Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK-Akt-eNOS pathway in the isoprenaline-induced oxidative stress model

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

Neal, B., Perkovic, V., Mahaffey, K. W., de Zeeuw, D., Fulcher, G., Erondu, N., Shaw, W., Law, G., Desai, M., & Matthews, D. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611925 · Cited by 7,830 · see citing works

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

Jollow, D. J., Mitchell, J. R., ZAMPAGLIONE, N. G., & Gillette, J. R. (2008) · Pharmacology · doi:10.1159/000136485 · Cited by 3,291 · see citing works

Diabetic Kidney Disease: Challenges, Progress, and Possibilities

Alicic, R. Z., Rooney, M. T., & Tuttle, K. R. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11491116 · Cited by 2,898 · see citing works

Advanced oxidation protein products as a novel marker of oxidative stress in uremia

Witko‐Sarsat, V., Friedlander, M. A., Capeillère‐Blandin, C., Nguyen‐Khoa, T., Nguyen, A., Zingraff, J., Jungers, P., & Descamps‐Latscha, B. (1996) · Kidney International · doi:10.1038/ki.1996.186 · Cited by 2,000 · see citing works

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982 · see citing works

The Autoxidation of Human Red Cell Lipids Induced by Hydrogen Peroxide

Stocks, J., & Dormandy, T. L. (1971) · British Journal of Haematology · doi:10.1111/j.1365-2141.1971.tb00790.x · Cited by 973 · see citing works

Akt Promotes Survival of Cardiomyocytes In Vitro and Protects Against Ischemia-Reperfusion Injury in Mouse Heart

Fujio, Y., Nguyen, T. U., Wencker, D., Kitsis, R. N., & Walsh, K. (2000) · Circulation · doi:10.1161/01.cir.101.6.660 · Cited by 846 · see citing works

The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease

Remuzzi, G., Perico, N., Macia, M. L., & Ruggenenti, P. L. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.09911.x · Cited by 505 · see citing works

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

(2017) · New England Journal of Medicine · doi:10.1056/nejmc1712572 · Cited by 415 · see citing works

Lipopolysaccharide-induced changes in plasma nitrite and nitrate concentrations in rats and mice: pharmacological evaluation of nitric oxide synthase inhibitors

Tracey, W. R., Tse, J., & Carter, G. (1995) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24521-9 · Cited by 310 · see citing works

Quantitative PCR tissue expression profiling of the human SGLT2 gene and related family members

Chen, J., Williams, S., Ho, S., Loraine, H., Hagan, D. L., Whaley, J. M., & Feder, J. N. (2010) · Diabetes Therapy · doi:10.1007/s13300-010-0006-4 · Cited by 308 · see citing works

Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease

Siragy, H. M., & Carey, R. M. (2010) · American Journal of Nephrology · doi:10.1159/000313363 · Cited by 297 · see citing works

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway

Vucicevic, L. M., Misirkic-Marjanovic, M., Janjetović, K., Vilimanovich, U., Sudar-Milovanovic, E. M., Isenović, E. R., Prica, M., Harhaji-Trajkovic, L. M., Kravic‐Stevovic, T., Bumbasirevic, V. Z., et al. (2010) · Autophagy · doi:10.4161/auto.7.1.13883 · Cited by 248 · see citing works

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M., & Salt, I. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-23420-4 · Cited by 240 · see citing works

Blood pressure effects of sodium–glucose co-transport 2 (SGLT2) inhibitors

Oliva, R., & Bakris, G. L. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.02.003 · Cited by 218 · see citing works

AMP-Activated Protein Kinase

Salt, I. P., & Hardie, D. G. (2017) · Circulation Research · doi:10.1161/circresaha.117.309633 · Cited by 186 · see citing works

SYMPATHETIC NERVOUS SYSTEM, DIABETES, AND HYPERTENSION

Perin, P. C., Maule, S. V., & Quadri, R. (2001) · Clinical and Experimental Hypertension · doi:10.1081/ceh-100001196 · Cited by 175 · see citing works

SGLT2 Inhibitor, Canagliflozin, Attenuates Myocardial Infarction in the Diabetic and Nondiabetic Heart

Lim, V. G., Bell, R. M., Arjun, S., Kolatsi‐Joannou, M., Long, D. A., & Yellon, D. M. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2018.10.002 · Cited by 162 · see citing works

iNOS expression requires NADPH oxidase‐dependent redox signaling in microvascular endothelial cells

Wu, F. Y., Tyml, K., & Wilson, J. X. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21495 · Cited by 135 · see citing works

Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation

Sayour, A. A., Korkmaz‐Icöz, S., Loganathan, S., Ruppert, M., Sayour, N. V., Oláh, A., Benke, K., Brune, M., Benkő, R., Horvath, E. M., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1881-8 · Cited by 135 · see citing works

Cardamom powder supplementation prevents obesity, improves glucose intolerance, inflammation and oxidative stress in liver of high carbohydrate high fat diet induced obese rats

Rahman, M. M., Alam, M. A., Ulla, A., Sumi, F. A., Subhan, N., Khan, T., Sikder, B., Hossain, H., Reza, H. M., & Alam, M. A. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0539-x · Cited by 106 · see citing works

SGLT2 inhibitors: their potential reduction in blood pressure

Maliha, G., & Townsend, R. R. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.11.001 · Cited by 95 · see citing works

Canagliflozin: a sodium glucose co‐transporter 2 inhibitor for the treatment of type 2 diabetes mellitus

