Cited by 223Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismGut microbiota and health

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Metabolic Messengers: bile acids

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Perino, Alessia, Schoonjans, Kristina·2022·Nature Metabolism

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Abstract

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their actions, through activation of the dedicated BA receptors FXR and TGR5, control the body’s integrated physiological metabolic responses. Alterations in BA abundance or signalling are associated with metabolic diseases including obesity, type 2 diabetes, non-alcoholic steatohepatitis and atherosclerosis. Consequently, modulation of the BA pool could be a valid therapeutic approach, as demonstrated in preclinical and clinical models. Here we provide a historical summary of the discovery of BAs and their receptors, as well as a summary on the role of BA signalling in the control of energy homeostasis. Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis.

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Authors: Perino, A., & Schoonjans, K.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Schoonjans, Kristina
ORCID: Perino, Alessia
Schoonjans, Kristina
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2022-03-25
Volume: 4
Issue: 4
Pages: 416-423
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-022-00559-z
OpenAlex: W4221038382
Cited by: 223
References: 126
Citations by year: 2026: 54 · 2025: 63 · 2024: 61 · 2023: 32 · 2022: 13
FWCI: 5.16
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: cc-by-nc-nd
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: AXA Research Fund
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNSF N° 310030_189178, CRSII5_180317/1)
Stiftelsen Kristian Gerhard Jebsen
École Polytechnique Fédérale de Lausanne
"la Caixa" Foundation (HR17-00601)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: bile acids, bile acid receptors, farnesoid X receptor, TGR5, energy homeostasis, nutrient sensing, metabolic disorders, obesity, type 2 diabetes, nonalcoholic steatohepatitis, atherosclerosis, bile acid signaling
MeSH terms: Bile Acids and Salts, Biochemical Phenomena, Liver, Signal Transduction

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