Therapeutic potential of melatonin in colorectal cancer: Focus on lipid metabolism and gut microbiota

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works

Global patterns and trends in colorectal cancer incidence and mortality

Arnold, M., Sierra, M. S., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2016) · Gut · doi:10.1136/gutjnl-2015-310912 · Cited by 5,250 · see citing works

Colorectal cancer

Dekker, E., Tanis, P. J., Vleugels, J. L. A., Kasi, P. M., & Wallace, M. B. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32319-0 · Cited by 5,189 · see citing works

Colorectal cancer statistics, 2020

Siegel, R. L., Miller, K. D., Sauer, A. G., Fedewa, S. A., Butterly, L. F., Anderson, J. C., Cercek, A., Smith, R. A., & Jemal, A. (2020) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21601 · Cited by 4,970 · see citing works

Gut microbiota in health and disease

Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Agus, A., Planchais, J., & Sokol, H. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.003 · Cited by 3,180 · see citing works

The gut flora as a forgotten organ

O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791 · see citing works

Dynamics and functions of lipid droplets

Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740 · see citing works

Global colorectal cancer burden in 2020 and projections to 2040

Xi, Y., & Xu, P. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101174 · Cited by 2,503 · see citing works

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works

The role of the gut microbiota in nutrition and health

Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,203 · see citing works

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192 · see citing works

Melatonin as an antioxidant: under promises but over delivers

Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,741 · see citing works

Colorectal cancer

Kuipers, E. J., Grady, W. M., Lieberman, D. A., Seufferlein, T. T. W., Sung, J. J. �., Boelens, P. G., van de Velde, C. J. �., & Watanabe, T. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.65 · Cited by 1,683 · see citing works

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Platten, M., Nollen, E. A. A., Röhrig, U. F., Fallarino, F., & Opitz, C. A. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0016-5 · Cited by 1,586 · see citing works

Analysis of <i>Fusobacterium</i> persistence and antibiotic response in colorectal cancer

Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., et al. (2017) · Science · doi:10.1126/science.aal5240 · Cited by 1,574 · see citing works

Gut microbiome development along the colorectal adenoma-carcinoma sequence

Feng, Q., Liang, S., Jia, H., Stadlmayr, A., Tang, L., Lan, Z., Zhang, D., Xia, H., Xu, X., Jie, Z., et al. (2015) · Nature Communications · doi:10.1038/ncomms7528 · Cited by 1,506 · see citing works

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

Boulangé, C. L., Neves, A. L., Chilloux, J., Nicholson, J. K., & Dumas, M.-E. (2016) · Genome Medicine · doi:10.1186/s13073-016-0303-2 · Cited by 1,438 · see citing works

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A., van Hoeck, A., Wood, H. M., Nomburg, J., Gurjao, C., Manders, F., Dalmasso, G., Stege, P. B., et al. (2020) · Nature · doi:10.1038/s41586-020-2080-8 · Cited by 1,208 · see citing works

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

Dejea, C. M., Fathi, P., Craig, J. M., Boleij, A., Taddese, R., Geis, A. L., Wu, X., DeStefano Shields, C. E., Hechenbleikner, E. M., Huso, D. L., et al. (2018) · Science · doi:10.1126/science.aah3648 · Cited by 1,105 · see citing works

Lipid metabolism reprogramming and its potential targets in cancer

Cheng, C., Geng, F., Cheng, X., & Guo, D. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0301-4 · Cited by 862 · see citing works

Gut microbiota imbalance and colorectal cancer

Gagnière, J. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.501 · Cited by 856 · see citing works

Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

Zhang, H., & Zhang, Y. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12162 · Cited by 816 · see citing works

Functional MT1 and MT2 Melatonin Receptors in Mammals

Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 816 · see citing works

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Tan, D.-X., Manchester, L., Esteban-Zubero, E., Zhou, Z., & Reiter, R. (2015) · Molecules · doi:10.3390/molecules201018886 · Cited by 719 · see citing works

The Human Gut Bacterial Genotoxin Colibactin Alkylates DNA

Wilson, M. R., Jiang, Y., Villalta, P. W., Stornetta, A., Boudreau, P. D., Carrá, A., Brennan, C. A., Chun, E., Ngo, L., Samson, L. D., et al. (2019) · Science · doi:10.1126/science.aar7785 · Cited by 635 · see citing works

Melatonin: The chemical expression of darkness

Reiter, R. J. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90087-9 · Cited by 634 · see citing works

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

Liu, X., Shin, N., Koblish, H. K., Yang, G., Wang, Q., Wang, K., Leffet, L., Hansbury, M., Thomas, B. A., Rupar, M. J., et al. (2010) · Blood · doi:10.1182/blood-2009-09-246124 · Cited by 549 · see citing works

Western diet induces dysbiosis with increased <i>E coli</i> in CEABAC10 mice <i>,</i> alters host barrier function favouring AIEC colonisation

Martinez-Medina, M., Denizot, J., Dreux, N., Robin, F., Billard, E., Bonnet, R., Darfeuille-Michaud, A., & Barnich, N. (2014) · Gut · doi:10.1136/gutjnl-2012-304119 · Cited by 539 · see citing works

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer

Buc, E., Dubois, D., Sauvanet, P., Raisch, J., Delmas, J., Darfeuille-Michaud, A., Pezet, D., & Bonnet, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056964 · Cited by 535 · see citing works

Human gut microbiome: the second genome of human body

Zhu, B., Wang, X., & Li, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0093-z · Cited by 535 · see citing works

SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER

Sancho, E., Batlle, E., & Clevers, H. C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.092805 · Cited by 531 · see citing works

Fusobacterium nucleatum associates with stages of colorectal neoplasia development, colorectal cancer and disease outcome

Flanagan, L., Schmid, J., Ebert, M., Soucek, P., Kunicka, T., Liska, V., Bruha, J., Neary, P., Dezeeuw, N., Tommasino, M., et al. (2014) · European Journal of Clinical Microbiology &amp; Infectious Diseases · doi:10.1007/s10096-014-2081-3 · Cited by 498 · see citing works

Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota

Chen, D., Jin, D., Huang, S., Wu, J., Xu, M., Liu, T., Dong, W., Liu, X., Wang, S., Zhong, W., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.019 · Cited by 495 · see citing works

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer

Prendergast, G. C., Smith, C., Thomas, S., Mandik‐Nayak, L., Laury‐Kleintop, L. D., Metz, R. A., & Muller, A. J. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1549-4 · Cited by 484 · see citing works

Colonization of the Human Gut by <i>E. coli</i> and Colorectal Cancer Risk

Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works

The role of melatonin in the cells of the innate immunity: a review

Calvo, J. R., González-Yanes, C., & y Aibar, M. D. M. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12075 · Cited by 417 · see citing works

Melatonin reprogramming of gut microbiota improves lipid dysmetabolism in high‐fat diet‐fed mice

Yin, J., Li, Y., Han, H. L., Chen, S., Gao, J., Liu, G., Wu, X., Deng, J., Yu, Q., Huang, X., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12524 · Cited by 384 · see citing works

CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis

Wang, Y.-N., Zeng, Z.-L., Lu, J., Wang, Y., Liu, Z., He, M.-M., Zhao, Q., Wang, Z., Li, T., Lu, Y., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0384-z · Cited by 382 · see citing works

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Cotte, A. K., Aires, V., Fredon, M., Limagne, E., Dérangère, V., Thibaudin, M., Humblin, É., Scagliarini, A., de Barros, J.-P. P., Hillon, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02732-5 · Cited by 365 · see citing works

Association of <i>Fusobacterium nucleatum</i> with immunity and molecular alterations in colorectal cancer

Nosho, K. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i2.557 · Cited by 344 · see citing works

Identification of highly elevated levels of melatonin in bone marrow: its origin and significance

Tan, D., Manchester, L. C., Reiter, R. J., Qi, W., Zhang, M., Weintraub, S. T., Cabrera, J., Sainz, R. M., & Mayo, J. C. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00125-7 · Cited by 343 · see citing works

Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

Nath, A., Li, I., Roberts, L. R., & Chan, C. (2015) · Scientific Reports · doi:10.1038/srep14752 · Cited by 336 · see citing works

Lipid rafts as major platforms for signaling regulation in cancer

Mollinedo, F., & Gajate, C. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.10.003 · Cited by 309 · see citing works

Melatonin and cell death: differential actions on apoptosis in normal and cancer cells

Sainz, R. M., Mayo, J. C., Rodrı́guez, C., Tan, D. X., López‐Burillo, S., & Reiter, R. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2319-1 · Cited by 305 · see citing works

Clinical Uses of Melatonin: Evaluation of Human Trials

Sanchez-Barcelo, E. J., Mediavilla, M. D., Tan, D. X., & Reiter, R. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791233689 · Cited by 301 · see citing works

Role of melatonin in sleep deprivation‐induced intestinal barrier dysfunction in mice

Gao, T., Wang, Z., Dong, Y., Cao, J., Lin, R., Wang, X., Yu, Z., & Chen, Y. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12574 · Cited by 301 · see citing works

The role of cholesterol metabolism in cancer.

Ding, X., Zhang, W., Li, S., & Yang, H. (2019) · Europe PMC (PubMed Central) · Cited by 301 · see citing works

Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.

Tamarkin, L., Cohen, M., Roselle, D., Reichert, C. M., Lippman, M. E., & Chabner, B. A. (1981) · PubMed · Cited by 296 · see citing works

Cancer metastasis: Mechanisms of inhibition by melatonin

Su, S., Hsieh, M., Yang, W., Chung, W., Reiter, R. J., & Yang, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12370 · Cited by 285 · see citing works

Melatonin prevents obesity through modulation of gut microbiota in mice

Xu, P., Wang, J., Hong, F., Wang, S., Jin, X., Xue, T., Jia, L., & Zhai, Y. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12399 · Cited by 281 · see citing works

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

Yang, J., & Yu, J. Q. (2018) · Protein & Cell · doi:10.1007/s13238-018-0543-6 · Cited by 280 · see citing works

Circadian rhythm and the gut microbiome

Voigt, R. M., Forsyth, C. B., Green, S. J., Engen, P. A., & Keshavarzian, A. (2016) · International Review of Neurobiology · doi:10.1016/bs.irn.2016.07.002 · Cited by 274 · see citing works

Clock Gene Expression in the Murine Gastrointestinal Tract: Endogenous Rhythmicity and Effects of a Feeding Regimen

Hoogerwerf, W. A., Hellmich, H. L., Cornélissen, G., Franz Halberg, A., Shahinian, V. B., Bostwick, J., Savidge, T., & Cassone, V. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.009 · Cited by 268 · see citing works

Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity

Paulose, J. K., Wright, J. M., Patel, A., & Cassone, V. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146643 · Cited by 264 · see citing works

Melatonin as antioxidant, geroprotector and anticarcinogen

Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Anisimov, S. V., Vesnushkin, G. M., & Vinogradova, I. A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.012 · Cited by 263 · see citing works

Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers

Mira‐Pascual, L., Cabrera‐Rubio, R., Ocon, S. M., Costales, P., Parra, A., Suárez, A., Morís, F., Rodrigo, L., Mira, Á., & Collado, M. C. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0963-x · Cited by 260 · see citing works

Distribution, function and physiological role of melatonin in the lower gut

Chen, C.-Q. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i34.3888 · Cited by 255 · see citing works

NF-κB pathways in the development and progression of colorectal cancer

Patel, M., Horgan, P. G., McMillan, D. C., & Edwards, J. (2018) · Translational research · doi:10.1016/j.trsl.2018.02.002 · Cited by 251 · see citing works

Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

Wang, C., Li, P., Xuan, J., Zhu, C., Liu, J., Shan, L., Du, Q., Ren, Y., & Ye, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477890 · Cited by 231 · see citing works

The gut microbiota in conventional and serrated precursors of colorectal cancer

Peters, B. A., Dominianni, C., Shapiro, J. A., Church, T. R., Wu, J., Miller, G., Yuen, E., Freiman, H. J., Lustbader, I., Salik, J., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0218-6 · Cited by 230 · see citing works

Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition

van Duijnhoven, F. J. B., Bueno-de-Mesquita, H. B., Calligaro, M., Jenab, M., Pischon, T., Jansen, E. H. J. M., Frohlich, J., Ayyobi, A. F., Overvad, K., Toft‐Petersen, A. P., et al. (2011) · Gut · doi:10.1136/gut.2010.225011 · Cited by 222 · see citing works

Melatonin and Cancer Hallmarks

Talib, W. H. (2018) · Molecules · doi:10.3390/molecules23030518 · Cited by 218 · see citing works

Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects

Soleimani, A., Mojarrad, M. Z., Bahmani, F., Taghizadeh, M., Ramezani, M., Ebrahimi, M. T., Jafari, P., Esmaillzadeh, A., & Asemi, Z. (2016) · Kidney International · doi:10.1016/j.kint.2016.09.040 · Cited by 215 · see citing works

Melatonin signaling in T cells: Functions and applications

Ren, W., Liu, G., Chen, S., Yin, J., Wang, J., Tan, B., Wu, G., Bazer, F. W., Peng, Y., Li, Y., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12394 · Cited by 213 · see citing works

Tryptophan Nutrition and Metabolism: An Overview

Peters, J. C. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5952-4_32 · Cited by 212 · see citing works

Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression

Zhang, L., Su, P., Xu, C., Chen, C., Liang, A., Du, K., Peng, Y., & Huang, D. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00803.x · Cited by 210 · see citing works

Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer

Zaytseva, Y. Y., Rychahou, P. G., Gulhati, P., Elliott, V. A., Mustain, W. C., O'Connor, K., Morris, A. J., Sunkara, M., Weiss, H. L., Lee, E. Y., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4057 · Cited by 208 · see citing works

Melatonin: functions and ligands

Singh, M., & Jadhav, H. R. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.04.014 · Cited by 206 · see citing works

Shifts in the Fecal Microbiota Associated with Adenomatous Polyps

Hale, V. L., Chen, J., Johnson, S. P., Harrington, S. C., Yab, T. C., Smyrk, T. C., Nelson, H., Boardman, L. A., Druliner, B. R., Levin, T. R., et al. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0337 · Cited by 200 · see citing works

