Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis

KEGG: Kyoto Encyclopedia of Genes and Genomes

Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works

KEGG: new perspectives on genomes, pathways, diseases and drugs

Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y., & Morishima, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkw1092 · Cited by 8,865 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

KEGG as a reference resource for gene and protein annotation

Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M., & Tanabe, M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1070 · Cited by 7,387 · see citing works

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181 · see citing works

Assessing mitochondrial dysfunction in cells

Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436 · see citing works

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., & Hall, M. N. (2004) · Nature Cell Biology · doi:10.1038/ncb1183 · Cited by 2,097 · see citing works

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

Kliman, H. J., Nestler, J. E., SERMASI, E., Sanger, J. M., & Strauss, J. F. (1986) · Endocrinology · doi:10.1210/endo-118-4-1567 · Cited by 1,572 · see citing works

mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

Cunningham, J. T., Rodgers, J. T., Arlow, D. H., Vazquez, F., Mootha, V. K., & Puigserver, P. (2007) · Nature · doi:10.1038/nature06322 · Cited by 1,488 · see citing works

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., & Sabatini, D. M. (2009) · Cell · doi:10.1016/j.cell.2009.03.046 · Cited by 1,202 · see citing works

MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data

Doniger, S. W., Salomonis, N., Dahlquist, K. D., VRANIZAN, K. M., Lawlor, S. C., & Conklin, B. R. (2003) · Genome biology · doi:10.1186/gb-2003-4-1-r7 · Cited by 865 · see citing works

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation

Morita, M., Gravel, S.-P., Chénard, V., Sikström, K., Zheng, L., Alain, T., Gandin, V., Avizonis, D., Arguello, M., Zakaria, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.001 · Cited by 842 · see citing works

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

Bentzinger, C. F., Romanino, K., Cloëtta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.002 · Cited by 640 · see citing works

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

Schieke, S. M., Phillips, D., McCoy, J. P., Aponte, A. M., Shen, R.-F., Balaban, R. S., & Finkel, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603536200 · Cited by 623 · see citing works

TOR signalling in bugs, brain and brawn

Jacinto, E., & Hall, M. N. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1018 · Cited by 560 · see citing works

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

Zhang, H., Cicchetti, G., Onda, H., Koon, H. B., Asrican, K., Bajraszewski, N., Vázquez, F., Carpenter, C. L., & Kwiatkowski, D. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17222 · Cited by 538 · see citing works

The expanding TOR signaling network

Martin, D. E., & Hall, M. N. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.008 · Cited by 496 · see citing works

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

Zhang, H., Cicchetti, G., Onda, H., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317222 · Cited by 482 · see citing works

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

Peng, T., Golub, T. R., & Sabatini, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5575-5584.2002 · Cited by 393 · see citing works

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Yung, H.-W., Calabrese, S., Hynx, D., Hemmings, B. A., Cetin, I., Charnock-Jones, D. S., & Burton, G. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071193 · Cited by 388 · see citing works

Direct control of mitochondrial function by mTOR

Ramanathan, A., & Schreiber, S. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912074106 · Cited by 365 · see citing works

mTOR, translational control and human disease

Tee, A. R., & Blenis, J. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.11.005 · Cited by 320 · see citing works

Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies

Jansson, N., Rosario, F. J., Gaccioli, F., Lager, S., Jones, H. N., Roos, S., Jansson, T., & Powell, T. L. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2667 · Cited by 305 · see citing works

Mammalian target of rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth

Roos, S., Jansson, N., Palmberg, I., Säljö, K., Powell, T. L., & Jansson, T. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129676 · Cited by 283 · see citing works

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

Shende, P., Plaisance, I., Morandi, C., Pellieux, C., Berthonneche, C., Zorzato, F., Krishnan, J., Lerch, R. A., Hall, M. N., Rüegg, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.977066 · Cited by 239 · see citing works

Role of oxidative stress and antioxidant supplementation in pregnancy disorders

Poston, L., Igosheva, N., Mistry, H. D., Seed, P. T., Shennan, A. H., Rana, S., Karumanchi, S. A., & Chappell, L. C. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.001156 · Cited by 204 · see citing works

Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia

Mandò, C., De Palma, C., Stampalija, T., Anelli, G. M., Figus, M., Novielli, C., Parisi, F., Clementi, E., Ferrazzi, E., & Cetin, I. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2013 · Cited by 196 · see citing works

New Insights into mTOR Signaling: mTORC2 and Beyond

Alessi, D. R., Pearce, L. R., & García‐Martínez, J. M. (2009) · Science Signaling · doi:10.1126/scisignal.267pe27 · Cited by 188 · see citing works

Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238014 · Cited by 185 · see citing works

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

Rosario, F. J., Jansson, N., Kanai, Y., Prasad, P. D., Powell, T. L., & Jansson, T. (2011) · Endocrinology · doi:10.1210/en.2010-1153 · Cited by 176 · see citing works

Roles of mitochondria in human disease

Duchen, M. R., & Szabadkai, G. (2010) · Essays in Biochemistry · doi:10.1042/bse0470115 · Cited by 167 · see citing works

Impaired mitochondrial function in human placenta with increased maternal adiposity

Mele, J., Muralimanoharan, S., Maloyan, A., & Myatt, L. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00025.2014 · Cited by 163 · see citing works

Contractile activity-induced adaptations in the mitochondrial protein import system

Takahashi, M. T., Chesley, A., Freyssenet, D. G., & Hood, D. A. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.5.c1380 · Cited by 139 · see citing works

Antenatal manifestations of mitochondrial respiratory chain deficiency

von Kleist-Retzow, J., Cormier‐Daire, V., Viot, G., Goldenberg, A., Mardach, B., Amiel, J., Saada, P., Dumez, Y., Brunelle, F., Saudubray, J., et al. (2003) · The Journal of Pediatrics · doi:10.1067/s0022-3476(03)00130-6 · Cited by 136 · see citing works

Down‐regulation of placental mTOR, insulin/IGF‐I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

Kavitha, J., Rosario, F. J., Nijland, M. J., McDonald, T. J., Wu, G., Kanai, Y., Powell, T. L., Nathanielsz, P. W., & Jansson, T. (2013) · The FASEB Journal · doi:10.1096/fj.13-242271 · Cited by 131 · see citing works

Increased Placental Nutrient Transport in a Novel Mouse Model of Maternal Obesity with Fetal Overgrowth

Rosario, F. J., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Obesity · doi:10.1002/oby.21165 · Cited by 128 · see citing works

Impaired Mitochondrial Function in the Preimplantation Embryo Perturbs Fetal and Placental Development in the Mouse1

Wakefield, S. L., Lane, M., & Mitchell, M. (2010) · Biology of Reproduction · doi:10.1095/biolreprod.110.087262 · Cited by 115 · see citing works

Higher Mitochondrial DNA Content in Human IUGR Placenta

Lattuada, D., Colleoni, F., Martinelli, A., Garretto, A., Magni, R., Radaelli, T., & Cetin, I. (2008) · Placenta · doi:10.1016/j.placenta.2008.09.012 · Cited by 101 · see citing works

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

Chen, Y., Rosario, F. J., Shehab, M. A., Powell, T. L., Gupta, M. B., & Jansson, T. (2015) · Clinical Science · doi:10.1042/cs20150511 · Cited by 97 · see citing works

Isolation and Culture of Term Human Trophoblast Cells

Petroff, M. G., Phillips, T. A., Ka, H., Pace, J. L., & Hunt, J. S. (2005) · Humana Press eBooks · doi:10.1385/1-59259-983-4:201 · Cited by 95 · see citing works

Effect of restriction of placental growth on fetal and utero-placental metabolism.

Owens, J. A., Falconer, J. S., & Robinson, J. S. (1987) · PubMed · Cited by 89 · see citing works

Comparative study on gene set and pathway topology-based enrichment methods

Bayerlová, M., Jung, K., Krämer, F., Klemm, F., Bleckmann, A., & Beißbarth, T. (2015) · BMC Bioinformatics · doi:10.1186/s12859-015-0751-5 · Cited by 88 · see citing works

Isolation, purification and in vitro differentiation of cytotrophoblast cells from human term placenta

Li, L., & Schust, D. J. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0070-8 · Cited by 78 · see citing works

