The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory
Open accessAbstract
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.
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“the disruption of myelin homeostasis adversely contributes to many neurological disorders, such as multiple sclerosis, leukodystrophies, and dementia.6,7,8,9,10”
From Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function (2025) · cites this paper as [9]
Experimental — accuracy not yet measuredIn the citing paper
“The myelinogenesis and remyelination capacities of oligodendrocyte precursor cells (OPCs) also decrease.148”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [148]
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Cites
Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685
A century of trends in adult human height
NCD Risk Factor Collaboration (NCD-RisC) (2016) · eLife · doi:10.7554/elife.13410 · Cited by 1,558
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177
The ageing cortical synapse: hallmarks and implications for cognitive decline
Morrison, J. H., & Baxter, M. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3200 · Cited by 965
Top-down suppression deficit underlies working memory impairment in normal aging
Gazzaley, A., Cooney, J. W., Rissman, J., & D'Esposito, M. (2005) · Nature Neuroscience · doi:10.1038/nn1543 · Cited by 934
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
Kang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3390 · Cited by 808
Rejuvenation of Regeneration in the Aging Central Nervous System
Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649
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White matter aging drives microglial diversity
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Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease
Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346
Self-citationMyelin plasticity: sculpting circuits in learning and memory
Xin, W., & Chan, J. R. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00379-8 · Cited by 329
Self-citationLipid droplets in the nervous system
Ralhan, I., Chang, C.-L., Lippincott-Schwartz, J., & Ioannou, M. S. (2021) · Journal of Cell Biology · doi:10.1083/jcb.202102136 · Cited by 281
Metadata
- Authors
- Wang, F., Ren, S.-Y., Chen, J.-F., Liu, K., Li, R.-X., Li, Z.-F., Hu, B., Niu, J.-Q., Xiao, L., Chan, J. R., & Mei, F.
- Affiliations
- Army Medical University (CN)
- University of California, San Francisco (US)
- Corresponding author
- Chan, Jonah R.
- Mei, Feng
- Venue
- Nature Neuroscience
- Published
- 2020-02-10
- Volume
- 23
- Issue
- 4
- Pages
- 481-486
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC7306053
- OpenAlex
- W3005119588
- Cited by
- 348
- References
- 22
- Citations by year
- 2026: 51 · 2025: 58 · 2024: 53 · 2023: 44 · 2022: 59 · 2021: 57 · 2020: 24
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Natural Science Foundation of Beijing Municipality (7172156)
- Chongqing Science and Technology Commission (CSTCKJCXLJRC07)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS062796, R01NS097428, R01NS095889)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (A130141)
- National Natural Science Foundation of China (31771120)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- myelination, myelin degeneration, aging, spatial memory, cognitive decline, oligodendrocyte precursor cells, Olig2, clemastine, oligodendrocyte differentiation, myelin
- MeSH terms
- Oligodendrocyte Precursor Cells, Oligodendrocyte Transcription Factor 2, Aging, Animals, Demyelinating Diseases, Myelin Basic Protein, Memory Disorders, Mice, Transgenic, Myelin Sheath, Oligodendroglia, Mice
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