Periodontal status and lung function decline in the community: the Hisayama study.
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Abstract This study aimed to determine whether periodontal status is related to a decline in lung function in a general Japanese population. We followed a total of 1,650 community-dwelling individuals (≥40 years) without chronic obstructive pulmonary disease, with at least one teeth, for 3 years. Periodontal status was assessed at baseline by clinical attachment loss (CAL) and probing pocket depth (PPD) at two sites for each tooth, and the mean values were calculated for each subject. Lung function was measured at baseline and follow-up using spirometry, and longitudinal decline in forced expiratory volume in one second (FEV1) was calculated. Multivariate Poisson regression with robust error variance was used to estimate risk ratio (RR). After adjusting for potential confounders including smoking status, there was a tendency for the adjusted RR of developing rapid lung function decline (≥160 mL/3years, the highest quartile of the distribution of FEV1 declines) to increase as mean CAL levels increased (P trend = 0.039). Likewise, a positive association was observed between mean PPD levels and RR of developing rapid lung function decline (P trend = 0.047). Our findings suggest deterioration of periodontal status could be a risk factor for rapid lung function decline in the general Japanese population.
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Poor oral hygiene habits can lead to the accumulation of many periodontal microorganisms in the oral cavity, and oral dysbiosis can accelerate lung function decline, which in turn can increase the incidence of pneumonia.
“Poor oral hygiene habits can lead to the accumulation of many periodontal microorganisms in the oral cavity, and oral dysbiosis can accelerate lung function decline (Takeuchi et al., 2018; Winning et al., 2019), which in turn can increase the incidence of pneumonia (Kumar, 2017).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Takeuchi et al., 2018
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- Authors
- Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., Ninomiya, T., Nakanishi, Y., Inoue, H., & Yamashita, Y.
- Affiliations
- Kyushu University (JP)
- Kagoshima University (JP)
- Corresponding author
- Yamashita, Yoshihisa
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-09-06
- Volume
- 8
- Issue
- 1
- Pages
- 13354-13354
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6127313
- OpenAlex
- W2889515301
- Cited by
- 20
- References
- 40
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science (16H05557, 17K17375, 16H05850)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- periodontal health, lung function decline, clinical attachment loss, probing depth, FEV1 decline, periodontitis, smoking, community-dwelling adults, Hisayama Study
- MeSH terms
- Aged, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Japan, Lung, Male, Middle Aged, Periodontium, Risk Factors, Pulmonary Disease, Chronic Obstructive
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