miRNAs as potential therapeutic targets for age-related macular degeneration
Open accessAbstract
Since their recent discovery, miRNAs have been shown to play critical roles in a variety of pathophysiological processes. Such processes include pathological angiogenesis, the oxidative stress response, immune response and inflammation, all of which have been shown to have important and interdependent roles in the pathogenesis and progression of age-related macular degeneration (AMD). Here we present a brief review of the pathological processes involved in AMD and review miRNAs and other noncoding RNAs involved in regulating these processes. Specifically, we discuss several candidate miRNAs that show promise as AMD therapeutic targets due to their direct involvement in choroidal neovascularization or retinal pigment epithelium atrophy. We discuss potential miRNA-based therapeutics and delivery methods for AMD and provide future directions for the field of miRNA research with respect to AMD. We believe the future of miRNAs in AMD therapy is promising.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Ranibizumab for Neovascular Age-Related Macular Degeneration
Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., & Kim, R. Y. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054481 · Cited by 5,886 · see citing works
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 4,269 · see citing works
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
Ranibizumab versus Verteporfin for Neovascular Age-Related Macular Degeneration
Brown, D. M., Kaiser, P. K., Michels, M., Soubrane, G., Heier, J. S., Kim, R. Y., Sy, J. P., & Schneider, S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa062655 · Cited by 3,522 · see citing works
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104053441406 · Cited by 2,921 · see citing works
Prevalence of Age-Related Macular Degeneration in the United States
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,742 · see citing works
Many roads to maturity: microRNA biogenesis pathways and their regulation
Winter, J. J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,646 · see citing works
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works
Wiklund, R. A., & Rosenbaum, S. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710163371606 · Cited by 2,159 · see citing works
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051 · see citing works
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866 · see citing works
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,825 · see citing works
Self-citationmiR-126 Regulates Angiogenic Signaling and Vascular Integrity
Fish, J. E., Santoro, M. M., Morton, S. U., Yu, S., Yeh, R.-F., Wythe, J. D., Ivey, K. N., Bruneau, B. G., Stainier, D. Y. R., & Srivastava, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.008 · Cited by 1,728 · see citing works
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S., & Ørum, H. (2009) · Science · doi:10.1126/science.1178178 · Cited by 1,654 · see citing works
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589 · see citing works
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,480 · see citing works
Age-related macular degeneration
Jager, R. D., Mieler, W. F., & Miller, J. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801537 · Cited by 1,379 · see citing works
Tili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304 · see citing works
The AMD Genetics Clinical Study Group, Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1750 · Cited by 1,075 · see citing works
A MicroRNA Signature of Hypoxia
Kulshreshtha, R., Ferracin, M., Wojcik, S. E., Garzon, R., Alder, H., Agosto-Perez, F. J., Davuluri, R., Liu, C.-G., Croce, C. M., Negrini, M., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01395-06 · Cited by 1,055 · see citing works
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
Dews, M., Homayouni, A., Yu, D., Murphy, D. A., Sevignani, C., Wentzel, E. A., Furth, E. E., Lee, W. M., Enders, G. H., Mendell, J. T., et al. (2006) · Nature Genetics · doi:10.1038/ng1855 · Cited by 1,049 · see citing works
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
Cheloufi, S., Dos Santos, C. O., Chong, M. M. W., & Hannon, G. J. (2010) · Nature · doi:10.1038/nature09092 · Cited by 1,026 · see citing works
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959 · see citing works
Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912 · see citing works