Rosenthal, N., Meininger, G. E., Ways, K., Polidori, D., Desai, M. G., Qiu, R., Alba, M., Vercruysse, F., Balis, D. A., Shaw, W. C., et al. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12852 · Cited by 91 · see citing works

Attenuation of myocardial ischemia-reperfusion injury with nitric oxide replacement therapy

Lefer, A. M. (1995) · The Annals of Thoracic Surgery · doi:10.1016/0003-4975(95)00423-i · Cited by 87 · see citing works

Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats

Ulla, A., Mohamed, M. K., Sikder, B., Rahman, A. T., Sumi, F. A., Hossain, M., Reza, H. M., Rahman, G. M. S., & Alam, M. A. (2017) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-017-0136-7 · Cited by 80 · see citing works

Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease

Zhang, Y., Thai, K., Kepecs, D. M., & Gilbert, R. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144640 · Cited by 79 · see citing works

Protective effect of (−)-epigallocatechin-gallate (EGCG) on lipid peroxide metabolism in isoproterenol induced myocardial infarction in male Wistar rats: A histopathological study

Devika, P. T., & Prince, P. S. M. (2007) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.10.011 · Cited by 78 · see citing works

Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats

Alam, M. A., Hossain, M., Rahman, M. M., Subhan, N., Mamun, M. A. A., Ulla, A., Reza, H. M., & Alam, M. A. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2017.1321078 · Cited by 73 · see citing works

Sodium glucose transporter-2 inhibition has no renoprotective effects on non-diabetic chronic kidney disease

Ma, Q., Steiger, S., & Anders, H. (2017) · Physiological Reports · doi:10.14814/phy2.13228 · Cited by 73 · see citing works

Isoproterenol Induces Vascular Oxidative Stress and Endothelial Dysfunction via a Giα-Coupled β2-Adrenoceptor Signaling Pathway

Davel, A. P., Brum, P. C., & Rossoni, L. V. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091877 · Cited by 63 · see citing works

Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta

Davel, A. P., Fukuda, L. E., Sá, L. L. D., Munhoz, C. D., Scavone, C., Sanz‐Rosa, D., Cachofeiro, V., Lahera, V., & Rossoni, L. V. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2007 · Cited by 61 · see citing works

Efficacy of Composite Extract from Leaves and Fruits of Medicinal Plants Used in Traditional Diabetic Therapy against Oxidative Stress in Alloxan-Induced Diabetic Rats

Tiwari, B. K., Kumar, D., Abidi, A. B., & Rizvi, S. I. (2014) · ISRN Pharmacology · doi:10.1155/2014/608590 · Cited by 57 · see citing works

Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on cisplatin-induced nephrotoxicity in mice

Abdelrahman, A. M., Suleimani, Y. M. A., Shalaby, A. A., Ashique, M., Manoj, P., Nemmar, A., & Ali, B. H. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-018-1564-7 · Cited by 53 · see citing works

Agonist-stimulated reactive oxygen species formation regulates β2-adrenergic receptor signal transduction

Moniri, N. H., & Daaka, Y. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.03.016 · Cited by 46 · see citing works

Nicorandil enhances the efficacy of mesenchymal stem cell therapy in isoproterenol-induced heart failure in rats

Mohamed, S. S., Ahmed, L. A., Attia, W., & Khattab, M. M. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.10.004 · Cited by 40 · see citing works

Phenolic Content Analysis of Aloe vera Gel and Evaluation of the Effect of Aloe Gel Supplementation on Oxidative Stress and Fibrosis in Isoprenaline-Administered Cardiac Damage in Rats

Sumi, F. A., Sikder, B., Rahman, M. M., Lubna, S. R., Ulla, A., Hossain, H., Jahan, I. A., Alam, M. A., & Subhan, N. (2019) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2019.24.3.254 · Cited by 40 · see citing works

Genistein activates endothelial nitric oxide synthase in broiler pulmonary arterial endothelial cells by an Akt-dependent mechanism

Yang, Y., Nie, W., Yuan, J., Zhang, B., Wang, Z., Wu, Z., & Guo, Y. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.11.078 · Cited by 34 · see citing works

The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkersviamodulation of inflammatory cytokines in type 2 diabetic rats

Safhi, M. M., Anwer, T., Khan, G., Siddiqui, R., Moni, S. S., & Alam, M. F. (2018) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2018.22.5.493 · Cited by 32 · see citing works

AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo

Lieberthal, W., Tang, M., Abate, M. T., Lusco, M. A., & Levine, J. S. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00553.2018 · Cited by 29 · see citing works

The Role of β-Adrenergic Overstimulation in the Early Stages of Renal Injury

de Ponte, M. C., Casare, F. A. M., Costa-Pessoa, J. M., Cardoso, V. G., Malnic, G., de Mello-Aires, M., Volpini, R. A., Thieme, K., & Oliveira‐Souza, M. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000485931 · Cited by 21 · see citing works

Effects of Prolonged Propranolol Treatment on Left Ventricular Remodeling and Oxidative Stress After Myocardial Infarction in Rats

Mansuy, P., Mougenot, N., Ramirez‐Gil, J. F., Bonnefont‐Rousselot, D., Raillecove, F., Michel Komajda, N., & Lechat, P. P. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200005000-00019 · Cited by 20 · see citing works

Neuroglobin protects cardiomyocytes against apoptosis and cardiac hypertrophy induced by isoproterenol in rats.

