AD pathogenesis.”
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Emerging role of interaction between m6A and main ncRNAs in gastrointestinal (GI) cancers
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Online Databases in Circular RNAs
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Self-citationThe emerging role of circular RNAs in neuropsychiatric disorders
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“Furthermore, Dube et al. identi fi ed 3,547 differentially expressed circRNAs, including 28 transcripts whose expression levels strongly correlated with dementia severity, neuropathological progression, and AD diagnosis [65].”
InfluentialUnderstanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt
Ibáñez, L., Pottier, C. P., Beric, A., Western, D., Ali, M., & Cruchaga, C. (2026) · Annals of Neurology · doi:10.1002/ana.78170 · Cited by 6
“In general, large-scale proteomic and transcriptomic studies have identi fi ed panels of proteins 103,104,115,137,174 and transcripts 49,72,91,92 that have higher discriminative power than single protein measurements and that tend to represent underlying biological pathways, such as glial activation…”
Self-citationEarly detection of Alzheimer’s disease with circular RNA from blood
(2026) · Nature Medicine · doi:10.1038/s41591-026-04563-8 · Cited by 2
Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases
Bai, Y., & Yao, H. (2023) · Current Medical Science · doi:10.1007/s11596-023-2784-8 · Cited by 2
“These two circRNAs were markedly associated with neuropathological AD and were reported as potentially novel diagnostic biomarkers for AD [75] .”
BackgroundCharacterization of the circRNA Landscape in Interleukin-4 Induced Anti-Inflammatory Microglia
Li, C., Wang, H., Tang, Y., & Wu, J. (2023) · Biomedicines · doi:10.3390/biomedicines11123239 · Cited by 2
“Note that the expression of circRNAs is tissue-specific [17]; for example, in the brain, circRNA levels in the olfactory bulb, prefrontal cortex, hippocampus and cerebellum are higher than those in other brain regions [45]. circRNAs can also gradually accumulate in synapses with aging [46], which…”
BackgroundResultInfluentialRecent Advances in the Role of Non-coding RNAs in Fetal Alcohol Spectrum Disorders
Pritha, A. N., Pasmay, A. A., & Noor, S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-81908-7_7 · Cited by 3
The circRNA and Role in Alzheimer’s Disease: From Regulation to Therapeutic and Diagnostic Targets
Li, W., & Jin, G. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.99893 · Cited by 2
“[101] found that circRNA expression significantly associated with the diagnosis of AD, the severity of clinical dementia, and the severity of neuropathology.”
BackgroundAyyildiz, D., Monziani, A., Tripathi, T., Döring, J., Bergonzoni, G., Kerschbamer, E., Leva, F. D., Pennati, E., Donini, L., Kovalenko, M. V., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.27.474266 · Cited by 2
Alkhazaali-Ali, Z., Negah, S. S., Boroumand, A. R., Farkhad, N. K., Khodadoust, M. A., Ganjali, R., & Tavakol‐Afshari, J. (2024) · Preprints.org · doi:10.20944/preprints202404.0301.v1 · Cited by 2
Kelly, D. J., Bicker, S., Winterer, J., Nanda, P., Germain, P., Dieterich, C., & Schratt, G. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.09.588686 · Cited by 2
Wylie, W., Mellios, N., & Bourgeois, J. A. (2025) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20240086 · Cited by 1
Presence of Alzheimer's disease variants in circular RNA of PSEN1 and PSEN2
Johnson, I. P., Peterson, T. M., Gudsnuk, K. M., Keene, C. D., Bird, T. D., Jayadev, S., Valdmanis, P. N., & Course, M. M. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251350112 · Cited by 1
“12,13 CircPSEN1 levels speci fi cally have been shown to change in cases of autosomal dominant AD.”
