Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans
Open accessAbstract
Fatty acid transporter protein (FATP)-1 mRNA expression was investigated in skeletal muscle and in subcutaneous abdominal adipose tissue of 17 healthy lean, 13 nondiabetic obese, and 16 obese type 2 diabetic subjects. In muscle, FATP-1 mRNA levels were higher in lean women than in lean men (2.2 ± 0.1 vs. 0.6 ± 0.2 amol/μg total RNA, P < 0.01). FATP-1 mRNA expression was decreased in skeletal muscle in obese women both in nondiabetic and in type 2 diabetic patients ( P < 0.02 vs. lean women in both groups), and in all women there was a negative correlation with basal FATP-1 mRNA level and body mass index ( r = −0.74, P < 0.02). In men, FATP-1 mRNA was expressed at similar levels in the three groups both in skeletal muscle (0.6 ± 0.2, 0.6 ± 0.2, and 0.8 ± 0.2 amol/μg total RNA in lean, obese, and type 2 diabetic male subjects) and in adipose tissue (0.9 ± 0.2 amol/μg total RNA in the 3 groups). Insulin infusion (3 h) reduced FATP-1 mRNA levels in muscle in lean women but not in lean men. Insulin did not affect FATP-1 mRNA expression in skeletal muscle in obese nondiabetic or in type 2 diabetic subjects nor in subcutaneous adipose tissue in any of the three groups. These data show a gender-related difference in the expression of the fatty acid transporter FATP-1 in skeletal muscle of lean individuals and suggest that changes in FATP-1 expression may not contribute to a large extent to the alterations in fatty acid uptake in obesity and/or type 2 diabetes.
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Sex differences in the effects of type 2 diabetes on gene expression have been previously reported for fatty acid transporter protein 1 in human muscle.
“In any case, sex differences in the effects of type 2 diabetes on gene expression have been previously reported for fatty acid transporter protein 1 in human muscle (44).”
From Expression of <i>Mfn2</i>, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle (2005) · cites this paper as [44]
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- Authors
- Binnert, C., Koistinen, H. A., Martin, G., Andreelli, F., Ebeling, P., Koivisto, V. A., Laville, M., Auwerx, J., & Vidal, H.
- Affiliations
- Inserm (FR)
- Helsinki University Hospital (FI)
- Institut de génétique et de biologie moléculaire et cellulaire (FR)
- Institut National de la Santé et de la Recherche Médicale Unité-449 and Centre de Recherche en Nutrition Humaine de Lyon, Faculté de Médecine R.T.H. Laënnec, F-69372 Lyon;
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2000-11-01
- Volume
- 279
- Issue
- 5
- Pages
- E1072-E1079
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W2108583870
- Cited by
- 97
- References
- 35
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 6 · 2021: 3 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 5
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- FATP1, skeletal muscle, subcutaneous adipose tissue, obesity, type 2 diabetes, sex differences, insulin, body mass index, fatty acid uptake, gene expression
- MeSH terms
- Abdomen, Adipose Tissue, Adult, Blood Glucose, Carrier Proteins, Diabetes Mellitus, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Female, Humans, Insulin, Male, Middle Aged, Obesity, RNA, Messenger, Sex Characteristics, Glucose Clamp Technique, Gene Expression, Body Mass Index, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Membrane Transport Proteins, Fatty Acid Transport Proteins
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