Therapeutic in vivo gene transfer for genetic disease using AAV: Progress and challenges
Mingozzi, F., & High, K. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2988 · Cited by 893 · see citing works
Maguire, A. M., High, K. A., Auricchio, A., Wright, J. F., Pierce, E. A., Testa, F., Mingozzi, F., Bennicelli, J. L., Ying, G.-S., Rossi, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61836-5 · Cited by 865 · see citing works
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., et al. (2010) · Science · doi:10.1126/science.1190809 · Cited by 836 · see citing works
Complement C3 variant and the risk of age-related macular degeneration
Yates, J. R. W., Sepp, T., Matharu, B. K., Khan, J. C., Thurlby, D. A., Shahid, H., Clayton, D. G., Hayward, C., Morgan, J., Wright, A. F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072618 · Cited by 829 · see citing works
Evolution of geographic atrophy of the retinal pigment epithelium
Sarks, J. P., Sarks, S. H., & Killingsworth, M. C. (1988) · Eye · doi:10.1038/eye.1988.106 · Cited by 802 · see citing works
Age-related macular degeneration
de Jong, P. T. V. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062326 · Cited by 787 · see citing works
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
MicroRNA sponges: Progress and possibilities
Ebert, M. S., & Sharp, P. A. (2010) · RNA · doi:10.1261/rna.2414110 · Cited by 762 · see citing works
Friedman, D. S. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.7.1019 · Cited by 656 · see citing works
MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia
Zhong, H., Lv, Q., Ye, W., Wong, C.-K. A., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., Yang, B. B., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000116 · Cited by 653 · see citing works
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B. C., Kuziel, W. A., Rollins, B. J., & Ambati, B. K. (2003) · Nature Medicine · doi:10.1038/nm950 · Cited by 631 · see citing works
The Promise of MicroRNA Replacement Therapy
Bader, A. G., Brown, D., & Winkler, M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2010 · Cited by 618 · see citing works
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601 · see citing works
Molecular pathology of age-related macular degeneration
Ding, X., Patel, M., & Chan, C.-C. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.10.001 · Cited by 582 · see citing works
Bazzoni, F., Rossato, M., Fabbri, M., Gaudiosi, D., Mirolo, M., Mori, L., Tamassia, N., Mantovani, A., Cassatella, M. A., & Locati, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810909106 · Cited by 548 · see citing works
The Role of Apoptosis in Age-Related Macular Degeneration
Dunaief, J. L. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.11.1435 · Cited by 527 · see citing works
MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation
Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.005 · Cited by 523 · see citing works
Inflammation and the Degenerative Diseases of Aging
McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 519 · see citing works
Lee, D. Y., Deng, Z., Wang, C.-H., & Yang, B. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706901104 · Cited by 517 · see citing works
Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500 · see citing works
Macrophage Depletion Inhibits Experimental Choroidal Neovascularization
Sakurai, E., Anand, A., Ambati, B. K., van Rooijen, N., & Ambati, J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0097 · Cited by 498 · see citing works
MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
Liu, L.-Z., Li, C.-Y., Chen, Q., Yi, J., Carpenter, R. L., Jiang, Y., Kung, H., Lai, L., & Jiang, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019139 · Cited by 492 · see citing works
The Role of Inflammation in the Pathogenesis of Age-related Macular Degeneration
Donoso, L. A., Kim, D. S., Frost, A. T., Callahan, A., & Hageman, G. S. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2005.12.001 · Cited by 480 · see citing works
miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells
Würdinger, T., Tannous, B. A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X. O., & Krichevsky, A. M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.005 · Cited by 460 · see citing works
Magenta, A., Cencioni, C., Fasanaro, P., Zaccagnini, G., Greco, S., Sarra-Ferraris, G., Antonini, A., Martelli, F., & Capogrossi, M. C. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.42 · Cited by 456 · see citing works