Liu, Z., Zhang, X., Qiao, Y., Xu, W., Ma, C., Gu, H., Zhou, X., Shi, L., Changxing, C. U. I., Xia, D., et al. (2015) · PubMed Central · Cited by 16 · see citing works

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives.

Bhatti, J. S., Sehrawat, A., Mishra, J., Sidhu, I. S., Navik, U., Khullar, N., Kumar, S., Bhatti, G. K., & Reddy, P. (2022) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2022.03.019 · Cited by 649 · see citing works

Neuroprotective effect of SGLT2 inhibitors.

Pawlos, A., Broncel, M., Woźniak, E., & Gorzelak-Pabiś, P. (2021) · Molecules · doi:10.3390/molecules26237213 · Cited by 304 · see citing works

An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors

Salvatore, T., Galiero, R., Caturano, A., Rinaldi, L., Martino, A. D., Albanese, G., Salvo, J. D., Epifani, R., Marfella, R., Docimo, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073651 · Cited by 266 · see citing works

Inflammation and Oxidative Stress in Diabetic Kidney Disease: The Targets for SGLT2 Inhibitors and GLP-1 Receptor Agonists

Winiarska, A., Knysak, M., Nabrdalik, K., Gumprecht, J., & Stompór, T. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910822 · Cited by 195 · see citing works

A kidney perspective on the mechanism of action of sodium glucose co-transporter 2 inhibitors

Sen, T., & Heerspink, H. J. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.016 · Cited by 161 · see citing works

SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits

Preda, A., Montecucco, F., Carbone, F., Camici, G. G., Lüscher, T. F., Kraler, S. C., & Liberale, L. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae047 · Cited by 193 · see citing works

Emergence of SGLT2 Inhibitors as Powerful Antioxidants in Human Diseases

Tsai, K., Chen, Y., Chiou, T. T., Chu, T., Li, L., Ng, H., Lee, W., & Lee, C. (2021) · Antioxidants · doi:10.3390/antiox10081166 · Cited by 135 · see citing works

Therapeutic Advances in Diabetic Nephropathy

Sawaf, H., Thomas, G., Taliercio, J. J., Nakhoul, G., Vachharajani, T. J., & Mehdi, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020378 · Cited by 120 · see citing works

SGLT2 Inhibitors as Calorie Restriction Mimetics: Insights on Longevity Pathways and Age-Related Diseases

Hoong, C. W. S., & Chua, M. W. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab079 · Cited by 112 · see citing works

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

Huang, K., Luo, X., Liao, B., Li, G., & Feng, J. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01816-5 · Cited by 112 · see citing works

Immunomodulatory Effects of SGLT2 Inhibitors—Targeting Inflammation and Oxidative Stress in Aging

Schönberger, E., Mihaljević, V., Steiner, K., Šarić, S., Kurevija, T., Majnarić, L. T., Bilić-Čurčić, I., & Canecki-Varžić, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20176671 · Cited by 83 · see citing works

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function

Yan, Y., Li, M., Lin, J., Ji, Y., Wang, K., Yan, D., Shen, Y., Wang, W., Huang, Z., Jiang, H., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.947387 · Cited by 81 · see citing works

Effects of SGLT2 Inhibitors on Ion Homeostasis and Oxidative Stress associated Mechanisms in Heart Failure

Gager, G. M., von Lewinski, D., Sourij, H., Jilma, B., Eyileten, C., Filipiak, K., Hülsmann, M., Kubica, J., Postula, M. A., & Siller-Matula, J. M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112169 · Cited by 70 · see citing works

Ganoderic acids-rich ethanol extract from Ganoderma lucidum protects against alcoholic liver injury and modulates intestinal microbiota in mice with excessive alcohol intake

Guo, W., Cao, Y.-J., You, S.-Z., Wu, Q., Zhang, F., Han, J., Lv, X., Rao, P., Ai, L., & Ni, L. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.02.013 · Cited by 62 · see citing works

SGLT2 inhibitors improve kidney function and morphology by regulating renal metabolic reprogramming in mice with diabetic kidney disease

Lu, Y.-P., Zhang, Z., Wu, H., Fang, L.-J., Hu, B., Tang, C., Zhang, Y., Yin, L., Tang, D., Zheng, Z., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03629-8 · Cited by 57 · see citing works

Efficacy and safety of drugs for people with type 2 diabetes mellitus and chronic kidney disease on kidney and cardiovascular outcomes: A systematic review and network meta-analysis of randomized controlled trials

Yang, Q., Lang, Y., Yang, W., Yang, F., Yang, J., Wu, Y., Xiao, X., Qin, C., Zou, Y., Zhao, Y., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110592 · Cited by 59 · see citing works

SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice

Soares, R. N., Ramirez‐Perez, F. I., Cabral-Amador, F. J., Morales‐Quinones, M., Foote, C. A., Ghiarone, T., Sharma, N., Power, G. J., Smith, J. A. H., Rector, R. S., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00563-x · Cited by 58 · see citing works

SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis

Long, Q., Li, L., Yang, H., Yang, L., Yang, H., Zhu, Y., Tang, Y., Liu, C., & Yuan, J. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109024 · Cited by 55 · see citing works

Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors

Mashayekhi, M., Safa, B. I., Gonzalez, M. S. C., Kim, S. F., & Echouffo-Tcheugui, J. B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.02.003 · Cited by 53 · see citing works

Canagliflozin ameliorates ulcerative colitis via regulation of TLR4/MAPK/NF-κB and Nrf2/PPAR-γ/SIRT1 signaling pathways

