Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain
Open accessAbstract
The intrauterine period is a critical time wherein developmental exposure can influence risk for chronic disease including childhood obesity. Using umbilical cord-derived mesenchymal stem cells (uMSC) from offspring born to normal-weight and obese mothers, we tested the hypothesis that changes in infant body composition over the first 5 months of life correspond with differences in cellular metabolism and transcriptomic profiles at birth. Higher long-chain acylcarnitine concentrations, lipid transport gene expression, and indicators of oxidative stress in uMSC-adipocytes were related to higher adiposity at 5 months of age. In uMSC-myocytes, lower amino acid concentrations and global differential gene expression for myocyte growth, amino acid biosynthesis, and oxidative stress were related to lower infant percent fat-free mass at 5 months of age, particularly in offspring of obese mothers. This is the first evidence of human infant adipocyte- or myocyte-related alterations in cellular metabolic pathways that correspond with increased adiposity and lower fat-free mass in early infancy. These pathways might reflect the effects of an adverse maternal metabolic environment on the fetal metabolome and genome. Our findings suggest that programmed differences in infant stem cell metabolism correspond with differences in body composition in early life, a known contributor to obesity risk.
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There is a positive correlation between the preference of mesenchymal stem cell fate decisions towards the adipocyte lineage and infant adiposity.
“Previous work has shown there is a positive correlation between the preference of mesenchymal stem cell fate decisions towards the adipocyte lineage and infant adiposity [88, 146].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [146]
The Results section links higher infant adiposity at five months with altered lipid transport and metabolism in uMSC-derived adipocytes. But the Methods section says the cells were exposed to adipocyte or myocyte differentiation media; the paper does not show that the stem cells preferentially chose the adipocyte lineage. The claimed correlation with lineage fate decisions is therefore unsupported. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHigher adiposity in infants of obese mothers is linked to increased lipid species content and lipid transport gene expression in differentiated adipocytes and elevated oxidative stress, lower amino acid concentrations, and expression of growth-promoting genes in their differentiated neonatal myocytes.
“Higher adiposity in infants of obese mothers was also linked to increased lipid species content and lipid transport gene expression in differentiated adipocytes and elevated oxidative stress, lower amino acid concentrations and expression of growth-promoting genes in their differentiated neonatal myocytes [146].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [146]
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Cites
STRING v10: protein–protein interaction networks, integrated over the tree of life
Szklarczyk, D., Franceschini, A., Wyder, S., Forslund, K., Heller, D., Huerta-Cepas, J., Simonovic, M., Roth, A., Santos, A., Tsafou, K. P., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1003 · Cited by 10,436 · see citing works
More powerful procedures for multiple significance testing
Hochberg, Y., & Benjamini, Y. (1990) · Statistics in Medicine · doi:10.1002/sim.4780090710 · Cited by 2,715 · see citing works
Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37048 · Cited by 1,253 · see citing works
Soga, T., Baran, R., Suematsu, M., Ueno, Y., Ikeda, S., Sakurakawa, T., Kakazu, Y., Ishikawa, T., Robert, M., Nishioka, T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601876200 · Cited by 740 · see citing works
Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
McCurdy, C. E., Bishop, J. M., Williams, S., Grayson, B. E., Smith, M. S., Friedman, J. E., & Grove, K. L. (2009) · Journal of Clinical Investigation · doi:10.1172/jci32661 · Cited by 599 · see citing works
Self-citationAdams, S. H., Hoppel, C. L., Lok, K. H., Zhao, L., Wong, S. W., Minkler, P. E., Hwang, D. H., Newman, J. W., & Garvey, W. T. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103754 · Cited by 598 · see citing works
Increased fetal adiposity: a very sensitive marker of abnormal in utero development
Catalano, P. M., Thomas, A., Huston-Presley, L., & Amini, S. B. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(03)00828-7 · Cited by 519 · see citing works
Increased neonatal fat mass, not lean body mass, is associated with maternal obesity
Sewell, M. F., Huston-Presley, L., Super, D. M., & Catalano, P. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.014 · Cited by 429 · see citing works
Acylcarnitines—old actors auditioning for new roles in metabolic physiology
McCoin, C. S., Knotts, T. A., & Adams, S. H. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.129 · Cited by 356 · see citing works
Starling, A. P., Brinton, J. T., Glueck, D. H., Shapiro, A. L. B., Harrod, C. S., Lynch, A. M., Siega‐Riz, A. M., & Dabelea, D. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.094946 · Cited by 271 · see citing works
Self-citationLaboratory Guide to the Methods in Biochemical Genetics
Blau, N., Duran, M., & Gibson, M. K. (2008) · Springer eBooks · doi:10.1007/978-3-540-76698-8 · Cited by 245 · see citing works
Acylcarnitines: potential implications for skeletal muscle insulin resistance
Aguer, C., McCoin, C. S., Knotts, T. A., Thrush, A. B., Ono‐Moore, K. D., McPherson, R., Dent, R., Hwang, D. H., Adams, S. H., & Harper, M. (2014) · The FASEB Journal · doi:10.1096/fj.14-255901 · Cited by 243 · see citing works
Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study
Shapiro, A. L. B., Kaar, J. L., Crume, T., Starling, A. P., Siega‐Riz, A. M., Ringham, B. M., Glueck, D. H., Norris, J. M., Barbour, L. A., Friedman, J. E., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.79 · Cited by 172 · see citing works
Self-citationChildhood Obesity Is Associated with Changes in the Serum Metabolite Profile
Wahl, S., Yu, Z., Kleber, M., Singmann, P., Holzapfel, C., He, Y., Mittelstraß, K., Polonikov, A., Prehn, C. P., Römisch‐Margl, W., et al. (2012) · Obesity Facts · doi:10.1159/000343204 · Cited by 169 · see citing works
Pastore, A., Alisi, A., Giovamberardino, G. D., Crudele, A., Ceccarelli, S., Panera, N., Dionisi‐Vici, C., & Nobili, V. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151121202 · Cited by 122 · see citing works
Yan, X., Huang, Y., Zhao, J.-X., Long, N., Uthlaut, A. B., Zhu, M.-J., Ford, S. P., Nathanielsz, P. W., & Du, . (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.089649 · Cited by 115 · see citing works
Boyle, K. E., Patinkin, Z. W., Shapiro, A. L. B., Baker, P. R., Dabelea, D., & Friedman, J. E. (2016) · Diabetes · doi:10.2337/db15-0849 · Cited by 115 · see citing works
Self-citation2-Aminobutyric acid modulates glutathione homeostasis in the myocardium
Irino, Y., Toh, R., Nagao, M., Mori, T., Honjo, T., Shinohara, M., Tsuda, S., Nakajima, H., Satomi‐Kobayashi, S., Shinke, T., et al. (2016) · Scientific Reports · doi:10.1038/srep36749 · Cited by 110 · see citing works
Thorn, S. R., Baquero, K. C., Newsom, S., Kasmi, K. E., Bergman, B., Shulman, G., Grove, K., & Friedman, J. (2014) · Diabetes · doi:10.2337/db14-0276 · Cited by 109 · see citing works
Self-citationMaternal BMI and Glycemia Impact the Fetal Metabolome
Lowe, W. L., Bain, J. R., Nodzenski, M., Reisetter, A. C., Muehlbauer, M. J., Stevens, R. D., Ilkayeva, O., Lowe, L. P., Metzger, B. E., Newgard, C. B., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2452 · Cited by 109 · see citing works
