Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain
Open accessAbstract
The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2(+) cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous progenitors maintain their density is unknown. We generated NG2-mEGFP mice and used in vivo two-photon imaging to study their dynamics in the adult brain. Time-lapse imaging revealed that NG2(+) cells in the cortex were highly dynamic; they surveyed their local environment with motile filopodia, extended growth cones and continuously migrated. They maintained unique territories though self-avoidance, and NG2(+) cell loss though death, differentiation or ablation triggered rapid migration and proliferation of adjacent cells to restore their density. NG2(+) cells recruited to sites of focal CNS injury were similarly replaced by a proliferative burst surrounding the injury site. Thus, homeostatic control of NG2(+) cell density through a balance of active growth and self-repulsion ensures that these progenitors are available to replace oligodendrocytes and participate in tissue repair.
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6-OHDA causes dopamine containing nerve terminals to degenerate, which leads to oligodendrocyte precursor cell infiltration.
“6-OHDA causes dopamine containing nerve terminals to degenerate, which leads to oligodendrocyte precursor cell infiltration.24,25”
From Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism (2016) · cites this paper as [24]
The Introduction (page unavailable) says NG2+ cell proliferation increases in chronic neurodegenerative disease, but does not address 6-OHDA, degeneration of dopamine-containing terminals, or precursor-cell infiltration after that degeneration. Searches for 6-OHDA and dopaminergic terminal degeneration found no passage establishing the claimed sequence. (LLM, conf=0.76)
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- Authors
- Hughes, E. G., Kang, S. H., Fukaya, M., & Bergles, D. E.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Bergles, Dwight E
- Venue
- Nature Neuroscience
- Published
- 2013-04-28
- Volume
- 16
- Issue
- 6
- Pages
- 668-676
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3807738
- OpenAlex
- W2059276463
- Cited by
- 808
- References
- 56
- Citations by year
- 2026: 41 · 2025: 53 · 2024: 65 · 2023: 66 · 2022: 62 · 2021: 92 · 2020: 70 · 2019: 71 · 2018: 61 · 2017: 70 · 2016: 48 · 2015: 47 · 2014: 51 · 2013: 10
- FWCI
- 19.28
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS050274, F32NS076098, NS051509, P30NS050274, R01NS051509)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- oligodendrocyte precursor cells, cell proliferation, cell migration, cell death, cell differentiation, filopodia, growth cones, central nervous system injury, remyelination, adult brain, cortical progenitors
- MeSH terms
- Animals, Cell Count, Cell Differentiation, Cell Movement, Cerebral Cortex, Homeostasis, Mice, Transgenic, Oligodendroglia, Cell Death, Cell Proliferation, Mice, Neural Stem Cells, Time-Lapse Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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