Fetal programming of atherosclerosis: Possible role of the mitochondria

Leduc, L., Levy, E. H., Bouity-Voubou, M., & DELVIN, E. E. (2010) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2009.12.005 · Cited by 76 · see citing works

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023238 · Cited by 69 · see citing works

Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats

Mayeur, S., Lancel, S., Theys, N., Lukaszewski, M., Duban‐Deweer, S., Bastide, B., Hachani, J., Cecchelli, R., Breton, C., Gabory, A., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00332.2012 · Cited by 65 · see citing works

Mitochondrial DNA content and methylation in fetal cord blood of pregnancies with placental insufficiency

Novielli, C., Mandò, C., Tabano, S. M., Anelli, G. M., Fontana, L., Antonazzo, P. G. M., Miozzo, M. R., & Cetin, I. (2017) · Placenta · doi:10.1016/j.placenta.2017.05.008 · Cited by 63 · see citing works

Multiple functions of syncytiotrophoblast mitochondria

Martı́nez, F., Olvera-Sánchez, S., Esparza-Perusquía, M., Gómez-Chang, E., & Flores-Herrera, Ó. (2015) · Steroids · doi:10.1016/j.steroids.2015.09.006 · Cited by 61 · see citing works

Involvement of estrogen-related receptor-γ and mitochondrial content in intrauterine growth restriction and preeclampsia

Poidatz, D., Santos, E. D., Duval, F., Moindjie, H., Serazin-Leroy, V., Vialard, F., de Mazancourt, P., & Dieudonné, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.05.005 · Cited by 58 · see citing works

Mitochondrial Import Receptors Tom20 and Tom22 Have Chaperone-like Activity

Yano, M., Terada, K., & Mori, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311710200 · Cited by 55 · see citing works

Tom20-mediated mitochondrial protein import in muscle cells during differentiation

Grey, J. Y., Connor, M. K., Gordon, J. W., Yano, M., Mori, M., & Hood, D. A. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.5.c1393 · Cited by 55 · see citing works

Methods for siRNA-mediated Reduction of mRNA and Protein Expression in Human Placental Explants, Isolated Primary Cells and Cell Lines

Forbes, K. A., Desforges, M., Garside, R., Aplin, J., & Westwood, M. (2008) · Placenta · doi:10.1016/j.placenta.2008.10.003 · Cited by 51 · see citing works

mTOR folate sensing links folate availability to trophoblast cell function

Rosario, F. J., Powell, T. L., & Jansson, T. (2017) · The Journal of Physiology · doi:10.1113/jp272424 · Cited by 48 · see citing works

Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC

Rosario, F. J., Powell, T. L., & Jansson, T. (2016) · Scientific Reports · doi:10.1038/srep31705 · Cited by 47 · see citing works

Signal Anchor Sequence Insertion into the Outer Mitochondrial Membrane

Millar, D. G., & Shore, G. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.25823 · Cited by 36 · see citing works

Measurement of mitochondrial respiration in trophoblast culture

Maloyan, A., Mele, J., Muralimanohara, B., & Myatt, L. (2012) · Placenta · doi:10.1016/j.placenta.2012.01.016 · Cited by 33 · see citing works

Mitochondrial DNA in Placenta: Associations with Fetal Growth and Superoxide Dismutase Activity

Díaz, M., Aragonès, G., Sánchez‐Infantes, D., Bassols, J., Pérez‐Cruz, M., de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2014) · Hormone Research in Paediatrics · doi:10.1159/000366079 · Cited by 27 · see citing works

Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse?

Chiaratti, M. R., Malik, S., Diot, A., Rapa, E., Macleod, L., Morten, K., Vatish, M., Boyd, R., & Poulton, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130631 · Cited by 24 · see citing works

1,25-dihydroxy vitamin D3 stimulates System A amino acid transport in primary human trophoblast cells

Chen, Y.-Y., Powell, T., & Jansson, T. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.009 · Cited by 21 · see citing works

Regulation and metabolic functions of mTORC1 and mTORC2.