Role of FATP in parenchymal cell fatty acid uptake
Pohl, J., Ring, A., Hermann, T., & Stremmel, W. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2004.06.004 · Cited by 109 · see citing works
Elshorbagy, A. K., Valdivia‐Garcia, M., Refsum, H., & Butte, N. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044166 · Cited by 101 · see citing works
Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans
Binnert, C., Koistinen, H. A., Martin, G., Andreelli, F., Ebeling, P., Koivisto, V. A., Laville, M., Auwerx, J., & Vidal, H. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1072 · Cited by 97 · see citing works
Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors
Rodriguez, M. A. D. L. R., & Kersten, S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.007 · Cited by 94 · see citing works
Bell, J. A., Reed, M. A., Consitt, L. A., Martin, O. J., Haynie, K. R., Hulver, M. W., Muoio, D. M., & Dohm, G. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1596 · Cited by 87 · see citing works
Systematic review of ophthalmate as a novel biomarker of hepatic glutathione depletion
Dello, S. A. W. G., Neis, E. P. J. G., Jong, M. C. D., van Eijk, H. M. H., Kicken, C. H., Damink, S. W. M. O., & Dejong, C. H. C. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.10.008 · Cited by 84 · see citing works
Hivert, M., Rifas‐Shiman, S. L., Gillman, M. W., & Oken, E. (2016) · Obesity · doi:10.1002/oby.21511 · Cited by 79 · see citing works
Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques
McCurdy, C. E., Schenk, S., Hetrick, B., Houck, J. A., Drew, B. G., Kaye, S., Lashbrook, M., Bergman, B. C., Takahashi, D. L., Dean, T. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86612 · Cited by 76 · see citing works
Self-citationLongitudinal changes in infant body composition: association with childhood obesity
Koontz, M. B., Gunzler, D. D., Presley, L. H., & Catalano, P. M. (2014) · Pediatric Obesity · doi:10.1111/ijpo.253 · Cited by 75 · see citing works
Boyle, K. E., Patinkin, Z. W., Shapiro, A. L. B., Bader, C., Vanderlinden, L. A., Kechris, K. J., Janssen, R. C., Ford, R. J., Smith, B. K., Steinberg, G. R., et al. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.012 · Cited by 74 · see citing works
Self-citationDíaz‐Ruiz, A., Guzmán‐Ruiz, R., Moreno‐Castellanos, N., García‐Ríos, A., Delgado‐Casado, N., Membrives, A., Túnez, I., Bekay, R. E., Fernández‐Real, J. M., Tovar, S. A., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5939 · Cited by 73 · see citing works
McCoin, C. S., Knotts, T. A., Ono‐Moore, K. D., Oort, P. J., & Adams, S. H. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00602.2014 · Cited by 71 · see citing works
Fat Storage-inducing Transmembrane Protein 2 Is Required for Normal Fat Storage in Adipose Tissue
Miranda, D. A., Kim, J.-H., Nguyen, L. N., Cheng, W., Tan, B. C., Goh, V. J., Tan, J. S. Y., Yaligar, J., KN, B. P., Velan, S. S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547687 · Cited by 71 · see citing works
Boyle, K. E., Newsom, S. A., Janssen, R. C., Lappas, M., & Friedman, J. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1943 · Cited by 70 · see citing works
Self-citationGanu, R., Harris, R. A., Collins, K., & Aagaard, K. M. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.306 · Cited by 70 · see citing works
Pereira, M. J., Skrtic, S., Katsogiannos, P., Abrahamsson, N., Sidibeh, C. O., Dahgam, S., Månsson, M., Risérus, U., Kullberg, J., & Eriksson, J. W. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.008 · Cited by 65 · see citing works
Baker, P. R., Boyle, K. E., Koves, T. R., Ilkayeva, O., Muoio, D. M., Houmard, J. A., & Friedman, J. E. (2015) · Obesity · doi:10.1002/oby.21046 · Cited by 60 · see citing works
Self-citationDevelopment of Early Adiposity in Infants of Mothers With Gestational Diabetes Mellitus