Althagafy, H. S., Ali, F. E. M., Hassanein, E. H. M., Mohammedsaleh, Z. M., El-Sayed, M. I. K., Atwa, A. M., Sayed, A. M. M., & Soubh, A. A. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176166 · Cited by 39 · see citing works

A Role for SGLT-2 Inhibitors in Treating Non-diabetic Chronic Kidney Disease

Vecchio, L. D., Beretta, A., Jovane, C., Peiti, S., & Genovesi, S. (2021) · Drugs · doi:10.1007/s40265-021-01573-3 · Cited by 36 · see citing works

Inhibition of oxidative stress and apoptosis by camel milk mitigates cyclosporine‐induced nephrotoxicity: Targeting Nrf2/HO‐1 and AKT/eNOS/NO pathways

Arab, H. H., Eid, A. H., Gad, A. M., Yahia, R., Mahmoud, A. M., & Kabel, A. M. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2277 · Cited by 34 · see citing works

Repurposing SGLT2 Inhibitors for Neurological Disorders: A Focus on the Autism Spectrum Disorder

Nakhal, M. M., Aburuz, S., Sadek, B. S., & Akour, A. A. (2022) · Molecules · doi:10.3390/molecules27217174 · Cited by 32 · see citing works

Canagliflozin Mitigated Cognitive Impairment in Streptozotocin-Induced Sporadic Alzheimer’s Disease in Mice: Role of AMPK/SIRT-1 Signaling Pathway in Modulating Neuroinflammation

Khamies, S. M., El-Yamany, M. F., & Ibrahim, S. M. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10140-y · Cited by 32 · see citing works

Dapagliflozin Ameliorates Diabetic Kidney Disease via Upregulating Crry and Alleviating Complement Over-activation in db/db Mice

Chang, D., Li, X.-Q., Chen, M., & Zhao, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729334 · Cited by 31 · see citing works

Canagliflozin attenuates thioacetamide-induced liver injury through modulation of HMGB1/RAGE/TLR4 signaling pathways

Abdelmageed, M. E., & Abdelrahman, R. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121654 · Cited by 31 · see citing works

NOX-NOS crosstalk in the liver-brain axis: Novel insights for redox regulation and neurodegenerative diseases

Lee, S.-S., & Yoo, Y. C. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103807 · Cited by 32 · see citing works

Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3, JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1–7 signals

Hassanein, E. H. M., Saleh, F. M., Ali, F. E. M., Rashwan, E. K., Atwa, A. M., & El‐Ghafar, O. A. M. A. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2143371 · Cited by 28 · see citing works

The Pathophysiological Basis of Diabetic Kidney Protection by Inhibition of SGLT2 and SGLT1

Oe, Y., & Vallon, V. (2022) · Kidney and Dialysis · doi:10.3390/kidneydial2020032 · Cited by 27 · see citing works

Signaling Pathways of Podocyte Injury in Diabetic Kidney Disease and the Effect of Sodium-Glucose Cotransporter 2 Inhibitors

Chen, X., Wang, J., Lin, Y., Liu, Y., & Zhou, T. (2022) · Cells · doi:10.3390/cells11233913 · Cited by 27 · see citing works

Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms

Afşar, B., & Afşar, R. E. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00442-4 · Cited by 28 · see citing works

Shenling Baizhu powder alleviates non-alcoholic fatty liver disease by modulating autophagy and energy metabolism in high-fat diet-induced rats

Pan, M., Deng, Y., Qiu, Y., Pi, D., Zheng, C., Liang, Z., Zhen, J., Fan, W. H., Song, Q., Pan, J., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155712 · Cited by 26 · see citing works

Modulation of AMPK by esomeprazole and canagliflozin mitigates methotrexate-induced hepatotoxicity: involvement of MAPK/JNK/ERK, JAK1/STAT3, and PI3K/Akt signaling pathways

El‐Dessouki, A. M., Kaml, M. E., & El-Yamany, M. F. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-03908-3 · Cited by 25 · see citing works

Empagliflozin Relaxes Resistance Mesenteric Arteries by Stimulating Multiple Smooth Muscle Cell Voltage-Gated K+ (KV) Channels

Hasan, A., & Hasan, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910842 · Cited by 24 · see citing works

Canagliflozin Ameliorates Oxidative Stress and Autistic-like Features in Valproic-Acid-Induced Autism in Rats: Comparison with Aripiprazole Action

Nakhal, M. M., Jayaprakash, P., Aburuz, S., Sadek, B. S., & Akour, A. A. (2023) · Pharmaceuticals · doi:10.3390/ph16050769 · Cited by 23 · see citing works

Glucose-lowering drugs with cardiovascular benefits as modifiers of critical elements of the human life history

Avogaro, A., de Kreutzenberg, S. V., Morieri, M. L., Fadini, G. P., & Prato, S. D. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00247-9 · Cited by 21 · see citing works

Protective antioxidative and anti-inflammatory actions of β-caryophyllene against sulfasalazine-induced nephrotoxicity in rat

Refaat, B., & El‐Boshy, M. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702211073804 · Cited by 21 · see citing works

Canagliflozin Inhibits Human Endothelial Cell Inflammation through the Induction of Heme Oxygenase-1

Peyton, K. J., Behnammanesh, G., Durante, G. L., & Durante, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158777 · Cited by 21 · see citing works

Exploring the cardioprotective effects of canagliflozin against cisplatin‐induced cardiotoxicity: Role of iNOS/NF‐κB, Nrf2, and Bax/cytochrome C/Bcl‐2 signals