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

Jiménez‐Aranda, A., Fernández‐Vázquez, G., Campos, D., Tassi, M., Velasco‐Perez, L., Tan, D. X., Reiter, R. J., & Agil, A. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12089 · Cited by 189 · see citing works

Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review

Bizzarri, M., Proietti, S., Cucina, A., & Reiter, R. J. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.834890 · Cited by 189 · see citing works

Melatonin in macrophage biology: Current understanding and future perspectives

Xia, Y., Chen, S., Zeng, S., Zhao, Y., Zhu, C., Deng, B., Zhu, G., Yin, Y., Wang, W., Hardeland, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12547 · Cited by 188 · see citing works

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

Park, S.-Y., Jang, W., Yi, E.-Y., Jang, J.-Y., Jung, Y., Jeong, J., & Kim, Y.-J. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00742.x · Cited by 187 · see citing works

Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota

Ren, W., Wang, P., Yan, J., Liu, G., Zeng, B., Hussain, T., Peng, C., Yin, J., Li, T., Wei, H., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12448 · Cited by 175 · see citing works

Thirty four years since the discovery of gastrointestinal melatonin.

Bubenik, G. A. (2008) · PubMed · Cited by 175 · see citing works

Localization, Physiological Significance and Possible Clinical Implication of Gastrointestinal Melatonin

Bubenik, G. A. (2001) · Neurosignals · doi:10.1159/000046903 · Cited by 161 · see citing works

Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights

Ye, P., Xi, Y., Huang, Z., & Xu, P. (2020) · Cancers · doi:10.3390/cancers12061408 · Cited by 160 · see citing works

Melatonin and its ubiquitous anticancer effects

Bhattacharya, S., Patel, K. K., Dehari, D., Agrawal, A. K., & Singh, S. K. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03617-5 · Cited by 158 · see citing works

Epidemiological Trends in Colorectal Cancer in China: An Ecological Study

Zhu, J., Tan, Z., Hollis‐Hansen, K., Zhang, Y., Yu, C., & Li, Y. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4362-4 · Cited by 157 · see citing works

Is there a role for melatonin in supportive care?

Lissoni, P. (2002) · Supportive Care in Cancer · doi:10.1007/s005200100281 · Cited by 153 · see citing works

High Fat Diet Causes Depletion of Intestinal Eosinophils Associated with Intestinal Permeability

Johnson, A. M. F., Costanzo, A. E., Gareau, M. G., Armando, A. M., Quehenberger, O., Jameson, J., & Olefsky, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122195 · Cited by 150 · see citing works

Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer

Ferdinande, L., Decaestecker, C., Verset, L., Mathieu, A., Lopez, X. M., Negulescu, A.-M., Maerken, T. V., Salmon, I. J., Cuvelier, C. A., & Demetter, P. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.513 · Cited by 148 · see citing works

Melatonin in Peripheral Nerve

Lerner, A. B., Case, J. D., Mori, W., & Wright, M. R. (1959) · Nature · doi:10.1038/1831821a0 · Cited by 146 · see citing works

Melatonin regulates lipid metabolism in porcine oocytes

Jin, J., Lee, S., Taweechaipaisankul, A., Kim, G. A., & Lee, B. C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12388 · Cited by 146 · see citing works

Immunohistological localization of melatonin in the rat digestive system

Bubenik, G. A., Brown, G. M., & Grota, L. J. (1977) · Cellular and Molecular Life Sciences · doi:10.1007/bf01946561 · Cited by 144 · see citing works

Fluorescent sterols as tools in membrane biophysics and cell biology

Wüstner, D. (2006) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2006.12.004 · Cited by 144 · see citing works

Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways

Liu, R., Fu, A., Hoffman, A. E., Zheng, T., & Zhu, Y. (2013) · BMC Cell Biology · doi:10.1186/1471-2121-14-1 · Cited by 140 · see citing works

Localization of Melatonin in the Digestive Tract of the Rat

Bubenik, G. A. (2008) · Hormone Research · doi:10.1159/000179137 · Cited by 136 · see citing works

Localization of a circadian clock in mammalian photoreceptors

Tosini, G., Davidson, A. J., Fukuhara, C., Kasamatsu, M., & Castañón‐Cervantes, O. (2007) · The FASEB Journal · doi:10.1096/fj.07-8371com · Cited by 136 · see citing works

Interplay between bile acids and the gut microbiota promotes intestinal carcinogenesis

Wang, S., Dong, W., Liu, L., Xu, M., Wang, Y., Liu, T., Zhang, Y., Wang, B., & Cao, H. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.22999 · Cited by 132 · see citing works

Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells

Hong, Y., Won, J., Lee, Y., Lee, S., Park, K., Chang, K., & Hong, Y. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12119 · Cited by 130 · see citing works

Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN

Ran, H., Zhu, Y., Deng, R., Zhang, Q., Liu, X., Feng, M., Zhong, J., Lin, S., Tong, X., & Su, Q. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0711-9 · Cited by 129 · see citing works

IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer

Koliaraki, V., Pasparakis, M., & Kollias, G. A. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150542 · Cited by 128 · see citing works

Pinealectomy Reduces Melatonin Levels in the Serum but Not in the Gastrointestinal Tract of Rats

Bubenik, G. A., & Brown, G. M. (1997) · Neurosignals · doi:10.1159/000109107 · Cited by 123 · see citing works

Melatonin and breast cancer: Evidences from preclinical and human studies

Kubatka, P., Žúbor, P., Büsselberg, D., Kwon, T. K., Adamek, M., Petrovič, D., Opatřilová, R., Gazdíková, K., Čaprnda, M., Rodrigo, L., et al. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.12.018 · Cited by 122 · see citing works

Phospholipase D2-Dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid

Tsukahara, T., Tsukahara, R., Fujiwara, Y., Yue, J., Cheng, Y., Guo, H., Bolen, A. L., Zhang, C., Balázs, L., Re, F., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.022 · Cited by 120 · see citing works

Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice

Murata, S., Yanagisawa, K., Fukunaga, K., Oda, T., Kobayashi, A., Sasaki, R., & Ohkohchi, N. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01596.x · Cited by 117 · see citing works

Impact of Melatonin on Skeletal Muscle and Exercise

Stacchiotti, A., Favero, G., & Rodella, L. F. (2020) · Cells · doi:10.3390/cells9020288 · Cited by 115 · see citing works

Cellular mechanisms involved in the melatonin inhibition of HT‐29 human colon cancer cell proliferation in culture

García‐Navarro, A., González‐Puga, C., Escames, G., López, L. C., López, A., López‐Cantarero, M., Camacho, E., Espinosa, A., Gallo, M. Á., & Acuña-Castroviejo, D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00463.x · Cited by 114 · see citing works

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

Braun, K., Oeckl, J., Westermeier, J., Li, Y., & Klingenspor, M. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.165381 · Cited by 113 · see citing works

Targeting Dietary and Microbial Tryptophan-Indole Metabolism as Therapeutic Approaches to Colon Cancer

