Metabolic Messengers: bile acids

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

Wahlstrom, A. M., Sayin, S. I., Marschall, H., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.005 · Cited by 2,969

Identification of a nuclear receptor for bile acids

Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220

The Enzymes, Regulation, and Genetics of Bile Acid Synthesis

Russell, D. W. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161712 · Cited by 2,069

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,924

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.001 · Cited by 1,885

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636

A G Protein-coupled Receptor Responsive to Bile Acids

Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628

Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors

Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487

Identification of a nuclear receptor that is activated by farnesol metabolites

Forman, B. M., Goode, E., Chen, J., Oro, A. E., Bradley, D. J., Perlmann, T., Noonan, D. J., Burka, L. T., McMorris, T., Lamph, W. W., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90530-8 · Cited by 1,210

Identification of membrane-type receptor for bile acids (M-BAR)

Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

Chávez-Talavera, O., Tailleux, A., Lefebvre, P., & Staels, B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.01.055 · Cited by 970

FXR is a molecular target for the effects of vertical sleeve gastrectomy

Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931

Deiodinases: implications of the local control of thyroid hormone action

Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845

Gut Microbiota Orchestrates Energy Homeostasis during Cold

Chevalier, C., Stojanović, O., Colin, D. J., Suarez-Zamorano, N., Tarallo, V., Veyrat-Durebex, C., Rigo, D., Fabbiano, S., Stevanović, A., Hagemann, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.004 · Cited by 829

Review: microbial transformations of human bile acids

Guzior, D. V., & Quinn, R. A. (2021) · Microbiome · doi:10.1186/s40168-021-01101-1 · Cited by 795

6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

Pellicciari, R., Fiorucci, S., Camaioni, E., Clerici, C., Costantino, G., Maloney, P. R., Morelli, A., Parks, D. J., & Willson, T. M. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm025529g · Cited by 743

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine · doi:10.1038/nm.3760 · Cited by 738

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

Li, F., Jiang, C., Krausz, K. W., Li, Y., Albert, I., Hao, H., Fabre, K. M., Mitchell, J. B., Patterson, A. D., & Gonzalez, F. J. (2013) · Nature Communications · doi:10.1038/ncomms3384 · Cited by 705

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism

Gribble, F. M., & Reimann, F. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0168-8 · Cited by 670

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

Arab, J. P., Karpen, S. J., Dawson, P. A., Arrese, M., & Trauner, M. (2017) · Hepatology · doi:10.1002/hep.28709 · Cited by 634

Diversification of host bile acids by members of the gut microbiota

Winston, J. A., & Theriot, C. M. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1674124 · Cited by 597

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism

Patti, M., Houten, S. M., Bianco, A. C., Bernier, R., Larsen, P. R., Holst, J. J., Badman, M. K., Maratos‐Flier, E., Mun, E. C., Pihlajamaki, J., et al. (2009) · Obesity · doi:10.1038/oby.2009.102 · Cited by 591

A metabolic pathway for bile acid dehydroxylation by the gut microbiome

Funabashi, M., Grove, T. L., Wang, M., Varma, Y., McFadden, M. E., Brown, L. C., Guo, C., Higginbottom, S., Almo, S. C., & Fischbach, M. A. (2020) · Nature · doi:10.1038/s41586-020-2396-4 · Cited by 590

Global chemical effects of the microbiome include new bile-acid conjugations

Quinn, R. A., Melnik, A. V., Vrbanac, A., Fu, T., Patras, K. A., Christy, M. P., Bodai, Z., Belda-Ferre, P., Tripathi, A., Chung, L. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2047-9 · Cited by 579

Intestine farnesoid X receptor agonist and the gut microbiota activate G‐protein bile acid receptor‐1 signaling to improve metabolism

Pathak, P., Xie, C., Nichols, R. G., Ferrell, J. M., Boehme, S., Krausz, K. W., Patterson, A. D., Gonzalez, F. J., & Chiang, J. Y. L. (2018) · Hepatology · doi:10.1002/hep.29857 · Cited by 567

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J., Brocker, C. N., Desai, D., Amin, S. G., Bisson, W. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms10166 · Cited by 559

