Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients
Abstract
BACKGROUND: We planned to analyze the prevalence and distribution of beta-amyloid deposition in the HIV+ brain in the HAART era. Our working hypothesis is that long term survival, aging and the secondary effects of HAART may contribute to increased beta-amyloid accumulation in this patient population. METHODS: Paraffin embedded archival brain autopsy tissues were assessed by immunocytochemistry for beta-amyloid. Detailed in-vivo neuro-behavioral assessments and ApoE genotyping were available for a subset of the studied population. RESULTS: Immunoreactivity with the antibodies 4G8 and 6E10 was found predominantly in neuronal soma and dystrophic axonal processes. Extracellular, often perivascular plaques were also identified in many cases. CONCLUSIONS: We propose that prolonged HAART and aging may contribute to an overall increase in amyloid deposition, potentially mediated by inhibition of insulin degradation enzyme (IDE) or disruption of the axonal transport of the amyloid precursor protein.
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Brains from post-mortem HIV patients display increased levels of deposited Aβ and hyperphosphorylated tau compared to age-matched controls.
“Moreover, brains from post‐mortem HIV patients display increased levels of deposited amyloid beta (Aβ) and hyperphosphorylated tau compared to age‐matched controls, suggesting pathological links exist between Alzheimer’s disease and HAD (Green et al, 2005; Anthony et al, 2006; Achim et al, 2009).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Green et al, 2005
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Alzheimer's disease gene signature says: beware of brain viral infections
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Self-citationMolecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
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Cognitively unimpaired HIV-positive subjects do not have increased11C-PiB
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- Authors
- Green, D. A., Masliah, E., Vinters, H. V., Beizai, P., Moore, D. J., & Achim, C. L.
- Affiliations
- University of Pittsburgh (US)
- University of California San Diego (US)
- University of California, Los Angeles (US)
- Corresponding author
- Achim, Cristian L
- Venue
- AIDS
- Published
- 2005-03-04
- Volume
- 19
- Issue
- 4
- Pages
- 407-411
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2033154907
- Cited by
- 299
- References
- 17
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 5 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 20 · 2019: 25 · 2018: 19 · 2017: 19 · 2016: 16 · 2015: 9 · 2014: 24 · 2013: 17 · 2012: 7
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- AIDS (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca035040-03, 5r01mh058528-05)
- National Institute on Aging (P50AG016570)
- National Institute of Mental Health (MH58528)
- National Institute of Allergy and Infectious Diseases (U01AI035040, U01 AI/CA 35040)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Keywords
- amyloid-beta deposition, HIV-associated neurocognitive disorders, HIV, highly active antiretroviral therapy, aging, amyloid plaques, APOE genotype, insulin-degrading enzyme, amyloid precursor protein, axonal transport
- MeSH terms
- Adult, Aged, Amyloidosis, Brain Diseases, Female, Humans, Male, Middle Aged, HIV Infections, Amyloid beta-Peptides, Paraffin Embedding, Antiretroviral Therapy, Highly Active
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