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Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

Mugridge, Jeffrey S., Coller, Jeff, Gross, John D.·2018·Nature Structural & Molecular Biology

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Abstract

5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5'-3' RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5' and 3' RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications.

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Authors: Mugridge, J. S., Coller, J., & Gross, J. D.
Affiliations: University of California, San Francisco (US)
Case Western Reserve University (US)
Corresponding author: Gross, John D.
ORCID: Mugridge, Jeffrey S.
Coller, Jeff
Gross, John D.
Venue: Nature Structural & Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2018-12
Volume: 25
Issue: 12
Pages: 1077-1085
ISSN: 1545-9985 (ISSN-L)
1545-9993
DOI: 10.1038/s41594-018-0164-z
OpenAlex: W2901347859
Cited by: 133
References: 120
Citations by year: 2026: 9 · 2025: 12 · 2024: 27 · 2023: 9 · 2022: 23 · 2021: 22 · 2020: 25 · 2019: 6
FWCI: 1.30
Type: journal article
Language: en
Update notices: correction (2018-12-21)
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Structural & Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM080465)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: deadenylation, decapping, liquid phase separation, RNA modification, gene expression regulation, mRNA quality control
MeSH terms: Gene Expression Regulation, Models, Molecular, RNA, Messenger, RNA Stability

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Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

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