Ali, F. E. M., Hassanein, E. H. M., El‐Ghafar, O. A. M. A., Rashwan, E. K., Saleh, F. M., & Atwa, A. M. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23309 · Cited by 21 · see citing works

Cardioprotective Effects of Sodium Glucose Cotransporter 2 Inhibition in Angiotensin II-Dependent Hypertension Are Mediated by the Local Reduction of Sympathetic Activity and Inflammation

Castoldi, G., Carletti, R., Ippolito, S., Colzani, M., Pelucchi, S., Zerbini, G., Perseghin, G., Zatti, G., & Gioia, C. R. T. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310710 · Cited by 21 · see citing works

An iridoid glycoside from Cornus officinalis balances intestinal microbiome disorder and alleviates alcohol-induced liver injury

Han, X., Liu, J., Bai, Y., Hang, A., Lu, T., & Mao, C. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104488 · Cited by 21 · see citing works

Canagliflozin protects against sepsis capillary leak syndrome by activating endothelial α1AMPK

Angé, M., Poortere, J. D., Ginion, A., Battault, S., Dechamps, M., Muccioli, G. G., Roumain, M., Morelle, J., Druart, S., Mathivet, T., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-93156-1 · Cited by 21 · see citing works

Dapagliflozin induces vasodilation in resistance-size mesenteric arteries by stimulating smooth muscle cell KV7 ion channels

Hasan, A., Menon, S. N., Zerin, F., & Hasan, R. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09503 · Cited by 20 · see citing works

Preclinical Studies of Canagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, and Donepezil Combined Therapy in Alzheimer’s Disease

Stanciu, G. D., Ababei, D. C., Solcan, C., Bild, V., Ciobîcă, A., Chiriac, S. I. B., Ciobanu, L., & Tamba, B.-I. (2023) · Pharmaceuticals · doi:10.3390/ph16111620 · Cited by 20 · see citing works

Polyphenol-enriched Penthorum chinense Pursh ameliorates alcohol-related liver injury through Ras/Raf/MEK/ERK pathway: Integrating network pharmacology and experiment validation

Li, R., Wu, D., Hu, J., Ba, Y., Ba, Y., Zou, L., & Hu, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117513 · Cited by 18 · see citing works

SGLT2 inhibitor dapagliflozin protects the kidney in a murine model of Balkan nephropathy

Oe, Y., Kim, Y. C., Sidorenko, V. S., Zhang, H., Kanoo, S., Lopez, N., Goodluck, H. A., Crespo‐Masip, M., & Vallon, V. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00228.2023 · Cited by 18 · see citing works

The Protective Effect of Auricularia cornea var. Li. Polysaccharide on Alcoholic Liver Disease and Its Effect on Intestinal Microbiota

Wang, T., Jia, Z., An, C., Ren, P., Yang, Y., Wang, W., & Su, L. (2023) · Molecules · doi:10.3390/molecules28248003 · Cited by 18 · see citing works

Amelioration of diabetic kidney injury with dapagliflozin is associated with suppressing renal HMGB1 expression and restoring autophagy in obese mice

Feng, B., Yang, F., Liu, J., Sun, Q., Meng, R., & Zhu, D. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108409 · Cited by 17 · see citing works

Canagliflozin alleviates experimentally induced benign prostate hyperplasia in a rat model: exploring potential mechanisms involving mir-128b/EGFR/EGF and JAK2/STAT3 signaling pathways through in silico and in vivo investigations

Elbaz, E. M., Darwish, A., Gad, A. M., Rahman, A. A. S. A., & Safwat, M. H. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175993 · Cited by 18 · see citing works

Antioxidative and Anti‐Inflammatory Protective Effects of β‐Caryophyllene against Amikacin‐Induced Nephrotoxicity in Rat by Regulating the Nrf2/AMPK/AKT and NF‐κB/TGF‐β/KIM‐1 Molecular Pathways

Rajab, B. S., Albukhari, T. A., Khan, A. A., Refaat, B., Almehmadi, S. J., Nasreldin, N., Elshopakey, G. E., & El‐Boshy, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4212331 · Cited by 16 · see citing works

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

Rojas-Solé, C., Pinilla-González, V., Lillo‐Moya, J., González-Fernández, T., Saso, L., & Rodrigo, R. (2023) · Redox Report · doi:10.1080/13510002.2023.2289740 · Cited by 20 · see citing works

Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure

Hasan, A., Zerin, F., Menon, S. N., Alam, M. A., & Hasan, R. (2022) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2022.09.004 · Cited by 15 · see citing works

Neuroprotective Effects of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors (Gliflozins) on Diabetes-Induced Neurodegeneration and Neurotoxicity: A Graphical Review

Gholami, M., Coleman‐Fuller, N., Salehirad, M., Darbeheshti, S., & Motaghinejad, M. (2024) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_5_23 · Cited by 14 · see citing works

Canagliflozin potentially promotes renal protection against glycerol-induced acute kidney injury by activating the AMPK/SIRT1/FOXO-3a/PGC-1α and Nrf2/HO-1 pathways

Bishr, A., Atwa, A. M., El-Mokadem, B. M., & El-Din, M. N. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04017-x · Cited by 14 · see citing works

Protective Effects of 2-Methoxyestradiol on Acute Isoproterenol-Induced Cardiac Injury in Rats

