miR302a and 122 are deregulated in small extracellular vesicles from ARPE-19 cells cultured with H2O2
Open accessAbstract
Age related macular degeneration (AMD) is a common retina-related disease leading to blindness. Little is known on the origin of the disease, but it is well documented that oxidative stress generated in the retinal pigment epithelium and choroid neovascularization are closely involved. The study of circulating miRNAs is opening new possibilities in terms of diagnosis and therapeutics. miRNAs can travel associated to lipoproteins or inside small Extracellular Vesicles (sEVs). A number of reports indicate a significant deregulation of circulating miRNAs in AMD and experimental approaches, but it is unclear whether sEVs present a significant miRNA cargo. The present work studies miRNA expression changes in sEVs released from ARPE-19 cells under oxidative conditions (i.e. hydrogen peroxide, H 2 O 2 ). H 2 O 2 increased sEVs release from ARPE-19 cells. Moreover, 218 miRNAs could be detected in control and H 2 O 2 induced-sEVs. Interestingly, only two of them (hsa-miR-302a and hsa-miR-122) were significantly under-expressed in H 2 O 2 -induced sEVs. Results herein suggest that the down regulation of miRNAs 302a and 122 might be related with previous studies showing sEVs-induced neovascularization after oxidative challenge in ARPE-19 cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
miR-122-5p can suppress pro-inflammatory cytokine production and oxidative stress by targeting MAPK pathway components, including ERK and JNK.
“Previous studies have reported that miR-122-5p can suppress pro-inflammatory cytokine production and oxidative stress by targeting MAPK pathway components, including ERK and JNK 30 .”
From rAAV-mediated Multi-miRNA Delivery Targeting MAPK Pathway Suppresses Laser-induced Choroidal Neovascularization in Mice (2026) · cites this paper as [30]
The Discussion (page unavailable) reports that pre-miR-122 protects against H2O2-induced oxidative stress. It does not report suppression of pro-inflammatory cytokine production or identify ERK, JNK, or other MAPK components as targets; it instead names mitochondrial ribosomal protein S11. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe three selected miRNAs-hsa-miR-122-5p, hsa-let-7a-5p, and hsa-miR-26a-5p-provide complementary and comprehensive coverage of almost all critical genes associated with the MAPK signaling pathway.
“From this analysis, we selected the three abundant miRNAs-hsa-miR-122-5p, hsa-let-7a-5p, and hsa-miR26a-5p-based on their complementary and comprehensive coverage of almost all the critical genes associated with the MAPK signaling pathway 27-33 as analyzed using miRTarBase version 8.0 and TarBase v8.0 integrated within miRNet (Figure S1).”
From rAAV-mediated Multi-miRNA Delivery Targeting MAPK Pathway Suppresses Laser-induced Choroidal Neovascularization in Mice (2026) · cites this paper as [30]
The Results section on pathway analysis discusses let-7a and miR-122, but does not say that they cover critical MAPK genes. Searches for MAPK, miR-26a-5p, and comprehensive gene coverage found no passage supporting the three-miRNA coverage claim; the paper instead describes other pathways and uses different target-prediction tools. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
Mittelbrunn, M., Gutiérrez‐Vázquez, C., Villarroya‐Beltri, C., González, S., Sánchez‐Cabo, F., González, M. A., Bernad, A., & Sánchez‐Madrid, F. (2011) · Nature Communications · doi:10.1038/ncomms1285 · Cited by 1,768 · see citing works
Skjerdal, T., Gefferth, A., Spajic, M., Gaston, E., Cesare, A. D., Vitali, S. F., Pasquali, F., Bovo, F., Manfreda, G., Mancusi, R., et al. (2017) · BioMed Research International · doi:10.1155/2017/6353510 · Cited by 1,178 · see citing works
Creemers, E. E., Tijsen, A. J., & Pinto, Y. M. (2012) · Circulation Research · doi:10.1161/circresaha.111.247452 · Cited by 1,017 · see citing works
Exosomes: endosomal-derived vesicles shipping extracellular messages
Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 1,013 · see citing works
Bhaskaran, M., & Mohan, M. (2013) · Veterinary Pathology · doi:10.1177/0300985813502820 · Cited by 614 · see citing works
Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483 · see citing works
Bukong, T. N., Momen‐Heravi, F., Kodys, K., Bala, S., & Szabó, G. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004424 · Cited by 407 · see citing works
Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters
Zhou, Q., Gallagher, R., Ufret-Vincenty, R., Li, X., Olson, E. N., & Wang, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105254108 · Cited by 341 · see citing works
van Balkom, B. W. M., Eisele, A. S., Pegtel, D. M., Bervoets, S., & Verhaar, M. C. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26760 · Cited by 294 · see citing works
Age‐Related Macular Degeneration: New Paradigms for Treatment and Management of AMD
Hernández-Zimbrón, L. F., Zamora-Alvarado, R., la Paz, L. D. O.-D., Vélez-Montoya, R., Zenteno, E., Gulías-Cañizo, R., Quiroz–Mercado, H., & González-Salinas, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8374647 · Cited by 239 · see citing works
Atienzar‐Aroca, S., Flores‐Bellver, M., Serrano‐Heras, G., Martínez‐Gil, N., Barcia, J. M., Aparicio, S. F., Pérez‐Cremades, D., García‐Verdugo, J. M., Díaz-Llopis, M., Romero, F. J., et al. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12834 · Cited by 232 · see citing works
Self-citationMao, Z., Li, S., Zhang, L., Yao, M., Zhou, Z., & Chen, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7621561 · Cited by 217 · see citing works
MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases
Kumar, S., Vijayan, M., Bhatti, J. S., & Reddy, P. H. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.013 · Cited by 216 · see citing works
MicroRNAs Regulate Ocular Neovascularization
Shen, J., Yang, X., Xie, B., Chen, Y., Swaim, M., Hackett, S. F., & Campochiaro, P. A. (2008) · Molecular Therapy · doi:10.1038/mt.2008.104 · Cited by 214 · see citing works
Oxidative Stress and MicroRNAs in Vascular Diseases
Magenta, A., Greco, S., Gaetano, C., & Martelli, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917319 · Cited by 194 · see citing works
Baker, J. R., Vuppusetty, C., Colley, T., Papaioannou, A. Ι., Fenwick, P. S., Donnelly, L., Ito, K., & Barnes, P. J. (2016) · Scientific Reports · doi:10.1038/srep35871 · Cited by 175 · see citing works
The miR-302-367 cluster as a potential stemness regulator in ESCs
Jesus, A. B.-D., Lucena-Aguilar, G., & Menéndez, P. R. (2009) · Cell Cycle · doi:10.4161/cc.8.3.7554 · Cited by 165 · see citing works
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa
Loscher, C. J., Hokamp, K., Kenna, P. F., Ivens, A. C., Humphries, P., Palfi, A., & Farrar, G. J. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r248 · Cited by 135 · see citing works
Biasutto, L., Chiechi, A., Couch, R., Liotta, L. A., & Espina, V. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.005 · Cited by 126 · see citing works
High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs
Karali, M., Persico, M., Mutarelli, M., Carissimo, A., Pizzo, M., Marwah, V. S., Ambrosio, C., Pinelli, M., Carrella, D., Ferrari, S., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw039 · Cited by 119 · see citing works
Romano, G. L., Platania, C. B. M., Drago, F., Salomone, S., Ragusa, M., Barbagallo, C., Pietro, C. D., Purrello, M., Reibaldi, M., Avitabile, T., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00168 · Cited by 117 · see citing works
Drewry, M. D., Challa, P., Kuchtey, J., Navarro, I. D., Helwa, I., Hu, Y., Mu, H., Stamer, W. D., Kuchtey, R. W., & Liu, Y. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy040 · Cited by 107 · see citing works
Effect of miR-23 on Oxidant-Induced Injury in Human Retinal Pigment Epithelial Cells
Lin, H., Qian, J., Castillo, A. C., Long, B., Keyes, K. T., Chen, G., & Ye, Y. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6632 · Cited by 104 · see citing works
MicroRNA-30b-Mediated Regulation of Catalase Expression in Human ARPE-19 Cells
Haque, R., Chun, E., Howell, J. C., Sengupta, T., Chen, D., & Kim, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042542 · Cited by 103 · see citing works
An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology
Berber, P., Graßmann, F., Kiel, C., & Weber, B. H. F. (2016) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-016-0234-z · Cited by 95 · see citing works
MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD
Ménard, C., Rezende, F., Miloudi, K., Wilson, A. M., Tétreault, N., Hardy, P., SanGiovanni, J. P., Guire, V. D., & Sapieha, P. S. (2016) · Oncotarget · doi:10.18632/oncotarget.8280 · Cited by 92 · see citing works
Evaluation of circulating miRNAs in wet age-related macular degeneration.
