Involved microRNAs in alternative polyadenylation intervene in breast cancer via regulation of cleavage factor “CFIm25”
Open accessAbstract
Cleavage factor “CFIm25”, as a key repressor at proximal poly (A) site, negatively correlates to cell proliferation and tumorigenicity in various cancers. Hence, understanding CFIm25 mechanism of action in breast cancer would be a great benefit. To this aim four steps were designed. First, potential miRNAs that target 3′-UTR of CFIm25 mRNA, retrieved from Targetscan web server. Second, screened miRNAs were profiled in 100 breast cancer and 100 normal adjacent samples. Third, miRNAs that their expression was inversely correlated to the CFIm25, overexpressed in MDA-MB-231 cell line, and their effect on proliferation and migration monitored via MTT and wound healing assays, respectively. Fourth, interaction of miRNAs of interest with 3′-UTR of CFIm25 confirmed via luciferase assay and western blot. Our results indicate that CFIm25 considerably down-regulates in human breast cancer tissue. qRT-PCR assay, luciferase test, and western blotting confirm that CFIm25 itself could be directly regulated by oncomiRs such as miR-23, -24, -27, -135, -182 and -374. Besides, according to MTT and wound healing assays of cell lines, CFIm25 knockdown intensifies cell growth, proliferation and migration. Our results also confirm indirect impact of CFIm25 on regulation of mRNA’s 3′–UTR length, which then control corresponding miRNAs’ action. miRNAs directly control CFIm25 expression level, which then tunes expression of the oncogenes and tumor proliferation. Therefore, regulation of CFIm25 expression level via miRNAs is expected to improve treatment responses in breast cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Analysis of 100 breast cancer and 100 normal adjacent samples confirmed that miRNAs directly control expression levels of CFIm25, subsequently regulating oncogenes and tumor proliferation.
“Analysis and screening of miRNAs in 100 cases of breast cancer and 100 cases of normal adjacent samples also confirmed that miRNAs directly control the expression levels of CFIm25, subsequently regulating the expression of oncogenes and tumor proliferation [83].”
From Recent advances of miR-23 in human diseases and growth development (2025) · cites this paper as [83]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 5,910 · see citing works
The role of MicroRNAs in human cancer
Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,507 · see citing works
Sotiriou, C. P., Wirapati, P., Loi, S., Harris, A. L., Fox, S., Smeds, J., Nordgren, H., Farmer, P. J., Praz, V., Haibe‐Kains, B., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj052 · Cited by 2,060 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349 · see citing works
Alternative polyadenylation of mRNA precursors
Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179 · see citing works
A Brief Review on the Mechanisms of miRNA Regulation
Cai, Y., Yu, X., Hu, S., & Yu, J. M. (2009) · Genomics Proteomics & Bioinformatics · doi:10.1016/s1672-0229(08)60044-3 · Cited by 997 · see citing works
Enhancer function: new insights into the regulation of tissue-specific gene expression
Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929 · see citing works
Alternative cleavage and polyadenylation: extent, regulation and function
Elkon, R., Ugalde, A. P., & Agami, R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3482 · Cited by 805 · see citing works
Mechanism and regulation of mRNA polyadenylation
Colgan, D. F., & Manley, J. L. (1997) · Genes & Development · doi:10.1101/gad.11.21.2755 · Cited by 784 · see citing works
Mechanisms and Consequences of Alternative Polyadenylation
