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Cited by 53Ultrasound and Hyperthermia ApplicationsNanoplatforms for cancer theranosticsPhotoacoustic and Ultrasonic Imaging

Improving tumor treatment through intratumoral injection of drug-loaded magnetic nanoparticles and low-intensity ultrasound

Open access
Hosseinpour, Asma, Soltani, Madjid, Souri, Mohammad·2024·Scientific Reports
DOI 10.1038/s41598-024-52003-9PMC PMC10791673
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Abstract

The intratumoral injection of therapeutic agents responsive to external stimuli has gained considerable interest in treating accessible tumors due to its biocompatibility and capacity to reduce side effects. For the first time, a novel approach is explored to investigate the feasibility of utilizing low-intensity ultrasound in combination with intratumoral injection of drug-loaded magnetic nanoparticles (MNPs) to thermal necrosis and chemotherapy with the objective of maximizing tumor damage while avoiding harm to surrounding healthy tissue. In this study, a mathematical framework is proposed based on a multi-compartment model to evaluate the effects of ultrasound transducer’s specifications, MNPs size and distribution, and drug release in response to the tumor microenvironment characteristics. The results indicate that while a higher injection rate may increase interstitial fluid pressure, it also simultaneously enhances the concentration of the therapeutic agent. Moreover, by increasing the power and frequency of the transducer, the acoustic pressure and intensity can be enhanced. This, in turn, increases the impact on accumulated MNPs, resulting in a rise in temperature and localized heat generation. Results have demonstrated that smaller MNPs have a lower capacity to generate heat compared to larger MNPs, primarily due to the impact of sound waves on them. It is worth noting that smaller MNPs have been observed to have enhanced diffusion, allowing them to effectively spread within the tumor. However, their smaller size also leads to rapid elimination from the extracellular space into the bloodstream. To summarize, this study demonstrated that the local injection of MNPs carrying drugs not only enables localized chemotherapy but also enhances the effectiveness of low-intensity ultrasound in inducing tissue thermal necrosis. The findings of this study can serve as a valuable and reliable resource for future research in this field and contribute to the development of personalized medicine.

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Crossref · 10.1038/s41598-024-52003-9

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43 of 43 references verified0 citation errors · 0 not checkable

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  • Overexpression of resistance proteins, such as P-glycoprotein (P-gp), which are members of the ATP class of drug transporters, is one of the most significant mechanisms in MDR tumors.

    “The overexpression of resistance proteins, such as P-glycoprotein (P-gp), which are members of the ATP class of drug transporters, is one of the most significant mechanisms in MDR tumors.”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [244]

    The Methods section models drug transport and cellular influx and efflux, while Results and discussion describes doxorubicin binding to proteins in the interstitial space (page numbers unavailable). Neither addresses P-glycoprotein, ATP-class drug transporters, or their role in multidrug-resistant tumors; searches for those terms and resistance-protein overexpression found no relevant passage. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

  • P-gp expression rises in patients by up to 75% after therapy.

    “In addition, P-gp expression rises in patients by up to 75% after therapy.”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [244]

    The Methods and Results and discussion sections address modeled drug delivery and tumor response, but do not report P-gp expression in patients after therapy. Searches for “P-gp,” “P-glycoprotein,” and “75%” found no passage supporting the claimed increase. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • Newer forms of treatment, such as proteasome inhibitors and immunomodulatory medications, are similarly hampered since they are P-gp substrates.

    “However, there is evidence that more recent forms of treatment, such as proteasome inhibitors and immunomodulatory medications, are similarly hampered since they are P-gp substrates.”

    From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [244]

    The Introduction discusses systemic chemotherapy toxicity, and the Methods describe drug transport, but neither addresses P-gp substrates. Searches for proteasome inhibitors, immunomodulatory medications, and P-glycoprotein found no passage supporting the claimed mechanism. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 1

  1. [11]Sadeghi-Goughari M Jeon S Kwon H-J Magnetic nanoparticles-enhanced focused ultrasound heating: Size effect, mechanism, and performance analysis Nanotechnology 2020 31 245101 10.1088/1361-6528/ab7cea 32135521 · DOI

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Authors
Hosseinpour, A., Soltani, M., & Souri, M.
Affiliations
  • K. N. Toosi University of Technology (IR)
  • University of Waterloo (CA)
  • Pasteur Institute of Iran (IR)
Corresponding author
Soltani, Madjid
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2024-01-16
Volume
14
Issue
1
Pages
1452-1452
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-024-52003-9
PMC
PMC10791673
OpenAlex
W4390901434
Cited by
53
References
43
Citations by year
2026: 12 · 2025: 25 · 2024: 16
FWCI
5.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
Keywords
intratumoral injection, magnetic nanoparticles, low-intensity ultrasound, thermal necrosis, drug delivery, multi-compartment model, nanoparticle size, interstitial fluid pressure, drug release, tumor microenvironment, local chemotherapy, nanoparticle diffusion, nanoparticle clearance
MeSH terms
Humans, Hyperthermia, Induced, Necrosis, Neoplasms, Injections, Intralesional, Nanoparticles, Magnetite Nanoparticles, Tumor Microenvironment

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