Inter-organ cross-talk in metabolic syndrome

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479

IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040

Ogurtsova, K., Fernandes, J. D. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D. A., Shaw, J. E., & Makaroff, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.024 · Cited by 7,138

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

The hormone resistin links obesity to diabetes

Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755

Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010.

Ogden, C., Carroll, M., Kit, B., & Flegal, K. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.40 · Cited by 4,128

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013

The Global Epidemic of the Metabolic Syndrome

Saklayen, M. G. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0812-z · Cited by 3,990

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444

A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus

Nauck, M. A., Heimesaat, M. M., Orskov, C., Holst, J. J., Ebert, R., & Creutzfeldt, W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116186 · Cited by 1,651

The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans.

Gnanapavan, S., Kola, B., Bustin, S., Morris, D., McGee, P. J., Fairclough, P., Bhattacharya, S., Carpenter, R., Grossman, A., & Korbonits, M. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.6.8739 · Cited by 1,507

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

Flint, A., Raben, A., Astrup, A., & Holst, J. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci990 · Cited by 1,402

Prevalence of the metabolic syndrome in the United States, 2003-2012

Aguilar, M., Bhuket, T., Torres, S., Liu, B., & Wong, R. J. (2015) · JAMA · doi:10.1001/jama.2015.4260 · Cited by 1,267

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Goldstein, J. L., & Brown, M. S. (2015) · Cell · doi:10.1016/j.cell.2015.01.036 · Cited by 1,233

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Cao, H., Gerhold, K. A., Mayers, J. R., Wiest, M. M., Watkins, S. M., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,174

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,036

Long-term effects of lifestyle intervention or metformin on diabetes development and microvascular complications over 15-year follow-up: the Diabetes Prevention Program Outcomes Study

(2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00291-0 · Cited by 1,029

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Shibata, R., Sato, K., Pimentel, D. R., Takemura, Y., Kihara, S., Ohashi, K., Funahashi, T., Ouchi, N., & Walsh, K. (2005) · Nature Medicine · doi:10.1038/nm1295 · Cited by 982

The immunology of atherosclerosis

Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982

Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice

Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 974

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., & Rossetti, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14120 · Cited by 955

Incretin hormones: Their role in health and disease

Nauck, M. A., & Meier, J. J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13129 · Cited by 950

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922

Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein

Hotamışlıgil, G. S., Johnson, R. S., Distel, R. J., Ellis, R., Papaioannou, V. E., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.274.5291.1377 · Cited by 915

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911

Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

Zhang, X., Yeung, D. C. Y., Karpisek, M., Stejskal, D., Zhou, Z.-G., Liu, F., Wong, R. L. C., Chow, W.-S., Tso, A. W. K., Lam, K. S. L., et al. (2008) · Diabetes · doi:10.2337/db07-1476 · Cited by 908

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

Yore, M. M., Syed, I., Moraes‐Vieira, P. M., Zhang, T., Herman, M. A., Homan, E. A., Patel, R. T., Lee, J., Chen, S., Peroni, O. D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.035 · Cited by 868

Interleukin-6 in acute exercise and training: what is the biological relevance?

Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817

Adiponectin acts in the brain to decrease body weight

Qi, Y., Takahashi, N., Hileman, S. M., Patel, H. R., Berg, A. H., Pajvani, U. B., Scherer, P. E., & Ahima, R. S. (2004) · Nature Medicine · doi:10.1038/nm1029 · Cited by 809

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

Calkin, A. C., & Tontonoz, P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3312 · Cited by 779

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Furuhashi, M., Tuncman, G., Görgün, C. Z., Makowski, L., Atsumi, G., Vaillancourt, E., Kono, K., Babaev, V. R., Fazio, S., Linton, M. F., et al. (2007) · Nature · doi:10.1038/nature05844 · Cited by 730

Sex hormone-binding globulin and risk of type 2 diabetes in women and men

Ding, E. L., Song, Y., Manson, J. E., Hunter, D. J., Lee, C. C., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0804381 · Cited by 726

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.-J., Mehta, H., Hevener, A. L., de Cabo, R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.009 · Cited by 715

Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

Makowski, L., Boord, J. B., Maeda, K., Babaev, V. R., Uysal, K. T., Morgan, M. A., Parker, R. A., Suttles, J., Fazio, S., Hotamışlıgil, G. S., et al. (2001) · Nature Medicine · doi:10.1038/89076 · Cited by 696

Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine

Erspamer, V., & Asero, B. (1952) · Nature · doi:10.1038/169800b0 · Cited by 674

Adiponectin-mediated modulation of hypertrophic signals in the heart

Shibata, R., Ouchi, N., Ito, M., Kihara, S., Shiojima, I., Pimentel, D. R., Kumada, M., Sato, K., Schiekofer, S., Ohashi, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1137 · Cited by 671

The Cardiovascular Biology of Glucagon-like Peptide-1

Drucker, D. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.009 · Cited by 665

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., Montez, J. M., Rohani, S., Feinstein, P. G., Mombaerts, P., & Friedman, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13914 · Cited by 664

A Meta-Analysis of the Effect of Glucagon-Like Peptide-1 (7-36) Amide on Ad Libitum Energy Intake in Humans

Verdich, C., Flint, A., Gutzwiller, J., Näslund, E. B., Beglinger, C., Hellström, P. M., Long, S. J., Morgan, L., Holst, J. J., & Astrup, A. V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7877 · Cited by 657

Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

Guo, S. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 648

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., et al. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.209 · Cited by 641

Adiponectin, the past two decades

Wang, Z. V., & Scherer, P. E. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw011 · Cited by 609

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Deng, Z., Poliakov, A., Hardy, R. W., Clements, R. H., Liu, C., Liu, Y., Wang, J., Xiang, X., Zhang, S., Zhuang, X., et al. (2009) · Diabetes · doi:10.2337/db09-0216 · Cited by 596

Serotonin regulates pancreatic beta cell mass during pregnancy

Kim, H., Toyofuku, Y., Lynn, F. C., Chak, E., Uchida, T., Mizukami, H., Fujitani, Y., Kawamori, R., Miyatsuka, T., Kosaka, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2173 · Cited by 586

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.015 · Cited by 583

Selective deletion of leptin receptor in neurons leads to obesity

Cohen, P., Zhao, C., Cai, X., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113914 · Cited by 554

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

Bookout, A. L., de Groot, M. H. M., Owen, B. M., Lee, S., Gautron, L., Lawrence, H. L., Ding, X., Elmquist, J. K., Takahashi, J. S., Mangelsdorf, D. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3249 · Cited by 545

FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss

Owen, B. M., Ding, X., Morgan, D. A., Coate, K. C., Bookout, A. L., Rahmouni, K., Kliewer, S. A., & Mangelsdorf, D. J. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.012 · Cited by 523

The brown fat–enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

Wang, G.-X., Zhao, X.-Y., Meng, Z., Kern, M., Dietrich, A., Chen, Z., Cozacov, Z., Zhou, D., Okunade, A. L., Su, X., et al. (2014) · Nature Medicine · doi:10.1038/nm.3713 · Cited by 515

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations

Nauck, M. A., Bartels, E., Ørskov, C., Ebert, R., & Creutzfeldt, W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.4.8473405 · Cited by 505

Suppression of body fat accumulation in myostatin-deficient mice

McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505

Ghrelin action in the brain controls adipocyte metabolism

Theander-Carrillo, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25811 · Cited by 465

Leptin Directly Alters Lipid Partitioning in Skeletal Muscle

Muoio, D. M., Dohm, G. L., Fiedorek, F. T., Tapscott, E. B., Coleman, R., & Dohn, G. L. (1997) · Diabetes · doi:10.2337/diab.46.8.1360 · Cited by 464

Unraveling the Regulation of Hepatic Metabolism by Insulin

Titchenell, P. M., Lazar, M. A., & Birnbaum, M. J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.03.003 · Cited by 457

Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P., & Pedersen, B. K. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1643 · Cited by 455

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

Potthoff, M. J., Boney-Montoya, J., Choi, M., He, T., Sunny, N. E., Satapati, S., Suino-Powell, K., Xu, H. E., Gerard, R. D., Finck, B. N., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.019 · Cited by 431

Hormonal regulation of hepatic glucose production in health and disease

Lin, H. V., & Accili, D. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.003 · Cited by 429

