Cited by 408Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsImmune cells in cancer

Senescence-associated inflammatory responses: aging and cancer perspectives

Lasry, Audrey, Ben-Neriah, Yinon·2015·Trends in Immunology

Abstract

Senescent cells, albeit not proliferating, are metabolically and transcriptionally active, thereby capable of affecting their microenvironment, notably via the production of inflammatory mediators. These mediators maintain and propagate the senescence process to neighboring cells, and then recruit immune cells for clearing senescent cells. Among the inflammatory cues are molecules with pronounced tumor-controlling properties, both growth and invasion factors and inhibitory factors, working directly or via recruited immune cells. These senescence-inflammatory effects also prevail within tumors, mediated by the senescent tumor cells and the senescent tumor stroma. Here, we review the course and impact of senescence-associated inflammatory responses in aging and cancer. We propose that controlling senescence-associated inflammation by targeting specific inflammatory mediators may have a beneficial therapeutic effect in treatment of cancer and aging-related diseases.

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Crossref · 10.1016/j.it.2015.02.009

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150 of 150 references verified0 citation errors · 0 not checkable

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  • The local low-grade inflammation that characterizes aging is triggered by senescent cells and is intimately related to age-related diseases such as cardiovascular diseases and cancer.

    “Of note, the local low-grade inflammation that characterizes aging is triggered by senescent cells and is intimately related to age-related diseases such as cardiovascular diseases and cancer (5, 291, 292).”

    From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [291]

  • The nine established hallmarks of aging have all been shown to be connected with sustained systemic inflammation.

    “have all been shown to be linked to sustained systemic inflammation7–16.”

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Authors
Lasry, A., & Ben-Neriah, Y.
Affiliations
Hebrew University of Jerusalem (IL)
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2015-04
Volume
36
Issue
4
Pages
217-228
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2152877666
Cited by
408
References
152
Citations by year
2026: 13 · 2025: 29 · 2024: 35 · 2023: 49 · 2022: 46 · 2021: 54 · 2020: 48 · 2019: 32 · 2018: 35 · 2017: 41 · 2016: 19 · 2015: 7
FWCI
4.16
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Israel Science Foundation
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
senescence-associated inflammation, cellular senescence, aging, cancer, senescence-associated secretory phenotype, tumor microenvironment, immune cell recruitment, senolytics, inflammatory mediators, age-related diseases
MeSH terms
Aging, Humans, Inflammation, Neoplasms

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