Greathouse, K. L., & Wyatt, M. (2021) · Nutrients · doi:10.3390/nu13041189 · Cited by 111 · see citing works

SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation

Gao, Y., Nan, X., Shi, X., Mu, X., Liu, B., Zhu, H., Yao, B., Liu, X., Yang, T., Hu, Y., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5904-x · Cited by 110 · see citing works

Melatonin, Immune Function and Cancer

Srinivasan, V., Pandi-Perumal, S. R., Brzezinski, A., Bhatnagar, K. P., & Cardinali, D. P. (2011) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/187221411799015408 · Cited by 109 · see citing works

Localization of Aa-nat mRNA in the rat retina by fluorescence in situ hybridization and laser capture microdissection

Liu, C., Fukuhara, C., Wessel, J. H., Iuvone, P. M., & Tosini, G. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0822-1 · Cited by 107 · see citing works

Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis‐associated colon carcinogenesis

Trivedi, P. P., Jena, G., Tikoo, K., & Kumar, V. R. P. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22274 · Cited by 106 · see citing works

The gut microbiota at the intersection of bile acids and intestinal carcinogenesis: An old story, yet mesmerizing

Liu, T., Song, X., Khan, S., Li, Y., Guo, Z., Li, C., Wang, S., Dong, W., Liu, W., Wang, B., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32563 · Cited by 106 · see citing works

Melatonin reduces endothelin‐1 expression and secretion in colon cancer cells through the inactivation of FoxO‐1 and NF ‐ κβ

León, J., Casado, J., Ruiz, S. M. J., Zurita, M. S., González‐Puga, C., Rejón, J. D., Gila, A., de Rueda, P. M., Pavón, E. J., Reiter, R. J., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12131 · Cited by 105 · see citing works

Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure

Hong, F., Pan, S., Xu, P., Xue, T., Wang, J., Guo, Y., Li, J., Qiao, X., Li, L., & Zhai, Y. (2020) · Cells · doi:10.3390/cells9020489 · Cited by 105 · see citing works

Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition

Ou, J., Miao, H., Ma, Y., Guo, F., Deng, J., Wei, X., Zhou, J., Xie, G., Shi, H., Xue, B., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.016 · Cited by 104 · see citing works

Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms

Lissoni, P. (2007) · Pathologie Biologie · doi:10.1016/j.patbio.2006.12.025 · Cited by 102 · see citing works

Chemotherapy: induction of stress responses

Tiligada, E. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01272 · Cited by 101 · see citing works

Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning

Xiao, W., Xiong, Z., Xiong, W., Yuan, C., Xiao, H., Ruan, H., Song, Z., Wang, C., Bao, L., Cao, Q., et al. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12607 · Cited by 101 · see citing works

Melatonin induces apoptosis of colorectal cancer cells through HDAC 4 nuclear import mediated by C a MKII inactivation

Wei, J., Li, W., Zhou, L., Lu, Q., & He, W. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12226 · Cited by 100 · see citing works

Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin‐1β

Mannino, G., Caradonna, F., Cruciata, I., Lauria, A., Perrone, A. F., & Gentile, C. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12598 · Cited by 99 · see citing works

Melatonin and enterochromaffine cells

Райхлин, Н. Т., & Kvetnoy, I. M. (1976) · Acta Histochemica · doi:10.1016/s0065-1281(76)80092-x · Cited by 97 · see citing works

Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations.

Cerea, G., Vaghi, M. M., Ardizzoia, A., Villa, S., Bucovec, R., Mengo, S., Gardani, G., Tancini, G., & Lissoni, P. (2003) · PubMed · Cited by 95 · see citing works

Melatonin concentrations in serum and tissues of porcine gastrointestinal tract and their relationship to the intake and passage of food

Bubenik, G. A., Pang, S. F., Hacker, R. R., & Smith, P. S. (1996) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1996.tb00294.x · Cited by 94 · see citing works

Consequences of Essential Fatty Acids

Lands, B. (2012) · Nutrients · doi:10.3390/nu4091338 · Cited by 92 · see citing works

EXPRESSION OF CONCERN: Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPβ transcriptional activity

Alonso‐Vale, M. I. C., Peres, S. B., Vernochet, C., Farmer, S. R., & Lima, F. B. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00705.x · Cited by 92 · see citing works

In vitro effects of melatonin on cell proliferation in a colon adenocarcinoma line

Farriol, M., Venereo, Y., Orta, X., Castellanos, J. M., & Segovia‐Silvestre, T. (2000) · Journal of Applied Toxicology · doi:10.1002/(sici)1099-1263(200001/02)20:1 · Cited by 91 · see citing works

Light-at-Night-Induced Circadian Disruption, Cancer and Aging

Anisimov, V. N., Vinogradova, I. A., Панченко, А. В., Popovich, I. G., & Zabezhinski, M. A. (2013) · Current Aging Science · doi:10.2174/1874609811205030002 · Cited by 91 · see citing works

Melatonin, an inhibitory agent in breast cancer

Nooshinfar, E., Safaroghli‐Azar, A., Bashash, D., & Akbari, M. E. (2016) · Breast Cancer · doi:10.1007/s12282-016-0690-7 · Cited by 91 · see citing works

Ocular Clocks: Adapting Mechanisms for Eye Functions and Health

Felder‐Schmittbuhl, M., Buhr, E. D., Dkhissi‐Benyahya, O., Hicks, D., Peirson, S. N., Ribelayga, C., Sandu, C., Spessert, R., & Tosini, G. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24957 · Cited by 89 · see citing works

Melatonin synthesis in chicken retina: Effect of kainic acid-induced lesions on the diurnal rhythm and D2-dopamine receptor-mediated regulation of serotonin N-acetyltransferase activity

Zawilska, J. B., & Iuvone, P. M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90138-w · Cited by 87 · see citing works

Rhythmic changes in colonic motility are regulated by period genes

Hoogerwerf, W. A., Shahinian, V. B., Cornélissen, G., Franz Halberg, A., Bostwick, J., Timm, J. C., Bartell, P. A., & Cassone, V. M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00402.2009 · Cited by 87 · see citing works

Melatonin Treatment Alleviates Spinal Cord Injury-Induced Gut Dysbiosis in Mice

Jing, Y., Yang, D., Bai, F., Zhang, C., Qin, C., Li, D., Wang, L., Yang, M., Chen, Z., & Li, J. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6012 · Cited by 87 · see citing works

Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome

Simon, S. L., McWhirter, L., Diniz Behn, C., Bubar, K. M., Kaar, J. L., Pyle, L., Rahat, H., Garcia-Reyes, Y., Carreau, A.-M., Wright, K. P., et al. (2019) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2018-02385 · Cited by 87 · see citing works

Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal cancer

Baró, L., Jc, H. T., Núñez, M.-C., Jiménez-Rios, J.-A., & Gil, Á. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.328 · Cited by 86 · see citing works

Opposing associations of serum n‐3 and n‐6 polyunsaturated fatty acids with colorectal adenoma risk: An endoscopy‐based case–control study

