Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes
Open accessAbstract
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations of melatonin. Melatonin supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein (C/EBP) β, and C/EBPα expression and promoted the differentiation of BIPs into adipocytes with large lipid droplets and high cellular triacylglycerol (TAG) levels. Melatonin also significantly enhanced lipolysis and up-regulated the expression of lipolytic genes and proteins, including hormone sensitive lipase (HSL), adipocyte triglyceride lipase (ATGL), and perilipin 1 (PLIN1). Moreover, melatonin reduced intracellular reactive oxygen species (ROS) levels by increasing the expression levels and activities of superoxide dismutase 1 (SOD1) and glutathione peroxidase 4 (GPX4). Finally, the positive effects of melatonin on adipogenesis, lipolysis, and redox status were reversed by treatment with luzindole, anantagonist of nonspecific melatonin receptors 1 (MT1) and 2 (MT2), and 4-phenyl-2-propionamidotetraline (4P-PDOT), a selective MT2 antagonist. These results reveal that melatonin promotes TAG accumulation via MT2 receptor during differentiation in BIPs.
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Melatonin has prominent impacts on circadian rhythm, immunity, energy metabolism, and endocrine system.
“Furthermore, melatonin has prominent impacts on the circadian rhythm, immunity, energy metabolism, and endocrine system. 5,10”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [10]
The Introduction (page unavailable) says melatonin regulates actions related to circadian rhythms and neuroendocrine function, and reports roles in energy metabolism regulation. It does not address immunity, so the citation does not support that part of the sentence. (LLM, conf=0.88)
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“10,12,14 Strengths and limitations of the study An important strength of the present work was the small omission rate, and great admission rate of the subjects to the supplements in both arms, considering possible confounders and using individualized dietary plans for weight reduction as an…”
- Authors
- Yang, W., Tang, K., Wang, Y., Zhang, Y., & Zan, L.
- Affiliations
- Northwest A&F University (CN)
- Corresponding author
- Tang, Keqiong
- Zan, Linsen
- Venue
- Scientific Reports
- Published
- 2017-11-08
- Volume
- 7
- Issue
- 1
- Pages
- 15080-15080
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5678110
- OpenAlex
- W2767146658
- Cited by
- 50
- References
- 73
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 9 · 2018: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (31402044)
- Fundamental Research Funds for the Central Universities (Z109021603, Z109021619)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- melatonin, MT2 receptor, adipogenesis, triglyceride accumulation, lipolysis, PPARγ, C/EBP, hormone-sensitive lipase, PLIN1, reactive oxygen species, superoxide dismutase 1, GPX4, luzindole, redox state
- MeSH terms
- Perilipin-1, Animals, Cattle, Cell Differentiation, Cells, Cultured, Gene Expression Regulation, Lipase, Lipolysis, Male, Melatonin, Tetrahydronaphthalenes, Triglycerides, Adipocytes, Receptor, Melatonin, MT2, Adipogenesis
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