Circular RNAs as Biomarkers in the Diagnosis of Human Diseases
Özdemir, S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-96-9428-0_14 · Cited by 1
The Internal Ribosome Entry Site in Circular RNAs
Fernandes, Q., Yoosuf, Z. S. K. M., Mestiri, S., Assami, L., Makni‐Maalej, K., Shahab Uddin, M. S., Merhi, M., & Dermime, S. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-96-9428-0_9 · Cited by 1
Calisir, H.-N., Akcay, S., Bal, E., Ozfiliz-Kilbas, P., Özden, B., & Ayhan‐Sahin, B. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11013-0 · Cited by 1
Aluminum Exposure Leads to Aβ Deposition via the ciRs-7 Pathway
Zhang, L., Ma, Y., Fang, H., Gong, Y., Li, C., Meng, H., Song, J., Lu, X., Zhang, H., Niu, Q. L., et al. (2025) · Biological Trace Element Research · doi:10.1007/s12011-025-04801-z · Cited by 1
Cai, Y., Zheng, Z., Xu, H., Zhu, Y., Zepeda, J. C., Grueter, B. A., Wang, X., Ku, T., Duan, Y., Tsang, H. W. S., et al. (2026) · Science Advances · doi:10.1126/sciadv.ads7509 · Cited by 2
“In particular, circHomer1 levels are decreased in postmortem brain samples from individuals with schizophrenia and bipolar disorder ( 18 , 24 ), Alzheimer’s disease ( 79 , 80 ), and fronto-temporal lobe degeneration ( 81 ).”
Dysregulated circRNA Expression in Juvenile Myoclonic Epilepsy
Söylemez, F., Arslan, S., Kimyon, A. S., & KALEAĞASI, Ş. H. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08928-7 · Cited by 1
“Recent studies have implicated circRNAs in various neurological disorders, including epilepsy; however, their role in JME has not yet been explored (Dube et al., 2019; Ghafouri-Fard et al., 2022; Wang et al., 2024; Chen et al., 2023).”
The emerging role of circular RNAs in neurodegenerative diseases and viral infections
Medina, F., & Bellizzi, A. (2026) · Journal of NeuroVirology · doi:10.1007/s13365-026-01324-8 · Cited by 1
“Notably, some circRNAs showed more vari - ance in cognitive measures than APOE4 allele levels, high - lighting their potential functional importance (Dube et al. 2019).”
InfluentialShabanov, P. D., Иванович, В. В., Savelieva, L. P., & Romashova, Y. E. (2023) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf334925 · Cited by 1
Epigenetics of Alzheimer’s Disease: Past, Present and Future
Adiga, D., Eswaran, S., Sriharikrishnaa, S., Khan, N. G., Kabekkodu, S. P., & Kumar, D. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815136142123010005 · Cited by 1
Research on Circular RNA Expression Profiles in the Photoaging Mouse Model.
Li, Q., Lin, M., Xie, Y., Zhang, J., & Lai, W. (2023) · PubMed Central · doi:10.30498/ijb.2023.351439.3445 · Cited by 1
“CircRNAs have been implicated in multiple diseases, including cardiovascular disease (3), Alzheimer’s disease (4), and cancers (5, 6), thereby highlighting their potential as diagnostic and therapeutic targets.”
BackgroundLiu, H., Jin, M., Ji, M., Zhang, W., Liu, A., & Wang, T. (2021) · Research Square · doi:10.21203/rs.3.rs-815669/v1 · Cited by 1
Ivanov, A., Mattei, D., Radscheit, K., Compagnion, A., Pett, J. P., Herzel, H., Paolicelli, R. C., Piwecka, M., Meyer, U., & Beule, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.18.492346 · Cited by 1
“Moreover, the deregulation of circRNAs has been implicated in neurodegenerative, psychiatric, and neurodevelopmental disorders [Piwecka et al., 2017; Zimmerman et al., 2020; Zhang et al., 2020; Dube et al., 2019; Yang et al., 2019; Zhang & Brian 2021].”