Pot, G. K., Geelen, A., van Heijningen, E. B., Siezen, C. L. E., van Kranen, H. J., & Kampman, E. (2008) · International Journal of Cancer · doi:10.1002/ijc.23729 · Cited by 86 · see citing works

Decreased High-Density Lipoprotein Cholesterol and Increased Low-Density Cholesterol Levels in Patients with Colorectal Adenomas

Bayerdörffer, E., Mannes, G. A., Richter, W. O., Ochsenkuhn, T., Seeholzer, G., Kopcke, W., Wiebecke, B., & Paumgartner, G. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-7-199304010-00001 · Cited by 85 · see citing works

Role of melatonin on production and preservation of gametes and embryos: A brief review

Cruz, M. H. C., Leal, C. L. V., da Cruz, J. F., Tan, D., & Reiter, R. J. (2014) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2014.01.011 · Cited by 84 · see citing works

Melatonin, A Natural Programmed Cell Death Inducer in Cancer

Sánchéz‐Hidalgo, M., Guerrero, J. M., Villegas, I., Packham, G., & de la Lastra, C. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712801661013 · Cited by 82 · see citing works

Melatonin inhibits Warburg-dependent cancer by redirecting glucose oxidation to the mitochondria: a mechanistic hypothesis

Reiter, R. J., Sharma, R., Ma, Q., Rosales‐Corral, S., & Chuffa, L. G. D. A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03438-1 · Cited by 79 · see citing works

Light pollution, reproductive function and cancer risk.

Stiborová, M., Martínek, V., Schmeiser, H. H., & Frei, E. (2006) · PubMed · Cited by 77 · see citing works

The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas

Nussinov, R., Muratcioğlu, S., Tsai, C., Jang, H., Gürsoy, A., & Keskin, Ö. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0165 · Cited by 77 · see citing works

Phagocytic Activity of Cultured Retinal Pigment Epithelial Cells from Chick Embryo: Inhibition by Melatonin and Cyclic AMP, and Its Reversal by Taurine and Cyclic GMP

Ogino, N., Matsumura, M., Shirakawa, H., & Tsukahara, I. (2009) · Ophthalmic Research · doi:10.1159/000265239 · Cited by 76 · see citing works

Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice

Zhu, D., Ma, Y., Ding, S., Jiang, H., & Fang, J. Q. (2018) · BioMed Research International · doi:10.1155/2018/2607679 · Cited by 74 · see citing works

Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function

Liu, K., Yu, W., Wei, W., Zhang, X., Tian, Y., Sherif, M., Liu, X., Dong, C., Wu, W., Zhang, L., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m087619 · Cited by 74 · see citing works

Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice

Farias, T. D. S. M. D., Cruz, M. M., Sa, R. C. D. C. D., Severi, I., Perugini, J., Senzacqua, M., Cerutti, S. M., Giordano, A., Cinti, S., & Alonso-Vale, M. I. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00750 · Cited by 74 · see citing works

Mechanisms Underlying Tumor Suppressive Properties of Melatonin

Bondy, S. C., & Campbell, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082205 · Cited by 73 · see citing works

Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes

Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72 · see citing works

Melatonin and Vitamin D Interfere with the Adipogenic Fate of Adipose-Derived Stem Cells

Basoli, V., Santaniello, S., Cruciani, S., Ginesu, G. C., Cossu, M. L., Delitala, A., Serra, P. A., Ventura, C., & Maioli, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050981 · Cited by 72 · see citing works

Characteristics of fecal gut microbiota in patients with colorectal cancer at different stages and different sites

Sheng, Q., Du, H., Cheng, X., Cheng, X.-B., Tang, Y., Pan, L., Wang, Q., & Lin, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10841 · Cited by 70 · see citing works

Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases

Reiter, R. J., Sharma, R., & Rosales‐Corral, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020764 · Cited by 68 · see citing works

The emergence of melatonin in oncology: Focus on colorectal cancer

Gil‐Martín, E., Egea, J., Reiter, R. J., & Romero, A. (2019) · Medicinal Research Reviews · doi:10.1002/med.21582 · Cited by 67 · see citing works

Fatty acid synthase enhances colorectal cancer cell proliferation and metastasis via regulating AMPK/mTOR pathway

Lü, T., Sun, L., Wang, Z., Zhang, Y., He, Z., & Xu, C. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s199369 · Cited by 66 · see citing works

Possible Involvement of the Nuclear RZR/ROR-Alpha Receptor in the Antitumor Action of Melatonin on Murine Colon 38 Cancer

Winczyk, K., Pawlikowski, M., Guerrero, J. M., & Karasek, M. (2002) · Tumor Biology · doi:10.1159/000068569 · Cited by 64 · see citing works

Cholesterol metabolism and colorectal cancers

Jacobs, R. J., Voorneveld, P. W., Kodach, L. L., & Hardwick, J. C. H. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.07.010 · Cited by 64 · see citing works

Blockage of melatonin receptors impairs p53-mediated prevention of DNA damage accumulation

Santoro, R., Mori, F., Marani, M., Grasso, G., Cambria, M. A., Blandino, G., Muti, P. C., & Strano, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt025 · Cited by 62 · see citing works

Melatonin: A Molecule for Reducing Breast Cancer Risk

González-González, A., Mediavilla, M., & Sánchez‐Barceló, E. J. (2018) · Molecules · doi:10.3390/molecules23020336 · Cited by 62 · see citing works

Melatonin Inhibits Reactive Oxygen Species‐Driven Proliferation, Epithelial‐Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer

Liu, R., Wang, H.-L., Deng, M., Wen, X., Mo, Y., Chen, F., Zou, C.-L., Duan, W.-F., Li, L., & Nie, X. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3510970 · Cited by 62 · see citing works

Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract

Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M. E., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D., et al. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.260 · Cited by 60 · see citing works

The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)

Zmijewski, M. A., Sweatman, T. W., & Slominski, A. T. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.04.010 · Cited by 59 · see citing works

Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS

Zou, Z., Liu, T., Li, Y., Chen, P., Peng, X., Ma, C., Zhang, W., & Li, P. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.025 · Cited by 59 · see citing works

Melatonin promotes differentiation of 3T3‐L1 fibroblasts

González, A., Garcia, V. A., Martínez‐Campa, C., Alonso‐González, C., & Cos, S. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00911.x · Cited by 58 · see citing works

Gastrointestinal melatonin: cellular identification and biological role.

