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Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance
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This study aimed to determine if there is an association between dysbiosis and nonalcoholic fatty liver disease (NAFLD) independent of obesity and insulin resistance (IR). This is a prospective cross-sectional study assessing the intestinal microbiome (IM) of 39 adults with biopsy-proven NAFLD (15 simple steatosis [SS]; 24 nonalcoholic steatohepatitis [NASH]) and 28 healthy controls (HC). IM composition (llumina MiSeq Platform) in NAFLD patients compared to HC were identified by two statistical methods (Metastats, Wilcoxon). Selected taxa was validated using quantitative PCR (qPCR). Metabolites in feces and serum were also analyzed. In NAFLD, 8 operational taxonomic units, 6 genera, 6 families and 2 phyla (Bacteroidetes, Firmicutes) were less abundant and; 1 genus ( Lactobacillus ) and 1 family (Lactobacillaceae) were more abundant compared to HC. Lower abundance in both NASH and SS patients compared to HC were confirmed by qPCR for Ruminococcus, Faecalibacterium prausnitzii and Coprococcus . No difference was found between NASH and SS. This lower abundance in NAFLD (NASH+SS) was independent of BMI and IR. NAFLD patients had higher concentrations of fecal propionate and isobutyric acid and serum 2-hydroxybutyrate and L-lactic acid. These findings suggest a potential role for a specific IM community and functional profile in the pathogenesis of NAFLD.
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“Furthermore, diseases linked to dyslipidemia, such as non-alcoholic liver disease and atherosclerosis, are associated with changes in gut microbiota profile.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [43]
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools
Quast, C., Pruesse, E., Yilmaz, P., Gerken, J., Schweer, T., Yarza, P., Peplies, J., & Glöckner, F. O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1219 · Cited by 33,055
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,772
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Schloss, P. D., Westcott, S. L., Ryabin, T., Hall, J. R., Hartmann, M., Hollister, E. B., Lesniewski, R. A., Oakley, B. B., Parks, D. H., Robinson, C. J., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.01541-09 · Cited by 19,549
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Research works printed but not linked: 1
- Doelle, H. W. Bacterial Metabolism. Second edn, 416–419 (Academic Press, Inc., 1975).
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Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493
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Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., et al. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0057 · Cited by 1,103
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Aron‐Wisnewsky, J., Vigliotti, C., Witjes, J. J., Le, P. T., Holleboom, A. G., Verheij, J., Nieuwdorp, M., & Clément, K. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0269-9 · Cited by 1,132
Targher, G., Byrne, C. D., & Tilg, H. (2020) · Gut · doi:10.1136/gutjnl-2020-320622 · Cited by 879
Role and Mechanism of Gut Microbiota in Human Disease
Chen, Y., Zhou, J., & Wang, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625913 · Cited by 695
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Wu, J., Wang, K., Wang, X., Pang, Y., & Jiang, C. (2020) · Protein & Cell · doi:10.1007/s13238-020-00814-7 · Cited by 592
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Geng, J., Ni, Q., Sun, W., Li, L., & Feng, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112678 · Cited by 422
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Oh, T. G., Kim, S. M., Caussy, C., Fu, T., Guo, J. P., Bassirian, S., Singh, S., Madamba, E. V., Bettencourt, R., Richards, L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.005 · Cited by 344
Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial
Yaskolka Meir, A., Rinott, E., Tsaban, G., Zelicha, H., Kaplan, A., Rosen, P., Shelef, I., Youngster, I., Shalev, A., Blüher, M., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323106 · Cited by 287
Григорьева, И. Н. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm11010013 · Cited by 293
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Zhang, S., Zhao, J., Xie, F., He, H., Johnston, L. J., Dai, X., Wu, C., & Ma, X. (2021) · Obesity Reviews · doi:10.1111/obr.13316 · Cited by 223
Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease
Sookoian, S. C., Salatino, A., Castaño, G. O., Landa, M. S., Fijalkowky, C., Garaycoechea, M. E., & Pirola, C. J. (2020) · Gut · doi:10.1136/gutjnl-2019-318811 · Cited by 207
Velázquez, K. T., Enos, R. T., Bader, J. E., Sougiannis, A. T., Carson, M. S., Chatzistamou, I., Carson, J. A., Nagarkatti, P. S., Nagarkatti, M., & Murphy, E. A. (2019) · World Journal of Hepatology · doi:10.4254/wjh.v11.i8.619 · Cited by 197