Szwed, A., Kim, E., & Jacinto, E. (2021) · Physiological Reviews · doi:10.1152/physrev.00026.2020 · Cited by 723 · see citing works

Developmental origins of metabolic diseases

Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 483 · see citing works

Human placental development and function

Cindrová‐Davies, T., & Sferruzzi-Perri, A. N. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.039 · Cited by 280 · see citing works

Placental Function in Maternal Obesity

Kelly, A. C., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20190266 · Cited by 227 · see citing works

Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

Aye, I. L. M. H., Aiken, C., Jones, D. S., & Smith, G. C. S. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.11.005 · Cited by 154 · see citing works

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

Colson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 145 · see citing works

Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction

Dumolt, J. H., Powell, T. L., & Jansson, T. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.02.001 · Cited by 106 · see citing works

Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism

Kramer, A. C., Jansson, T., Bale, T. L., & Powell, T. L. (2023) · Development · doi:10.1242/dev.202088 · Cited by 110 · see citing works

Placental adaptations supporting fetal growth during normal and adverse gestational environments

Sferruzzi-Perri, A. N., López‐Tello, J., & Salazar‐Petres, E. (2022) · Experimental Physiology · doi:10.1113/ep090442 · Cited by 104 · see citing works

Quiescence Entry, Maintenance, and Exit in Adult Stem Cells

Mohammad, K., Dakik, P., Medkour, Y., Mitrofanova, D., & Titorenko, V. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092158 · Cited by 90 · see citing works

Novel roles of mechanistic target of rapamycin signaling in regulating fetal growth†

Gupta, M. B., & Jansson, T. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy249 · Cited by 69 · see citing works

Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR

Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 66 · see citing works

The mTOR pathway in reproduction: from gonadal function to developmental coordination

Correia, B., Sousa, M. I., & Ramalho‐Santos, J. (2019) · Reproduction · doi:10.1530/rep-19-0057 · Cited by 63 · see citing works

Reactive oxygen species control protein degradation at the mitochondrial import gate

McMinimy, R. A., Manford, A. G., Gee, C. L., Chandrasekhar, S., Mousa, G. A., Chuang, J., Phu, L., Shih, K. Y., Rose, C. M., Kuriyan, J., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.004 · Cited by 59 · see citing works

Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain

Yip, H., Dubey, N. K., Lin, K., Sung, P., Chiang, J. Y., Chu, Y., Huang, C., Chen, Y., Deng, Y.-H., Cheng, J. H.-C., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111593 · Cited by 59 · see citing works

Neddylation regulation of mitochondrial structure and functions

Zhou, Q., Zheng, Y., & Sun, Y. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00569-6 · Cited by 51 · see citing works

mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model

Jeffries, M. A., McLane, L. E., Khandker, L., Mather, M. L., Evangelou, A. V., Kantak, D., Bourne, J. N., Macklin, W. B., & Wood, T. L. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1377-20.2021 · Cited by 41 · see citing works

Regulation of placental amino acid transport in health and disease

Shimada, H., Powell, T. L., & Jansson, T. (2024) · Acta Physiologica · doi:10.1111/apha.14157 · Cited by 42 · see citing works

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

Sletten, A. C., Davidson, J. W., Yağabasan, B., Moores, S., Schwaiger-Haber, M., Fujiwara, H., Gale, S. E., Jiang, X., Sidhu, R., Gelman, S. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25457-y · Cited by 40 · see citing works

Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice

Akhaphong, B., Baumann, D. C., Beetch, M., Lockridge, A. D., Jo, S., Wong, A., Zemanovic, T., Mohan, R., Fondevilla, D. L., Sia, M., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.149271 · Cited by 37 · see citing works

mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells

Rosario, F. J., Powell, T. L., Gupta, M. B., Cox, L. A., & Jansson, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.583801 · Cited by 34 · see citing works

Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development

Hu, X., & Zhang, L. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.07.011 · Cited by 36 · see citing works

Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases

Aman, Y., Ryan, B. J., Torsetnes, S. B., Knapskog, A., Watne, L. O., McEwan, W. A., & Fang, E. F. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.02.008 · Cited by 35 · see citing works

MTOR Signaling and Metabolism in Early T Cell Development

Werlen, G., Jain, R., & Jacinto, E. (2021) · Genes · doi:10.3390/genes12050728 · Cited by 34 · see citing works

Gestational Diabetes Mellitus and Energy-Dense Diet: What Is the Role of the Insulin/IGF Axis?