Hareeri, R. H., Alam, A. M., Bagher, A. M., Alamoudi, A. J., Aldurdunji, M. M., Shaik, R. A., Eid, B. G., & Ashour, O. M. (2023) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2023.101787 · Cited by 14 · see citing works

Sodium glucose cotransporter-2 inhibitors and heart disease: Current perspectives

Mondal, S., Pramanik, S., Khare, V. R., Fernandez, C. J., & Pappachan, J. M. (2024) · World Journal of Cardiology · doi:10.4330/wjc.v16.i5.240 · Cited by 14 · see citing works

The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias

Huang, C., Wei, Z., Zheng, N., Yan, J., Zhang, J., Ye, X., & Zhao, W. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14618 · Cited by 14 · see citing works

Canagliflozin ameliorates high glucose-induced apoptosis in NRK-52E cells via inhibiting oxidative stress and activating AMPK/mTOR-mediated autophagy

Liu, H., Chen, W., Wan, S., Chen, Y., Fu, M., Wang, Z., Xiong, F., & Zhang, Y. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08855-x · Cited by 14 · see citing works

Sodium-Glucose Co-Transporter 2 Inhibitors: Mechanism of Action and Efficacy in Non-Diabetic Kidney Disease from Bench to Bed-Side

Abdelrahman, A. M., Awad, A. S., & Abdel‐Rahman, E. M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13040956 · Cited by 11 · see citing works

Protective effects of l-carnitine on isoprenaline -induced heart and kidney dysfunctions: Modulation of inflammation and oxidative stress-related gene expression in rats

Chisty, T. T. E., Sarif, S., Jahan, I., Ismail, I. N., Chowdhury, F. I., Siddiqua, S., Yasmin, T., Islam, M. N., Khan, F., Subhan, N., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25057 · Cited by 11 · see citing works

Unfavorable effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on the skeletal system of nondiabetic rats.

Londzin, P., Brudnowska, A., Kurkowska, K., Wilk, K., Olszewska, K., Ziembiński, Ł., Janas, A., Cegieła, U., & Folwarczna, J. (2022) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2022.113679 · Cited by 10 · see citing works

Sodium Glucose Cotransporter-2 Inhibitors in Non-Diabetic Kidney Disease: Evidence in Experimental Models

Castoldi, G., Carletti, R., Barzaghi, F., Meani, M., Zatti, G., Perseghin, G., Gioia, C. R. T. D., & Zerbini, G. (2024) · Pharmaceuticals · doi:10.3390/ph17030362 · Cited by 10 · see citing works

Sodium–Glucose Cotransporter 2 Inhibitors as Potential Antioxidant Therapeutic Agents in Cardiovascular and Renal Diseases

Patel, T., Zheng, H., & Patel, K. P. (2025) · Antioxidants · doi:10.3390/antiox14030336 · Cited by 9 · see citing works

The SGLT2 inhibitor canagliflozin attenuates mitochondrial oxidative stress and alterations of calcium handling induced by high glucose in human cardiac fibroblasts

Varzideh, F., Kansakar, U., Wilson, S., Jankauskas, S. S., & Santulli, G. (2024) · Cell Cycle · doi:10.1080/15384101.2025.2492423 · Cited by 10 · see citing works

Unveiling the podocyte-protective effect of sodium-glucose cotransporter-2 inhibitors

Jiang, B., Cheng, Z., Wang, D., Liu, F., Wang, J., Fu, H., & Mao, J. (2024) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.24.144 · Cited by 9 · see citing works

Canagliflozin alleviates acetaminophen-induced renal and hepatic injury in mice by modulating the p-GSK3β/Fyn-kinase/Nrf-2 and p-AMPK-α/STAT-3/SOCS-3 pathways

Bishr, A., El-Mokadem, B. M., & Gomaa, A. A. (2025) · Scientific Reports · doi:10.1038/s41598-024-82163-7 · Cited by 9 · see citing works

Unlocking the therapeutic potential of canagliflozin in NAFLD: Insights into AMPK/SIRT1-mediated lipophagy

El‐Ashmawy, N. E., Al‐Ashmawy, G. M., Kamel, A. A., & Khedr, E. G. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167666 · Cited by 9 · see citing works

Neflamapimod inhibits endothelial cell activation, adhesion molecule expression, leukocyte attachment and vascular inflammation by inhibiting p38 MAPKα and NF-κB signaling

Menon, S. N., Zerin, F., Ezewudo, E., Simon, N. P., Menon, S. N., Daniel, M. L., Green, A. J., Pandey, A., Mackay, C., Hafez, S. S., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115683 · Cited by 9 · see citing works

AMPK-mediated autophagy is involved in the protective effect of canagliflozin in the vitamin D3 plus nicotine calcification model in rats

Hewedy, W. A., Abdulmalek, S. A., Ghareeb, D. A., & Habiba, E. S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02627-x · Cited by 9 · see citing works

The influence of SGLT2 inhibitors on oxidative stress in heart failure and chronic kidney disease in patients with type 2 diabetes

Nabrdalik-Leśniak, D., Nabrdalik, K., Irlik, K., Janota, O., Kwiendacz, H., Szromek‐Białek, P., Maziarz, M., Stompór, T. P., Gumprecht, J., & Lip, G. Y. H. (2023) · Endokrynologia Polska · doi:10.5603/ep.a2023.0039 · Cited by 8 · see citing works

Indapamide Increases IRS1 Expression and Modifies Adiponectin/NLRP3/PPARγ Crosstalk in Type 2 Diabetic Rats