Hrncir, T., Hrncirova, L., Kverka, M., Hromádka, R., Machova, V., Trckova, E., Kostovcikova, K., Králíčková, P., Krejsek, J., & Tlaskalová‐Hogenová, H. (2021) · Microorganisms · doi:10.3390/microorganisms9050957 · Cited by 183
The role of the gut microbiome in chronic liver disease: the clinical evidence revised
Schwenger, K. J. P., Clermont‐Dejean, N. M., & Allard, J. P. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.04.004 · Cited by 179
Self-citationSharpton, S. R., Ajmera, V. H., & Loomba, R. S. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.065 · Cited by 177
Fang, W., Xue, H., Chen, X., Chen, K., & Ling, W. (2019) · Journal of Nutrition · doi:10.1093/jn/nxy324 · Cited by 168
Burra, P., Bizzaro, D., Gonta, A., Shalaby, S., Gambato, M., Morelli, M. C., Trapani, S., Floreani, A., Marra, F., Brunetto, M. R., et al. (2021) · Liver International · doi:10.1111/liv.14943 · Cited by 165
Risk assessment with gut microbiome and metabolite markers in NAFLD development
Leung, H., Long, X., Ni, Y., Qian, L., Nychas, E., Siliceo, S. L., Pohl, D., Hanhineva, K., Liu, Y., Xu, A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk0855 · Cited by 152
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Albhaisi, S. A. M., Bajaj, J. S., & Sanyal, A. J. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00118.2019 · Cited by 155
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Tanaka, N., Kimura, T., Fujimori, N., Nagaya, T., Komatsu, M., & Tanaka, E. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i2.163 · Cited by 144
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Li, F., Ye, J., Shao, C., & Zhong, B. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01440-w · Cited by 118
Choi, B. S.-Y., Daniel, N., Houde, V. P., Ouellette, A., Marcotte, B., Varin, T. V., Vors, C., Feutry, P., Ilkayeva, O., Ståhlman, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23782-w · Cited by 114
Drożdż, K., Nabrdalik, K., Hajzler, W., Kwiendacz, H., Gumprecht, J., & Lip, G. Y. H. (2021) · Nutrients · doi:10.3390/nu14010103 · Cited by 115
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Hu, W., Gao, W., Liu, Z., Fang, Z., Wang, H., Zhao, J., Zhang, H., Lu, W., & Chen, W. (2022) · Nutrients · doi:10.3390/nu14142945 · Cited by 104
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Kanda, T., Goto, T., Hirotsu, Y., Masuzaki, R., Moriyama, M., & Omata, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041525 · Cited by 97
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Jiang, W., Yu, X., Kosik, R. O., Song, Y., Qiao, T., Tong, J., Liu, S., Fan, S., Luo, Q., Chai, L., et al. (2020) · Thyroid · doi:10.1089/thy.2020.0193 · Cited by 94
Alferink, L. J. M., Radjabzadeh, D., Erler, N. S., Vojinović, D., Medina‐Gómez, C., Uitterlinden, A. G., de Knegt, R. J., Amin, N., Ikram, M. A., Janssen, H. L. A., et al. (2020) · Hepatology · doi:10.1002/hep.31417 · Cited by 87
Liang, D., Zhang, L., Chen, H., Zhang, H., Hu, H., & Dai, X. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.209 · Cited by 87
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Xie, Y., Zou, X., Han, J., Zhang, Z., Feng, Z., Ouyang, Q., Hua, S., Liu, Z., Li, C., Cai, Y., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114081 · Cited by 80
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Niederseer, D., Wernly, B., Aigner, E. S., Stickel, F., & Datz, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030467 · Cited by 87
Hodges, J. K., Sasaki, G. Y., & Bruno, R. S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108478 · Cited by 80
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Sun, R., Xu, D., Wei, Q., Zhang, B., Aa, J., Wang, G., & Xie, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109721 · Cited by 75
Hernández-Baixauli, J., Quesada‐Vázquez, S., Mariné-Casadó, R., Cardoso, K. G., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Baselga‐Escudero, L. (2020) · Nutrients · doi:10.3390/nu12030806 · Cited by 74
Su, X. B., Chen, S., Liu, J., Feng, Y., Han, E., Hao, X., Liao, M., Cai, J., Zhang, S., Niu, J., et al. (2023) · Obesity Reviews · doi:10.1111/obr.13646 · Cited by 80
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Dongiovanni, P., Paolini, E., Corsini, A., Sirtori, C. R., & Ruscica, M. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13519 · Cited by 73
Qian, M., Liu, J., Zhao, D., Cai, P., Pan, C., Jia, W., Gao, Y., Zhang, Y., Zhang, N., Zhang, Y., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.014 · Cited by 71
Jian, C., Luukkonen, P. K., Sädevirta, S., Yki‐Järvinen, H., & Salonen, A. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.05.008 · Cited by 70
Ahmed, B. A., Ong, F. J., Barra, N. G., Blondin, D. P., Gunn, E., Oreskovich, S. M., Szamosi, J. C., Syed, S. A., Hutchings, E. K., Konyer, N. B., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100397 · Cited by 70
The Role of Gut-Derived Microbial Antigens on Liver Fibrosis Initiation and Progression
Chen, D., Le, T. H., Shahidipour, H., Read, S. A., & Ahlenstiel, G. (2019) · Cells · doi:10.3390/cells8111324 · Cited by 71
