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Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory
Open accessAbstract
Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.
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“the disruption of myelin homeostasis adversely contributes to many neurological disorders, such as multiple sclerosis, leukodystrophies, and dementia.6,7,8,9,10”
From Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function (2025) · cites this paper as [9]
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“The myelinogenesis and remyelination capacities of oligodendrocyte precursor cells (OPCs) also decrease.148”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [148]
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Metadata
- Authors
- Wang, F., Ren, S.-Y., Chen, J.-F., Liu, K., Li, R.-X., Li, Z.-F., Hu, B., Niu, J.-Q., Xiao, L., Chan, J. R., & Mei, F.
- Affiliations
- Army Medical University (CN)
- University of California, San Francisco (US)
- Corresponding author
- Chan, Jonah R.
- Mei, Feng
- Venue
- Nature Neuroscience
- Published
- 2020-02-10
- Volume
- 23
- Issue
- 4
- Pages
- 481-486
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC7306053
- OpenAlex
- W3005119588
- Cited by
- 348
- References
- 22
- Citations by year
- 2026: 51 · 2025: 58 · 2024: 53 · 2023: 44 · 2022: 59 · 2021: 57 · 2020: 24
- FWCI
- 18.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Natural Science Foundation of Beijing Municipality (7172156)
- Chongqing Science and Technology Commission (CSTCKJCXLJRC07)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS062796, R01NS097428, R01NS095889)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (A130141)
- National Natural Science Foundation of China (31771120)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- myelination, myelin degeneration, aging, spatial memory, cognitive decline, oligodendrocyte precursor cells, Olig2, clemastine, oligodendrocyte differentiation, myelin
- MeSH terms
- Oligodendrocyte Precursor Cells, Oligodendrocyte Transcription Factor 2, Aging, Animals, Demyelinating Diseases, Myelin Basic Protein, Memory Disorders, Mice, Transgenic, Myelin Sheath, Oligodendroglia, Mice
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