Logan, K., Emsley, R., Jeffries, S., Andrzejewska, I., Hyde, M. J., Gale, C., Chappell, K. E., Mandalia, S., Santhakumaran, S., Parkinson, J. R. C., et al. (2016) · Diabetes Care · doi:10.2337/dc16-0030 · Cited by 58 · see citing works
Kelstrup, L., Hjort, L., Houshmand‐Oeregaard, A. S., Clausen, T. D., Hansen, N. S., Broholm, C., Borch‐Johnsen, L., Mathiesen, E. R., Vaag, A. A., & Damm, P. (2016) · Diabetes · doi:10.2337/db16-0227 · Cited by 56 · see citing works
Castillo, H., Santos, I. S., & Matijasevich, A. (2015) · Maternal and Child Nutrition · doi:10.1111/mcn.12186 · Cited by 52 · see citing works
Howe, L. D., Chaturvedi, N., Lawlor, D. A., Ferreira, D. L. S., Fraser, A., Smith, G. D., Tilling, K. M., & Hughes, A. D. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000269 · Cited by 49 · see citing works
Predictors of Infant Body Composition at 5 Months of Age: The Healthy Start Study
Sauder, K. A., Kaar, J. L., Starling, A. P., Ringham, B. M., Glueck, D. H., & Dabelea, D. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.014 · Cited by 49 · see citing works
Self-citationBaker, P. R., Patinkin, Z. W., Shapiro, A. L. B., de la Houssaye, B. A., Woontner, M., Boyle, K. E., Vanderlinden, L. A., Dabelea, D., & Friedman, J. E. (2017) · JCI Insight · doi:10.1172/jci.insight.94200 · Cited by 46 · see citing works
Self-citationDesmarchelier, C., Martin, J., Planells, R., Gastaldi, M., Nowicki, M., Goncalves, A., Valéro, R., Lairon, D., & Borel, P. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3962 · Cited by 44 · see citing works
Perng, W., Ringham, B., Glueck, D., Sauder, K. A., Starling, A., Belfort, M., & Dabelea, D. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.149617 · Cited by 33 · see citing works
Self-citationda Silva, N. P., de Souza, F. I. S., Pendezza, A. I., Fonseca, F. L. A., Hix, S., de Oliveira, A. C., Sarni, R. O. S., & D’Almeida, V. (2012) · Nutrition · doi:10.1016/j.nut.2012.05.015 · Cited by 31 · see citing works
Thrush, A. B., Zhang, R., Chen, W., Seifert, E. L., Quizi, J., McPherson, R., Dent, R., & Harper, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1726 · Cited by 24 · see citing works
Cheng, G., Bolzenius, K., Joslowski, G., Günther, A. L. B., Kroke, A., Heinrich, J., & Buyken, A. E. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.131 · Cited by 22 · see citing works
Gong, Y.-Y., Liu, Y.-Y., Li, J., Su, L., Yu, S., Zhu, X.-N., Cao, X.-P., & Xiao, H.-P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113784 · Cited by 20 · see citing works
Defect in α-ketobutyrate metabolism: a new inborn error
Yang, W., & Roth, K. S. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90284-0 · Cited by 18 · see citing works
Nanri, H., Shirasawa, T., Ochiai, H., Nomoto, S., Hoshino, H., & Kokaze, A. (2017) · Child Care Health and Development · doi:10.1111/cch.12455 · Cited by 17 · see citing works
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Perng, W., Oken, E., & Dabelea, D. (2019) · Diabetologia · doi:10.1007/s00125-019-4914-1 · Cited by 111 · see citing works
Self-citationFriedman, J. E. (2018) · Diabetes · doi:10.2337/dbi17-0011 · Cited by 106 · see citing works
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Gyllenhammer, L. E., Entringer, S., Buß, C., & Wadhwa, P. D. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2713 · Cited by 72 · see citing works
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Baker, P. R., & Friedman, J. E. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120846 · Cited by 61 · see citing works
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Rodgers, A., & Sferruzzi-Perri, A. N. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00790-w · Cited by 57 · see citing works
Barbour, L. A. (2019) · Diabetes Care · doi:10.2337/dci18-0048 · Cited by 57 · see citing works
MASLD in children: integrating epidemiological trends with mechanistic and translational advances.
