Inter-organ cross-talk in metabolic syndrome

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040

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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

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Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

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The hormone resistin links obesity to diabetes

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Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.

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Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

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Polyphenols from whole millet grain (Setaria italica) alleviate glucose and lipid homeostasis in diet‐induced obese mice by increasing endogenous GLP ‐1

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Galantamine improves glycemic control and diabetic nephropathy in Leprdb/db mice

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Impact of Bmal1 Rescue and Time-Restricted Feeding on Liver and Muscle Proteomes During the Active Phase in Mice

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Regulation of host metabolic health by parasitic helminths

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Ginger and turmeric lipid-solubles attenuate heated oil-induced hepatic inflammation via the downregulation of NF-kB in rats

Zarei, M., Acharya, P., & Talahalli, R. R. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118856 · Cited by 15

Molecular and cellular regulation of thermogenic fat

Wang, C., Wang, X., & Hu, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215772 · Cited by 14

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

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Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

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Theabrownin from Pu-erh tea attenuated high-fat diet-induced metabolic syndrome in rat by regulating microRNA and affecting gut microbiota

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A Multitarget Approach to Evaluate the Efficacy of Aquilaria sinensis Flower Extract against Metabolic Syndrome

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CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding

Sarver, D. C., Xu, C., Aja, S. M., & Wong, G. W. (2022) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00002.2022 · Cited by 14

Type 2 Diabetes Mellitus as a Multisystem Disease: From Insulin Resistance to Organ Crosstalk—A Narrative Review

Fuentes-Barría, H., Aguilera-Eguía, R. A., Flores-Fernández, C., Angarita, L., & Alarcón-Rivera, M. (2026) · Biomedicines · doi:10.3390/biomedicines14040752 · Cited by 19

An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism

Castaño, C., Novials, A., & Párrizas, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032071 · Cited by 14

Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development

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Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest

Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.573581 · Cited by 16

Exosomes from Short-Term High-Fat or High-Sucrose Fed Mice Induce Hepatic Steatosis through Different Pathways

Castaño, C., Novials, A., & Párrizas, M. (2022) · Cells · doi:10.3390/cells12010169 · Cited by 14

Overview of bergamot leaves extract (Citrus bergamia) effect on the RedOx/Inflammatory scenario in obesity target organs in an animal model of metabolic syndrome

Siqueira, J. S., Nakandakare-Maia, E. T., Vieira, T. A., Palacio, T. L. N., Belin, M. A. F., Baron, G., Bazan, S. G. Z., Ferron, A. J. T., Aldini, G., Francisqueti‐Ferron, F. V., et al. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106042 · Cited by 12

Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway

Song, H., Lü, J., & Deng, R. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401926 · Cited by 13

Multitissue single-cell analysis reveals differential cellular and molecular sensitivity between fructose and high-fat high-sucrose diets

Chen, Y.-W., Ahn, I. S., Wang, S. S.-M., Majid, S., Diamante, G., Cely, I., Zhang, G., Cabanayan, A., Komzyuk, S., Bonnett, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115690 · Cited by 14

Cardiac-derived TGF-β1 confers resistance to diet-induced obesity through the regulation of adipocyte size and function

Longenecker, J. Z., Petrosino, J. M., Martens, C. R., Hinger, S. A., Royer, C. J., Dorn, L. E., Branch, D. A., Serrano, J., Stanford, K. I., Kyriazis, G. A., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101343 · Cited by 14

iMS2Net: A Multiscale Networking Methodology to Decipher Metabolic Synergy of Organism

Dong, J., Peng, Q., Deng, L., Liu, J., Huang, W., Zhou, X., Zhao, C., & Cai, Z. (2022) · iScience · doi:10.1016/j.isci.2022.104896 · Cited by 12

Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796

Long, A., Liu, Y., Fang, X., Jia, L., Li, Z., Hu, J., Wu, S., Chen, C., Huang, P., & Wang, Y. (2023) · Cell Research · doi:10.1038/s41422-023-00782-7 · Cited by 11

Effects of Natural Alternative Sweeteners on Metabolic Diseases

Kim, E. (2023) · Clinical Nutrition Research · doi:10.7762/cnr.2023.12.3.229 · Cited by 15

Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis

Jun, H., Liu, S., Knights, A. J., Zhu, K., Ma, Y., Gong, J., Lenhart, A. E., Peng, X., Huang, Y., Ginder, J. P., et al. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002728 · Cited by 11

Cognitive outcomes in patients treated with neuromuscular electrical stimulation after coronary artery bypass grafting