The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice

Cariou, B., van Harmelen, K., Durán-Sandoval, D., van Dijk, T. H., Grefhorst, A., Abdelkarim, M., Caron, S., Torpier, G., Fruchart, J., Gonzalez, F. J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510258200 · Cited by 546

Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

Fiorucci, S., & Distrutti, E. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.09.001 · Cited by 539

Microbiota-induced obesity requires farnesoid X receptor

Parséus, A., Sommer, N., Sommer, F., Caesar, R., Molinaro, A., Ståhlman, M., Greiner, T. U., Perkins, R., & Bäckhed, F. (2016) · Gut · doi:10.1136/gutjnl-2015-310283 · Cited by 492

Molecular physiology of bile acid signaling in health, disease, and aging

Perino, A., Demagny, H., Velazquez-Villegas, L., & Schoonjans, K. (2021) · Physiological Reviews · doi:10.1152/physrev.00049.2019 · Cited by 481

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

Fiorucci, S., Antonelli, E., Rizzo, G., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pellicciari, R., & Morelli, A. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.001 · Cited by 472

FXR Regulates Intestinal Cancer Stem Cell Proliferation

Fu, T., Coulter, S., Yoshihara, E., Oh, T. G., Fang, S., Cayabyab, F., Zhu, Q., Zhang, T., Leblanc, M., Liu, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.036 · Cited by 463

Beyond intestinal soap—bile acids in metabolic control

Kuipers, F., Bloks, V. W., & Groen, A. K. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.60 · Cited by 462

The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

Sun, L., Cai, J., & Gonzalez, F. J. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00404-2 · Cited by 459

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Broeders, E. P. M., Nascimento, E. B. M., Havekes, B., Brans, B. T., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B. P., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.002 · Cited by 452

Role of bile acids in metabolic control

Molinaro, A., Wahlström, A., & Marschall, H.-U. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2017.11.002 · Cited by 447

Bile acid transporters and regulatory nuclear receptors in the liver and beyond

Halilbasic, E., Claudel, T., & Trauner, M. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.08.002 · Cited by 415

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Sorrentino, G., Perino, A., Yıldız, E., Alam, G. E., Sleiman, M. S. B., Gioiello, A., Pellicciari, R., & Schoonjans, K. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.05.067 · Cited by 415

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

Gonzalez, F. J., Jiang, C., & Patterson, A. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.057 · Cited by 382

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

Brighton, C. A., Rievaj, J., Kuhre, R. E., Glasssmith, L. L., Schoonjans, K., Holst, J. J., Gribble, F. M., & Reimann, F. M. (2015) · Endocrinology · doi:10.1210/en.2015-1321 · Cited by 366

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

Hofmann, A. F., & Hagey, L. R. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r049437 · Cited by 365

Fifty years of advances in bile acid synthesis and metabolism

Russell, D. W. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800026-jlr200 · Cited by 358

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

Ziętak, M., Kovatcheva‐Datchary, P., Markiewicz, L. H., Ståhlman, M., Kozak, L. P., & Bäckhed, F. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.001 · Cited by 358

Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

Ahmad, T. R., & Haeusler, R. A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0266-7 · Cited by 348

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

Prawitt, J., Abdelkarim, M., Stroeve, J. H. M., Popescu, I. R., Duez, H., Velagapudi, V., Dumont, J., Bouchaert, E., van Dijk, T. H., Lucas, A., et al. (2011) · Diabetes · doi:10.2337/db11-0030 · Cited by 339

Targeting the alternative bile acid synthetic pathway for metabolic diseases

Jia, W. P., Wei, M., Rajani, C., & Zheng, X. (2020) · Protein & Cell · doi:10.1007/s13238-020-00804-9 · Cited by 330

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F.-A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4357 · Cited by 318

Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice

Maruyama, T., Tanaka, K., Suzuki, J., Miyoshi, H., Harada, N., Nakamura, T., Miyamoto, Y., Kanatani, A., & Tamai, Y. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06546 · Cited by 297

Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation

Vassileva, G., Golovko, A., Markowitz, L., Abbondanzo, S. J., Zeng, M., Yang, S., Hoos, L. M., Tetzloff, G. G., Levitan, D. J., Murgolo, N., et al. (2006) · Biochemical Journal · doi:10.1042/bj20060537 · Cited by 281

Discovery of 6α-Ethyl-23( S )-methylcholic Acid ( S -EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

Pellicciari, R., Gioiello, A., Macchiarulo, A., Thomas, C., Rosatelli, E., Natalini, B., Sardella, R., Pruzanski, M., Roda, A., Pastorini, E., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm901390p · Cited by 269

Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease

Hegyi, P., Maléth, J., Walters, J. R., Hofmann, A. F., & Keely, S. J. (2018) · Physiological Reviews · doi:10.1152/physrev.00054.2017 · Cited by 269

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

Just, S., Mondot, S., Ecker, J., Wegner, K., Rath, E., Gau, L., Streidl, T., Hery-Arnaud, G., Schmidt, S., Lesker, T. R., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0510-8 · Cited by 269

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue

Velazquez-Villegas, L. A., Perino, A., Lemos, V., Zietak, M., Nomura, M., Pols, T. W. H., & Schoonjans, K. (2018) · Nature Communications · doi:10.1038/s41467-017-02068-0 · Cited by 268

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

渡辺, 光., Horai, Y., Houten, S. M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248203 · Cited by 266

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

Pathak, P., Liu, H., Boehme, S., Xie, C., Krausz, K. W., Gonzalez, F. J., & Chiang, J. Y. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.784322 · Cited by 265

FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Lan, T., Morgan, D. A., Rahmouni, K., Sonoda, J., Fu, X., Burgess, S. C., Holland, W. L., Kliewer, S. A., & Mangelsdorf, D. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.005 · Cited by 261

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas

Kuhre, R. E., Albrechtsen, N. J. W., Larsen, O., Jepsen, S. L., Balk-Møller, E., Andersen, D. B., Deacon, C. F., Schoonjans, K., Reimann, F. M., Gribble, F. M., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.007 · Cited by 245

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

Thaler, J. P., Guyenet, S. J., Dorfman, M. D., Wisse, B. E., & Schwartz, M. W. (2013) · Diabetes · doi:10.2337/db12-1605 · Cited by 215

Hypothalamic bile acid-TGR5 signaling protects from obesity

Castellanos-Jankiewicz, A., Guzmán‐Quevedo, O., Fénelon, V. S., Zizzari, P., Quarta, C., Bellocchio, L., Tailleux, A., Charton, J., Fernandois, D., Henricsson, M., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.009 · Cited by 211

An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice

Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., et al. (2016) · Diabetes · doi:10.2337/db16-0663 · Cited by 201

Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis

Wu, Q., Liang, X., Wang, K., Lin, J., Wang, X., Wang, P., Zhang, Y., Nie, Q., Liu, H., Zhang, Z., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.007 · Cited by 201

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Ding, L., Sousa, K. M., Jin, L., Dong, B., Kim, B., Ramírez, R., Xiao, Z., Gu, Y., Yang, Q., Wang, J., et al. (2016) · Hepatology · doi:10.1002/hep.28689 · Cited by 186

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

Ryan, K. K., Kohli, R., Gutierrez-Aguilar, R., Gaitonde, S. G., Woods, S. C., & Seeley, R. J. (2013) · Endocrinology · doi:10.1210/en.2012-1891 · Cited by 185

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

Harach, T., Pols, T. W. H., Nomura, M., Maida, A., 渡辺, 光., Auwerx, J. H., & Schoonjans, K. (2012) · Scientific Reports · doi:10.1038/srep00430 · Cited by 183

Long-term efficacy and safety of obeticholic acid for patients with primary biliary cholangitis: 3-year results of an international open-label extension study

Trauner, M., Nevens, F., Shiffman, M. L., Drenth, J. P. H., Bowlus, C. L., Vargas, V., Andreone, P., Hirschfield, G. M., Pencek, R., Malecha, E. S., et al. (2019) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30094-9 · Cited by 180

Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery

Albaugh, V. L., Banan, B., Antoun, J., Xiong, Y., Guo, Y. P., Ping, J., Alikhan, M. M., Clements, B. A., Abumrad, N. N., & Flynn, C. R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.11.017 · Cited by 178

Antibiotic effects on gut microbiota and metabolism are host dependent

Fujisaka, S., Ussar, S., Clish, C. B., Devkota, S., Dreyfuss, J. M., Sakaguchi, M., Soto, M., Konishi, M., Softic, S., Altındiş, E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86674 · Cited by 171

Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance

Ma, Y., Huang, Y., Yan, L., Gao, M., & Liu, D. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-0986-7 · Cited by 169

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

Marcelin, G., Jo, Y., Li, X., Schwartz, G. J., Zhang, Y., Dun, N. J., Lyu, R., Blouet, C., Chang, J. K., & Chua, S. C. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.10.002 · Cited by 168

Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases

Devkota, S., & Chang, E. B. (2015) · Digestive Diseases · doi:10.1159/000371687 · Cited by 167

Central anorexigenic actions of bile acids are mediated by TGR5

Perino, A., Velázquez‐Villegas, L. A., Bresciani, N., Sun, Y., Huang, Q. D., Fénelon, V. S., Castellanos-Jankiewicz, A., Zizzari, P., Bruschetta, G., Jin, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00398-4 · Cited by 159

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

Perino, A., & Schoonjans, K. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 157

Therapeutic uses of animal biles in traditional Chinese medicine: An ethnopharmacological, biophysical chemical and medicinal review

Wang, D. Q. ‐. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9952 · Cited by 144

In vitro and in vivo characterization of Clostridium scindens bile acid transformations

Marion, S., Studer, N., Desharnais, L., Menin, L., Escrig, S., Meibom, A., Hapfelmeier, S., & Bernier‐Latmani, R. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1549420 · Cited by 143

Metabolic Messengers: fibroblast growth factor 15/19

Gadaleta, R. M., & Moschetta, A. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0074-3 · Cited by 138

Genetic determinants of gut microbiota composition and bile acid profiles in mice

Kemis, J. H., Linke, V., Barrett, K. L., Boehm, F. J., Traeger, L. L., Keller, M. P., Rabaglia, M. E., Schueler, K. L., Stapleton, D. S., Gatti, D. M., et al. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008073 · Cited by 136

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis in ob/ob Mice

Zhang, Y., Ge, X., Heemstra, L. A., Chen, W., Xu, J., Smith, J. L., Ma, H., Kasim, N., Edwards, P. A., & Novak, C. M. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1157 · Cited by 128

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

Jadhav, K. S., Xu, Y., Xu, Y., Li, Y., Xu, J., Zhu, Y., Adorini, L., Lee, Y., Kasumov, T., Yin, L., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.005 · Cited by 124

Bile Formation and Secretion

Boyer, J. L. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00519.x · Cited by 124

The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes

Evers, S. S., Sandoval, D. A., & Seeley, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034423 · Cited by 120

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

Contreras, C., González‐García, I., Seoane‐Collazo, P., Martínez‐Sánchez, N., Liñares‐Pose, L., Rial‐Pensado, E., Fernø, J., Tena‐Sempere, M., Casals, N., Diéguez, C., et al. (2016) · Diabetes · doi:10.2337/db15-1547 · Cited by 114

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

渡辺, 光., Morimoto, K., Houten, S. M., Kaneko-Iwasaki, N., Sugizaki, T., Horai, Y., Mataki, C., Sato, H., Murahashi, K., Arita, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038286 · Cited by 113

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

Ferrell, J. M., Boehme, S., Li, F., & Chiang, J. Y. L. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m064709 · Cited by 112

Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans

Morville, T. H., Sahl, R. E., Trammell, S. A. J., Svenningsen, J. S., Gillum, M. P., Helge, J. W., & Clemmensen, C. (2018) · JCI Insight · doi:10.1172/jci.insight.122737 · Cited by 112

The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice

Sasaki, T., Kuboyama, A., Mita, M., Murata, S., Shimizu, M., Inoue, J., Mori, K., & Sato, R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002733 · Cited by 109

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications

Kemper, J. K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.11.011 · Cited by 108

