A comparative study between conventional chemotherapy and photothermal activated nano-sized targeted drug delivery to solid tumor
Abstract
Delivery of chemotherapeutic medicines to solid tumors is critical for optimal therapeutic success and minimal adverse effects. We mathematically developed a delivery method using thermosensitive nanocarriers activated by light irradiation. To assess its efficacy and identify critical events and parameters affecting therapeutic response, we compared this method to bolus and continuous infusions of doxorubicin for both single and multiple administrations. A hybrid sprouting angiogenesis approach generates a semi-realistic microvascular network to evaluate therapeutic drug distribution and microvascular heterogeneity. A pharmacodynamics model evaluates treatment success based on tumor survival cell percentage. The study found that whereas bolus injection boosted extracellular drug concentration levels by 90%, continuous infusion improved therapeutic response due to improved bioavailability. Cancer cell death increases by 6% with several injections compared to single injections due to prolonged chemotherapeutic medication exposure. However, responsive nanocarriers supply more than 2.1 times more drug than traditional chemotherapy in extracellular space, suppressing tumor development longer. Also, controlled drug release decreases systemic side effects substantial through diminishing the concentration of free drug in the circulation. The primary finding of this work highlights the significance of high bioavailability in treatment response. The results indicate that responsive nanocarriers contribute to increased bioavailability, leading to improved therapeutic benefits. By including drug delivery features in a semi-realistic model, this numerical study sought to improve drug-bio interaction comprehension. The model provides a good framework for understanding preclinical and clinical targeted oncology study outcomes.
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P-gp expression rises in patients by up to 75% after therapy.
“In addition, P-gp expression rises in patients by up to 75% after therapy.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [243]
Overexpression of resistance proteins, such as P-glycoprotein (P-gp), which are members of the ATP class of drug transporters, is one of the most significant mechanisms in MDR tumors.
“The overexpression of resistance proteins, such as P-glycoprotein (P-gp), which are members of the ATP class of drug transporters, is one of the most significant mechanisms in MDR tumors.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [243]
Newer forms of treatment, such as proteasome inhibitors and immunomodulatory medications, are similarly hampered since they are P-gp substrates.
“However, there is evidence that more recent forms of treatment, such as proteasome inhibitors and immunomodulatory medications, are similarly hampered since they are P-gp substrates.”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [243]
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Mahmoodi, M., Nouri, M., Ghodousi, M., Mohseni, A., Ebrahimzadeh, M. A., Heidari, A., Ebrahimi, S., Pishbin, E., Rahdar, A., & Pandey, S. (2024) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2024.113765 · Cited by 5 · see citing works
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PID controller system development to enhance hyperthermia-mediated drug delivery
Adabbo, G., Andreozzi, A., Iasiello, M., Napoli, G., & Vanoli, G. P. (2026) · Applied Mathematical Modelling · doi:10.1016/j.apm.2026.117031
Sirtuin-targeted therapies: current challenges, clinical trials, and future directions
Barik, B., Badhei, L., & Desimone, M. F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45380-9.00019-5
- Authors
- Kiani Shahvandi, M., Souri, M., Tavasoli, S., Moradi Kashkooli, F., Kar, S., & Soltani, M.
- Affiliations
- Pasteur Institute of Iran (IR)
- K. N. Toosi University of Technology (IR)
- American University of the Middle East (KW)
- BC Cancer Agency (CA)
- Corresponding author
- Soltani, M.
- Venue
- Computers in Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 166
- Pages
- 107574
- ISSN
- 0010-4825 (ISSN-L)
- OpenAlex
- W4387541566
- Cited by
- 37
- References
- 70
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 21
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Computers in Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- photothermal therapy, targeted drug delivery, solid tumors, doxorubicin, bolus injection, continuous infusion, drug bioavailability, microvascular networks, cancer cell death, controlled drug release, systemic side effects, drug distribution
- MeSH terms
- Nanoparticle Drug Delivery System, Antineoplastic Agents, Doxorubicin, Humans, Models, Biological, Neoplasms, Drug Delivery Systems, Nanoparticles
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