Martín‐Estal, I., & Castorena‐Torres, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.916042 · Cited by 37 · see citing works

Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice

Salazar‐Petres, E., Pereira‐Carvalho, D., López‐Tello, J., & Sferruzzi-Perri, A. N. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac056 · Cited by 32 · see citing works

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation

Li, M., Wu, X., Jing, W.-Q., Hou, W.-K., Hu, S. C., & Yan, W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06017-2 · Cited by 28 · see citing works

Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

Venit, T., Sapkota, O., Abdrabou, W. S., Palanikumar, L., Pasricha, R., Mahmood, S. R., Said, N. H. E., Sherif, S., Thomas, S. A., Abdelrazig, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42093-w · Cited by 27 · see citing works

Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor

Artoni, F., Grützmacher, N., & Demetriades, C. (2023) · Aging Cell · doi:10.1111/acel.13888 · Cited by 25 · see citing works

Placental mTOR Signaling and Sexual Dimorphism in Metabolic Health across the Lifespan of Offspring

Beetch, M., & Alejandro, E. U. (2021) · Children · doi:10.3390/children8110970 · Cited by 22 · see citing works

Transferrin receptor is necessary for proper oligodendrocyte iron homeostasis and development

Cheli, V. T., González, D. A. S., Wan, R., Rosenblum, S. L., Denaroso, G., Angeliu, C. G., Smith, Z. I., Wang, C., & Paez, P. M. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1383-22.2023 · Cited by 21 · see citing works

Ruminant Placental Adaptation in Early Maternal Undernutrition: An Overview

Toschi, P., & Baratta, M. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.755034 · Cited by 21 · see citing works

Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway

Chang, Y., He, B., Wang, C., Li, W., Tao, S., Chen, J., Wang, Y., Yang, L., Wu, Y., Wu, Z., et al. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2491638 · Cited by 23 · see citing works

Association of placental nutrient sensing pathways with birth weight

Lazo-de-la-Vega-Monroy, M.-L., Mata-Tapia, K.-A., García-Santillán, J.-A., Corona-Figueroa, M.-A., Gónzalez-Domínguez, M.-I., Gomez-Zapata, H.-M., Malacara, J. M., Daza-Benítez, L., & Barbosa‐Sabanero, G. (2020) · Reproduction · doi:10.1530/rep-20-0186 · Cited by 20 · see citing works

The Nitrate-Nitrite-Nitric Oxide Pathway: Potential Role in Mitigating Oxidative Stress in Hypertensive Disorders of Pregnancy

Barbosa, P. O., Tanus-Santos, J. E., Cavalli, R. D. C., Bengtsson, T., Montenegro, M. F., & Sandrim, V. C. (2024) · Nutrients · doi:10.3390/nu16101475 · Cited by 19 · see citing works

mTOR regulates PRMT1 expression and mitochondrial mass through STAT1 phosphorylation in hepatic cell.

Zhang, X., Li, L., Li, Y., Li, Z., Zhai, W., Sun, Q.-Z., Yang, X.-J., Roth, M., & Lu, S.-M. (2021) · Biochimica et biophysica acta. Molecular cell research · doi:10.1016/j.bbamcr.2021.119017 · Cited by 18 · see citing works

Maternal glucagon-like peptide-1 is positively associated with fetal growth in pregnancies complicated with obesity

Dumolt, J. H., Rosario, F. J., Kramer, A. C., Horwitz, S., Powell, T. L., & Jansson, T. (2023) · Clinical Science · doi:10.1042/cs20220890 · Cited by 17 · see citing works

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Diniz, M. S., Grilo, L. F., Tocantins, C., Falcão‐Pires, I., & Pereira, S. P. (2023) · Metabolites · doi:10.3390/metabo13070845 · Cited by 17 · see citing works

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Kelly, A. C., Kramer, A. W., Rosario, F. J., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20201050 · Cited by 15 · see citing works

Gestational exposure to BPA alters the expression of glucose and lipid metabolic mediators in the placenta: Role in programming offspring for obesity

Molangiri, A., Varma, S., Boga, N. S., Das, P., Duttaroy, A. K., & Basak, S. (2024) · Toxicology · doi:10.1016/j.tox.2024.153957 · Cited by 14 · see citing works

