Investigation of drug release modulation from poly(2-oxazoline) micelles through ultrasound
Open accessAbstract
Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zero-order and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.
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Along with stimulation time, such parameters resulted in a variation of dexamethasone release from 6% to 105%.
“Along with stimulation time, such parameters resulted in a variation of dexamethasone release from 6% to 105%.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [209]
This study indicated the effect of the type of copolymer used and ultrasound wave on the amount of released drug.
“This study indicated the effect of the type of copolymer used and ultrasound wave on the amount of released drug.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [209]
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- Authors
- Salgarella, A. R., Zahoranová, A., Šrámková, P., Majerčíková, M., Pavlova, E., Luxenhofer, R., Kronek, J., Lacík, I., & Ricotti, L.
- Affiliations
- Scuola Superiore Sant'Anna (IT)
- Polymer Institute of the Slovak Academy of Sciences (SK)
- Slovak University of Technology in Bratislava (SK)
- University of Würzburg (DE)
- Corresponding author
- Ricotti, Leonardo
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-07-02
- Volume
- 8
- Issue
- 1
- Pages
- 9893-9893
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6028437
- OpenAlex
- W2810555541
- Cited by
- 57
- References
- 71
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 6 · 2019: 5
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Online Publication Service of Würzburg University (Würzburg University) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- European Commission
- Agentúra na Podporu Výskumu a Vývoja (APVV-15-0485, APVV-14-0858)
- Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- ultrasound-triggered drug release, dexamethasone, polymeric micelles, block copolymers, hydrophobic drug release, Ritger-Peppas model, zero-order release, stimuli-responsive drug carriers
- MeSH terms
- Dynamic Light Scattering, Chromatography, High Pressure Liquid, Dexamethasone, Drug Carriers, Micelles, Oxazoles, Polymers, Ultrasonics, Drug Delivery Systems, Microscopy, Electron, Transmission, Hydrophobic and Hydrophilic Interactions
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