Kvetnoy, I. M., Ингель, И. Э., Kvetnaia, T. V., Nk, M., Рапопорт, С. И., Райхлин, Н. Т., Trofimov, A. V., & Yuzhakov, V. V. (2002) · PubMed · Cited by 58 · see citing works

Melatonin attenuates (‐)‐epigallocatehin‐3‐gallate‐triggered hepatotoxicity without compromising its downregulation of hepatic gluconeogenic and lipogenic genes in mice

Wang, D., Wei, Y., Wang, T., Wan, X., Yang, C. S., Reiter, R. J., & Zhang, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12281 · Cited by 57 · see citing works

Helicobacter pyloriand serum kynurenine-tryptophan ratio in patients with colorectal cancer

Engin, A. B. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i12.3636 · Cited by 57 · see citing works

Melatonin content in plasma and large intestine of patients with colorectal carcinoma before and after surgery

Vician, M., Zeman, M., Herichová, I., Juráni, M., Blazicek, P., & Matis, P. (1999) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1999.tb00612.x · Cited by 57 · see citing works

Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS/hTERT signaling and cancer-stem cell traits

Hao, J., Fan, W., Li, Y., Tang, R., Tian, C., Yang, Q., Zhu, T., Diao, C., Hu, S. C., Chen, M., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1036-z · Cited by 57 · see citing works

EXPRESSION OF CONCERN: Melatonin prevents cadmium‐induced bone damage: First evidence on an improved osteogenic/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism

Knani, L., Bartolini, D., Kechiche, S., Tortoioli, C., Murdolo, G., Moretti, M., Messaoudi, I., Reiter, R. J., & Galli, F. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12597 · Cited by 54 · see citing works

Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics

Pariente, R., Bejarano, I., Espino, J., Rodríguez, A. B., & Pariente, J. A. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3441-3 · Cited by 53 · see citing works

Melatonin and colon carcinogenesis

Anisimov, V. N., Popovich, I. G., Shtylik, A. V., Zabezhinski, M. A., Ben-Huh, H., Gurevich, P., Berman, V., Tendler, Y., & Zusman, I. (2000) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(00)80022-6 · Cited by 53 · see citing works

Effect of Lactobacillus rhamnosus hsryfm 1301 on the Gut Microbiota and Lipid Metabolism in Rats Fed a High-Fat Diet

Chen, D., Yang, Z., Chen, X., Huang, Y., Yin, B., Guo, F., Zhao, H., Huang, J., Yun, W., & Gu, R. (2015) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1409.09085 · Cited by 52 · see citing works

Plasma Melatonin Levels in Patients Suffering From Colorectal Carcinoma

Khoory, R., & Stemme, D. (1988) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1988.tb00651.x · Cited by 52 · see citing works

Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer

Winczyk, K., Pawlikowski, M., & Karasek, M. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.310213.x · Cited by 52 · see citing works

Melatonin-Induced Changes in Cytosolic Calcium Might be Responsible for Apoptosis Induction in Tumour Cells

Chovancova, B., Hudecová, S., Lencesova, L., Babula, P., Režuchová, I., Penesová, A., Grman, M., Moravčík, R., Zeman, M., & Križanová, O. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485290 · Cited by 52 · see citing works

Does the use of melatonin overcome drug resistance in cancer chemotherapy?

Asghari, M. H., Ghobadi, E., Moloudizargari, M., Fallah, M., & Abdollahi, M. R. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.024 · Cited by 52 · see citing works

New Issues About Melatonin and its Effects on the Digestive System

Motilva, V., Cabeza, J., & La Lastra, C. (2001) · Current Pharmaceutical Design · doi:10.2174/1381612013397681 · Cited by 51 · see citing works

Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia

Ou, T.-H., Tung, Y., Yang, T.-H., & Chien, Y. (2019) · Nutrients · doi:10.3390/nu11040748 · Cited by 51 · see citing works

Shift work and colorectal cancer risk in the MCC-Spain case–control study

Papantoniou, K., Castaño‐Vinyals, G., Espinosa, A., Turner, M. C., Alonso, M. H., Martín, V., Aragonés, N., Pérez‐Gómez, B., Pozo, B. M., Gómez‐Acebo, I., et al. (2017) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3626 · Cited by 50 · see citing works

Melatonin promotes triacylglycerol accumulation via MT2 receptor during differentiation in bovine intramuscular preadipocytes

Yang, W., Tang, K., Wang, Y., Zhang, Y., & Zan, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-12780-y · Cited by 50 · see citing works

Intestinal microorganisms involved in colorectal cancer complicated with dyslipidosis

Han, S., Pan, Y., Xi, Y., Da, M., Wei, Q., Gao, Y., Quan, Q., & Ru, L. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1507255 · Cited by 50 · see citing works

Melatonin Decreases Glucose Metabolism in Prostate Cancer Cells: A 13C Stable Isotope-Resolved Metabolomic Study

Hevia, D., González‐Menéndez, P., Fernandez-Fernandez, M., Cueto, S., Rodríguez‐González, P., Alonso, J. I. G., Mayo, J. C., & Sainz, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081620 · Cited by 49 · see citing works

Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways

Chen, W., An, P., Quan, X., Zhang, J., Zhou, Z., Zou, L.-P., & Luo, H. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i33.6111 · Cited by 48 · see citing works

Involvement of adiponectin in early stage of colorectal carcinogenesis

Tae, C. H., Kim, S., Jung, S.-A., Joo, Y.-H., Shim, K., Jung, H., Kim, T. H., Cho, M.-S., Kim, K. H., & Kim, J. S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-811 · Cited by 47 · see citing works

Germ-Free Status and Colon Tumor Induction by N-Methyl-N'-Nitro-N-Nitrosoguanidine

Weisburger, J. H., Reddy, B. S., Narisawa, T., & Wynder, E. L. (1975) · Experimental Biology and Medicine · doi:10.3181/00379727-148-38700 · Cited by 47 · see citing works

Diabetes induces changes in melatonin concentrations in peripheral tissues of rat.

Stebelová, K., Herichová, I., & Zeman, M. (2007) · PubMed · Cited by 46 · see citing works

Colorectal cancer: role of commensal bacteria and bystander effects

Wang, X., & Huycke, M. M. (2015) · Gut Microbes · doi:10.1080/19490976.2015.1103426 · Cited by 46 · see citing works

Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades

Park, J., Yoon, J., & Park, B. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.010 · Cited by 46 · see citing works

Effects of ghrelin, leptin and melatonin on the levels of reactive oxygen species, antioxidant enzyme activity and viability of the HCT 116 human colorectal carcinoma cell line

Bułdak, R. J., Pilc, K., Bułdak, Ł., WITKOWSKA, D., Kukla, M., Polaniak, R., & Żwirska-Korczala, K. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3599 · Cited by 44 · see citing works

Deletion of intestinal epithelial insulin receptor attenuates high-fat diet-induced elevations in cholesterol and stem, enteroendocrine, and Paneth cell mRNAs

Andres, S. F., Santoro, M. A., Mah, A. T., Keku, J., Bortvedt, A., Blue, R. E., & Lund, P. K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00287.2014 · Cited by 44 · see citing works

Melatonin and 2[125I]Iodomelatonin binding sites in the human colon

Poonl, A. M. S., Mak, A. S. Y., & Luk, H. T. (1996) · Endocrine Research · doi:10.3109/07435809609030499 · Cited by 44 · see citing works

Screening for enterotoxigenic Bacteroides fragilis in stool samples

Keenan, J. I., Aitchison, A., Purcell, R. V., Greenlees, R., Pearson, J. F., & Frizelle, F. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.004 · Cited by 43 · see citing works

Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo

Wang, Q., Sun, Z., Du, L., Xu, C., Wang, Y., Yang, B., He, N., Wang, J., Ji, K., Liu, Y., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123974 · Cited by 43 · see citing works

Influence of melatonin on cell proliferation, antioxidative enzyme activities and lipid peroxidation in 3T3-L1 preadipocytes--an in vitro study.