Rapid manipulation of mitochondrial morphology in a living cell with iCMM

Miyamoto, T., Uosaki, H., Mizunoe, Y., Han, S., Goto, S., Yamanaka, D., Masuda, M., Yoneyama, Y., Nakamura, H., Hattori, N., et al. (2021) · Cell Reports Methods · doi:10.1016/j.crmeth.2021.100052 · Cited by 14 · see citing works

Exposure to Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells

Elkin, E. R., Bridges, D., Harris, S. M., & Loch-Caruso, R. K. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00356 · Cited by 14 · see citing works

Tadalafil Treatment of Mice with Fetal Growth Restriction and Preeclampsia Improves Placental mTOR Signaling

Tanaka, K., Tanaka, H., Tachibana, R., Yoshikawa, K., Kawamura, T., Takakura, S., Takeuchi, H., & Ikeda, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031474 · Cited by 13 · see citing works

Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort

Keleher, M. R., Erickson, K., Kechris, K. J., Yang, I. V., Dabelea, D., Friedman, J. E., Boyle, K. E., & Jansson, T. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0574-y · Cited by 12 · see citing works

A Targeting Trained Immunity Nanofiber Scaffold for Large Bone Defect Repair

Zhan, J., Chen, Z., Liu, J., Pang, Q.-M., Lei, M., Liu, J., Song, Y., Huang, W., & Dong, L. (2025) · Advanced Fiber Materials · doi:10.1007/s42765-025-00548-3 · Cited by 11 · see citing works

Characterization of the Primary Human Trophoblast Cell Secretome Using Stable Isotope Labeling With Amino Acids in Cell Culture

Rosario, F. J., Pardo, S., Michelsen, T. M., Erickson, K., MOORE, L. G., Powell, T. L., Weintraub, S. T., & Jansson, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.704781 · Cited by 11 · see citing works

Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability

Rosario, F. J., Chopra, A., Biggar, K. K., Powell, T. L., Gupta, M. B., & Jansson, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087273 · Cited by 10 · see citing works

DMC-BH derivative DMC-GF inhibits the growth of glioma stem cells by targeting the TRIM33/SLC25A1/mitochondrial oxidative phosphorylation pathway

Shi, L., Fei, X., Huang, J. M., Bao, H., Sun, Z., & Sun, G. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06355-z · Cited by 10 · see citing works

Maternal metabolic status and in-vitro culture conditions during embryonic genome activation deregulate the expression of energy-related genes in the bovine 16-cells embryo

Rabaglino, M. B., Forde, N., Besenfelder, U., Havlíček, V., Blum, H., Graf, A., Wolf, E., & Lonergan, P. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290689 · Cited by 10 · see citing works

20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells

Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works

Potential Role of the mTORC1-PGC1α-PPARα Axis under Type-II Diabetes and Hypertension in the Human Heart

Hang, T., Lumpuy‐Castillo, J., Goikoetxea‐Usandizaga, N., Azkargorta, M., Aldámiz‐Echevarría, G., Martínez‐Milla, J., Forteza, A., Cortina, J. M., Egido, J., Elortza, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108629 · Cited by 9 · see citing works

Toward the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis

Martínez, N., Chorna, N., González‐Crespo, S., Villanueva, L., Montes‐Rodríguez, I. M., Meléndez, L. M., Roche-Lima, A., Carrasquillo-Carrión, K., Santiago, E., Rymond, B. C., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-86671-8 · Cited by 8 · see citing works

Effects of vitrification and the superovulated environment on placental function and fetal growth in an IVF mouse model

Roeca, C. M., Silva, E., Barentsen, C., Powell, T. L., & Jansson, T. (2020) · Molecular Human Reproduction · doi:10.1093/molehr/gaaa047 · Cited by 7 · see citing works

Placental mTOR signalling links mitochondrial dysfunction, nutrient transport and neonatal beta cell perturbations in mice

Beetch, M., Oribamise, E. I., Jo, S., Clifton, B., Larson, S. N., Hausmann, A., Wong, A., Akhaphong, B., Morgan, E., & Alejandro, E. U. (2025) · Diabetologia · doi:10.1007/s00125-025-06542-z · Cited by 6 · see citing works