Re, V. L., Russelli, G., Gerfo, E. L., Alduino, R., Bulati, M., Iannolo, G., Terzo, D., Martucci, G., Anzani, S., Panarello, G., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1209905 · Cited by 12

Transcriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome

Pei, Y., Risal, S., Jiang, H., Lu, H., Lindgren, E., Stener‐Victorin, E., & Deng, Q. (2023) · Communications Biology · doi:10.1038/s42003-022-04362-0 · Cited by 12

The beneficial and detrimental effects of prolactin hormone on metabolic syndrome: A double‐edge sword

Zaidalkilani, A. T., Al-Kuraishy, H. M., Al-Gareeb, A. I., Alexiou, A. T., Papadakis, M., AL-Farga, A. M., Alghamdi, O. A., Bahaa, M. M., Alrouji, M., Alshammari, M. S., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70067 · Cited by 11

New insights into the inter-organ crosstalk mediated by ChREBP

Carbinatti, T., Régnier, M., Parlati, L., Benhamed, F., & Postic, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1095440 · Cited by 13

A revisit of drugs and potential therapeutic targets against non-alcoholic fatty liver disease: learning from clinical trials

Zhu, S., Wu, Z., Wang, W., Wei, L., & Zhou, H. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02216-y · Cited by 10

Ginger and turmeric lipid-solubles attenuate heated oil-induced cardio-hepatic oxidative stress via the up-regulation of nuclear factor erythroid 2-related factor 2 and decrease blood pressure in rats

Zarei, M., Acharya, P., & Talahalli, R. R. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003967 · Cited by 10

Capsiate-Rich Fraction of Capsicum annuum Induces Muscular Glucose Uptake, Ameliorates Rosiglitazone-Induced Adipogenesis, and Exhibits Activation of NRs Regulating Multiple Signaling Pathways

Chae, H., Cantrell, C. L., Khan, I. A., Jarret, R. L., & Khan, S. I. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06148 · Cited by 9

The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective

Yu, X., Li, M., & Li, H. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118846 · Cited by 13

Predicting cross-tissue hormone–gene relations using balanced word embeddings

Jadhav, A. K., Kumar, T., Raghavendra, M., Loganathan, T., & Narayanan, M. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac578 · Cited by 8

CTRP13 ablation improves systemic glucose and lipid metabolism

Chen, F., Sarver, D. C., Saqib, M., Zhou, M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101824 · Cited by 9

Robust and generalizable artificial intelligence for multi-organ segmentation in ultra-low-dose total-body PET imaging: a multi-center and cross-tracer study

Wang, H., Qiao, X., Ding, W., Chen, G., Miao, Y., Guo, R., Zhu, X., Cheng, Z., Xu, J., Li, B., et al. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07156-8 · Cited by 8

Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research

Kim, J.-H., Yu, S.-M., & Son, J. W. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.302 · Cited by 8

Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism

Moon, S. H., Dilthey, B. G., Guan, S., Sims, H. F., Pittman, S. K., Keith, A. L., Jenkins, C. M., Weihl, C. C., & Gross, R. W. (2023) · iScience · doi:10.1016/j.isci.2023.106895 · Cited by 8

Systematic Review and Meta-Analysis of the Usefulness of Epicardial Fat Thickness as a Non-Invasive Marker of the Presence and Severity of Nonalcoholic Fatty Liver Disease

Orci, L. A., Jornayvaz, F. R., Toso, C., & Gariani, K. (2022) · Biomedicines · doi:10.3390/biomedicines10092204 · Cited by 8

Liver as a nexus of daily metabolic cross talk

Litwin, C., & Koronowski, K. B. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.06.001 · Cited by 8

The effect of 60 days of 6° head-down-tilt bed rest on circulating adropin, irisin, retinol binding protein-4 (RBP4) and individual metabolic responses in young, healthy males

Ward, K., Mulder, E. R., Frings‐Meuthen, P., O’Gorman, D. J., & Cooper, D. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1435448 · Cited by 7

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Shi, Y., Li, W., Yu, X., Zhao, Y., Zhu, D., Song, Y., Zhao, Z., Gu, Y., Wei, B. K., Li, L., et al. (2025) · Advanced Science · doi:10.1002/advs.202415956 · Cited by 10

Endocrine regulation of metabolic crosstalk between liver and brown adipose tissue by natural active ingredients

Chen, Q.-C., Cai, W., Ni, Q., Lin, S., Jiang, C., Yi, Y., Liu, L., Liu, Q., & Shen, C. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01793-7 · Cited by 7

Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk

Samadian, Z., Samadian, L., & Arabzadeh, E. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01710-x · Cited by 8

Novel cardiovascular metabolic risk factor mechanisms and therapeutic opportunities

Evans, P. C., Vilahur, G., Kleinbongard, P., Osto, E., Remme, C. A., Madonna, R., Aksentijević, D., Sourij, H., Davidson, S. M., Santovito, D., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag116 · Cited by 8

Mitochondrial Open Reading Frame of the 12S rRNA Type-c: Potential Therapeutic Candidate in Retinal Diseases

Mohtashami, Z., Singh, M. K., Neto, F. J. T., Salimiaghdam, N., Hasanpour, H., & Kenney, M. C. (2023) · Antioxidants · doi:10.3390/antiox12020518 · Cited by 9

Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity

Giovenzana, A., Bezzecchi, E., Bichisecchi, A., Cardellini, S., Ragogna, F., Pedica, F., Invernizzi, F., di Filippo, L., Tomajer, V., Aleotti, F., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109032 · Cited by 7

Modulation of gut microbiota by crude gac aril polysaccharides ameliorates diet-induced obesity and metabolic disorders

Lu, T.-J., Chiou, W.-C., Huang, H., Pan, H., Sun, C.-Y., Way, T., & Huang, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.133164 · Cited by 11

SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance

Li, D., Zhu, J., Zhang, M., Shi, Q., Guo, R., Zhang, D., Zheng, P., Zhang, H., Li, G., Wu, J., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115496 · Cited by 7

Integration of UHPLC-MS and mass spectrometry imaging techniques revealed the protective mechanism of Gushudan in postmenopausal osteoporosis rats via branched-chain amino acid metabolism based on the ‘kidney-bone’ axis

Ren, M., Wang, Y., Yuan, Y., Du, H., Liang, Q., Qin, F., & Xiong, Z. (2025) · Journal of Chromatography B · doi:10.1016/j.jchromb.2025.124540 · Cited by 6

The liver clock modulates circadian rhythms in white adipose tissue

Vlassakev, I., Savva, C., Renzi, G., Ilamathi, H. S., Mamand, D. R., Smith, J. G., Greco, C., Litwin, C., Zhang, Q., Velez, L., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102249 · Cited by 6

Chemical Composition and Therapeutic Potential of Syngonium podophyllum L. Leaves against Hypercholesterolemia in Rats: Liver, Kidney, and Heart Crosstalk

Ahmed, Y. R., El-Hagrassi, A. M., Nasr, N. N., Abdallah, W. E., & Hamed, M. A. A. (2023) · Current Bioactive Compounds · doi:10.2174/0115734072270545231107044558 · Cited by 6

Association of Serum Bile Acid Profile with Diet and Physical Activity Habits in Japanese Middle-Aged Men

Aoi, W., Koyama, T., Honda, A., Takagi, T., & Naito, Y. (2024) · Nutrients · doi:10.3390/nu16193381 · Cited by 8

Loss of CTRP10 results in female obesity with preserved metabolic health

Chen, F., Sarver, D. C., Saqib, M., Vélez, L. M., Aja, S. M., Seldin, M. M., & Wong, G. W. (2024) · eLife · doi:10.7554/elife.93373.3 · Cited by 8

Three pandemics at once: Noninfectious (cancer), infectious (COVID-19), and behavioral (hypokinesia)

Golubev, A., Semiglazova, Т. Y., Алексеевна, К. В., Каспаров, Б., Belyaev, А. М., & Anisimov, V. N. (2021) · Voprosy Onkologii · doi:10.37469/0507-3758-2021-67-2-163-180 · Cited by 6

Inter-organ Crosstalk and the Effect on the Aging Process in Obesity

Armutçu, F., & Özen, O. A. (2023) · Current Aging Science · doi:10.2174/1874609816666230223110458 · Cited by 6

Exercise Rescues Obesogenic-Related Genes in the Female Hypothalamic Arcuate Nucleus: A Potential Role of miR-211 Modulation

Rapps, K., Marco, A., Pe’er-Nissan, H., Kisliouk, T., Stemp, G., Yadid, G., Weller, A., & Meiri, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137188 · Cited by 6

Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities

Ngowi, E. E., Lu, T., Liu, Q., Xie, X., Wang, N., Luo, L., Deng, L., Zhou, Y., Zhang, Z., & Qiao, A. (2024) · Biology · doi:10.3390/biology13120976 · Cited by 5

International Symposium on Ruminant Physiology: Endocrine adaptations to demanding physiological states in ruminants