Visceral Adiposity and the Risk of Metabolic Syndrome Across Body Mass Index

Shah, R. V., Murthy, V. L., Abbasi, S. A., Blankstein, R., Kwong, R. Y., Goldfine, A. B., Jerosch-Herold, M., Lima, J. A. C., Ding, J., & Allison, M. A. (2014) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2014.07.017 · Cited by 427

Adipsin: A Circulating Serine Protease Homolog Secreted by Adipose Tissue and Sciatic Nerve

Cook, K. S., Min, H. Y., Johnson, D., Chaplinsky, R. J., Flier, J. S., Hunt, C. R., & Spiegelman, B. M. (1987) · Science · doi:10.1126/science.3299705 · Cited by 427

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

Wei, W., Dutchak, P. A., Wang, X., Ding, X., Wang, X., Bookout, A. L., Goetz, R., Mohammadi, M., Gerard, R. D., Dechow, P. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200797109 · Cited by 426

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife · doi:10.7554/elife.00065 · Cited by 420

The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity

Makowski, L., Brittingham, K. C., Reynolds, J. M., Suttles, J., & Hotamışlıgil, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413788200 · Cited by 413

An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State

Crewe, C., Joffin, N., Rutkowski, J. M., Kim, M., Zhang, F., Towler, D. A., Gordillo, R., & Scherer, P. E. (2018) · Cell · doi:10.1016/j.cell.2018.09.005 · Cited by 411

Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients

Muscelli, E., Mari, A., Casolaro, A., Camastra, S., Seghieri, G., Gastaldelli, A., Holst, J. J., & Ferrannini, E. (2008) · Diabetes · doi:10.2337/db07-1315 · Cited by 409

The metabolic actions of glucagon revisited

Habegger, K. M., Heppner, K. M., Geary, N., Bartness, T. J., DiMarchi, R., & Tschöp, M. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.187 · Cited by 406

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

Paulmann, N., Grohmann, M., Voigt, J.-P., Bert, B., Vowinckel, J., Bader, M., Skelin, M., Jevšek, M., Fink, H., Rupnik, M., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000229 · Cited by 404

Adiponectin Replenishment Ameliorates Obesity-Related Hypertension

Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000222368.43759.a1 · Cited by 400

Attenuated GLP-1 secretion in obesity: cause or consequence

Ranganath, L. R., Beety, J. M., Morgan, L. M., Wright, J. W., Howland, R., & Marks, V (1996) · Gut · doi:10.1136/gut.38.6.916 · Cited by 394

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

Guo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0584 · Cited by 375

Inflammation and Immunity in Diseases of the Arterial Tree: Players and Layers

Libby, P., & Hansson, G. K. (2015) · Circulation Research · doi:10.1161/circresaha.116.301313 · Cited by 372

Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis

Miao, J., Ling, A. V., Manthena, P. V., Gearing, M. E., Graham, M. J., Crooke, R. M., Croce, K. J., Esquejo, R. M., Clish, C. B., Morbid Obesity Study Group, et al. (2015) · Nature Communications · doi:10.1038/ncomms7498 · Cited by 368

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

Tabata, M., Kadomatsu, T., Fukuhara, S., Miyata, K., Ito, Y., Endo, M., Urano, T., Zhu, H. J., Tsukano, H., Tazume, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.003 · Cited by 367

Thirty sweet years of GLUT4

Klip, A., McGraw, T. E., & James, D. E. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.008351 · Cited by 365

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice

Sun, Y., Asnicar, M., Saha, P., Chan, L., & Smith, R. G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.004 · Cited by 358

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Stanford, K. I., Lynes, M. D., Takahashi, H., Baer, L. A., Arts, P. J., May, F. J., Lehnig, A. C., Middelbeek, R. J. W., Richard, J. J., So, K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.020 · Cited by 355

Global Health Effects of Overweight and Obesity

Gregg, E. W., & Shaw, J. E. (2017) · New England Journal of Medicine · doi:10.1056/nejme1706095 · Cited by 343

Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism

Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338

Increased secretion and expression of myostatin in skeletal muscle from extremely obese women

Hittel, D. S., Berggren, J. R., Shearer, J., Boyle, K., & Houmard, J. A. (2009) · Diabetes · doi:10.2337/db08-0943 · Cited by 324

Deaths: leading causes for 2010.

