Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats
Open accessAbstract
BACKGROUND: The objective of the present study aimed to investigate the effect of CoQ10 treatment on isoprenaline (ISO)-induced cardiac remodeling in rats. METHODS: Rats were divided into three groups namely Control group, ISO treated group and CoQ10 + ISO treated group, each consisting of 6 rats. The cardiac specific CK-MB, AST, ALT activity and other oxidative stress parameters were estimated in heart and kidneys. Additionally histological examination was also performed to visualize the inflammatory cells infiltration and fibrosis in both tissues. RESULTS: Administration of ISO resulted in an increase in the heart-to-body weight (HW/BW) ratio and an also increased the serum CK-MB, AST and ALT enzyme activity. Serum levels of lipid peroxidation products, and oxidative stress markers showed significant increase in ISO-treated rats. Histopathological examination of heart tissue revealed focal areas of endocardium degeneration, mononuclear cells infiltration, fibrous tissue deposition, and increased thickness of the myocardium of left ventricle. Similar degeneration was also found in kidneys. Treatment with CoQ10 (100 mg/kg) significantly improved the oxidative stresses in ISO treated rats. Moreover, CoQ10 treatment prevented inflammatory cells infiltration and reduced fibrosis in ISO administered rats. CONCLUSION: In conclusion, our study provides evidence that CoQ10 may prevent the development of cardiac remodeling, and fibrosis in ISO administered rats.
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CoQ10 lowers the level of plasma markers of muscular damage, including CK.
“Ulla et al. (2017) and Cirilli et al. (2021) stated that CoQ10 lowered the level of plasma markers of muscular damage, the CK level, which was in line with our results.”
From Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle? (2023) · cites this paper as Ulla et al. 2017
The Results report that CoQ10 significantly lowered plasma CK-MB activity in isoprenaline-treated aged rats, and the Discussion identifies CK-MB as a marker of myocardial necrosis. The paper does not establish a reduction in total CK or in markers of muscular damage generally; its finding is specific to cardiac injury in this rat model. Page numbers were not provided in our copy. (LLM, conf=0.85)
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Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
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- Authors
- Ulla, A., Mohamed, M. K., Sikder, B., Rahman, A. T., Sumi, F. A., Hossain, M., Reza, H. M., Rahman, G. M. S., & Alam, M. A.
- Affiliations
- North South University (BD)
- Corresponding author
- Reza, Hasan Mahmud
- Alam, Md Ashraful
- Venue
- BMC Pharmacology and Toxicology
- Published
- 2017-04-20
- Volume
- 18
- Issue
- 1
- Pages
- 29-29
- ISSN
- 2050-6511 (ISSN-L)
- PMC
- PMC5399319
- OpenAlex
- W2605450659
- Cited by
- 80
- References
- 69
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 15 · 2019: 11 · 2018: 5 · 2017: 2
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Pharmacology and Toxicology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- North South University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- coenzyme Q10, isoproterenol, cardiac remodeling, myocardial fibrosis, oxidative stress, lipid peroxidation, myocardial injury, kidney injury, inflammatory cell infiltration, aging, cardioprotection
- MeSH terms
- Aging, Animals, Fibrosis, Isoproterenol, Male, Ubiquinone, Oxidative Stress, Ventricular Remodeling, Rats, Long-Evans, Rats
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