Di Giammartino, D. C., Nishida, K., & Manley, J. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.017 · Cited by 737 · see citing works
Predicting RNA-Protein Interactions Using Only Sequence Information
Muppirala, U. K., Honavar, V., & Dobbs, D. L. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-489 · Cited by 575 · see citing works
Oncogenes and Tumor Suppressor GenesPreprint
Lee, E. Y., & Muller, W. J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003236 · Cited by 515 · see citing works
Xia, Z., Donehower, L., Cooper, T., Neilson, J., Wheeler, D., Wagner, E., & Li, W. (2014) · Nature Communications · doi:10.1038/ncomms6274 · Cited by 509 · see citing works
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
Masamha, C. P., Xia, Z., Yang, J., Albrecht, T. R., Li, M., Shyu, A., Li, W., & Wagner, E. J. (2014) · Nature · doi:10.1038/nature13261 · Cited by 449 · see citing works
Regulation of Epidermal Growth Factor Receptor Signaling in Human Cancer Cells by MicroRNA-7
Webster, R. J., Giles, K. M., Price, K. J., Zhang, P. M., Mattick, J. S., & Leedman, P. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804280200 · Cited by 445 · see citing works
Grillo, G., Turi, A., Licciulli, F., Mignone, F., Liuni, S., Banfi, S., Gennarino, V. A., Horner, D. S., Pavesi, G., Picardi, E., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp902 · Cited by 308 · see citing works
Alternative cleavage and polyadenylation: the long and short of it
Tian, B., & Manley, J. L. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.03.005 · Cited by 307 · see citing works
Fu, Y., Sun, Y., Li, Y., Li, J., Rao, X., Chen, C., & Xu, A. (2011) · Genome Research · doi:10.1101/gr.115295.110 · Cited by 270 · see citing works
Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation
Zhu, Y., Wang, X., Forouzmand, E., Jeong, J., Qiao, F., Sowd, G. A., Engelman, A., Xie, X. S., Hertel, K. J., & Shi, Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.11.031 · Cited by 221 · see citing works
Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin.
Heimann, R., Lan, F., McBride, R., & Hellman, S. (2000) · PubMed · Cited by 170 · see citing works
Alternative mRNA polyadenylation in eukaryotes: an effective regulator of gene expression
Lutz, C. S., & Moreira, A. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.47 · Cited by 145 · see citing works
The role of microRNAs in cancer: diagnostic and prognostic biomarkers and targets of therapies
Corsini, L. R., Bronte, G., Terrasi, M., Amodeo, V., Fanale, D., Fiorentino, E., Cicero, G., Bazan, V., & Russo, A. D. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.650632 · Cited by 127 · see citing works
Tan, S. H., Li, H., Zhang, W., Shao, Y., Liu, Y., Guan, H., Wu, J. F., Kang, Y., Zhao, J., Yu, Q., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0280-6 · Cited by 126 · see citing works
Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer
Lembo, A., Cunto, F. D., & Provero, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031129 · Cited by 115 · see citing works
Alternative Polyadenylation: Methods, Findings, and Impacts
Chen, W., Jia, Q., Song, Y., Fu, H., Wei, G., & Ni, T. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.06.001 · Cited by 103 · see citing works
Grottke, A., Ewald, F., Lange, T., Nörz, D. S., Herzberger, C., Bach, J., Grabinski, N., Gräser, L., Höppner, F., Nashan, B., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146370 · Cited by 85 · see citing works
Kouhkan, F., Mobarra, N., Zomorrod, M. S., Keramati, F., Rad, S. M. A. H., Fathi‐Roudsari, M., Tavakoli, R., Hajarizadeh, A., Ziaei, S., Lahmy, R., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103225 · Cited by 74 · see citing works
