Cited by 280Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and ObesityAdipose Tissue and Metabolism

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Inter-organ cross-talk in metabolic syndrome

Priest, Christina, Tontonoz, Peter·2019·Nature Metabolism

DOI 10.1038/s42255-019-0145-5

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Abstract

Maintenance of systemic homeostasis and the response to nutritional and environmental challenges require the coordination of multiple organs and tissues. To respond to various metabolic demands, higher organisms have developed a system of inter-organ communication through which one tissue can affect metabolic pathways in a distant tissue. Dysregulation of these lines of communication contributes to human pathologies, including obesity, diabetes, liver disease and atherosclerosis. In recent years, technical advances such as data-driven bioinformatics, proteomics and lipidomics have enabled efforts to understand the complexity of systemic metabolic cross-talk and its underlying mechanisms. Here, we provide an overview of inter-organ signals and their roles in metabolic control, and highlight recent discoveries in the field. We review peptide, small-molecule and lipid mediators secreted by metabolic tissues, as well as the role of the central nervous system in orchestrating peripheral metabolic functions. Finally, we discuss the contributions of inter-organ signalling networks to the features of metabolic syndrome.

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Authors: Priest, C., & Tontonoz, P.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Tontonoz, Peter
ORCID: Tontonoz, Peter
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2019-12-09
Volume: 1
Issue: 12
Pages: 1177-1188
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-019-0145-5
OpenAlex: W2993039085
Cited by: 279
References: 209
Citations by year: 2026: 36 · 2025: 47 · 2024: 54 · 2023: 50 · 2022: 46 · 2021: 27 · 2020: 19
FWCI: 3.39
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK120851)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: inter-organ communication, metabolic syndrome, systemic homeostasis, obesity, diabetes mellitus, liver disease, atherosclerosis, lipid mediators, central nervous system regulation
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Receptor Cross-Talk, Metabolic Syndrome

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