The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages
Open accessAbstract
The ability of bacteriophages to kill bacteria is well known, as is their potential use as alternatives to antibiotics. As such, bacteriophages reach high doses locally through infection of their bacterial host in the human body. In this study we assessed the gene expression profile of peripheral blood monocytes from six donors for twelve immunity-related genes (i.e. CD14, CXCL1, CXCL5, IL1A, IL1B, IL1RN, IL6, IL10, LYZ, SOCS3, TGFBI and TNFA) induced by Staphylococcus aureus phage ISP and four Pseudomonas aeruginosa phages (i.e. PNM, LUZ19, 14-1 and GE-vB_Pae-Kakheti25). The phages were able to induce clear and reproducible immune responses. Moreover, the overall immune response was very comparable for all five phages: down-regulation of LYZ and TGFBI, and up-regulation of CXCL1, CXCL5, IL1A, IL1B, IL1RN, IL6, SOCS3 and TNFA. The observed immune response was shown to be endotoxin-independent and predominantly anti-inflammatory. Addition of endotoxins to the highly purified phages did not cause an immune response comparable to the one induced by the (endotoxin containing) phage lysate. In addition, the use of an intermediate level of endotoxins tipped the immune response to a more anti-inflammatory response, i.e. up-regulation of IL1RN and a strongly reduced expression of CXCL1 and CXCL5.
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Cites
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SOCS3 regulates the plasticity of gp130 signaling
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Interleukin-6, a mental cytokine
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Cited by
Jault, P., Leclerc, T., Jennes, S., Pirnay, J. P., Que, Y.-A., Resch, G., Rousseau, A. F., Ravat, F., Carsin, H., Le Floch, R., et al. (2019) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30482-1 · Cited by 874
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
Sweere, J. M., Van Belleghem, J. D., Ishak, H., Bach, M. S., Popescu, M., Sunkari, V., Kaber, G., Manasherob, R., Suh, G. A., Cao, X., et al. (2019) · Science · doi:10.1126/science.aat9691 · Cited by 478
Self-citationInteractions between Bacteriophage, Bacteria, and the Mammalian Immune System
Van Belleghem, J. D., Dąbrowska, K., Vaneechoutte, M., Barr, J. J., & Bollyky, P. L. (2018) · Viruses · doi:10.3390/v11010010 · Cited by 408
Self-citationStandardized bacteriophage purification for personalized phage therapy
Luong, T., Salabarria, A.-C., Edwards, R. A., & Roach, D. R. (2020) · Nature Protocols · doi:10.1038/s41596-020-0346-0 · Cited by 274
Bacteriophages and the Immune System
Popescu, M., Van Belleghem, J. D., Khosravi, A., & Bollyky, P. L. (2021) · Annual Review of Virology · doi:10.1146/annurev-virology-091919-074551 · Cited by 178
Metadata
- Authors
- Van Belleghem, J. D., Clement, F., Merabishvili, M., Lavigne, R., & Vaneechoutte, M.
- Venue
- Scientific Reports
- Published
- 2017-08-14
- Volume
- 7
- Issue
- 1
- Pages
- 8004-8004
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2743296461
- Cited by
- 244
- References
- 5
- FWCI
- 15.43
- Type
- journal article
- Language
- en
- Open access
- gold
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- Van Belleghem, J. D., Clement, F., Merabishvili, M., Lavigne, R., & Vaneechoutte, M. (2017). Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages. Scientific Reports. https://doi.org/10.1038/s41598-017-08336-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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