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Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance
Open accessAbstract
This study aimed to determine if there is an association between dysbiosis and nonalcoholic fatty liver disease (NAFLD) independent of obesity and insulin resistance (IR). This is a prospective cross-sectional study assessing the intestinal microbiome (IM) of 39 adults with biopsy-proven NAFLD (15 simple steatosis [SS]; 24 nonalcoholic steatohepatitis [NASH]) and 28 healthy controls (HC). IM composition (llumina MiSeq Platform) in NAFLD patients compared to HC were identified by two statistical methods (Metastats, Wilcoxon). Selected taxa was validated using quantitative PCR (qPCR). Metabolites in feces and serum were also analyzed. In NAFLD, 8 operational taxonomic units, 6 genera, 6 families and 2 phyla (Bacteroidetes, Firmicutes) were less abundant and; 1 genus ( Lactobacillus ) and 1 family (Lactobacillaceae) were more abundant compared to HC. Lower abundance in both NASH and SS patients compared to HC were confirmed by qPCR for Ruminococcus, Faecalibacterium prausnitzii and Coprococcus . No difference was found between NASH and SS. This lower abundance in NAFLD (NASH+SS) was independent of BMI and IR. NAFLD patients had higher concentrations of fecal propionate and isobutyric acid and serum 2-hydroxybutyrate and L-lactic acid. These findings suggest a potential role for a specific IM community and functional profile in the pathogenesis of NAFLD.
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“Furthermore, diseases linked to dyslipidemia, such as non-alcoholic liver disease and atherosclerosis, are associated with changes in gut microbiota profile.”
From Dietary lipids, gut microbiota and lipid metabolism (2019) · cites this paper as [43]
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Metadata
- Authors
- Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S. E., Lou, W., & Allard, J. P.
- Affiliations
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Allard, Johane P.
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-01-23
- Volume
- 8
- Issue
- 1
- Pages
- 1466-1466
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5780381
- OpenAlex
- W2803148575
- Cited by
- 283
- References
- 59
- Citations by year
- 2026: 18 · 2025: 32 · 2024: 31 · 2023: 34 · 2022: 35 · 2021: 60 · 2020: 34 · 2019: 27 · 2018: 10
- FWCI
- 11.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American College of Gastroenterology
- University of Alberta
- University of Toronto
- Canadian Institutes of Health Research (86922_1, 89705_1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, gut microbiota, dysbiosis, obesity, insulin resistance, Bacteroidetes, Firmicutes, Faecalibacterium prausnitzii, Ruminococcus, Coprococcus, Lactobacillus, short-chain fatty acids, propionate, isobutyric acid, 2-hydroxybutyrate, L-lactic acid, gut microbiota metabolites
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Cross-Sectional Studies, Feces, Female, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Prospective Studies, Body Mass Index, Young Adult, Dysbiosis, Non-alcoholic Fatty Liver Disease
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