Samaha, M. M., Helal, M. G., El‐Sherbiny, M., Said, E., & Salem, H. A. (2022) · Antioxidants · doi:10.3390/antiox11040691 · Cited by 8 · see citing works

Neflamapimod induces vasodilation in resistance mesenteric arteries by inhibiting p38 MAPKα and downstream Hsp27 phosphorylation

Pandey, A., Zerin, F., Menon, S. N., Tithi, T. I., Nguyen, K. P., Vo, T., Daniel, M. L., Hafez, S. S., Alam, M. A., & Hasan, R. (2022) · Scientific Reports · doi:10.1038/s41598-022-08877-8 · Cited by 7 · see citing works

Exploring the correlation between periodontal disease and serum biomarkers in haemodialysis patients

Basha, M. M., Alkadasi, B. A., Al-Hajri, M., Al‐Sharani, H. M., & Elayah, S. A. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04826-1 · Cited by 7 · see citing works

Noncoding RNAs in chronic wound healing: Mechanisms, exosome therapeutics, and translational frontiers

Yang, L., & Lv, Y. (2026) · Journal of Tissue Engineering · doi:10.1177/20417314251410000 · Cited by 5 · see citing works

Modulating Sympathetic Nervous System With the Use of SGLT2 Inhibitors: Where There Is Smoke, There Is Fire?

Dimitriadis, K. S., Pitsiori, D., Alexiou, P., Pyrpyris, N., Sakalidis, A., Beneki, E., Iliakis, P., Tatakis, F., Theofilis, P., Tsioufis, P., et al. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001644 · Cited by 5 · see citing works

TLR4-IN-C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis.

Abdelsalam, H. M., Helal, M. G., & Abu‐Elsaad, N. (2022) · PubMed Central · doi:10.22038/ijbms.2022.67168.14727 · Cited by 5 · see citing works

SGLT2 inhibitor improves kidney function and morphology by regulating renal metabolism in mice with diabetic kidney disease

Yang, C., Xiao, C., Zhai, X., Liu, J. Y., & Yu, M. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108652 · Cited by 5 · see citing works

Nanomolar therapeutic concentrations of statins rapidly induce cerebral artery vasoconstriction by stimulating L-type calcium channels

Zerin, F., Hoque, N., Menon, S. N., Ezewudo, E., Simon, N. P., Sooreni, S., Shahid, M. S., Jones, M., Pandey, A., Gökçe, Y., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116970 · Cited by 5 · see citing works

A Network Pharmacology to Explore the Potential Targets of Canagliflozin and Dapagliflozin in Treating Atherosclerosis

Wang, J., Li, D., Ju, W., & Wang, H. (2022) · Journal of Vascular Diseases · doi:10.3390/jvd1010007 · Cited by 5 · see citing works

Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation

Abdel-Rahman, R. F., Alsugoor, M. H., Alsuhaymi, N., Fayed, H. M., Mahmoud, S. S., Ibrahim, F. A., & Elbaset, M. A. (2025) · Saudi Pharmaceutical Journal · doi:10.1007/s44446-025-00039-x · Cited by 4 · see citing works

Sodium-glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy

Gao, Z., Bao, J., Hu, Y., Tu, J., Ye, L., & Wang, L. (2023) · Current Drug Targets · doi:10.2174/1389450124666230907115831 · Cited by 4 · see citing works

Heterogeneous treatment effects of GLP‐1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real‐world target trial emulation

Tang, H., Donahoo, W. T., DeKosky, S. T., Lee, Y. A., Kotecha, P., Svensson, M., Bian, J., & Guo, J. S. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70313 · Cited by 4 · see citing works

Comparative risks of inflammatory bowel disease in patients with type 2 diabetes mellitus treated with SGLT-2 inhibitors versus DPP-4 inhibitors: a real-world nationwide cohort study

Yu, Y.-J., & Chien, W. (2025) · International Journal of Clinical Pharmacy · doi:10.1007/s11096-025-02026-7 · Cited by 4 · see citing works

Evaluating the potential impact of sodium–glucose cotransporter‐2 inhibitor “canagliflozin” on the hepatic damage triggered by hypertension in rats

Hassan, F. E., El‐Mosallamy, A. E. M. K., Khalifa, M. M., Aljuaydi, S. H., Ali, M. E., Hosny, S. A., & Bastawy, N. (2024) · Microscopy Research and Technique · doi:10.1002/jemt.24665 · Cited by 4 · see citing works

Renoprotective effects of dapagliflozin in an iron overload non-diabetic rat model

Fırat, S. N., Kuşkonmaz, Ş. M., Çaydere, M., Şeneş, M., Hücümenoğlu, S., & Çulha, C. (2022) · Advances in Medical Sciences · doi:10.1016/j.advms.2022.08.001 · Cited by 4 · see citing works

Canagliflozin Promotes Mitochondrial Biogenesis in Glycerol-Induced Acute Kidney Injury by Activating the AMPK/SIRT1/FOXO-3a/ PGC-1α and Nrf2/HO-1 TrajectoriesPreprint

Bishr, A., Atwa, A. M., El-Naggar, M. E., & El-Din, M. N. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3974361 · Cited by 4 · see citing works

Renal and metabolic effects of semaglutide plus canagliflozin vs canagliflozin alone in type 2 diabetic nephropathy

Miao, Y., He, P., Wang, D.-Y., Yan, L., Cao, H., & Shao, F.-M. (2026) · World Journal of Diabetes · doi:10.4239/wjd.v17.i2.112867 · Cited by 3 · see citing works