Oleic acid stimulation of amino acid uptake in primary human trophoblast cells is mediated by phosphatidic acid and mTOR signaling

Silva, E., Ferchaud‐Roucher, V., Kramer, A. W., Madi, L., Pantham, P., Chassen, S. S., Jansson, T., & Powell, T. L. (2023) · FASEB BioAdvances · doi:10.1096/fba.2023-00113 · Cited by 6 · see citing works

Postnatal and Juvenile Fluoxetine Treatment Evokes Sex-Specific, Opposing Effects on Mood-Related Behavior, Gene Expression, Mitochondrial Function, and Dendritic Architecture in the Rat Medial Prefrontal Cortex

Ghai, U., Chachra, P., Mendon, S., Janakiraman, B., Fanibunda, S. E., Sarkar, A., Gohil, D., Jayaprasad, A. B., Kukkemane, K., Singh, V. K., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.04.026 · Cited by 6 · see citing works

Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome

Callahan, T. J., Stefanski, A. L., Kim, J.-D., Baumgartner, W. A., Wyrwa, J. M., & Hunter, L. (2022) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789811270611_0034 · Cited by 5 · see citing works

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

Pabon, A., Bhupana, J. N., & Wong, C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02095 · Cited by 6 · see citing works

Sénothérapies

Véret, D., & Brondello, J. (2020) · médecine/sciences · doi:10.1051/medsci/2020220 · Cited by 5 · see citing works

mTORC1 and mTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells

Soliman, G. A., Abzalimov, R. R., & He, Y. (2022) · Nutrients · doi:10.3390/nu14153022 · Cited by 4 · see citing works

Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging

Havas, A. P., Rajesh, A., Lei, X., Proulx, J. M., Miller, K. N., Field, A. E., Davis, A., Teneche, M. G., Gandhi, A., Lee, J., et al. (2026) · Aging Cell · doi:10.1111/acel.70395 · Cited by 3 · see citing works

Trophoblast‐specific Deptor knockdown enhances trophoblast nutrient transport and fetal growth in mice

Nunes, L. G. A., Weingrill, R. B., Fredrick, S. B. J., Lorca, R. A., Lee, M., Atif, S. M., Chicco, A. J., Rosario, F. J., & Urschitz, J. (2025) · Acta Physiologica · doi:10.1111/apha.70012 · Cited by 4 · see citing works

Transcriptomic and functional profiling reveal autophagy inhibition and persistent bioenergetic collapse following parallel photodamage to lysosomes and mitochondria

Franco, M. S. F., Ravagnani, F. G., Marie, S. K. N., Oba‐Shinjo, S. M., de Assis, L. V. M., & Baptista, M. S. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113364 · Cited by 2 · see citing works

Tumor-suppressive function of methiothepin in human placental choriocarcinoma cells

Lee, J., Lim, W., & Song, G. (2020) · Reproduction · doi:10.1530/rep-20-0377 · Cited by 2 · see citing works

Mechanistic target of rapamycin signaling activity in the human placenta across gestation and in maternal obesity

Bidne, K. L., Erickson, K., Powell, T. L., & Jansson, T. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf007 · Cited by 1 · see citing works

Effect of Functional Electrical Stimulation Combined With Physical Exercise on Electron Transport Chain Activity in Peripheral Blood Cells of Stroke Patients

Larrea, A., Martín‐Odriozola, A., Astigarraga, E., Rodríguez‐de‐Pablo, C., Barreda‐Gómez, G., & Torrecilla, M. (2025) · Artificial Organs · doi:10.1111/aor.70031 · Cited by 1 · see citing works

Disentangling the biological information encoded in disordered mitochondrial morphology through its rapid elicitation by iCMMPreprint

Miyamoto, T., Uosaki, H., Mizunoe, Y., Goto, S., Yamanaka, D., Masuda, M., Yoneyama, Y., Nakamura, H., Hattori, N., Takeuchi, Y., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.22.166165

Regulation of oxidative phosphorylation by Nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in micePreprint

