The DOI matches its Crossref record; 129 of the 130 references it cites were found in a registry or an index.
Structural basis of mitochondrial transcription
Open accessAbstract
The mitochondrial genome is transcribed by a single-subunit DNA-dependent RNA polymerase (mtRNAP) and its auxiliary factors. Structural studies have elucidated how mtRNAP cooperates with its dedicated transcription factors to direct RNA synthesis: initiation factors TFAM and TFB2M assist in promoter-DNA binding and opening by mtRNAP while the elongation factor TEFM increases polymerase processivity to the levels required for synthesis of long polycistronic mtRNA transcripts. Here, we review the emerging body of structural and functional studies of human mitochondrial transcription, provide a molecular movie that can be used for teaching purposes and discuss the open questions to guide future directions of investigation.
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“TFAM is essential for mtDNA genome maintenance and initiates mitochondrial transcription by recruiting mitochondrial RNA polymerase (POLRMT) and mitochondrial transcription factor B (TFBM) to specific promoter regions on mtDNA (Hillen et al, 2017; Hillen et al, 2018).”
From The mitochondrial long non-coding RNA lncMtloop regulates mitochondrial transcription and suppresses Alzheimer’s disease (2024) · cites this paper as Hillen et al, 2018
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Cites
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Organization and regulation of gene transcription
Cramer, P. (2019) · Nature · doi:10.1038/s41586-019-1517-4 · Cited by 793
Self-citationMechanisms and regulation of protein synthesis in mitochondria
Kummer, E., & Ban, N. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00332-2 · Cited by 349
Small-molecule inhibitors of human mitochondrial DNA transcription
Bonekamp, N. A., Peter, B., Hillen, H. S., Felser, A., Bergbrede, T., Choidas, A., Horn, M., Unger, A., Lucrezia, R. D., Atanassov, I., et al. (2020) · Nature · doi:10.1038/s41586-020-03048-z · Cited by 269
Self-citationMitochondrial DNA Integrity: Role in Health and Disease
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Boguszewska, K., Szewczuk, M., Kaźmierczak-Barańska, J., & Karwowski, B. T. (2020) · Molecules · doi:10.3390/molecules25122857 · Cited by 152
“It may indicate that the polymerase-based transcription system was incorporated in eukaryotes early in the evolutionary process or that the proteobacterial system was replaced by phages in the process of evolution [84].”
BackgroundInfluential
Metadata
- Authors
- Hillen, H. S., Temiakov, D., & Cramer, P.
- Affiliations
- Max Planck Institute for Biophysical Chemistry (DE)
- Thomas Jefferson University (US)
- Corresponding author
- Hillen, Hauke S.
- Cramer, Patrick
- Venue
- Nature Structural & Molecular Biology
- Published
- 2018-09
- Volume
- 25
- Issue
- 9
- Pages
- 754-765
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC6583890
- OpenAlex
- W2890710316
- Cited by
- 111
- References
- 130
- Citations by year
- 2026: 6 · 2025: 22 · 2024: 15 · 2023: 11 · 2022: 19 · 2021: 14 · 2020: 15 · 2019: 8 · 2018: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Medicine Forum (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM104231, R01GM118941)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- mitochondrial transcription, mitochondrial RNA polymerase, TFAM, TFB2M, transcription factors, promoter binding, polymerase processivity, human mitochondria
- MeSH terms
- Humans, Mitochondria, Protein Conformation, Terminator Regions, Genetic, Transcription, Genetic, Evolution, Molecular, Mitochondrial Proteins, Transcriptional Elongation Factors
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