Cited by 118Circadian rhythm and melatoninRegulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

She, Meihua, Deng, Xiaojian, Guo, Zhenyu, Laudon, Moshe, Hu, Zhuowei, Liao, Duanfang, Hu, Xiaobo, Luo, Yi +2 more·2009·Pharmacological Research

Abstract

Evidences indicate that a complex relationship exists among sleep disorders, obesity and insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. In this study, we applied NEU-P11 on obese rats to assess its potential melatoninergic effects in vivo. Obese models were established using high-fat/high-sucrose-fed for 5 months. NEU-P11 (10mg/kg)/melatonin (4mg/kg)/vehicle were administered by a daily intraperitoneal injection respectively for 8 weeks. Our results showed that NEU-P11 or melatonin inhibited both body weight gain and deposit of abdominal fat with no influence on food intake. The impaired insulin sensitivity and antioxidative potency were improved and the levels of plasma glucose, total cholesterol (TC), triglycerides (TG) decreased with an increased in HDL-cholesterol (HDL-c) after NEU-P11 or melatonin administration. These data suggest that NEU-P11, like melatonin, decreased body weight gain and improved insulin sensitivity and metabolic profiles in obese rats. We conclude that NEU-P11 has a melatoninergic effect on regulating body weight in obese rats and also improving metabolic profiles and efficiently enhancing insulin sensitivity.

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Crossref · 10.1016/j.phrs.2009.01.005

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Authors
She, M., Deng, X., Guo, Z., Laudon, M., Hu, Z., Liao, D., Hu, X., Luo, Y., Shen, Q., & Su, Z.
Affiliations
  • University of South China (CN)
  • Neurim Pharmaceuticals (Israel) (IL)
  • Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2009-04
Volume
59
Issue
4
Pages
248-253
ISSN
1043-6618 (ISSN-L)
OpenAlex
W1997463511
Cited by
118
References
36
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 12 · 2013: 12 · 2012: 6
FWCI
3.44
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Natural Science Foundation of China
  • National Key Research and Development Program of China
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
melatonin receptor agonists, melatonin, obesity, insulin sensitivity, insulin resistance, high-fat high-sugar diet, weight gain, abdominal fat, oxidative stress, lipid metabolism, HDL cholesterol, sleep disorders
MeSH terms
Animals, Body Weight, Dietary Fats, Eating, Glucose, Insulin, Male, Melatonin, Obesity, Random Allocation, Body Mass Index, Rats, Sprague-Dawley, Oxidative Stress, Dietary Sucrose, Receptors, Melatonin, Rats

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