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Cited by 549

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Broadband (550–1350 nm) diffuse optical characterization of thyroid chromophores

Open access
Konugolu Venkata Sekar, Sanathana, Farina, Andrea, Dalla Mora, Alberto, Lindner, Claus, Pagliazzi, Marco, Mora, Mireia, Aranda, Gloria, Dehghani, Hamid, Durduran, Turgut, Taroni, Paola, Pifferi, Antonio·2018·Scientific Reports
DOI 10.1038/s41598-018-27684-8
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Abstract

Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin–key tissue constituents specific to the thyroid organ–in the visible to near infrared range are not fully available. Here, we present the optical characterization of tyrosine (powder), thyroglobulin (granular form) and iodine (aqueous solution) using a time domain broadband diffuse optical spectrometer in the 550–1350 nm range. Various systematic errors caused by physics of photo migration and sample inherent properties were effectively suppressed by means of advanced time domain diffuse optical methods. A brief comparison with various other known tissue constituents is presented, which reveals key spectral regions for the quantification of the thyroid absorbers in an in vivo scenario.

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Citations

Cites

Show all 25 references

Research works printed but not linked: 10

  1. Lindner, C. et al. Diffuse optical characterization of the healthy human thyroid tissue and two pathological case studies. PLoS One 11, 1–22 (2016). · doi:10.1371/journal.pone.0147851
  2. Brandao, M. P. et al. Optical characterization of normal, benign, and malignant thyroid tissue: A pilot study. J. Fluoresc. 25, 465–471 (2015). · doi:10.1007/s10895-015-1542-0
  3. Brandao, M. et al. Fluorescence lifetime of normal, benign, and malignant thyroid tissues. J. Biomed. Opt. 20, 67003 (2015). · doi:10.1117/1.jbo.20.6.067003
  4. Teixeira, C. S. B. et al. Thyroid tissue analysis through Raman spectroscopy. Analyst 134, 2361–70 (2009). · doi:10.1039/b822578h
  5. Zhang, X. et al. Intraoperative detection of thyroid carcinoma by fourier transform infrared spectrometry. J. Surg. Res. 171, 650–656 (2011). · doi:10.1016/j.jss.2010.05.031
  6. Suh, H. et al. Elastic light-scattering spectroscopy for discrimination of benign from malignant disease in thyroid nodules. Ann. Surg. Oncol. 18, 1300–5 (2011). · doi:10.1245/s10434-010-1452-y
  7. Taroni, P. et al. Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification. Opt. Express 17, 15932–15946 (2009). · doi:10.1364/oe.17.015932
  8. Farina, A. et al. Bandpass effects in time-resolved diffuse spectroscopy. Appl. Spectrosc. 63, 48–56 (2009). · doi:10.1366/000370209787169795
  9. Bargigia, I. et al. Diffuse optical techniques applied to wood characterisation. J. Near Infrared Spectrosc. 21, 259 (2013). · doi:10.1255/jnirs.1068
  10. Konugolu Venkata Sekar, S. et al. Broadband time-resolved diffuse optical spectrometer for clinical diagnostics: characterization and in-vivo measurements in the 600–1350 nm spectral range. Eur. Conf. Biomed. Opt. 9538, 95380R (2015).

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Metadata

Authors
Konugolu Venkata Sekar, S., Farina, A., Dalla Mora, A., Lindner, C., Pagliazzi, M., Mora, M., Aranda, G., Dehghani, H., Durduran, T., Taroni, P., & Pifferi, A.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-07-03
Volume
8
Issue
1
Pages
10015-10015
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-27684-8
OpenAlex
W2810800223
Cited by
549
References
25
FWCI
83.63
Type
journal article
Language
en
Open access
gold
Licence

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CoChat. (2026). Citation check: Broadband (550–1350 nm) diffuse optical characterization of thyroid chromophores. https://app.cochat.ai/papers/10.1038/s41598-018-27684-8
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Konugolu Venkata Sekar, S., Farina, A., Dalla Mora, A., Lindner, C., Pagliazzi, M., Mora, M., Aranda, G., Dehghani, H., Durduran, T., Taroni, P., & Pifferi, A. (2018). Broadband (550–1350 nm) diffuse optical characterization of thyroid chromophores. Scientific Reports. https://doi.org/10.1038/s41598-018-27684-8

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