Specificity, duplex degradation and subcellular localization of antagomirs
Krützfeldt, J., Kuwajima, S., Braich, R. S., Rajeev, K. G., Pena, J., Tuschl, T., Manoharan, M., & Stoffel, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm024 · Cited by 456 · see citing works
Anand, S., Majeti, B. K., Acevedo, L. M., Murphy, E. A., Mukthavaram, R., Scheppke, L., Huang, M., Shields, D. J., Lindquist, J. N., Lapinski, P. E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2186 · Cited by 455 · see citing works
AngiomiRs—Key regulators of angiogenesis
Wang, S., & Olson, E. N. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.04.002 · Cited by 448 · see citing works
Self-citationGrossniklaus, H. E., Ling, J. X., Wallace, T. M., Dithmar, S., Lawson, D., Cohen, C., Elner, V. M., Elner, S. G., & Sternberg, P. (2002) · PubMed · Cited by 434 · see citing works
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
Yamakuchi, M., Lotterman, C., Bao, C., Hruban, R. H., Karim, B. O., Mendell, J. T., Huso, D. L., & Lowenstein, C. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911082107 · Cited by 430 · see citing works
Chen, Z., Li, Y., Zhang, H., Huang, P., & Luthra, R. (2010) · Oncogene · doi:10.1038/onc.2010.193 · Cited by 426 · see citing works
Imamura, Y., Noda, S., Hashizume, K., Shinoda, K., Yamaguchi, M., Uchiyama, S., Shimizu, T., Mizushima, Y., Shirasawa, T., & Tsubota, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602131103 · Cited by 420 · see citing works
Espinosa‐Heidmann, D. G., Suñer, I. J., Hernandez, E. P., Monroy, D. C., Csaky, K. G., & Cousins, S. W. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0038 · Cited by 401 · see citing works
Perry, M. M., Moschos, S. A., Williams, A. E., Shepherd, N. J., Larner-Svensson, H. M., & Lindsay, M. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5689 · Cited by 387 · see citing works
MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4
Cheng, Y., Liu, X., Zhang, S., Lin, Y., Yang, J., & Zhang, C. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.01.008 · Cited by 368 · see citing works
The Association Between Cigarette Smoking and Ocular Diseases
Solberg, Y., Rosner, M., & Belkin, M. (1998) · Survey of Ophthalmology · doi:10.1016/s0039-6257(98)00002-2 · Cited by 366 · see citing works
Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126
Kuhnert, F., Mancuso, M. R., Hampton, J. P., Stankunas, K., Asano, T., Chen, C., & Kuo, C. J. (2008) · Development · doi:10.1242/dev.029736 · Cited by 344 · see citing works
Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters
Zhou, Q., Gallagher, R., Ufret-Vincenty, R., Li, X., Olson, E. N., & Wang, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105254108 · Cited by 341 · see citing works
Self-citationFavaro, E., Ramachandran, A., McCormick, R., Gee, H., Blancher, C., Crosby, M., Devlin, C., Blick, C., Buffa, F., Li, J.-L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010345 · Cited by 324 · see citing works
miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes
Li, Q., Laake, L. W. V., Huang, Y., Liu, S. J., Wendland, M. F., & Srivastava, D. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101547 · Cited by 321 · see citing works
Let-7 microRNA–mediated regulation of IL-13 and allergic airway inflammation
Kumar, M., Ahmad, T., Sharma, A. S., Mabalirajan, U., Kulshreshtha, A., Agrawal, A., & Ghosh, B. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.034 · Cited by 311 · see citing works
miR‐210: More than a silent player in hypoxia
Devlin, C. M., Greco, S., Martelli, F., & Ivan, M. (2011) · IUBMB Life · doi:10.1002/iub.427 · Cited by 289 · see citing works
Moschos, S. A., Williams, A. E., Perry, M. M., Birrell, M. A., Belvisi, M. G., & Lindsay, M. A. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-240 · Cited by 284 · see citing works
Solingen, C. V., Seghers, L., Bijkerk, R., Duijs, J. M. G. J., Roeten, M. K., van Oeveren‐Rietdijk, A. M., Baelde, H. J., Monge, M., Vos, J. B., de Boer, H. C., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00613.x · Cited by 267 · see citing works
MECHANICS OF OPTIC NERVE TRACTION ON THE RETINA DURING OCULAR ROTATION
Friedman, B. (1941) · Archives of ophthalmology · doi:10.1001/archopht.1941.00870100042005 · Cited by 261 · see citing works
Yang, K., He, Y. S., Wang, X. Q., Lu, L., Chen, Q., Liu, J., Sun, Z., & Shen, W. F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.009 · Cited by 258 · see citing works