Potential molecular mechanism of action of sodium-glucose co-transporter 2 inhibitors in the prevention and management of diabetic retinopathy

Zaini, L. M., Kartasasmita, A., Gondhowiardjo, T. D., Syukri, M., & Lesmana, R. (2022) · Expert Review of Ophthalmology · doi:10.1080/17469899.2022.2111302 · Cited by 3 · see citing works

Ivabradine curbs isoproterenol-induced kidney fibrosis

Baka, T., Stanko, P., Repova, K., Aziriova, S., Krajcirovicova, K., Barta, A., Zórad, Š., & Šimko, F. (2023) · General Physiology and Biophysics · doi:10.4149/gpb_2022057 · Cited by 3 · see citing works

Effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors, dapagliflozin and canagliflozin, on the musculoskeletal system in an experimental model of diabetes induced by high-fat diet and streptozotocin in rats.

Londzin, P., Zych, M., Janas, A., Siudak, S., & Folwarczna, J. (2025) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2025.117912 · Cited by 3 · see citing works

The effect of SGLT2 inhibitor and HIF-PHI on the podocyte-specific molecules and cytoskeleton of diabetic podocytes

Li, C., Ng, J. K., Chan, G. C., Fung, W. W., Chow, K., & Szeto, C. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04677-0 · Cited by 2 · see citing works

Potential Role of SGLT2 Inhibitors in the Treatment and Prevention of Diabetic Cardiomyopathy

Nandave, M. (2024) · Springer eBooks · doi:10.1007/978-981-97-7568-2_5 · Cited by 2 · see citing works

Sodium-Glucose Cotransporter 2 Therapy for Acute Organ Dysfunction in Critically Ill Patients

Gómez, H., & Derde, L. P. G. (2024) · JAMA · doi:10.1001/jama.2024.10171 · Cited by 2 · see citing works

Canagliflozin attenuates haloperidol-induced motor and spatial working memory deficits in mice: Evidence of its role in the treatment of Parkinson’s disease

Irokosu, E. S., Oladoja, F. A., Olayemi, S. O., & Ishola, I. O. (2024) · Pharmacological Research - Reports · doi:10.1016/j.prerep.2024.100025 · Cited by 1 · see citing works

Beyond glycemic control: the cardiac and hepatic benefits of SGLT2 and DPP-4 inhibitors in mitigating chronic cadmium-induced inflammation, oxidative/nitrative stress, apoptosis and fibrosis

Hassan, F. E., Hassanien, M. M., Selmy, A., Mahmoud, L. M., Darwish, A., & Aldreny, B. A. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2025.1752370 · Cited by 1 · see citing works

Inflammation as a therapeutic target to improve kidney and cardiovascular outcomes

Tuttle, K. R., Kanbay, M., Alicic, R. Z., Carrero, J. J., Çöpür, S., Navar, A. M., Neuen, B. L., Perkovic, V., Rossing, P. R., Marx, N., et al. (2026) · Nature Reviews Nephrology · doi:10.1038/s41581-026-01117-6 · Cited by 2 · see citing works

Mechanisms of SGLT2 inhibition in the kidney

Sen, T. (2023) · doi:10.33612/diss.659987622

Shenling Baizhu Powder Alleviates Nafld by Modulating Autophagy and Energy Metabolism in High-Fat Diet-Induced RatsPreprint

Pan, M., Deng, Y., Liang, Z., Pi, D., Zheng, C., Zhen, J., Fan, W. H., Song, Q., Pan, J., Li, Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4674253

Additional file 2 of SGLT2 inhibitors improve kidney function and morphology by regulating renal metabolic reprogramming in mice with diabetic kidney disease

Lu, Y.-P., Zhang, Z., Wu, H., Fang, L.-J., Hu, B., Tang, C., Zhang, Y., Yin, L., Tang, D., Zheng, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21117692

Canagliflozin provides cardioprotection and renoprotection against isoprenaline‐induced oxidative stress by stimulating AMPK‐Akt‐eNOS‐NO signaling axis

Hasan, R., Lasker, S., Hasan, A., Zamila, M., Zerin, F., Chowdhury, F. I., Rahman, M. M., Khan, F., Subhan, N., & Alam, M. A. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.03407

Canagliflozin Improves Renal Oxidative Stress and Inflammation in Ischemia-Reperfusion Syndrome in Rats

Vattimo, M. D. F. F., Ventura, S., Silva, E. D. O., & Debbas, V. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.20223311s1628c

Canagliflozin‐induced renal glutathione distribution mapping in non‐diabetic male rat kidneys

Watanabe, G., Horita, S., Moriya, R. F., Masuishi, Y., Misaka, S., Taira, S., Shimomura, K., Shimabukuro, M., & Kazama, J. J. (2025) · Physiological Reports · doi:10.14814/phy2.70320 · Cited by 3 · see citing works

Role of canagliflozin in ameliorating isoprenaline induced cardiomyocyte oxidative stress via the heme oxygenase-1 mediated pathway

Ahmed, A., Abdel-Rahman, D., & Hantash, E. M. (2023) · Biotechnic & Histochemistry · doi:10.1080/10520295.2023.2262390 · Cited by 2 · see citing works

Antidiabetic Drugs May Prevent Kidney DamagePreprint

Vattimo, M. D. F. F., Silva, E. D. O., Ventura, S., Lima, C., Garcia, J., Maia, A. O., silva, J. V. G., Vieira, G. H. F., & Victoria, C. D. D. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.19.563071