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TET2 chemically modifies tRNAs and regulates tRNA fragment levels
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“Both proteins have been associated with additional functions beyond DNA modification.30,31,32,33,34,35,36,37”
From Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging (2024) · cites this paper as [36]
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
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m6A RNA methylation promotes XIST-mediated transcriptional repression
Patil, D. P., Chen, C.-K., Pickering, B. F., Chow, A., Jackson, C., Guttman, M., & Jaffrey, S. R. (2016) · Nature · doi:10.1038/nature19342 · Cited by 1,747
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Chen, Q., Yan, M., Cao, Z., Li, X., Zhang, Y., Shi, J., Feng, G.-H., Peng, H., Zhang, X., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aad7977 · Cited by 1,470
Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
Sharma, U., Conine, C. C., Shea, J. M., Boskovic, A., Derr, A. G., Bing, X. Y., Belleannee, C., Kucukural, A., Serra, R. W., Sun, F., et al. (2016) · Science · doi:10.1126/science.aad6780 · Cited by 1,275
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
König, J., Zarnack, K., Rot, G., Curk, T., Kayikci, M., Zupan, B., Turner, D. J., Luscombe, N. M., & Ule, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1838 · Cited by 1,126
TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
Pastor, W. A., Aravind, L., & Rao, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3589 · Cited by 897 · cited 1×
“As our original screen was performed in mESCs and given that TET2 is highly expressed in these cells 32 as well as blastula-stage embryos 33 , we decided to study the biological role of TET2–RNA interactions in mESCs.”
Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)
Kumar, P., Kuscu, C., & Dutta, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.004 · Cited by 511
LTR-Retrotransposon Control by tRNA-Derived Small RNAs
Schorn, A. J., Gutbrod, M. J., LeBlanc, C., & Martienssen, R. (2017) · Cell · doi:10.1016/j.cell.2017.06.013 · Cited by 366
Self-citationLoss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells
Dawlaty, M. M., Breiling, A., Le, T., Barrasa, M. I., Raddatz, G., Gao, Q., Powell, B. E., Cheng, A. W., Faull, K. F., Lyko, F., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.03.003 · Cited by 338
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Cited by
Jakobsen, N. A., Turkalj, S., Zeng, A. G. X., Stoilova, B., Metzner, M., Rahmig, S., Nagree, M. S., Shah, S., Moore, R., Usukhbayar, B., et al. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.05.010 · Cited by 130
Metadata
- Authors
- He, C., Bozler, J., Janssen, K. A., Wilusz, J. E., Garcia, B. A., Schorn, A. J., & Bonasio, R.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2020-11-23
- Volume
- 28
- Issue
- 1
- Pages
- 62-70
- ISSN
- 1545-9993
- 1545-9985
- PMC
- PMC7855721
- Cited by
- 83
- References
- 12
- Language
- en
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- He, C., Bozler, J., Janssen, K. A., Wilusz, J. E., Garcia, B. A., Schorn, A. J., & Bonasio, R. (2021). TET2 chemically modifies tRNAs and regulates tRNA fragment levels. Nature Structural & Molecular Biology. https://doi.org/10.1038/s41594-020-00526-w