Ertekin, S., Yıldırım, Ö., Dinç, E., Ayaz, L., Fidancı, S. B., & Tamer, L. (2014) · PubMed Central · Cited by 87 · see citing works
Wu, J., Wang, R., Ye, Z., Sun, X., Chen, Z., Xia, F., Sun, Q., & Liu, L. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.121 · Cited by 84 · see citing works
The miR-302/367 cluster: a comprehensive update on its evolution and functions
Gao, Z., Zhu, X., & Dou, Y. (2015) · Open Biology · doi:10.1098/rsob.150138 · Cited by 83 · see citing works
miR-183/96 plays a pivotal regulatory role in mouse photoreceptor maturation and maintenance
Xiang, L., Chen, X., Wu, K., Zhang, C.-J., Zhou, G.-H., Lv, J., Sun, L., Cheng, F., Cai, X., & Jin, Z. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618757114 · Cited by 78 · see citing works
MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis.
Wang, Y., Xing, Q., Liu, X., Guo, Z., Li, C., & Sun, G. (2016) · Europe PMC (PubMed Central) · Cited by 76 · see citing works
A novel role of miR-302/367 in reprogramming
Kuo, C., Deng, J. H., Deng, Q., & Ying, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.058 · Cited by 75 · see citing works
Graßmann, F., Schoenberger, P. G. A., Brandl, C., Schick, T., Hasler, D., Meister, G., Fleckenstein, M., Lindner, M., Helbig, H., Fauser, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107461 · Cited by 70 · see citing works
Li, C., Deng, M., Hu, J., Li, X., Chen, L., Ju, Y., Hao, J., & Meng, S. (2016) · Oncotarget · doi:10.18632/oncotarget.7740 · Cited by 69 · see citing works
Serum MicroRNAs as Potential Biomarkers of AMD
Szemraj, M., Bielecka-Kowalska, A., Oszajca, K., Krajewska, M., Goś, R., Jurowski, P., Kowalski, M., & Szemraj, J. (2015) · Medical Science Monitor · doi:10.12659/msm.893697 · Cited by 68 · see citing works
miRNAs as potential therapeutic targets for age-related macular degeneration
Wang, S., Koster, K. M., He, Y., & Zhou, Q. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.11.176 · Cited by 67 · see citing works
Howell, J. C., Chun, E., Farrell, A., Hur, E. Y., Caroti, C. M., Iuvone, P. M., & Haque, M. R. (2013) · Europe PMC (PubMed Central) · Cited by 66 · see citing works
The expanding role of miR-302–367 in pluripotency and reprogramming
Lipchina, I., Studer, L., & Betel, D. (2012) · Cell Cycle · doi:10.4161/cc.19846 · Cited by 61 · see citing works
Mazzeo, A., Lopatina, T., Gai, C., Trento, M., Porta, M., & Beltramo, E. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.04.015 · Cited by 61 · see citing works
Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration
Ren, C., Liu, Q., Wei, Q., Cai, W., He, M., Du, Y., Xu, D., Yan, W., & Yu, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000467941 · Cited by 61 · see citing works
He, J.-F. (2014) · Medical Science Monitor · doi:10.12659/msm.890686 · Cited by 57 · see citing works
Evaluation of microRNA responses in ARPE-19 cells against the oxidative stress
Ayaz, L., & Dinç, E. (2017) · Cutaneous and Ocular Toxicology · doi:10.1080/15569527.2017.1355314 · Cited by 54 · see citing works
Serum miR-122 levels correlate with diabetic retinopathy
Pastukh, N., Meerson, A., Kalish, D., Jabaly, H., & Blum, A. (2019) · Clinical and Experimental Medicine · doi:10.1007/s10238-019-00546-x · Cited by 50 · see citing works
MicroRNA expression profile in retina and choroid in oxygen-induced retinopathy model
Desjarlais, M., Rivera, J. C., Lahaie, I., Cagnone, G., Wirt, M., Omri, S., & Chemtob, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218282 · Cited by 50 · see citing works
Three new circulating microRNAs may be associated with wet age-related macular degeneration
Elbay, A., Ercan, Ç., Akbaş, F., Bulut, H., & Özdemir, H. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2019.1637931 · Cited by 49 · see citing works
Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt’s lymphoma exosomes
Yoon, C., Kim, J., Park, G., Kim, S., Kim, D., Hur, D. Y., Kim, B., & Kim, Y. S. (2015) · Tumor Biology · doi:10.1007/s13277-015-3769-4 · Cited by 45 · see citing works
Maisto, R., Oltra, M. R., Vidal‐Gil, L., Martínez‐Gil, N., Sancho-Pellúz, J., Filippo, C. D., Rossi, S., Amico, M. D., Barcia, J. M., & Romero, F. J. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1568745 · Cited by 44 · see citing works
Self-citationJiao, X., Fan, Z., Chen, H., He, P., Li, Y., Zhang, Q., & Ke, C. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24829 · Cited by 42 · see citing works
Genini, S., Guziewicz, K. E., Beltran, W. A., & Aguirre, G. D. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-172 · Cited by 41 · see citing works
Yang, X., Weng, Z., Mendrick, D. L., & Shi, Q. (2014) · Toxicology Letters · doi:10.1016/j.toxlet.2014.01.013 · Cited by 40 · see citing works
Pan, J., Bhardwaj, M., Nagabhyru, P., Grossman, R. B., & Schardl, C. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115590 · Cited by 40 · see citing works
miRNAs, single nucleotide polymorphisms (SNPs) and age-related macular degeneration (AMD)
SanGiovanni, J. P., SanGiovanni, P. M., Sapieha, P. S., & Guire, V. D. (2017) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0898 · Cited by 39 · see citing works
Li, W., Zhang, Y., Lu, Z., Dong, L., Wang, F. E., Dong, R., & Li, X. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-8303 · Cited by 34 · see citing works
miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells
Tian, B., Maidana, D. E., Dib, B., Miller, J. B., Bouzika, P., Miller, J. W., Vavvas, D., & Lin, H.-J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160887 · Cited by 29 · see citing works
Kim, J. M., Cho, H. J., Kim, Y., Jung, S. H., Lee, D. W., & Kim, J. W. (2019) · Seminars in Ophthalmology · doi:10.1080/08820538.2019.1620791 · Cited by 29 · see citing works
miR-29a regulates the proliferation and differentiation of retinal progenitors by targeting Rbm8a
Zhang, Y., Shen, B., Zhang, D., Wang, Y., Tang, Z., Ni, N., Jin, X., Luo, M., Sun, H., & Gu, P. (2017) · Oncotarget · doi:10.18632/oncotarget.16669 · Cited by 27 · see citing works
Profiling the microRNA Expression in Human iPS and iPS-derived Retinal Pigment Epithelium
Wang, H.-C. H., Greene, W. A., Kaini, R. R., Shen-Gunther, J., Chen, H.-I. H., Car, H., & Wang, Y. (2014) · Cancer Informatics · doi:10.4137/cin.s14074 · Cited by 24 · see citing works
Impact of angiogenic activation and inhibition on miRNA profiles of human retinal endothelial cells
Pfeil, J. M., Wecker, T., Zhang, P. P., Cakir, B., Gruening, B., Agostini, H., Reuer, T., Ludwig, F., Boneva, S., Faerber, L., et al. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.01.006 · Cited by 22 · see citing works
Qin, C., Zha, W., Fan, R.-G., Ding, H., Xu, Y.-H., & Wang, C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7312 · Cited by 18 · see citing works
Li, D.-D., Zhong, B.-W., Zhang, H., Zhou, H., Luo, J., Yang, L., Xu, G.-C., Luan, C.-S., & Fang, J. (2016) · Molecular Biology Reports · doi:10.1007/s11033-016-4041-8 · Cited by 16 · see citing works
Chen, W., Zhuang, X., Qi, R., & Qiao, T. (2019) · PubMed Central · Cited by 15 · see citing works
Balla, H. Z., Theodorsson, E., & Ström, J. O. (2019) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2018.1519722 · Cited by 14 · see citing works
miR-25 Mediates Retinal Degeneration Via Inhibiting ITGAV and PEDF in Rat
Zhang, J., Wang, J., Zheng, L., Wang, M., Lu, Y., Li, Z., Lian, C., Mao, S., Hou, X., Li, S., et al. (2018) · Current Molecular Medicine · doi:10.2174/1566524018666171205122540 · Cited by 14 · see citing works
MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice
Song, L., Zhang, Z. R., Zhang, J., Zhu, X., He, L., Shi, Z., Gao, L., Li, Y., Hu, B., & Feng, F. (2015) · Genetics and Molecular Research · doi:10.4238/2015.october.26.22 · Cited by 14 · see citing works
Bai, J., Yu, J., Wang, J., Xue, B., He, N., Tian, Y., Yang, L., Wang, Y., Wang, Y., & Tang, Q. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5294105 · Cited by 13 · see citing works
Zhang, Y., Hu, D., Zhu, Y., Sun, H., Gu, P., Zhu, D., & Zhou, J. (2017) · BioMed Research International · doi:10.1155/2017/2647879 · Cited by 11 · see citing works
Dinç, E., Ayaz, L., & Kurt, A. H. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2017.0128 · Cited by 7 · see citing works
Glutathiolation Triggers Proteins for Degradation by the Ubiquitin- Proteasome Pathway
Zhang, X., Taylor, A., Liu, Y., & Shang, F. (2017) · Current Molecular Medicine · doi:10.2174/1566524017666171101165021 · Cited by 7 · see citing works
Introduction to Volume 1 of JOPT Special Issue
Sharif, N. A., Ohia, S. E., & Yorio, T. (2018) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2017.29037.int · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [43]Qin C MicroRNA-302a inhibits cell proliferation and invasion, and induces cell apoptosis in hepatocellular carcinoma by directly targeting VEGFA Mol. Med. Rep. 2017 16 6360 6367 10.3892/mmr.2017.7312 28849033 · DOI
Cited by
Sorted by citations
Micro RNAs in Regulation of Cellular Redox Homeostasis
Ciesielska, S., Ślęzak-Prochazka, I., Bil, P., & Rzeszowska‐Wolny, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116022 · Cited by 43 · see citing works
Martins, B. D., Pires, M. E., Ambrósio, A. F., Girão, H., & Fernandes, R. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01036-3 · Cited by 38 · see citing works
Extracellular vesicles in degenerative retinal diseases: A new therapeutic paradigm
Manai, F., Smędowski, A., Kaarniranta, K., Comincini, S., & Amadio, M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.11.035 · Cited by 36 · see citing works
Bridi, A., Andrade, G. M., del Collado, M., Sangalli, J. R., de Ávila, A. C. F. C. M., Motta, I. G., da Silva, J. C. B., Pugliesi, G., Silva, L. A., Meirelles, F. V., et al. (2021) · Molecular Reproduction and Development · doi:10.1002/mrd.23527 · Cited by 34 · see citing works
Extracellular miRNAs in redox signaling: Health, disease and potential therapies
Ruiz, G. P., Camara, H., Fazolini, N. P. B., & Mori, M. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.004 · Cited by 29 · see citing works
The Impact of miRNAs in Health and Disease of Retinal Pigment Epithelium
Intartaglia, D., Giamundo, G., & Conte, I. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.589985 · Cited by 25 · see citing works
Impact of angiogenic activation and inhibition on miRNA profiles of human retinal endothelial cells
Pfeil, J. M., Wecker, T., Zhang, P. P., Cakir, B., Gruening, B., Agostini, H., Reuer, T., Ludwig, F., Boneva, S., Faerber, L., et al. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.01.006 · Cited by 22 · see citing works
SS‐31 protect retinal pigment epithelial cells from H2O2‐induced cell injury by reducing apoptosis
Bai, J., Yang, Y., Wu, D., & Yang, F. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13484 · Cited by 21 · see citing works
Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation
Caserta, S., & Ghezzi, P. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.04.010 · Cited by 20 · see citing works
Extracellular Vesicles as Biomarkers and Therapeutics for Inflammatory Eye Diseases
Louie, H. H., Mugisho, O. O., Chamley, L. W., & Rupenthal, I. D. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00414 · Cited by 11 · see citing works
Oltra, M. R., Martínez-Santos, M., Ybarra, M., Rowland, H., Muriach, M., Romero, F. J., Sancho-Pellúz, J., & Barcia, J. M. (2022) · Antioxidants · doi:10.3390/antiox11050818 · Cited by 10 · see citing works