Nguyen, H. T., Gu, M., Werlinger, P., Cho, J.-H., Cheng, J., & Suh, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113436 · Cited by 64
Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease
Wang, C., Zhu, C., Shao, L., Ye, J., Shen, Y., & Ren, Y. (2019) · Mediators of Inflammation · doi:10.1155/2019/7659509 · Cited by 67
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Kim, H., Joo, E., Cheong, H. S., Kim, Y., Kim, H., Shin, H. C., Chang, Y., & Ryu, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081089 · Cited by 61
Impact of Altered Gut Microbiota and Its Metabolites in Cystic Fibrosis
Thavamani, A., Salem, I., Sferra, T. J., & Sankararaman, S. (2021) · Metabolites · doi:10.3390/metabo11020123 · Cited by 66
Soppert, J., Brandt, E. F., Heussen, N. M., Barzakova, E., Blank, L. M., Kuepfer, L., Hornef, M. W., Trebicka, J., Jankowski, J., Berres, M., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.11.030 · Cited by 58
Shin, J., Lee, Y., Song, E., Lee, D., Jang, S.-Y., Byeon, H. R., Hong, M.-G., Lee, S., Kim, H., Seo, J., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1123547 · Cited by 60
Yarahmadi, A., Afkhami, H., Javadi, A., & Kashfi, M. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01561-z · Cited by 61
Jadhav, K. S., & Cohen, T. S. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.592157 · Cited by 55
Mechanisms of hepatic and renal injury in lipid metabolism disorders in metabolic syndrome
Rong, J., Zhang, Z., Peng, X., Li, P., Zhao, T., & Zhong, Y. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.100394 · Cited by 56
Kuraji, R., Shiba, T., Dong, T. S., Numabe, Y., & Kapila, Y. L. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i6.967 · Cited by 53
High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD
Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M. J. G. T., Liu, J., Krawczyk, M. J., Nowag, A., Kretzschmar, A., Herweg, J., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1509 · Cited by 49
Phenotyping non‐alcoholic fatty liver disease by the gut microbiota: Ready for prime time?
Demir, M., Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M. J. G. T., Krawczyk, M. J., Nowag, A., Scholz, C. J., Kretzschmar, A., et al. (2020) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15071 · Cited by 50
He, L., Yao, D.-H., Wang, L., Zhang, L., & Bai, X. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.761836 · Cited by 49
Zhao, N., Yang, Y., Chen, C., Jing, T., Hu, Y., Xu, H., Wang, S., He, Y., Liu, E., & Cui, J. (2022) · Food & Function · doi:10.1039/d2fo02942a · Cited by 48
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Hui, D., Liu, L., Azami, N. L. B., Song, J., Huang, Y., Xu, W., Wu, C., Xie, D., Jiang, Y., Bian, Y., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1107071 · Cited by 48
Gudan, A., Kozłowska‐Petriczko, K., Wunsch, E., Bodnarczuk, T., & Stachowska, E. (2023) · Nutrients · doi:10.3390/nu15061323 · Cited by 55
Yang, C., Wu, J., Yang, L., Hu, Q., Li, L., Yang, Y., Jing Hua, H. U., Pan, D., & Zhao, Q. (2024) · Scientific Reports · doi:10.1038/s41598-024-72909-8 · Cited by 49
Magueresse‐Battistoni, B. L. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129212 · Cited by 47
Yadav, J., Liang, T., Qin, T., Nathan, N., Schwenger, K. J. P., Pickel, L., Xie, L., Lei, H., Winer, D. A., Maughan, H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101051 · Cited by 49
Self-citationIwaki, M., Kessoku, T., Ozaki, A., Kasai, Y., Kobayashi, T., Nogami, A., Honda, Y., Ogawa, Y., Imajo, K., Yoneda, M., et al. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15487 · Cited by 47
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Metadata
- Authors
- Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S. E., Lou, W., & Allard, J. P.
- Affiliations
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Allard, Johane P.
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-01-23
- Volume
- 8
- Issue
- 1
- Pages
- 1466-1466
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5780381
- OpenAlex
- W2803148575
- Cited by
- 283
- References
- 59
- Citations by year
- 2026: 18 · 2025: 32 · 2024: 31 · 2023: 34 · 2022: 35 · 2021: 60 · 2020: 34 · 2019: 27 · 2018: 10
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American College of Gastroenterology
- University of Alberta
- University of Toronto
- Canadian Institutes of Health Research (86922_1, 89705_1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, gut microbiota, dysbiosis, obesity, insulin resistance, Bacteroidetes, Firmicutes, Faecalibacterium prausnitzii, Ruminococcus, Coprococcus, Lactobacillus, short-chain fatty acids, propionate, isobutyric acid, 2-hydroxybutyrate, L-lactic acid, gut microbiota metabolites
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Cross-Sectional Studies, Feces, Female, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Prospective Studies, Body Mass Index, Young Adult, Dysbiosis, Non-alcoholic Fatty Liver Disease
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