Cited by 223Drug Transport and Resistance MechanismsCholesterol and Lipid MetabolismGut microbiota and health

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Metabolic Messengers: bile acids

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Perino, Alessia, Schoonjans, Kristina·2022·Nature Metabolism

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Abstract

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their actions, through activation of the dedicated BA receptors FXR and TGR5, control the body’s integrated physiological metabolic responses. Alterations in BA abundance or signalling are associated with metabolic diseases including obesity, type 2 diabetes, non-alcoholic steatohepatitis and atherosclerosis. Consequently, modulation of the BA pool could be a valid therapeutic approach, as demonstrated in preclinical and clinical models. Here we provide a historical summary of the discovery of BAs and their receptors, as well as a summary on the role of BA signalling in the control of energy homeostasis. Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis.

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Background
VSV infection and LPS treatment alter serum bile acid profiles, bile acid biosynthesis, and bile acid receptors in mice
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Self-citation
The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow nichePreprint
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Self-citation
The bile acid receptor TGR5 is a modulator of bone marrow adipose tissue and the hematopoietic nichePreprint
Calleja, A. A., Perino, A., Schyrr, F., Lopes, S. F., Delitsikou, V., Jalil, A., Kettenberger, U., Galavotti, M. C., Martins, A., Bataclan, C., et al. (2024) · eLife · doi:10.7554/elife.93124
Self-citation
A Prognostic Model of Hepatocellular Carcinoma Related to Crotonylation Was Constructed Based on TranscriptomicsPreprint
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High leafy and root vegetables and high rice dietary patterns were associated with primary and secondary bile acid levels in the feces
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The adaptive mechanism of Ctenopharyngodon idellus to dietary lipid levels: Insights from microbiota-mediated bile acid enterohepatic circulation
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Metabolomics analysis of antioxidant and lipid-lowering activities, colonic fermentation properties of quinoa bran polyphenol extract during in vitro digestion
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The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolismPreprint
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An Explainable Knowledge Graph-Driven Approach to Decipher the Link Between Brain Disorders and the Gut MicrobiomePreprint
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“This indicates that the identified mechanistic pathways are primarily mediated by metabolite–protein interactions and therapeutic associations, consistent with the known role of gut metabolites as biochemical messengers in the MGBA [47].”
GPR39-mediated molecular signaling by bile acids
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The role of bile acid dynamics in inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease
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“13 This multilayered regulatory network underscores the necessity of comprehensively characterizing BA profiles in IBD patients.”
Cholecystectomy Is Linked With Lower Respiratory Exchange Ratio and Higher Lipid Oxidation and Sleep Energy Expenditure
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“Besides their long recognized role in facilitation of lipid absorption, it is now known that BAs function as hormones regulating lipid, glucose, and energy metabolism [8] through the nuclear receptor farnesoid X receptor (FXR) and the G protein-coupled BA receptor 1 (GPBAR-1 or TGR5) [10].”
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L-β-Galactoglucan alleviates loperamide-induced constipation in mice and regulates gut microbiota and metabolism
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Alterations in secondary bile acids in adult-onset subclinical hypothyroidism with mild cognitive impairment
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Fucoidan Treatment Improves Diabetic Hyperglycemia and Dyslipidemia in Rodents: A Systematic Review and Meta-Analysis
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“Activation of intestinal TGR5 promotes GLP-1 secretion and improves glucose and lipid metabolism [92,93].”
Vitamin D 3 Metabolite-Enhanced Hepatic VDR–FXR Binding Attenuates Bile Acid Dysregulation-Induced Diarrhea in Weaned Piglets
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Gut microbiota-derived taurolithocholic acid modulates myofiber-type switching via p38 MAPK/PGC-1α signaling underlying breed differences between Arbor Acres and Taoyuan chickens
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Authors: Perino, A., & Schoonjans, K.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Schoonjans, Kristina
ORCID: Perino, Alessia
Schoonjans, Kristina
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2022-03-25
Volume: 4
Issue: 4
Pages: 416-423
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-022-00559-z
OpenAlex: W4221038382
Cited by: 223
References: 126
Citations by year: 2026: 54 · 2025: 63 · 2024: 61 · 2023: 32 · 2022: 13
FWCI: 5.16
Type: journal article
Language: en
Open access: green
infoscience.epfl.ch
Licence: cc-by-nc-nd
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders: AXA Research Fund
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNSF N° 310030_189178, CRSII5_180317/1)
Stiftelsen Kristian Gerhard Jebsen
École Polytechnique Fédérale de Lausanne
"la Caixa" Foundation (HR17-00601)
Topics: Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: bile acids, bile acid receptors, farnesoid X receptor, TGR5, energy homeostasis, nutrient sensing, metabolic disorders, obesity, type 2 diabetes, nonalcoholic steatohepatitis, atherosclerosis, bile acid signaling
MeSH terms: Bile Acids and Salts, Biochemical Phenomena, Liver, Signal Transduction

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