Self-citationOn the other end of the line: Extracellular vesicle-mediated communication in glaucoma
Lucci, C., & Groef, L. D. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1148956 · Cited by 8 · see citing works
Mao, K., & Wu, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7658921 · Cited by 8 · see citing works
Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium
Hernandez, B. J., Strain, M., Suarez, M. F., Stamer, W. D., Ashley‐Koch, A. E., Liu, Y., Klingeborn, M., & Rickman, C. B. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.13.57 · Cited by 8 · see citing works
Romero, F. J., Díaz-Llopis, M., Romero-Gomez, M. I., Miranda, M., Romero-Wenz, R., Sancho-Pellúz, J., Romero, B., Muriach, M., & Barcia, J. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031618 · Cited by 7 · see citing works
Self-citationAbundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance
Chen, X., Li, M., Wang, Y.-H., Mou, H., Wu, Z., Bao, S., Xu, Z.-H., Zhang, H., Wang, X., Zhang, C.-J., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.565543 · Cited by 6 · see citing works
The emerging role of extracellular vesicles in retinal diseases.
Sun, F., Xu, W., & Qian, H. (2021) · PubMed Central · Cited by 6 · see citing works
Scientometric analysis of extracellular vesicles in vision science (up to 2024)
Liao, F., Germaín, F., Ma, L., Wei, C., & Wang, T. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03703-5 · Cited by 6 · see citing works
Hunt, A. L., Khan, I., Wu, A. M. L., Makohon‐Moore, S. C., Hood, B. L., Conrads, K. A., Abulez, T. S., Ogata, J. D., Mitchell, D., Gist, G. D., et al. (2023) · Clinical & Experimental Metastasis · doi:10.1007/s10585-023-10233-7 · Cited by 3 · see citing works
Bastos, N. M., Goulart, R. S., Bridi, A., Mazzarella, R., Alves, L. R., Rosa, P. M. D. S., Strefezzi, R. D. F., Paskoski, L. B., Nociti, R. P., Sangalli, J. R., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326138 · Cited by 1 · see citing works
Han, J. W., Yang, J. Y., Kim, Y., An, S., Yoo, E., Park, I. H., Lee, S.-W., Lee, H.-J., Lee, T. G., Jung, W. H., et al. (2026) · Molecular Therapy: Nucleic Acids · doi:10.1016/j.omtn.2026.103101 · Cited by 1 · see citing works
Guo, H., Yan, R., Han, X., & Yu, W. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s612984
Wang, Y., Luo, T., Li, C., Zhou, L., Lin, H., & Yang, M. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111189
- Authors
- Oltra, M., Vidal-Gil, L., Maisto, R., Oltra, S. S., Romero, F. J., Sancho-Pelluz, J., & Barcia, J. M.
- Affiliations
- University of Campania "Luigi Vanvitelli" (IT)
- Universitat de València (ES)
- Generalitat Valenciana (ES)
- Venue
- Scientific Reports
- Published
- 2019-11-29
- Volume
- 9
- Issue
- 1
- Pages
- 17954-17954
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6884596
- OpenAlex
- W2991261760
- Cited by
- 24
- References
- 71
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RIUCV (Universidad Católica de Valencia San Vicente Martír) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Hispana (submittedVersion, cc-by)
- Funders
- Generalitat Valenciana (PROMETEO/2016/094)
- Conselleria d'Educació, Investigació, Cultura i Esport
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- miR-302a, miR-122, small extracellular vesicles, age-related macular degeneration, ARPE-19 cells, retinal pigment epithelium, oxidative stress, hydrogen peroxide, circulating microRNAs, choroidal neovascularization
- MeSH terms
- Extracellular Vesicles, Cell Line, Gene Expression Regulation, Humans, Hydrogen Peroxide, Down-Regulation, Oxidative Stress, MicroRNAs, Retinal Pigment Epithelium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