Heron, M. P. (2013) · PubMed · Cited by 317

Ghrelin Stimulates, Whereas Des-Octanoyl Ghrelin Inhibits, Glucose Output by Primary Hepatocytes

Gauna, C., Delhanty, P. J. D., Hofland, L. J., Janssen, J. A. M. J. L., Broglio, F., Ross, R. J. M., Ghigo, E., & van der Lely, A. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1069 · Cited by 300

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 297

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

Moraes‐Vieira, P. M., Yore, M. M., Dwyer, P., Syed, I., Aryal, P., & Kahn, B. B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.018 · Cited by 292

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291

Resistin competes with lipopolysaccharide for binding to toll‐like receptor 4

Tarkowski, A., Bjersing, J. L., Shestakov, A., & Bokarewa, M. I. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00899.x · Cited by 283

High Salt Intake

Ma, Y., He, F. J., & MacGregor, G. A. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05948 · Cited by 281

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production

Cao, H., Sekiya, M., Ertunc, M. E., Burak, M. F., Mayers, J. R., White, A., Inouye, K., Rickey, L., Erçal, B., Furuhashi, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.012 · Cited by 280

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis

Simcox, J., Geoghegan, G., Maschek, J. A., Bensard, C. L., Pasquali, M., Miao, R., Lee, S., Jiang, L., Huck, I., Kershaw, E. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.006 · Cited by 277

Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart

Oshima, Y., Ouchi, N., Sato, K., Izumiya, Y., Pimentel, D. R., & Walsh, K. (2008) · Circulation · doi:10.1161/circulationaha.108.767673 · Cited by 275

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia · doi:10.1002/glia.21049 · Cited by 274

Skeletal myocytes are a source of interleukin‐6 mRNA expression and protein release during contraction: evidence of fiber type specificity

Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 274

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Kliewer, S. A., & Mangelsdorf, D. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.004 · Cited by 273

Regulation of systemic energy homeostasis by serotonin in adipose tissues

Oh, C., Namkung, J., Go, Y., Shong, K. E., Kim, K., Kim, H., Park, B.-Y., Lee, H. W., Jeon, Y. H., Shong, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7794 · Cited by 271

Fibroblast Growth Factor 21—Metabolic Role in Mice and Men

Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00016 · Cited by 270

Long-term adaptation to electrically induced cycle training in severe spinal cord injured individuals

Mohr, T., Andersen, J. L., Biering-Sørensen, F., Galbo, H., Bangsbo, J., Wagner, A., & Kjaer, M. (1997) · Spinal Cord · doi:10.1038/sj.sc.3100343 · Cited by 263

Administration of Acylated Ghrelin Reduces Insulin Sensitivity, Whereas the Combination of Acylated Plus Unacylated Ghrelin Strongly Improves Insulin Sensitivity

Gauna, C., Meyler, F. M., Janssen, J. A. M. J. L., Delhanty, P. J. D., Abribat, T., van Koetsveld, P. M., Hofland, L. J., Broglio, F., Ghigo, E., & van der Lely, A. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0363 · Cited by 261

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.023 · Cited by 255

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

Soto, M., Cai, W., Konishi, M., & Kahn, C. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817391116 · Cited by 253

Insulin analogues in type 1 diabetes mellitus: Getting better all the time

Mathieu, C., Gillard, P., & Benhalima, K. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.39 · Cited by 248

The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15

Nielsen, A. R., & Pedersen, B. K. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-054 · Cited by 246

Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation

Sumara, G., Sumara, O., Kim, J. K., & Karsenty, G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.014 · Cited by 236

RBP4: a controversial adipokine

Kotnik, P., Fischer-Posovszky, P., & Wabitsch, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0431 · Cited by 233

FGF21 contributes to neuroendocrine control of female reproduction

Owen, B. M., Bookout, A. L., Ding, X., Lin, V. Y., Atkin, S. D., Gautron, L., Kliewer, S. A., & Mangelsdorf, D. J. (2013) · Nature Medicine · doi:10.1038/nm.3250 · Cited by 230

Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

Ferry, G., Tellier, E., Renouard-Try, A., Grès, S., Naime, I., Simon, M., Rodriguez, M., Boucher, J., Tack, I., Gesta, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301158200 · Cited by 230

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

Kong, X., Yao, T. S., Zhou, P., Kazak, L., Tenen, D. E., Lyubetskaya, A., Dawes, B. A., Tsai, L. T.-Y., Kahn, B. B., Spiegelman, B. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.004 · Cited by 223