BackgroundZimmerman, A. J., Weick, J. P., Papageorgiou, G., Mellios, N., & Brigman, J. L. (2022) · Research Square · doi:10.21203/rs.3.rs-1862282/v2 · Cited by 1
Circular RNAs may embed pieces of real-world sensory information into an episodic memoryPreprint
Asok, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.06.511043 · Cited by 1
“Indeed, Circular RNAs may provide a novel target and treatment strategy across several pathological conditions such as Alzheimer’s disease, post-traumatic stress disorder, anxiety, and many more (60).”
BackgroundAccurate Reconstruction of Circular RNAs from Complex Rolling Circular Long Reads with CircPlexPreprint
Zahin, T., Khan, I. M., & Shao, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.21.689841 · Cited by 1
“…circRNAs are emerging as promising therapeutic targets [15, 36, 30], while their stable and specific expression patterns also make them valuable as diagnostic biomarkers for a range of conditions, including cancers [18, 8, 26], autoimmune diseases, and neurodegenerative disorders [48, 23, 11].”
Assessing circular RNAs in Alzheimer diseasePreprint
Cervera‐Carles, L., Dols‐Icardo, O., González, A. C., Molina‐Porcel, L., Muñoz, L., & Clarimón, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/800342
“…analyzed in duplicate in a 7900HT Fast Real-Time PCR system (Applied Biosystems, Foster City, CA), using the Fast SYBR Green Master mix (Thermo Scientific), 200 nM of each primer and 30 ng of cDNA. circRNAs were assayed using the previously reported primers 4 , and GAPDH was used as normalizer.”
BackgroundMethodYang, D., Sun, K., Huang, F., Fan, H., Shi, T., Chen, X., & Lu, G. (2021) · Research Square · doi:10.21203/rs.3.rs-470299/v1
A TREM2 -derived circRNA is upregulated in the entorhinal cortex of Alzheimer’s disease patientsPreprint
Urdánoz‐Casado, A., de Gordoa, J. S., Robles, M., Roldán, M., Zelaya, M. V., Blanco‐Luquin, I., & Mendióroz, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.23.449571
CircHIPK3, Hsa_Circ_0014243 and Risk of Gallstone First and Second FormationPreprint
Wei, Y., He, R., Li, Y., Wu, M., Huang, Y., Li, Y., Zhang, Q., Ye, X., Feng, X., Tan, Y., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3942654
Kronika Miasta Poznania 1997 R.65 Nr4 ; Nasi dawni Jezuici
Jacek, W. (1997)
Book Review: The Doctrine of Continuous Voyage
Borchard, E. M. (1927) · bepress Legal Repository
Metadata
- Authors
- Dube, U., Del-Aguila, J. L., Li, Z., Budde, J. P., Jiang, S., Hsu, S., Ibanez, L., Fernandez, M. V., Farias, F., Norton, J., Gentsch, J., Wang, F., the Dominantly Inherited Alzheimer Network (DIAN), Allegri, R., Amtashar, F., Benzinger, T., Berman, S., Bodge, C., Brandon, S., Brooks, W., Buck, J., Buckles, V., Chea, S., Chrem, P., Chui, H., Cinco, J., Clifford, J., D’Mello, M., Donahue, T., Douglas, J., Edigo, N., Erekin-Taner, N., Fagan, A., Farlow, M., Farrar, A., Feldman, H., Flynn, G., Fox, N., Franklin, E., Fujii, H., Gant, C., Gardener, S., Ghetti, B., Goate, A., Goldman, J., Gordon, B., Gray, J., Gurney, J., Hassenstab, J., Hirohara, M., Holtzman, D., Hornbeck, R., DiBari, S. H., Ikeuchi, T., Ikonomovic, S., Jerome, G., Jucker, M., Kasuga, K., Kawarabayashi, T., Klunk, W., Koeppe, R., Kuder-Buletta, E., Laske, C., Levin, J., Marcus, D., Martins, R., Mason, N. S., Maue-Dreyfus, D., McDade, E., Montoya, L., Mori, H., Nagamatsu, A., Neimeyer, K., Noble, J., Norton, J., Perrin, R., Raichle, M., Ringman, J., Roh, J. H., Schofield, P., Shimada, H., Shiroto, T., Shoji, M., Sigurdson, W., Sohrabi, H., Sparks, P., Suzuki, K., Swisher, L., Taddei, K., Wang, J., Wang, P., Weiner, M., Wolfsberger, M., Xiong, C., Xu, X., Salloway, S., Masters, C. L., Lee, J.-H., Graff-Radford, N. R., Chhatwal, J. P., Bateman, R. J., Morris, J. C., Karch, C. M., Harari, O., & Cruchaga, C.
