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A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker
Open accessAbstract
Abstract Evidence of the long-term efficacy of digital therapies for smoking cessation that include a smartphone application (app) is limited. In this multi-center randomized controlled trial, we tested the efficacy of a novel digital therapy for smoking cessation: the “CureApp Smoking Cessation (CASC)” system, including a CASC smartphone app, a web-based patient management PC software for primary physicians, and a mobile exhaled carbon monoxide (CO) checker. A total of 584 participants with nicotine dependence were recruited from October 2017 to January 2018, and allocated 1:1 to the CASC intervention group or the control group. Both groups received a standard smoking cessation treatment with pharmacotherapy and counseling for 12 weeks. Meanwhile, the intervention group used the CASC system, and the control group used a control-app without a mobile CO checker, each for 24 weeks. The primary outcome was the biochemically validated continuous abstinence rate (CAR) from weeks 9 to 24. The main secondary outcome was an extended CAR from weeks 9 to 52. Except for 12 participants who did not download or use the apps, 285 participants were assigned to the intervention group, and 287, to the control. CAR from weeks 9 to 24 in the intervention group was significantly higher than that in the control group (63.9% vs. 50.5%; odds ratio [OR], 1.73; 95% confidence interval [CI], 1.24 to 2.42; P = 0.001). The CAR from weeks 9 to 52 was also higher in the intervention group than that in the control group (52.3% vs. 41.5%; OR, 1.55; 95% CI, 1.11 to 2.16; P = 0.010). No specific adverse events caused by the CASC system were reported. Augmenting standard face-to-face counseling and pharmacotherapy with a novel smartphone app, the CASC system significantly improved long-term CARs compared to standard treatment and a minimally supportive control app.
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“Masaki et al. (2020), in a study comparing a pharmacotherapy and counseling intervention combined with an App (CASC App) with a control group that received the same treatment with an App that had only the basic functions of the CASC App found that the experimental group had higher continuous abstinence rates than the control group from week 9 to 24 (63.9 % vs. 50.5 %, respectively) and from week 9”
From Evaluation of effectiveness and acceptability of a psychological treatment for smoking cessation combined with a smartphone App: A pilot study (2024) · cites this paper as Masaki et al., 2020
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“Some studies have shown evidence supporting the effect of m-Health on different fields of health [33–35].”
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Metadata
- Authors
- Masaki, K., Tateno, H., Nomura, A., Muto, T., Suzuki, S., Satake, K., Hida, E., & Fukunaga, K.
- Affiliations
- Keio University (JP)
- Kanazawa University (JP)
- The University of Osaka (JP)
- Corresponding author
- Tateno, Hiroki
- ORCID
- Venue
- npj Digital Medicine
- Published
- 2020-03-12
- Volume
- 3
- Issue
- 1
- Pages
- 35-35
- ISSN
- 2398-6352 (ISSN-L)
- PMC
- PMC7067789
- OpenAlex
- W3010960582
- Cited by
- 102
- References
- 29
- Citations by year
- 2026: 10 · 2025: 22 · 2024: 19 · 2023: 24 · 2022: 13 · 2021: 8 · 2020: 6
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Digital Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Keio University
- China Aerospace Science and Technology Corporation
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- smoking cessation, mobile application, digital therapy, exhaled carbon monoxide, nicotine dependence, continuous abstinence rate, long-term abstinence, pharmacotherapy, counseling
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