Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity
Open accessAbstract
Obesity and its medical complications represent a significant problem throughout the world. In recent decades, mechanisms underlying the progression of obesity have been intensively examined. The involvement of both the behavioral aspects, such as calorie‐rich diet, low physical activity and sleep deprivation, and the intrinsic factors, including adipose tissue deregulation, chronic inflammation, oxidative stress, and chronodisruption, has been identified. The circadian disturbances of the adipose tissue endocrine function have been correlated with obesity. Leptin and adiponectin are adipokines strongly associated with glucose and lipid metabolism and with energy balance. Their synthesis and secretion display circadian rhythms that are disturbed in the obese state. Hyperleptinemia resulting in leptin resistance, and hypo‐adiponectinemia have been linked to the pathophysiology of the obesity‐related disorders. A deficiency of melatonin, one of the consequences of sleep deprivation, has also been demonstrated to correlate with obesity. Melatonin is a pineal secretory product involved in numerous actions, such as regulation of internal biological clocks and energy metabolism, and it functions as an antioxidant and as an anti‐inflammatory agent. There exists a substantial amount of evidence supporting the beneficial effects of melatonin supplementation on obesity and its complications. In the current review, the results of studies related to the interactions between melatonin, and both leptin and adiponectin are discussed. Despite the existence of some inconsistencies, melatonin has been found to normalize the expression and secretion patterns of both adipokines. These results support the concept of melatonin as a potential therapeutic agent for obesity and related disorders.
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White adipose tissue (WAT) as a critical endocrine organ discharges bioactive molecules including adipokines that regulate lipid metabolism, energy balance, insulin sensitivity, angiogenesis immunity, and inflammation.
“White adipose tissue (WAT) as a critical endocrine organ discharges bioactive molecules including the adipokines regulate lipid metabolism, energy balance, insulin sensitivity, angiogenesis immunity, and inflammation. 7,8”
Adiponectin is a hormone secreted from subcutaneous and visceral WAT depots involved in regulation of lipid and glucose metabolism, ameliorates insulin sensitivity, modulates appetite and energy expenditure, and demonstrates anti-inflammatory and antiproliferative functions.
“Adiponectin a hormone that is secreted from subcutaneous and visceral WAT depots involved in the regulation of lipid and glucose metabolism, ameliorates insulin sensitivity, modulates appetite and energy expenditure, and demonstrates anti-inflammatory and antiproliferative functions. 8”
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“8 Our results also showed the beneficial effects of 6 g/d of melatonin for 40 days on adiponectin levels without any significant changes in leptin after adjustment for potential confounders.”
- Authors
- Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J.
- Affiliations
- Nicolaus Copernicus University (PL)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Szewczyk‐Golec, Karolina
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2015-07-14
- Volume
- 59
- Issue
- 3
- Pages
- 277-291
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W1614284823
- Cited by
- 153
- References
- 24
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 15 · 2023: 6 · 2022: 13 · 2021: 20 · 2020: 11 · 2019: 21 · 2018: 18 · 2017: 16 · 2016: 15 · 2015: 2
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, melatonin, leptin, adiponectin, adipokines, circadian rhythm, circadian rhythm disruption, leptin resistance, hyperleptinemia, sleep deprivation, melatonin supplementation, adipose tissue endocrine function, energy metabolism
- MeSH terms
- Animals, Humans, Melatonin, Obesity, Leptin, Adiponectin, Adipose Tissue, White, Adipokines
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