Schwimmer, J., Biddinger, S. B., & Ibrahim, S. H. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186422 · Cited by 41 · see citing works
Wesolowski, S. R., Mulligan, C., Janssen, R., Baker, P. R., Bergman, B., D'Alessandro, A., Nemkov, T., Maclean, K., Jiang, H., Dean, T., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.09.008 · Cited by 45 · see citing works
Self-citationType 2 Diabetes in Youth: the Role of Early Life Exposures
Rughani, A., Friedman, J. E., & Tryggestad, J. B. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01328-6 · Cited by 40 · see citing works
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ISGANAITIS, E. M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1170-1 · Cited by 36 · see citing works
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Jevtovic, F., Zheng, D., Houmard, J. A., Krassovskaia, P. M., Lopez, C. A., Wisseman, B., Steen, D. M., Broskey, N. T., Isler, C. M., DeVente, J., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad059 · Cited by 33 · see citing works
Mishra, S., Sevak, J. K., Das, A., Arimbasseri, G. A., Bhatnagar, S., & Gopinath, S. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-75102-9 · Cited by 32 · see citing works
Jevtovic, F., Zheng, D., Claiborne, A., Biagioni, E. M., Wisseman, B., Krassovskaia, P. M., Collier, D. N., Isler, C. M., DeVente, J., Neufer, P. D., et al. (2024) · Physiological Reports · doi:10.14814/phy2.16028 · Cited by 19 · see citing works
Wu, J., Gulati, S., Teague, A. M., Kim, Y.-S., Tryggestad, J. B., & Jiang, S. (2023) · Stem Cells and Development · doi:10.1089/scd.2022.0226 · Cited by 18 · see citing works
Jevtovic, F., Zheng, D., Houmard, J. A., Kern, K., Claiborne, A., Lopez, C. A., Broskey, N. T., Isler, C. M., DeVente, J., Newton, E. R., et al. (2023) · Obesity · doi:10.1002/oby.23829 · Cited by 17 · see citing works
Jevtovic, F., Lopez, C. A., Zheng, D., Cortright, R. N., Biagioni, E. M., Claiborne, A., Isler, C. M., DeVente, J., Houmard, J. A., May, L. E., et al. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00737.2022 · Cited by 13 · see citing works
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- Authors
- Baker, P. R., Patinkin, Z. W., Shapiro, A. L. B., de la Houssaye, B. A., Janssen, R. C., Vanderlinden, L. A., Dabelea, D., & Friedman, J. E.
- Affiliations
- University of Colorado Anschutz (US)
- Colorado School of Public Health (US)
- Corresponding author
- Baker, Peter R.
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-12-22
- Volume
- 7
- Issue
- 1
- Pages
- 18095-18095
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5741772
- OpenAlex
- W2777541288
- Cited by
- 33
- References
- 51
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- American Heart Association (14PRE18230008)
- Children's Hospital Colorado
- Georgia Clinical and Translational Science Alliance (UL1TR001082)
- National Institutes of Health (UL1TR001082)
- Nutrition Obesity Research Center, University of North Carolina (P30DK048520)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076648, R24DK090964, P30DK048520)
- National Center for Advancing Translational Sciences (TR001082)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD068372)
- Colorado Clinical and Translational Sciences Institute (UL1TR001082, TR001082)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- human umbilical cord mesenchymal stem cells, maternal obesity, infant adiposity, fat-free mass, long-chain acylcarnitines, oxidative stress, amino acid metabolism, adipocyte metabolism, fetal programming, early infancy, body composition, gene expression profiling
- MeSH terms
- Birth Weight, Cell Differentiation, Female, Gene Expression Regulation, Humans, Infant, Male, Gene Expression, Body Mass Index, Oxidative Stress, Gene Expression Profiling, Adiposity, Metabolomics, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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