Żwirska-Korczala, K., Jochem, J., Adamczyk-Sowa, M. H., Sowa, P., Polaniak, R., Birkner, E., Latocha, M. T., Pilc, K., & Suchanek-Raif, R. (2005) · PubMed · Cited by 42 · see citing works

Melatonin inhibits colon cancer RKO cell migration by downregulating Rho-associated protein kinase expression via the p38/MAPK signaling pathway

Liu, Z., Zou, D., Yang, X., Xue, X., Zuo, L., Zhou, Q., Hu, R., & Wang, Y. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7836 · Cited by 42 · see citing works

The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer

Abadi, S. H. M. H., Shirazi, A., Alizadeh, A. M., Changizi, V., Najafi, M., Khalighfard, S., & Nosrati, H. (2018) · Current Molecular Pharmacology · doi:10.2174/1874467211666180830150154 · Cited by 42 · see citing works

Spatial exploration is required for the formation of contextual fear memory.

McHugh, T. J., & Tonegawa, S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.335 · Cited by 39 · see citing works

Decreased expression of the melatonin receptor 1 in human colorectal adenocarcinomas.

Nemeth, C., Humpeler, S., Kállay, E., Mesteri, I., Svoboda, M., Rögelsperger, O., Klammer, N., Thalhammer, T., & Ekmekçioğlu, C. (2011) · PubMed · Cited by 38 · see citing works

Simultaneous measurement of serotonin and melatonin from the intestine of old mice: the effects of daily melatonin supplementation

Bertrand, P. P., Bertrand, R. L., Camello, P. J., & Pozo, M. J. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00760.x · Cited by 38 · see citing works

Clinical Study of Melatonin in Untreatable Advanced Cancer Patients

Lissoni, P., Barni, S., Tancini, G., Crispino, S., Paolorossi, F., Lucini, V., Mariani, M., Cattaneo, G., Esposti, D., Esposti, G., et al. (1987) · Tumori Journal · doi:10.1177/030089168707300508 · Cited by 37 · see citing works

Short photoperiod reverses obesity in Siberian hamsters via sympathetically induced lipolysis and Browning in adipose tissue

Ryu, V., Zarebidaki, E., Albers, H. E., Xue, B., & Bartness, T. J. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.07.011 · Cited by 36 · see citing works

Melatonin Promotes Apoptosis of Colorectal Cancer Cells via Superoxide-mediated ER Stress by Inhibiting Cellular Prion Protein Expression

Yun, C. W., Kim, S., Lee, J. H., & Lee, S. H. (2018) · Anticancer Research · doi:10.21873/anticanres.12681 · Cited by 36 · see citing works

Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

Ji, G., Zhou, W., Li, X., Du, J., Li, X., & Hao, H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11826 · Cited by 36 · see citing works

Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK

Zou, D., Wei, X., Hu, R., Yang, X., Zuo, L., Zhang, S., Zhu, H., Zhou, Q., Gui, S., & Wang, Y. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.14.5835 · Cited by 34 · see citing works

The melatonin action on stromal stem cells within pericryptal area in colon cancer model under constant light

Kannen, V., Marini, T., Zanette, D. L., Frajácomo, F. T. T., Silva, G. E. B., Silva, W. A., & Garcia, S. B. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.074 · Cited by 34 · see citing works

Biological effects of melatonin on human adipose‑derived mesenchymal stem cells

Heo, J., Pyo, S. S., Lim, J., Yoon, D. W., Kim, B. H., Kim, J., Kim, G., Lee, S., & Kim, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4356 · Cited by 34 · see citing works

Mechanisms of Melatonin in Obesity: A Review

Guan, Q., Wang, Z., Cao, J., Dong, Y., & Chen, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010218 · Cited by 142 · see citing works

The role of gut microbiota in intestinal disease: from an oxidative stress perspective

Sun, Y., Wang, X., Li, L., Zhong, C., Zhang, Y., Yang, X., Li, M., & Yang, C. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1328324 · Cited by 130 · see citing works

Hydrogel beads based on carboxymethyl cassava starch/alginate enriched with MgFe2O4 nanoparticles for controlling drug release

Fang, K., Zhang, Y., Yin, J., Yang, T., Li, K., Li, W., Li, J., & He, W. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.081 · Cited by 46 · see citing works

Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPARγ-driven lipid biosynthesis via regulating lipidome metabolic reprogramming

Shan, J., Li, X., Sun, R., Yao, Y., Sun, Y., Kuang, Q., Dai, X., & Sun, Y. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03154-0 · Cited by 37 · see citing works

Lipid Metabolism Interplay in CRC—An Update

Krauß, D., Fari, O., & Sibilia, M. C. (2022) · Metabolites · doi:10.3390/metabo12030213 · Cited by 36 · see citing works

Identification of IMPA2 as the hub gene associated with colorectal cancer and liver metastasis by integrated bioinformatics analysis

Wang, L., Liu, D., Liu, S., Liao, T., Jiao, Y., Jiang, X., Wang, Y., Chen, Y., Ma, H., & Cai, H. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101435 · Cited by 24 · see citing works

Tumor-associated macrophages facilitate oral squamous cell carcinomas migration and invasion by MIF/NLRP3/IL-1β circuit: A crosstalk interrupted by melatonin

Wang, L., Wang, C., Tao, Z.-Y., Zhu, W., Su, Y., & Choi, W. S. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166695 · Cited by 18 · see citing works

The mechanisms and roles of melatonin in gastrointestinal cancer

Gong, Y., Hou, F., Xiang, C., Li, C., Hu, G., & Chen, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1066698 · Cited by 18 · see citing works

Mechanism of Action of Melatonin as a Potential Adjuvant Therapy in Inflammatory Bowel Disease and Colorectal Cancer

Jurjus, A. R., Masri, J. E., Ghazi, M., Ayoubi, L. M. E., Soueid, L., Geagea, A. G., & Jurjus, R. A. (2024) · Nutrients · doi:10.3390/nu16081236 · Cited by 16 · see citing works

Association between sleep disturbance and metabolic dysfunctions in adipose tissue: Insights into melatonin's role

Ratwani, M., Bisht, S., & Prakash, S. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151978 · Cited by 20 · see citing works

Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma

Yao, H., Liu, P., Yao, L., & Li, X. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03374-6 · Cited by 15 · see citing works

The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs

Ostróżka-Cieślik, A. (2022) · Polymers · doi:10.3390/polym14163307 · Cited by 14 · see citing works

Melatonin and cisplatin co-treatment against cancer: A mechanistic review of their synergistic effects and melatonin’s protective actions

Rafiyan, M., Davoodvandi, A., Reiter, R. J., Mansournia, M. A., Manesh, S. M. R., Arabshahi, V., & Asemi, Z. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155031 · Cited by 9 · see citing works

Developmental and Early Life Origins of Hypertension: Preventive Aspects of Melatonin

Tain, Y., & Hsu, C. (2022) · Antioxidants · doi:10.3390/antiox11050924 · Cited by 9 · see citing works

Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

Kang, H., Huang, D., Jing, J., Zhang, W., Zhang, L., Wang, J., Liu, Z., Lin, H., Wang, Z., Zhang, L., et al. (2024) · Nano Research · doi:10.1007/s12274-024-6610-9 · Cited by 8 · see citing works

Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer

Bonilla-Vidal, L., Świtalska, M., Espina, M., Wietrzyk, J., García, M. L., Souto, E. B., Gliszczyńska, A., & Sánchez‐López, E. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.113573 · Cited by 6 · see citing works

Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts

Drobnik, M., Tomaszewska, A., Ryzko, J., Kędzia, A., Gałdyszyńska, M., Piera, L., Rydel, J., Szymański, J., & Drobnik, J. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00490-4 · Cited by 4 · see citing works

Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial

Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works

Melatonin Inhibiting Neuronal Cells Ferroptosis Through Lipid Metabolic Reprogramming

Wang, H., Gong, F., Zhao, W., Huang, Y., Zhou, C., & Wang, J. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05035-9 · Cited by 3 · see citing works

Ameliorating effects of melatonin on high-fat diet induced non-alcoholic fatty liver diseases and their associated pathologies: A comprehensive review

Ghosh, S., Khatoon, R., Sarkar, S., & Bandyopadhyay, D. (2023) · Melatonin Research · doi:10.32794/mr112500138 · Cited by 3 · see citing works

Diffusion Idiopathic Skeletal Hyperostosis (DISH), a Link between Gut Microbiota and Spinal Degenerative DiseasesPreprint

Ibrahim, I., Ayariga, J. A., Xu, J., Boakai, R. K., & Ajayi, O. S. (2023) · Preprints.org · doi:10.20944/preprints202310.1337.v1 · Cited by 3 · see citing works

Circadian disruption in colorectal cancer: Promise of chronotherapy as precision medicine

Paul, R., & Roychowdhury, A. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153923 · Cited by 2 · see citing works

The double burden of malnutrition and environmental enteric dysfunction as potential factors affecting gut-derived melatonin in children under adverse environments

Bezerra, A. N., Peixoto, C. L., Lopes, S. C., de Bruin, V. M. S., de Bruin, P. F. C., & Oriá, R. B. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1217173 · Cited by 2 · see citing works

Associations between sleep traits and colorectal cancer: a mendelian randomization analysis

Meng, X., Fan, E., Lv, D., Yang, Y., & Liu, S. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1416243 · Cited by 1 · see citing works

Melatonin’s anti-inflammatory and antioxidant effects in gallstone disease: A narrative review

Mirza, U. B., Sarfaraz, I., Kiran, Z., Sohail, D., Khan, R., Raza, A. A., & Samadi, A. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i9.110964 · Cited by 1 · see citing works

Repurposing melatonin for its potential roles in gastrointestinal cancers: highlighting the molecular mechanisms

Yousefipour, K., Rohani, S. S. R., Hosseini, S. M. M., Kafilzadeh, K., Alavi, N. S., & Firouzabadi, N. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04351-x · Cited by 1 · see citing works

Investigating the Development of Colorectal Cancer Based on Spatial Transcriptomics

Qi, Z., Gu, G., Huang, H., Lyu, B., Liu, Y., Wang, W., Zha, X., & Liu, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189256 · Cited by 1 · see citing works

Pineal gland

Jones, J., Gaillard, F., & Sciacca, F. (2009) · Radiopaedia.org · doi:10.53347/rid-5831

Melatonin as a promising factor in correction of the intestinal microbiome in inflammatory bowel diseases

Осиков, М. В., Grechishkin, M. V., Shishkova, Y. S., & Ilyinykh, M. A. (2023) · Вестник Пермского университета. Серия: Биология · doi:10.17072/1994-9952-2023-3-287-296

COVID-19, Long COVID, and Gastrointestinal Neoplasms: Exploring the Impact of Gut Microbiota and Oncogenic Interactions

do Rêgo, A. C. M., & Araújo-Filho, I. (2024) · Archives of Cancer Science and Therapy · doi:10.29328/journal.acst.1001045

Visual trends and hot research on the relationship between circadian rhythm and gut microbiota: a bibliometric analysis

Tang, W., Tan, Q., Cui, J., & Xiao, Z. (2025) · Biological Rhythm Research · doi:10.1080/09291016.2025.2480145

Identifying potential mechanisms of circadian rhythm-related gene marker prognosis, immune infiltration, and melatonin intervention in thyroid cancer based on bioinformatics and network pharmacology

Shi, D., Liu, J., Chen, Q., Chen, L., Yang, M., Yang, W., Li, C., & Cui, G. (2025) · Medicine · doi:10.1097/md.0000000000045486

Additional file 1 of Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma

Yao, H., Liu, P., Yao, L., & Li, X. (2024) · Figshare · doi:10.6084/m9.figshare.25910044

Multidimensional exploration of the relationship between gut microbiota and colorectal cancer: focus on clinical tumorigenesis and treatment

Zhang, H., Zhang, K., Liu, J., & Luo, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1807247

An epithelial cell fate-driven predictive model for liver metastasis risk in primary colorectal cancer through single-cell and multi-omics integration

Yin, M., Bo, X., Li, Y., Yu, S., Lin, Z., Wang, M., Wu, J., Zhou, M., Kong, L., Zhu, Y., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08375-9

Lipid metabolic reprogramming in colorectal cancer: A central hub integrating diet, microenvironment, and therapy resistance

宗小亚, Zu, W.-B., & Tang, D. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105600

Diffuse Idiopathic Skeletal Hyperostosis (DISH): Potential Links Between Gut Microbiota and Spinal Degenerative Diseases

Ibrahim, I., Lawrence, K., Forte, O. A., Huitt, L., Naidu, N. C., Ajibola, N., Xu, J., Boakai, R. K., Akabanda, F., Owusu‐Kwarteng, J., et al. (2026) · Nutrients · doi:10.3390/nu18193168

Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms

Shafabakhsh, R., Reiter, R. J., Davoodabadi, A., & Asemi, Z. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28833 · Cited by 10 · see citing works

Therapeutic Opportunities in Colorectal Cancer: Focus on Melatonin Antioncogenic Action

Wu, H., Liu, J., Yin, Y., Zhang, D., Xia, P., & Zhu, G. (2019) · BioMed Research International · doi:10.1155/2019/9740568 · Cited by 28 · see citing works

Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

Ji, G., Zhou, W., Li, X., Du, J., Li, X., & Hao, H. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11826 · Cited by 36 · see citing works

The emergence of melatonin in oncology: Focus on colorectal cancer

Gil‐Martín, E., Egea, J., Reiter, R. J., & Romero, A. (2019) · Medicinal Research Reviews · doi:10.1002/med.21582 · Cited by 67 · see citing works

Melatonin: An important anticancer agent in colorectal cancer

Mirza‐Aghazadeh‐Attari, M., Mohammadzadeh, A., Mostavafi, S., Mihanfar, A., Darband, S. G., Sadighparvar, S., Gholamzadeh, S., Majidinia, M., & Yousefi, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29049 · Cited by 37 · see citing works