Self-citationCell Cycle Regulation by Alternative Polyadenylation of CCND1
Wang, Q., He, G., Hou, M., Chen, L., Chen, S., Xu, A., & Fu, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-25141-0 · Cited by 72 · see citing works
Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019) · Kidney Cancer · doi:10.3233/kca-180043 · Cited by 68 · see citing works
MicroRNAs modulating angiogenesis: miR-129-1 and miR-133 act as angio-miR in HUVECs
Zomorrod, M. S., Hajifathali, A., Kouhkan, F., Mehdizadeh, M., Rad, S. M. A. H., & Soleimani, M. (2016) · Tumor Biology · doi:10.1007/s13277-016-4845-0 · Cited by 56 · see citing works
Self-citationMobarra, N., Shafiee, A., Rad, S. M. A. H., Tasharrofi, N., Zomorrod, M. S., Hafizi, M., Movahed, M., Kouhkan, F., & Soleimani, M. (2015) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-015-9872-4 · Cited by 50 · see citing works
Self-citationFrom polyadenylation to splicing: Dual role for mRNA 3' end formation factors
Misra, A., & Green, M. R. (2015) · RNA Biology · doi:10.1080/15476286.2015.1112490 · Cited by 46 · see citing works
Alternative polyadenylation factors link cell cycle to migration
Mitra, M., Johnson, E. L., Swamy, V. S., Nersesian, L., Corney, D. C., Robinson, D. G., Taylor, D. G., Ambrus, A., Jelínek, D., Wang, W., et al. (2018) · Genome biology · doi:10.1186/s13059-018-1551-9 · Cited by 45 · see citing works
CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function
Masamha, C. P., Xia, Z., Peart, N. J., Collum, S. D., Li, W., Wagner, E. J., & Shyu, A. (2016) · RNA · doi:10.1261/rna.055939.116 · Cited by 44 · see citing works
Li, W., Li, W., Laishram, R. S., Hoque, M., Ji, Z., Tian, B., & Anderson, R. A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx560 · Cited by 44 · see citing works
Parsons, C. J., Stefanovic, B., Seki, E., Aoyama, T., Latour, A. M., Marzluff, W. F., Rippe, R. A., & Brenner, D. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189118 · Cited by 40 · see citing works
Functional SNP in microRNA‐491‐5p binding site of MMP9 3′‐UTR affects cancer susceptibility
Pirouz, H. J., Jafari, N., Rastegari, M., Fathi‐Roudsari, M., Tasharrofi, N., Shokri, G., Tamaddon, M., Sazegar, H., & Kouhkan, F. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26471 · Cited by 39 · see citing works
Self-citationCFIm25 and alternative polyadenylation: Conflicting roles in cancer
Abadi, M. H. J. N., Shafabakhsh, R., Asemi, Z., Mirzaei, H. R., Sahebnasagh, R., Mirzaei, H., & Hamblin, M. R. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.114430 · Cited by 36 · see citing works
MicroRNA-181a promotes proliferation and inhibits apoptosis by suppressing CFIm25 in osteosarcoma
Zhu, Z.-J., Huang, P., Chong, Y., Kang, L., Huang, X., Zhu, Z.-X., & Nie, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5741 · Cited by 31 · see citing works
Silencing NUDT21 Attenuates the Mesenchymal Identity of Glioblastoma Cells via the NF-κB Pathway
Lou, J., Lan, Y., Gao, J., Ma, B., Yang, T., Yuan, Z., Zhang, H., Zhu, T., Pan, N., Leng, S., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00420 · Cited by 28 · see citing works
Zhang, L., & Zhang, W. (2018) · Cancer Management and Research · doi:10.2147/cmar.s173496 · Cited by 27 · see citing works
Torabi, S., Tamaddon, M., Asadolahi, M., Shokri, G., Tavakoli, R., Tasharrofi, N., Rezaei, R., Tavakolpour, V., Sazegar, H., & Kouhkan, F. (2018) · Immunogenetics · doi:10.1007/s00251-018-1087-x · Cited by 24 · see citing works
Self-citationTasharrofi, N., Kouhkan, F., Soleimani, M., Soheili, Z., Kabiri, M., Saber, M. M., & Dorkoosh, F. A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26160 · Cited by 20 · see citing works
