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Cited by 282Adrenal Hormones and DisordersHormonal and reproductive studiesStress Responses and Cortisol

Impaired Subjective Health Status in 256 Patients with Adrenal Insufficiency on Standard Therapy Based on Cross-Sectional Analysis

Hahner, Stefanie, Loeffler, Melanie, Fassnacht, Martin, Weismann, Dirk, Koschker, Ann-Cathrin, Quinkler, Marcus, Decker, Oliver, Arlt, Wiebke +1 more·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-0685
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Abstract

Background There is mounting evidence that current replacement regimens fail to restore health-related subjective health status fully in patients with adrenal insufficiency (AI). Here we evaluated the subjective health status in primary and secondary AI and the effect of concomitant disease. Methods In a cross-sectional study, all AI patients registered with the University Hospital Wuerzburg (n = 148) or with the German Self-Help Network (n = 200) were contacted by mail. Underlying diagnoses and comorbidities were verified by review of medical records. Patients were asked to complete three validated self-assessment questionnaires [Short Form 36 (SF-36), Giessen Complaint List (GBB-24), Hospital Anxiety and Depression Scale (HADS)]. Results were compared to sex- and age-matched controls drawn from the questionnaire-specific reference cohorts. Results We identified 348 patients, and 256 agreed to participate. Completed questionnaire sets were available from 210 patients [primary AI (n = 132), secondary AI (n = 78)]. Seven of eight SF-36 dimensions, all five GBB-24 scales, and the HADS anxiety score reflected significant impairment of subjective health status in both AI cohorts (all P Conclusion Patients with AI on current standard replacement suffer from significantly impaired health-related subjective health status, irrespective of origin of disease or concomitant disease. Future studies will have to assess whether more physiological glucocorticoid replacement strategies in AI…

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  • Patients with AI have impaired quality of life.

    “It is well established that patients with AI have impaired quality of life (QoL)”

    From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [69]

  • Current replacement regimens fail to restore subjective health status in affected individuals.

    “with current replacement regimens failing to restore subjective health status in affected individuals.69”

    From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [69]

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Authors
Hahner, S., Loeffler, M., Fassnacht, M., Weismann, D., Koschker, A.-C., Quinkler, M., Decker, O., Arlt, W., & Allolio, B.
Affiliations
  • University of Würzburg (DE)
  • Stiftung Charité (DE)
  • University Hospital Leipzig (DE)
  • University of Birmingham (GB)
Corresponding author
Allolio, Bruno
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2007-10-01
Volume
92
Issue
10
Pages
3912-3922
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-0685
OpenAlex
W2075461701
Cited by
282
References
8
Citations by year
2026: 8 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 14 · 2020: 16 · 2019: 12 · 2018: 16 · 2017: 15 · 2016: 14 · 2015: 22 · 2014: 27 · 2013: 14 · 2012: 17
FWCI
9.99
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
adrenal insufficiency, self-rated health, health-related quality of life, Addison's disease, secondary adrenal insufficiency, glucocorticoid replacement therapy, anxiety, depression, work disability, comorbidities
MeSH terms
Activities of Daily Living, Adrenal Insufficiency, Adult, Aged, Anxiety, Cross-Sectional Studies, Depression, Female, Glucocorticoids, Health Status, Humans, Male, Middle Aged, Occupations, Psychometrics, Surveys and Questionnaires, Cohort Studies, Comorbidity, Hormone Replacement Therapy

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