Contributions of basal and postprandial hyperglycemia over a wide range of A1C levels before and after treatment intensification in type 2 diabetes

Riddle, M., Umpierrez, G., DiGenio, A., Zhou, R., & Rosenstock, J. (2011) · Diabetes Care · doi:10.2337/dc11-0632 · Cited by 219

Health Effects of Overweight and Obesity in 195 Countries

(2017) · New England Journal of Medicine · doi:10.1056/nejmc1710026 · Cited by 219

Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

Guo, H., Jin, D., Zhang, Y., Wright, W. S., Bazuine, M., Brockman, D. A., Bernlohr, D., & Chen, X. (2010) · Diabetes · doi:10.2337/db09-1735 · Cited by 214

Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects

Feldman, B. J., Streeper, R. S., Farese, R. V., & Yamamoto, K. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607501103 · Cited by 211

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat

Leiria, L. O., Wang, C., Lynes, M. D., Yang, K., Shamsi, F., Sato, M. M., Sugimoto, S., Chen, E. Y.-S., Bussberg, V., Narain, N. R., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.001 · Cited by 205

Modulation of Angiogenesis during Adipose Tissue Development in Murine Models of Obesity

Vörös, G., Maquoi, E., Demeulemeester, D., Clerx, N., Collen, D., & LIJNEN, H. R. (2005) · Endocrinology · doi:10.1210/en.2005-0532 · Cited by 203

Glucose Ingestion Attenuates Interleukin‐6 Release from Contracting Skeletal Muscle in Humans

Febbraio, M. A., Steensberg, A., Keller, C., Starkie, R. L., Nielsen, H. B., Krustrup, P., Ott, P., Secher, N. H., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.042374 · Cited by 201

Central nervous system regulation of eating: Insights from human brain imaging

Farr, O. M., Li, C. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 201

Exercise induces a marked increase in plasma follistatin: Evidence that follistatin is a contraction-induced hepatokine

Hansen, J., Brandt, C., Nielsen, A. R., Hojman, P., Whitham, M., Febbraio, M. A., Pedersen, B. K., & Plomgaard, P. (2011) · Endocrinology · doi:10.1210/en.2010-0868 · Cited by 200

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

Syed, I., Lee, J., Moraes‐Vieira, P. M., Donaldson, C. J., Sontheimer-Phelps, A., Aryal, P., Wellenstein, K., Kolar, M. J., Nelson, A. T., Siegel, D. R., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.001 · Cited by 200

Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: Evidence for a skeletal muscle-to-fat signaling pathway

QUINN, L., STRAITBODEY, L., ANDERSON, B., ARGILES, J., & HAVEL, P. (2005) · Cell Biology International · doi:10.1016/j.cellbi.2005.02.005 · Cited by 199

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance

Gao, S., McMillan, R. P., Zhu, Q., Lopaschuk, G. D., Hulver, M. W., & Butler, A. A. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.01.005 · Cited by 197

Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization

Xie, Z., Wang, X., Liu, X., Du, H., Sun, C., Shao, X., Tian, J., Gu, X., Wang, H., Tian, J., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007442 · Cited by 194

Role of muscle-derived growth factors in bone formation.

Hamrick, M. W., McNeil, P. L., & Patterson, S. L. (2010) · PubMed · Cited by 192

DPP4 in Cardiometabolic Disease

Zhong, J., Maiseyeu, A., Davis, S. N., & Rajagopalan, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.305665 · Cited by 190

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Chen, Y., Buyel, J. J., Hanssen, M. J. W., Siegel, F., Pan, R., Naumann, J., Schell, M. J., van der Lans, A. A. J. J., Schlein, C., Fröhlich, H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11420 · Cited by 186

Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

Svane, M. S., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Nielsen, S., Kristiansen, V. B., Toräng, S., Wewer Albrechtsen, N. J., Rehfeld, J. F., Hartmann, B., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.121 · Cited by 185

Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: A potential role in body weight control

Carbó, N., López-Soriano, J., Costelli, P., Alvarez, B., Busquets, S., Baccino, F. M., Quinn, L. S., López-Soriano, F. J., & Argilés, J. M. (2001) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00188-4 · Cited by 174

Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats

Yasuda, T., Masaki, T., Kakuma, T., & Yoshimatsu, H. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00789-4 · Cited by 168

Clinical relevance of the bile acid receptor TGR5 in metabolism

van Nierop, F. S., Scheltema, M. J. V., Eggink, H. M., Pols, T. W. H., Sonne, D. P., Knop, F. K., & Soeters, M. R. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30155-3 · Cited by 163

Therapeutic Potential of Targeting the Ghrelin Pathway

Colldén, G., Tschöp, M. H., & Müller, T. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040798 · Cited by 161

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function

Svensson, K. J., Long, J. Z., Jedrychowski, M. P., Cohen, P., Lo, J. C., Serag, S., Kır, S., Shinoda, K., Tartaglia, J. A., Rao, R. R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.008 · Cited by 160

Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?

Flier, J. S., & Maratos–Flier, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.013 · Cited by 160

Insulin Therapy for Type 2 Diabetes Mellitus

Wallia, A., & Molitch, M. E. (2014) · JAMA · doi:10.1001/jama.2014.5951 · Cited by 159

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes · doi:10.2337/db13-0728 · Cited by 158

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158

Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression

Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.303116 · Cited by 157

The renin–angiotensin system in adipose tissue and its metabolic consequences during obesity

Frigolet, M. E., Torres, N., & Tovar, A. R. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.07.002 · Cited by 156

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032938 · Cited by 152

Analysis of next-generation genomic data in cancer: accomplishments and challenges

Ding, L., Wendl, M. C., Koboldt, D. C., & Mardis, E. R. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq391 · Cited by 148

Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans

Steensberg, A., Fischer, C. P., Sacchetti, M., Keller, C., Osada, T., Schjerling, P., van Hall, G., Febbraio, M. A., & Pedersen, B. K. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00631.x · Cited by 146

Computational reconstruction of the human skeletal muscle secretome

Bortoluzzi, S., Scannapieco, P., Cestaro, A., Danieli, G. A., & Schiaffino, S. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20803 · Cited by 136

Liver X receptors at the intersection of lipid metabolism and atherogenesis

Lee, S. D., & Tontonoz, P. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.042 · Cited by 135

Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities

Guo, K., McMinn, J. E., Ludwig, T. E., Yu, Y., Yang, G., Chen, L., Loh, D., Cai, L., Chua, S. C., & Zhang, Y. (2007) · Endocrinology · doi:10.1210/en.2007-0261 · Cited by 133

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

Kim, K. H., Kim, S., Han, D. H., Jo, Y. S., Lee, Y., & Lee, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-25098-0 · Cited by 130

Growth differentiation factor 15 predicts advanced fibrosis in biopsy‐proven non‐alcoholic fatty liver disease

Koo, B. K., Um, S. H., Seo, D. S., Joo, S. K., Bae, J. M., Park, J. H., Chang, M. S., Kim, J. H., Lee, J., Jeong, W., et al. (2017) · Liver International · doi:10.1111/liv.13587 · Cited by 129

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B., Singh, A. K., Zhang, X., Varela, L., Rotllan, N., Goedeke, L., Chaube, B., Camporez, J.-P., Vatner, D. F., Horvath, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 127

Hypertension as a Metabolic Disorder and the Novel Role of the Gut

Tanaka, M., & Itoh, H. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0964-5 · Cited by 120

Increased selenoprotein P levels in subjects with visceral obesity and nonalcoholic Fatty liver disease

Choi, H. Y., Hwang, S. Y., Lee, C. H., Hong, H. C., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., et al. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.63 · Cited by 111

Exercise induces white adipose tissue browning across the weight spectrum in humans

Otero-Díaz, B., Rodríguez-Flores, M., Sánchez-Muñoz, V., Monraz-Preciado, F., Ordoñez-Ortega, S., Becerril-Elias, V., Baay-Guzmán, G., Obando-Monge, R., García-García, E., Palacios-González, B., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01781 · Cited by 110

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G., & Kersten, S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m067363 · Cited by 103

Administration of ghrelin improves inflammation, oxidative stress, and apoptosis during and after non-alcoholic fatty liver disease development

Yan, L., Jie, H., Li, L., Chen, X.-H., Peng, H., Cao, M., & Zhang, Q. (2012) · Endocrine · doi:10.1007/s12020-012-9761-5 · Cited by 100