Role of TGR5 (GPBAR1) in Liver Disease

Häussinger, D., & Keitel, V. (2018) · Seminars in Liver Disease · doi:10.1055/s-0038-1669940 · Cited by 106

Identification of functional farnesoid X receptors in brain neurons

Huang, C., Wang, J., Hu, W., Wang, C., Lu, X., Tong, L., Wu, F., & Zhang, W. (2016) · FEBS Letters · doi:10.1002/1873-3468.12373 · Cited by 103

Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice

Ziętak, M., & Kozak, L. P. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00485.2015 · Cited by 97

Characterization of gut microbial structural variations as determinants of human bile acid metabolism

Wang, D., Doestzada, M., Chen, L., Andreu‐Sánchez, S., van den Munckhof, I., Augustijn, H. E., Koehorst, M., Ruiz-Moreno, A. J., Bloks, V. W., Riksen, N. P., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.11.003 · Cited by 96

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Chen, L., van den Munckhof, I., Schraa, K., ter Horst, R., Koehorst, M., van Faassen, M. H. J. R., van der Ley, C., Doestzada, M., Zhernakova, D. V., Kurilshikov, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108212 · Cited by 92

Fifty years with bile acids and steroids in health and disease

Sjövall, J. (2004) · Lipids · doi:10.1007/s11745-004-1288-1 · Cited by 84

Bile Acids Increase Independently From Hypocaloric Restriction After Bariatric Surgery

Jahansouz, C., Xu, H., Hertzel, A. V., Serrot, F. J., Kvalheim, N., Cole, A. J., Abraham, A. A., Luthra, G., Ewing, K., Leslie, D. B., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001552 · Cited by 84

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

Lund, M. L., Sorrentino, G., Egerod, K. L., Kroone, C., Mortensen, B., Knop, F. K., Reimann, F. M., Gribble, F. M., Drucker, D. J., de Koning, E. J. P., et al. (2020) · Diabetes · doi:10.2337/db19-0764 · Cited by 84

Increased Bile Acids and FGF19 After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Correlate with Improvement in Type 2 Diabetes in a Randomized Trial

Nemati, R., Lu, J., Dokpuang, D., Booth, M., Plank, L. D., & Murphy, R. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3216-x · Cited by 83

Bile acid alterations in nonalcoholic fatty liver disease, obesity, insulin resistance and type 2 diabetes: what do the human studies tell?

Chávez‐Talavera, O., Haas, J. T., Grzych, G., Tailleux, A., & Staels, B. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000597 · Cited by 83

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

Briere, D. A., Ruan, X., Cheng, C., Siesky, A. M., Fitch, T. E., Dominguez, C., Sanfeliciano, S. G., Montero, C., Suen, C. S., Xu, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136873 · Cited by 80

Enhancement of brown fat thermogenesis using chenodeoxycholic acid in mice

Teodoro, J. S., Zouhar, P., Flachs, P., Bardová, K., Janovská, P., Gomes, A. P., Duarte, F. V., Varela, A. T. I. F., Rolo, A. P., Palmeira, C. M., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.230 · Cited by 78

Plasma bile acids are not associated with energy metabolism in humans

Brufau, G., Bahr, M. J., Staels, B., Claudel, T., Ockenga, J., Böker, K. H. W., Murphy, E. J., Prado, K. B., Stellaard, F., Manns, M. P., et al. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-73 · Cited by 77

Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans

Ockenga, J., Valentini, L., Schuetz, T., Wohlgemuth, F., Glaeser, S., Omar, A., Kasim, E., DuPlessis, D., Featherstone, K., Davis, J. R., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2329 · Cited by 74

Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids

Watanabe, K., Igarashi, M., Li, X., Nakatani, A., Miyamoto, J., Inaba, Y., Sutou, A., Saito, T., Sato, T., Tachibana, N., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202083 · Cited by 73

Satiety induced by bile acids is mediated via vagal afferent pathways

Wu, X., Li, J., Lee, A. A., Lu, Y., Zhou, S.-Y., & Owyang, C. (2020) · JCI Insight · doi:10.1172/jci.insight.132400 · Cited by 72