Boisclair, Y. R., & Giesy, S. L. (2024) · Journal of Dairy Science · doi:10.3168/jds.2024-25799 · Cited by 5

Cardiac‐Focused Multi‐Organ Chips: Advanced Disease Modeling, Drug Testing, and Inter‐Organ Communication

Zhang, X., Wang, Y., Han, J., Zhao, W., Zhang, W., Li, X., Chen, J., Song, W., & Wang, L. (2025) · Advanced Biology · doi:10.1002/adbi.202400512 · Cited by 5

Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice

Li, Z., Tian, Z., Shi, X., Long, A., Wang, Y., Yang, Y., Wang, Y., Zhang, J., & Wang, Y. (2025) · Nature Communications · doi:10.1038/s41467-025-61963-z · Cited by 6

Dysregulation of the FGF21–Adiponectin Axis in a Large Cohort of Patients with Severe Obesity and Liver Disease

Castañé, H., Jiménez-Franco, A., Onoiu, A.-I., Cambra-Cortés, V., Hernández‐Aguilera, A., Parada, D., Riu, F., Antonio Zorzano, A., Camps, J., & Joven, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178510 · Cited by 7

Studies of Foxo1 over the Past 25 Years: Mechanisms of Insulin Resistance and Glucose Dysregulation

Yang, W., Guo, J. Z., Song, J., & Guo, S. (2026) · Cells · doi:10.3390/cells15020109 · Cited by 5

The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target

Li, Y., Chen, Y., & Ruan, X. Z. (2023) · Pediatric Discovery · doi:10.1002/pdi3.9 · Cited by 5

Effects of Fructose and Palmitic Acid on Gene Expression in Drosophila melanogaster Larvae: Implications for Neurodegenerative Diseases

Santos-Cruz, L. F., Sigrist-Flores, S. C., Castañeda-Partida, L., Heres-Pulido, M. E., Dueñas-García, I. E., Piedra‐Ibarra, E., Ponciano-Gómez, A., Jiménez-Flores, R., & Campos-Aguilar, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210279 · Cited by 5

Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach

Kozawa, S., Tejima, K., Takagi, S., Kuroda, M., Itoh, M. N., Kitamura, H., Niwa, T., Ogura, T., Natsume‐Kitatani, Y., & Sato, T. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-49281-0 · Cited by 6

Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

Chen, K., Liu, S., & Wei, Y. (2024) · Nano Research · doi:10.1007/s12274-023-6366-7 · Cited by 5

The Roles of Dietary, Nutritional and Lifestyle Interventions in Adipose Tissue Adaptation and Obesity

Bjørklund, G., Tippairote, T., Dadar, M., Lizcano, F., Aaseth, J., & Borisova, O. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200505090449 · Cited by 5

Buriti pulp oil did not improve high‐fat diet‐induced metabolic disorders in c57bl/6 mice

Aydos, L. R., do Amaral, L. A., Jacobowski, A. C., de Souza, R. S., Parisotto, E. B., de Menezes, M. B., Bittencourt, F. F., Fernandes, E. S., Silva, I. S., Portugal, L. C., et al. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13473 · Cited by 5

Feeding-induced hepatokines and crosstalk with multi-organ: A novel therapeutic target for Type 2 diabetes

Chen, R., Wang, Q., Wang, Y. Y., Wang, Y., Liu, J., Liao, Z., & Xiao, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1094458 · Cited by 5

Protective effect of Fu brick tea on high-fat diet-induced metabolic syndrome: relevant to protecting the intestinal barrier and regulating the gut microbiota

Fang, W., Zhou, F., Wang, K., Wen, S., Zeng, H., Xu, H., Tang, J., Huang, J., & Liu, Z. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250211 · Cited by 4

Baf60c in skeletal muscle regulates adipose tissue thermogenesis via Musclin-mediated endocrine signaling

Han, S., Lu, J., Peng, W., Lv, X., Zhang, Z., Liu, T., Mi, L., Gao, Y., Fu, J., & Meng, Z. (2025) · Life Metabolism · doi:10.1093/lifemeta/loaf015 · Cited by 4

The Use of Organoid Cultures in Advancing Nutrition Research

Menikdiwela, K. R., Lenis, M., & Storch, J. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100489 · Cited by 4

Spatial Lipid Metabolic Remodeling from Placenta to Multiple Suborgans during the Gestational Micro- or Nanoplastics Exposure

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Multi-organ network of cardiometabolic disease-depression multimorbidity revealed by phenotypic and genetic analyses of MR images

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