Sodium Intake Regulates Glucose Homeostasis through the PPARδ/Adiponectin-Mediated SGLT2 Pathway

Zhao, Y., Gao, P., Sun, F., Li, Q., Chen, J., Yu, H., Li, L., Wei, X., He, H., Lu, Z., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.019 · Cited by 100

Upregulation of Lipocalin 2 in Adipose Tissues of Severely Obese Women: Positive Relationship With Proinflammatory Cytokines

Auguet, T., Quintero, Y., Terra, X., Martínez, S., Lucas, A., Pellitero, S., Aguilar, C., Hernández, M., Castillo, D. D., & Richart, C. (2011) · Obesity · doi:10.1038/oby.2011.61 · Cited by 99

Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes

Burak, M. F., Inouye, K., White, A., Lee, A., Tuncman, G., Calay, E. S., Sekiya, M., Tirosh, A., Eguchi, K., Birrane, G., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac6336 · Cited by 99

Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients

Lee, M. J., Lee, S. A., Nam, B. Y., Park, S., Lee, S., Ryu, H. J., Kwon, Y. E., Kim, Y. L., Park, K. S., Oh, H. J., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.002 · Cited by 98

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Kim, T., Nason, S., Holleman, C., Pepin, M., Wilson, L., Berryhill, T. F., Wende, A. R., Steele, C., Young, M. E., Barnes, S., et al. (2018) · Diabetes · doi:10.2337/db17-1502 · Cited by 97

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 95

Hepatokines as a Link between Obesity and Cardiovascular Diseases

Yoo, H. J., & Choi, K. M. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.1.10 · Cited by 94

The role of hepassocin in the development of non-alcoholic fatty liver disease

Wu, H.-T., Lu, F.-H., Ou, H.-Y., Su, Y.-C., Hung, H.-C., Wu, J.-S., Yang, Y.-C., Wu, C.-L., & Chang, C.-J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.004 · Cited by 92

Circulating MOTS-c levels are decreased in obese male children and adolescents and associated with insulin resistance

Du, C., Zhang, C., Wu, W., Liang, Y., Wang, A., Wu, S., Zhao, Y., Hou, L., Ning, Q., & Luo, X. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12685 · Cited by 91

Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice

Rancoule, C., Attané, C., Grès, S., Fournel, A., Dusaulcy, R., Bertrand, C., Vinel, C., Tréguer, K., Prentki, M., Valet, P., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2891-3 · Cited by 89

Effect of gastric bypass surgery on the incretins

Laferrère, B. (2009) · Diabetes & Metabolism · doi:10.1016/s1262-3636(09)73458-5 · Cited by 89

Adipose tissue growth and regression are regulated by angiopoietin-1

Dallabrida, S. M., Zurakowski, D., Shih, S., Smith, L. E. H., Folkman, J., Moulton, K. S., & Rupnick, M. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.007 · Cited by 88

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84

Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise

He, Z., Gao, Y., Alhadeff, A. L., Castorena, C. M., Huang, Y., Lieu, L., Afrin, S., Sun, J. M., Betley, J. N., Guo, H., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.011 · Cited by 84

Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure

Li, C. Y., Cao, C.-Z., Xu, W., Cao, M., Yang, F., Dong, L., Yu, M., Zhan, Y.-Q., Gao, Y.-B., Li, W., et al. (2009) · Gut · doi:10.1136/gut.2008.171124 · Cited by 82

Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet–Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents

Cappellari, G. G., Zanetti, M., Semolic, A., Vinci, P., Ruozi, G., Falcione, A., Filigheddu, N., Guarnieri, G., Graziani, A., Giacca, M., et al. (2016) · Diabetes · doi:10.2337/db15-1019 · Cited by 82

Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes

Lee, S., Kim, W., Moon, S.-O., Sung, M. J., Kim, D. H., Kang, K. P., Jang, K. Y., Lee, S., Park, B. H., Koh, G. Y., et al. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl598 · Cited by 77

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

An, Y., Sun, K., Joffin, N., Zhang, F., Deng, Y., Donzé, O., Kusminski, C. M., & Scherer, P. E. (2017) · eLife · doi:10.7554/elife.24071 · Cited by 77