- Affiliations
- Washington University in St. Louis (US)
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR)
- University of Pittsburgh (US)
- Indiana University Bloomington (US)
- Mayo Clinic (US)
- University of Southern California (US)
- Edith Cowan University (AU)
- Columbia University (US)
- Hirosaki University (JP)
- German Center for Neurodegenerative Diseases (DE)
- University of Michigan (US)
- Osaka City University (JP)
- The University of Tokyo (JP)
- Asan Medical Center (KR)
- Brigham and Women's Hospital (US)
- University of California, San Francisco (US)
- The University of Melbourne (AU)
- University of Ulsan (KR)
- Harvard University (US)
- Corresponding author
- Cruchaga, Carlos
- ORCID
- Dube, Umber
- Li, Zeran
- Budde, John P
- Jiang, Shan
- Hsu, Simon
- Wang, Fengxian
- Allegri, Ricardo
- Benzinger, Tammie
- Berman, Sarah
- Brooks, William
- D’Mello, Mirelle
- Fagan, Anne
- Feldman, Howard
- Fox, Nick
- Franklin, Erin
- Fujii, Hisako
- Gardener, Samantha
- Ghetti, Bernardino
- Goate, Alison
- Goldman, Jill
- Gordon, Brian
- Gurney, Jenny
- Hassenstab, Jason
- Holtzman, David
- Hornbeck, Russ
- Ikeuchi, Takeshi
- Jucker, Mathias
- Kasuga, Kensaku
- Kawarabayashi, Takeshi
- Klunk, William
- Laske, Christoph
- Levin, Johannes
- Martins, Ralph
- McDade, Eric
- Mori, Hiroshi
- Noble, James
- Perrin, Richard
- Ringman, John
- Roh, Jee Hoon
- Schofield, Peter
- Shoji, Mikio
- Sohrabi, Hamid
- Suzuki, Kazushi
- Taddei, Kevin
- Wang, Jen
- Xiong, Chengjie
- Salloway, Stephen
- Masters, Colin L
- Lee, Jae-Hong
- Chhatwal, Jasmeer P
- Bateman, Randall J
- Morris, John C
- Karch, Celeste M
- Harari, Oscar
- Cruchaga, Carlos
- Venue
- Nature Neuroscience
- Published
- 2019-10-07
- Volume
- 22
- Issue
- 11
- Pages
- 1903-1912
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC6858549
- OpenAlex
- W2977553419
- Cited by
- 345
- References
- 63
- Citations by year
- 2026: 22 · 2025: 43 · 2024: 45 · 2023: 53 · 2022: 69 · 2021: 60 · 2020: 48 · 2019: 3
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Murdoch University Research Portal (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Edith Cowan University Research Online (Edith Cowan University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- DZNE Pub (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Institute on Aging (RF1AG053303, R01AG058501, RF1AG058501)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- circular RNA, Alzheimer's disease, parietal cortex, autosomal dominant Alzheimer's disease, microRNA binding sites, non-coding RNA, brain transcriptome
- MeSH terms
- RNA, Circular, Alzheimer Disease, Atlases as Topic, Humans, Parietal Lobe, RNA, Messenger, Severity of Illness Index, Case-Control Studies, Sequence Analysis, RNA, Gene Expression Profiling, MicroRNAs
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