Self-citationSmoking and Age-Related Maculopathy: The Blue Mountains Eye Study
Smith, W. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100140716016 · Cited by 255 · see citing works
MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells
Sabatel, C., Malvaux, L., Bovy, N., Deroanne, C., Lambert, V., Gonzalez, M.-L. A., Colige, A., Rakic, J., Noël, A., MARTIAL, J. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016979 · Cited by 253 · see citing works
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration
Apte, R. S., Richter, J., Herndon, J., & Ferguson, T. A. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030310 · Cited by 249 · see citing works
SOD2 knockdown mouse model of early AMD
Justilien, V., Pang, J.-J., Renganathan, K., Zhan, X., Crabb, J. W., Kim, S. R., Sparrow, J. R., Hauswirth, W. W., & Lewin, A. S. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0432 · Cited by 234 · see citing works
Kim, Y., Pae, H., Park, J. E., Lee, Y. C., Woo, J. M., Kim, N., Choi, Y. K., Lee, B.-S., Kim, S. R., & Chung, H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3153 · Cited by 222 · see citing works
Gong, A., Zhou, R., Hu, G., Li, X., Splinter, P. L., O’Hara, S. P., LaRusso, N. F., Soukup, G. A., Dong, H., & Chen, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1325 · Cited by 216 · see citing works
Tuo, J., Smith, B. C., Bojanowski, C. M., Meleth, A. D., Gery, I., Csaky, K. G., Chew, E. Y., & Chan, C.-C. (2004) · The FASEB Journal · doi:10.1096/fj.04-1862fje · Cited by 215 · see citing works
MicroRNAs Regulate Ocular Neovascularization
Shen, J., Yang, X., Xie, B., Chen, Y., Swaim, M., Hackett, S. F., & Campochiaro, P. A. (2008) · Molecular Therapy · doi:10.1038/mt.2008.104 · Cited by 214 · see citing works
Ryan, S. J. (1982) · Archives of Ophthalmology · doi:10.1001/archopht.1982.01030040784015 · Cited by 211 · see citing works
Dentelli, P., Rosso, A., Orso, F., Olgasi, C., Taverna, D., & Brizzi, M. F. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.206201 · Cited by 205 · see citing works
MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1α Expression and Tumor Angiogenesis
Cha, S.-T., Chen, P.-S., Johansson, G., Chu, C.-Y., Wang, M.-Y., Jeng, Y.-M., Yu, S.-L., Chen, J.-S., Chang, K.-J., Jee, S.-H., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2448 · Cited by 202 · see citing works
Grundmann, S., Hans, F. P., Kinniry, S., Heinke, J., Helbing, T., Bluhm, F., Sluijter, J. P. G., Hoefer, I. E., Pasterkamp, G., Bode, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.000323 · Cited by 194 · see citing works
Huang, R., Hu, G., Lin, B., Lin, Z., & Sun, C. (2010) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e3181ff46d7 · Cited by 189 · see citing works
Jennewein, C., von Knethen, A., Schmid, T., & Brüne, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.066399 · Cited by 183 · see citing works
Fleißner, F., Jazbutyte, V., Fiedler, J., Gupta, S. K., Yin, X., Xu, Q., Galuppo, P., Kneitz, S., Mayr, M., Ertl, G., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.216770 · Cited by 183 · see citing works
Mutharasan, R. K., Nagpal, V., Ichikawa, Y., & Ardehali, H. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01080.2010 · Cited by 175 · see citing works
Grisanti, S., & Tatar, O. (2008) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.05.002 · Cited by 163 · see citing works
Thulasingam, S., Massilamany, C., Gangaplara, A., Dai, H., Yarbaeva, S., Subramaniam, S., Riethoven, J.-J. M., Eudy, J. D., Lou, M. F., & Reddy, J. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0752-2 · Cited by 125 · see citing works
Li, G., Luna, C., Qiu, J., Epstein, D. L., & González, P. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6708 · Cited by 120 · see citing works
microRNA-24a is required to repress apoptosis in the developing neural retinaPreprint
McGann, J. C., & Harland, R. M. (2009) · Genes & Development · doi:10.1101/gad.1777709 · Cited by 116 · see citing works
Pogue, A. I., Li, Y. Y., Cui, J.-G., Zhao, Y., Kruck, T. P. A., Percy, M. E., Tarr, M. A., & Lukiw, W. J. (2009) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2009.05.012 · Cited by 112 · see citing works
Anti-VEGF therapy: comparison of current and future agents
Pieramici, D. J., & Rabena, M. (2008) · Eye · doi:10.1038/eye.2008.88 · Cited by 110 · see citing works
Apoptosis in Surgically Excised Choroidal Neovascular Membranes in Age-Related Macular Degeneration
