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Cited by 83Electrochemical sensors and biosensorsSpectroscopy Techniques in Biomedical and Chemical ResearchAnalytical Chemistry and Sensors

Tear Glucose Measurement by Reflectance Spectrum of a Nanoparticle Embedded Contact Lens

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Kim, Sooyeon, Jeon, Hee-Jae, Park, Sijin, Lee, Dong Yun, Chung, Euiheon·2020·Scientific Reports
DOI 10.1038/s41598-020-65103-zPMC PMC7237479
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Abstract

Glucose level is a primary indicator in the diagnosis and treatment of diabetes mellitus. According to the correlation between glucose concentration in blood and tears, measuring tear glucose can be an alternative to traditional strips test for blood glucose. Thus, measuring tear glucose levels could provide noninvasive monitoring of blood glucose. As a biocompatible biosensor, a nanoparticle embedded contact lens (NECL) is developed which is composed of glucose oxidase and cerium oxide (III). Using spectroscopy, we found the detectable changes in reflection spectrum of contact lenses with respect to the glucose concentration, and developed correlation curve of the reflection spectrum with known glucose level. Furthermore, we assessed tear glucose level and compared blood glucose level with the diabetic mouse model to evaluate this approach. Our algorithm for regular monitoring of glucose using contact lens biosensor may lead to noninvasive monitoring of tear glucose level. NECL may provide simple and noninvasive glucose monitoring based on the spectral changes in contact lens biosensor.

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  • Scientific data evidenced how commercially available test strips exhibit the required performance to evaluate glucose concentration in low-volume tears.

    “Scientific data evidenced how commercially available test strips exhibit the required performance to evaluate glucose concentration in low-volume tears 166-168.”

    From Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices (2022) · cites this paper as [167]

    The Introduction describes commercial test strips as part of finger-prick blood glucometers, while the Discussion reports tear-glucose measurements using a nanoparticle-embedded contact lens. Searches for commercially available strips and low-volume tears found no passage assessing whether test strips perform adequately with tear samples. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

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References 30 · Cited by 83

Research works printed but not linked: 26

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Authors
Kim, S., Jeon, H.-J., Park, S., Lee, D. Y., & Chung, E.
Affiliations
  • Gwangju Institute of Science and Technology (KR)
  • Hanyang University (KR)
Corresponding author
Chung, Euiheon
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2020-05-19
Volume
10
Issue
1
Pages
8254-8254
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-020-65103-z
PMC
PMC7237479
OpenAlex
W3027399444
Cited by
83
References
30
Citations by year
2026: 7 · 2025: 16 · 2024: 14 · 2023: 10 · 2022: 18 · 2021: 14 · 2020: 4
FWCI
3.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Research Foundation
  • Ministry of Science, ICT and Future Planning (NRF-2017M3C7A 1044964)
  • National Research Foundation of Korea (NRF-2019M3C7A1044964, NRF-2015M3A9E2030125, NRF‐2017M3C7A 1044964)
Topics
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
  • Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
Keywords
tear glucose, non-invasive glucose monitoring, glucose oxidase, cerium oxide nanoparticles, reflectance spectrum, diabetes mellitus, blood glucose, diabetic mouse model
MeSH terms
Animals, Contact Lenses, Diabetes Mellitus, Female, Glucose, Glucose Oxidase, Humans, Male, Mice, Inbred C57BL, Tears, Blood Glucose Self-Monitoring, Biosensing Techniques, Mice, Nanoparticles

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