Venit, T., Sapkota, O., Abdrabou, W. S., Palanikumar, L., Pasricha, R., Mahmood, S. R., Said, N. H. E., Thomas, S. A., Idaghdour, Y., Magzoub, M. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.30.498328

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR InhibitorPreprint

Artoni, F., Grützmacher, N., & Demetriades, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.10.519872

Effect of miRNA-99a along with TGF-?1(C/G +915) in female with secondary unexplained infertility

AL-Saeedi, S., & Altamemi, I. A. (2023) · AL-QADISIYAH MEDICAL JOURNAL · doi:10.28922/qmj.2023.19.1.20-23

HSD17B7 counters bone loss in estrogen deficiency via estrogen receptor stabilization and mediates the effect of raloxifenePreprint

Moon, Y. J., Zhang, J., Song, Y., Koo, J.-H., Chen, S., Jang, K. Y., Yoon, S., & Kim, J. R. (2025) · Research Square · doi:10.21203/rs.3.rs-6158228/v1

Placental mitochondrial respiration is inhibited in mice with trophoblast specific AdipoR2 overexpression

Shimada, H., Sakuragi, T., Barentsen, K., Erickson, K., Urschitz, J., Powell, T. L., Jansson, T., & Rosario, F. J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.025

In vitro exposure to the SARS-CoV-2 Spike protein subunit S1 leads to changes in several functional characteristics of human trophoblast cells

Carmo, F., Rodrigues, I., Ramalho, C. M. A., & Martel, F. (2026) · Placenta · doi:10.1016/j.placenta.2026.01.015

HSD17B7 Counters Bone Loss in Estrogen Deficiency via Estrogen Receptor Stabilization and Mediates the Effect of Raloxifene

Zhang, J., Song, Y., Koo, J., Chen, S., Jang, K. Y., Yoon, S., Kim, J. R., & Moon, Y. J. (2026) · MedComm · doi:10.1002/mco2.70623

The role of the GATOR1 complex in mitochondrial function and quality control

Zhang, H. (2025) · theses.fr (ABES) · doi:10.70675/1dad907cz4477z4068z81c2z087317cd244e

Epigenome-wide DNA methylation and spontaneous preterm birth among pregnant black women

Zhao, T., Zhao, Y., Reho, P., Samari, G., WAPNER, R., Hazi, A. K., Wu, H., & Barcelona, V. (2026) · Clinical Epigenetics · doi:10.1186/s13148-026-02151-8

Sexual Dimorphism in Placental mTORC1 Signaling, Amino Acid Transport, and Mitochondrial Respiration at Term

Shimada, H., Sakuragi, T., Zaegel, V., Kramer, A. W., Boyle, K. E., Powell, T. L., Jansson, T., & Rosario, F. J. (2026) · Antioxidants · doi:10.3390/antiox15080977

mTOR regulation of trophoblast transcriptome and mitochondrial respiration (1159.1)

Rosario, F. J., Cox, L. A., Lange, K. J., Muralimanoharan, S., Myatt, L., Powell, T. L., & Jansson, T. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1159.1 · Cited by 1 · see citing works

mTORC1 Transcriptional Regulation of Ribosome Subunits, Protein Synthesis, and Molecular Transport in Primary Human Trophoblast Cells

Rosario, F. J., Powell, T. L., Gupta, M. B., Cox, L. A., & Jansson, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.583801 · Cited by 34 · see citing works

Mechanistic Target of Rapamycin Complex 2 Regulation of the Primary Human Trophoblast Cell Transcriptome

Rosario, F. J., Kelly, A. C., Gupta, M. B., Powell, T. L., Cox, L. A., & Jansson, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.670980 · Cited by 15 · see citing works

Hypoxia reduces placental mTOR activation in a hypoxia-induced model of intrauterine growth restriction (IUGR)

Kimball, R., Wayment, M., Merrill, D., Wahlquist, T., Reynolds, P. R., & Arroyo, J. A. (2015) · Physiological Reports · doi:10.14814/phy2.12651 · Cited by 34 · see citing works

Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia

Mandò, C., De Palma, C., Stampalija, T., Anelli, G. M., Figus, M., Novielli, C., Parisi, F., Clementi, E., Ferrazzi, E., & Cetin, I. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2013 · Cited by 196 · see citing works