The DOI matches its Crossref record; 119 of the 120 references it cites were found in a registry or an index.
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
Abstract
5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5'-3' RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5' and 3' RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications.
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“A sufficiently long tail (100–150 bp) is necessary to interact with poly(A) binding proteins that form complexes necessary for initiating translation11,12 and protecting the cap from degradation by decapping enzymes13.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [13]
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mRNA vaccines for infectious diseases: principles, delivery and clinical translation
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The emerging role of RNA modifications in the regulation of mRNA stability
Boo, S. H., & Kim, Y. K. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0407-z · Cited by 588
Opportunities and Challenges in the Delivery of mRNA-Based Vaccines
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription
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Metadata
- Authors
- Mugridge, J. S., Coller, J., & Gross, J. D.
- Affiliations
- University of California, San Francisco (US)
- Case Western Reserve University (US)
- Corresponding author
- Gross, John D.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2018-12
- Volume
- 25
- Issue
- 12
- Pages
- 1077-1085
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2901347859
- Cited by
- 133
- References
- 120
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 27 · 2023: 9 · 2022: 23 · 2021: 22 · 2020: 25 · 2019: 6
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-12-21)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM080465)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Keywords
- deadenylation, decapping, liquid phase separation, RNA modification, gene expression regulation, mRNA quality control
- MeSH terms
- Gene Expression Regulation, Models, Molecular, RNA, Messenger, RNA Stability
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