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

Barchetta, I., Cimini, F. A., Ciccarelli, G., Baroni, M. G., & Cavallo, M. G. (2019) · Journal of Endocrinological Investigation · doi:10.1007/s40618-019-01052-3 · Cited by 77

NRG4: An Endocrine Link between Brown Adipose Tissue and Liver

Pfeifer, A. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.008 · Cited by 73

Circulating follistatin in relation to energy metabolism

Hansen, J. S., & Plomgaard, P. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.002 · Cited by 62

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice

Pflimlin, E., Bielohuby, M., Korn, M., Breitschopf, K., Löhn, M., Wohlfart, P., Konkar, A. A., Podeschwa, M. A. L., Bärenz, F., Pfenninger, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.028 · Cited by 61

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans

Romeo, S., Yin, W., Kozlitina, J., Pennacchio, L. A., Boerwinkle, E., Hobbs, H. H., & Cohen, J. C. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37118 · Cited by 58

Insulin actions in the mesolimbic dopamine system

Liu, S., & Borgland, S. L. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113006 · Cited by 52

Insights From Pre-Clinical and Clinical Studies on the Role of Innate Inflammation in Atherosclerosis Regression

Rahman, K., & Fisher, E. A. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00032 · Cited by 48

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects

Syed, I., Lee, J., Peroni, O. D., Yore, M. M., Moraes‐Vieira, P. M., Santoro, A. N., Wellenstein, K., Smith, U., McGraw, T. E., Saghatelian, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.007 · Cited by 48

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Wang, Y., Liu, L.-M., Li, W., Ye, W., Meng, X., Chen, F., Xiao, Q., Chen, J.-Y., & Zhou, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5637 · Cited by 46

Salt Induces Adipogenesis/Lipogenesis and Inflammatory Adipocytokines Secretion in Adipocytes

Lee, M., Sorn, S. R., Lee, Y., & Kang, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010160 · Cited by 46

Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice

Shimba, Y., Togawa, H., Senoo, N., Ikeda, M., Miyoshi, N., Morita, A., & Miura, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40643-1 · Cited by 44

β-aminoisobutyric acid protects against vascular inflammation through PGC-1β-induced antioxidative properties

Sawada, M., Yamamoto, H., Ogasahara, A., Tanaka, Y., & Kihara, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.06.141 · Cited by 44

Serum Adropin Levels Are Reduced in Adult Patients with Nonalcoholic Fatty Liver Disease

Kutlu, O., Altun, Ö., Dikker, O., Aktaş, H. Ş., Özsoy, N., Arman, Y., Çil, E. Ö., Özcan, M., Yoldemir, Ş. A., Akarsu, M., et al. (2019) · Medical Principles and Practice · doi:10.1159/000500106 · Cited by 44

The Gastrointestinal Tract: an Initial Organ of Metabolic Hypertension?

Zhu, Z., Xiong, S., & Liu, D. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443107 · Cited by 38

Effect of Ghrelin on Mortality and Cardiovascular Outcomes in Experimental Rat and Mice Models of Heart Failure: A Systematic Review and Meta-Analysis

Khatib, M. N., Shankar, A. H., Kirubakaran, R., Agho, K., Simkhada, P. P., Gaidhane, S., Saxena, D. B., Unnikrishnan, B., Gode, D., Gaidhane, A. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126697 · Cited by 35

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

A single-cell atlas of human and mouse white adipose tissue

Emont, M. P., Jacobs, C., Essene, A. L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jørgensen, A. M., Dashti, H., Stefek, A., et al. (2022) · Nature · doi:10.1038/s41586-022-04518-2 · Cited by 840

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus

Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Ma, Z., Zuo, T., Frey, N., & Rangrez, A. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01946-6 · Cited by 322

Inter‐organ communication: a gatekeeper for metabolic health

Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178

Inter-organ communication involved in metabolic regulation at the whole-body level

Katagiri, H. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00306-1 · Cited by 24

Roles of the interorgan neuronal network in the development of metabolic syndrome

Uno, K. (2016) · Diabetology International · doi:10.1007/s13340-016-0277-8 · Cited by 4

Lipid metabolites as metabolic messengers in inter-organ communication

Liu, S., Alexander, R., & Lee, C. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.05.002 · Cited by 57

Editorial: Intra and inter organ cross-talk and cellular communication

Denechaud, P., & Rabhi, N. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1209436 · Cited by 4