Hinton, D. R., He, S., & Lopez, P. F. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.2.203 · Cited by 110 · see citing works
Effect of miR-23 on Oxidant-Induced Injury in Human Retinal Pigment Epithelial Cells
Lin, H., Qian, J., Castillo, A. C., Long, B., Keyes, K. T., Chen, G., & Ye, Y. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6632 · Cited by 104 · see citing works
Mitchell, P. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.585394 · Cited by 102 · see citing works
Smoking and age-related maculopathy
Shami, I. E. (1997) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(97)90614-5 · Cited by 100 · see citing works
<i>Ccl2/Cx3cr1-</i>Deficient Mice: An Animal Model for Age-Related Macular Degeneration
Chan, C.-C., Ross, R. J., Shen, D., Ding, X., Majumdar, Z., Bojanowski, C. M., Zhou, M., Salem, Jr., Bonner, R., & Tuo, J. (2008) · Ophthalmic Research · doi:10.1159/000119862 · Cited by 98 · see citing works
The road toward microRNA therapeutics
Seto, A. G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.03.003 · Cited by 90 · see citing works
Gong, Y.-F., Xiang, L., & Shao, J.-Z. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804370 · Cited by 90 · see citing works
Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217
Beckman, J. D., Chen, C., Nguyen, J., Thayanithy, V., Subramanian, S., Steer, C. J., & Vercellotti, G. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148726 · Cited by 87 · see citing works
Kindzelskii, A. L., Elner, V. M., Elner, S. G., Yang, D., Hughes, B. A., & Petty, H. R. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200409062 · Cited by 85 · see citing works
Niu, Y., Mo, D., Qin, L., Wang, C., Li, A., Zhao, X. D., Wang, X., Xiao, S., Wang, Q., Xie, Y., et al. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03374.x · Cited by 70 · see citing works
MiR-204 regulate cardiomyocyte autophagy induced by hypoxia-reoxygenation through LC3-II
Jian, X., Zhu, X., Bin, H., Yu-feng, Z., Bo, K., Wang, Z., & Ni, X. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.01.029 · Cited by 51 · see citing works
Chang, C.-L., Au, L., Huang, S., Kwok, C., Ho, L., & Juan, C. (2010) · Endocrinology · doi:10.1210/en.2010-0493 · Cited by 40 · see citing works
Synowiec, E., Szaflik, J., Chmielewska, M., Woźniak, K., Skłodowska, A., Waszczyk, M., Dorecka, M., Błasiak, J., & Szaflik, J. P. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0955-3 · Cited by 33 · see citing works
Csaky, K. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.650 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions
Drag, S., Dotiwala, F., & Upadhyay, A. K. (2023) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.64.7.39 · Cited by 145 · see citing works
Murad, N., Kokkinaki, M., Gunawardena, N., Gunawan, M. S., Hathout, Y., Janczura, K. J., Theos, A. C., & Golestaneh, N. (2014) · The FEBS Journal · doi:10.1111/febs.13066 · Cited by 73 · see citing works
Oltra, M., Vidal-Gil, L., Maisto, R., Oltra, S. S., Romero, F. J., Sancho-Pelluz, J., & Barcia, J. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-54373-x · Cited by 24 · see citing works
Mutation-independent therapies for retinal diseases: focus on gene-based approaches
Carrella, S., Indrieri, A., Franco, B., & Banfi, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.588234 · Cited by 14 · see citing works
- Authors
- Wang, S., Koster, K. M., He, Y., & Zhou, Q.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Department of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX75390, USA
- Corresponding author
- Wang, Shusheng
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2012-03
- Volume
- 4
- Issue
- 3
- Pages
- 277-287
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC3313592
- OpenAlex
- W2151225614
- Cited by
- 67
- References
- 110
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Future Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- UT Southwestern Medical Center (EY021862 and EY020799)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- microRNA, age-related macular degeneration, therapeutic target, choroidal neovascularization, retinal pigment epithelium atrophy, pathological angiogenesis, oxidative stress, inflammation, non-coding RNA, miRNA-based therapy, microRNA delivery
- MeSH terms
- Animals, Humans, Inflammation, Macula Lutea, Macular Degeneration, Oxidative Stress, Choroidal Neovascularization, MicroRNAs, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