Self-citationWang, Y., Xu, Y., Yan, W., Han, P., Liu, J., Gong, J., Li, D., Ding, X., Wang, H., Lin, Z., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24364 · Cited by 19 · see citing works
Canonical and noncanonical RNA polyadenylation
Ustyantsev, I. G., Golubchikova, J. S., Borodulina, O. R., & Kramerov, D. A. (2017) · Molecular Biology · doi:10.1134/s0026893317010186 · Cited by 14 · see citing works
Mohammadi, Z., Shariati, L., Khanahmad, H., Kolahdouz, M., Kianpoor, F., Ghanbari, J., Hejazi, Z., Salehi, M., Nikpour, P., & Tabatabaiefar, M. A. (2015) · Molecular Biotechnology · doi:10.1007/s12033-015-9872-3 · Cited by 12 · see citing works
Optimization of a microRNA expression vector for function analysis of microRNA
Furukawa, N., Sakurai, F., Katayama, K., Seki, N., Kawabata, K., & Mizuguchi, H. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.001 · Cited by 12 · see citing works
Zomorrod, M. S., Kouhkan, F., Soleimani, M., Aliyan, A., & Tasharrofi, N. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.02.020 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A
Scarborough, A. M., Flaherty, J. N., Hunter, O. V., Liu, K., Kumar, A., Xing, C., Tu, B. P., & Conrad, N. K. (2021) · eLife · doi:10.7554/elife.64930 · Cited by 54 · see citing works
microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome
Tamaddon, M., Azimzadeh, M., & Tavangar, S. M. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17139 · Cited by 43 · see citing works
Self-citationAlternative polyadenylation: An enigma of transcript length variation in health and disease
Mohanan, N. K., Shaji, F., Koshre, G. R., & Laishram, R. S. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1692 · Cited by 41 · see citing works
The emerging roles of CFIm25 ( NUDT21/CPSF5 ) in human biology and disease
Masamha, C. P. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1757 · Cited by 28 · see citing works
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation
Wei, S., Huang, X., Zhu, Q. C., Chen, T., Zhang, Y., Tian, J., Pan, T., Zhang, L., Xie, T., Zhang, Q., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01336-z · Cited by 21 · see citing works
Emerging roles of alternative cleavage and polyadenylation (APA) in human disease
Dharmalingam, P., Mahalingam, R., Yalamanchili, H. K., Weng, T., Karmouty‐Quintana, H., Guha, A., & Thandavarayan, R. A. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30549 · Cited by 15 · see citing works
MicroRNA‐mediated metabolic reprogramming of chimeric antigen receptor T cells
Rad, S. M. A. H., Halpin, J. C., Tawinwung, S., Suppipat, K., Hirankarn, N., & McLellan, A. D. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12551 · Cited by 16 · see citing works
Bendrihem, K. A., Mouane, A., Azzi, M., Mihoubi, M. A., Atanassova, M., SAWICKA, B. H., Zahnit, W., & Messaoudi, M. (2025) · Phytotherapy Research · doi:10.1002/ptr.8481 · Cited by 15 · see citing works
NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer
Zhu, Y., Zhang, R., Zhang, Y., Cheng, X., Li, L., Wu, Z., & Ding, K. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.670353 · Cited by 15 · see citing works
Alavijeh, M. S., Maghsoudpour, A., Khayat, M., Rad, I., & Hatamie, S. (2021) · Journal of Mechanical Science and Technology · doi:10.1007/s12206-020-1242-9 · Cited by 12 · see citing works
Self-citationMukherjee, S., Barua, A., Wang, L., Tian, B., & Moore, C. L. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02114-1 · Cited by 11 · see citing works
Rostami, F. T., Hamedani, Z. T., Sadoughi, A., Mehrabadi, M., & Kouhkan, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-62064-5 · Cited by 8 · see citing works
Self-citationCharacterization and molecular targeting of CFIm25 ( NUDT21/CPSF5 ) mRNA using miRNAs
Khan, N., Gupta, M., & Masamha, C. P. (2025) · The FASEB Journal · doi:10.1096/fj.202402184r · Cited by 6 · see citing works
Memari, F., Tavakolpour, V., Mohajeri, N., Poopak, B., Fallah, P., Alizadeh, E., Kouhkan, F., & Zarghami, N. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02781-3 · Cited by 6 · see citing works
Self-citationRecent advances of miR-23 in human diseases and growth development
Qian, X., Jiang, Y., Yang, Y., Zhang, Y., Xu, N., Xu, B., Pei, K., Yu, Z., & Wu, W. (2025) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.12.010 · Cited by 5 · see citing works
The role of alternative polyadenylation in breast cancer
Qiao, P., Zhang, C., Shi, Y., & Du, H. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2024.1377275 · Cited by 5 · see citing works
Magnetic nanocomposite’s mechanism of action during the hyperthermia treatment of the breast cancer
Alavijeh, M. S., Rad, I., & Hatamie, S. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-02203-w · Cited by 5 · see citing works
Self-citationWang, X., Lin, Y., Li, Z., Li, Y.-Q., & Chen, M. (2024) · Cancer Informatics · doi:10.1177/11769351231180789 · Cited by 2 · see citing works
Kahangi, M. F., Tavakolpour, V., Mosleh, I. S., Oraee‐Yazdani, S., & Kouhkan, F. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01394-9 · Cited by 2 · see citing works
Self-citationZarghami, A., & Mirmalek, S. A. (2024) · Galen Medical Journal · doi:10.31661/gmj.v13i.3340 · Cited by 2 · see citing works
Mutual feedback regulation between Poly(A)-specific ribonuclease (PARN) and cognate microRNAs
Kyritsis, A. P., Beta, R. A. A., Scutelnic, D., Stravokefalou, V., Vescovo, V. D., Arsenopoulou, Z., Papikinos, K., Grasso, M., Fontana, F., Moutopoulou, P., et al. (2026) · Life Science Alliance · doi:10.26508/lsa.202503341 · Cited by 1 · see citing works
Wu, S., Hu, C., Wu, X., Zhou, X., & Huang, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.27.522044
Stępień, A., Pulimamidi, D., Plens-Gałąska, M., Lalonde, M., Kopczyńska, M., Kimurâ, H., Irshad, S., Gdula, M. R., Hamperl, S., & Kamieniarz-Gdula, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.02.691783
Zinz, R., Rohde, C., Pauli, C., Zhou, F., Syed, A. A., Heid, D., Shah, V., Wahl, N. A., Ray, A., Renders, S., et al. (2026) · Leukemia · doi:10.1038/s41375-026-03120-z
Stępień, A., Pulimamidi, D., Plens-Gałąska, M., Lalonde, M., Kopczyńska, M., Ostatek, K., Kapeliukha, M., Kimurâ, H., Irshad, S., Gdula, M. R., et al. (2026) · The EMBO Journal · doi:10.1038/s44318-026-00928-4
- Authors
- Tamaddon, M., Shokri, G., Hosseini Rad, S. M. A., Rad, I., Emami Razavi, À., & Kouhkan, F.
- Affiliations
- Stem Cell Technology Research Center (IR)
- Corresponding author
- Kouhkan, Fatemeh
- Venue
- Scientific Reports
- Published
- 2020-07-14
- Volume
- 10
- Issue
- 1
- Pages
- 11608-11608
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7360588
- OpenAlex
- W3042480935
- Cited by
- 25
- References
- 49
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2022: 5 · 2021: 6
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- CFIm25, microRNA, alternative polyadenylation, breast cancer, 3' UTR regulation, oncogenic microRNA, miR-23, miR-24, miR-27, miR-135, miR-182, cell proliferation, cell migration, MDA-MB-231 cells, tumor suppressor
- MeSH terms
- Breast Neoplasms, Cell Movement, Female, Humans, Gene Expression Regulation, Neoplastic, Computational Biology, Polyadenylation, RNA Interference, MicroRNAs, Cleavage And Polyadenylation Specificity Factor, Cell Line, Tumor, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