Fibroblast growth factor 19 entry into brain

Hsuchou, H., Pan, W., & Kastin, A. J. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-32 · Cited by 66

The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform

Hultman, K., Scarlett, J. M., Baquero, A. F., Cornea, A. M., Zhang, Y., Salinas, C. B. G., Brown, J. M., Morton, G. J., Whalen, E. J., Grove, K. L., et al. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24668 · Cited by 65

Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial

Risstad, H., Kristinsson, J. A., Fagerland, M. W., le Roux, C. W., Birkeland, K. I., Gulseth, H. L., Thorsby, P. M., Vincent, R. P., Engström, M., Olbers, T., et al. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.05.024 · Cited by 62

A metabolic pathway for bile acid dehydroxylation by the gut microbiomePreprint

Funabashi, M., Grove, T. L., Pascal, V., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/758557 · Cited by 57

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis

Carino, A., Marchianò, S., Biagioli, M., Bucci, M., Vellecco, V., Brancaleone, V., Fiorucci, C., Zampella, A., Monti, M. C., Distrutti, E., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201801373rr · Cited by 56

Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice

Carino, A., Cipriani, S., Marchianò, S., Biagioli, M., Scarpelli, P. T., Zampella, A., Monti, M. C., & Fiorucci, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-13102-y · Cited by 55

Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

Bozadjieva-Kramer, N., Shin, J. H., Shao, Y., Gutiérrez‐Aguilar, R., Li, Z., Heppner, K. M., Chiang, S., Vargo, S. G., Granger, K., Sandoval, D. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24914-y · Cited by 49

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice

Sasaki, T., Watanabe, Y., Kuboyama, A., Oikawa, A., Shimizu, M., Yamauchi, Y., & Sato, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.016203 · Cited by 47

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

Ding, L., Zhang, E., Yang, Q., Jin, L., Sousa, K. M., Dong, B., Wang, Y., Tu, J., Ma, X., Tian, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019388118 · Cited by 47

Farnesoid X receptor contributes to body weight-independent improvements in glycemic control after Roux-en-Y gastric bypass surgery in diet-induced obese mice

Li, K., Zou, J., Li, S., Guo, J., Shi, W., Wang, B., Zhang, P., Zhang, H., Zhang, P., Miao, Z., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.100980 · Cited by 38

Post-Translational Modifications of FXR; Implications for Cholestasis and Obesity-Related Disorders

Appelman, M. D., van der Veen, S. W., & van Mil, S. W. C. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.729828 · Cited by 38

Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice

Zheng, H., Townsend, R. L., Mumphrey, M. B., Gettys, T. W., Yu, S., Münzberg, H., Morrison, C. D., & Berthoud, H. (2018) · Obesity Surgery · doi:10.1007/s11695-018-3297-6 · Cited by 34

Chenodeoxycholic acid attenuates high‑fat diet‑induced obesity and hyperglycemia via the G protein‑coupled bile acid receptor 1 and proliferator‑activated receptor γ pathway

Chen, X., Liu, Y., Guo, Z., Chen, Y., Li, M., Huang, C., Chen, Z., & Meng, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5232 · Cited by 33

Chronic infusion of taurolithocholate into the brain increases fat oxidation in mice

Eggink, H. M., Tambyrajah, L. L., van den Berg, R., Mol, I. M., van den Heuvel, J. K., Koehorst, M., Groen, A. K., Boelen, A., Kalsbeek, A., Romijn, J. A., et al. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0503 · Cited by 31

SUPPRESSION OF APPETITE BY BILE ACIDS

Bray, G., & Gallagher, T. (1968) · The Lancet · doi:10.1016/s0140-6736(68)91415-3 · Cited by 28

Bile acid receptor TGR5 is critically involved in preference for dietary lipids and obesity

Bensalem, A., Murtaza, B., Hichami, A., Khan, A. S., Oulamara, H., Merlen, G., Berrichi, M., Agli, A.-N., Tordjmann, T., & Khan, N. A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108298 · Cited by 27

Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure

Fromme, T., Hüttinger, K., Maurer, S., Li, Y., Gantert, T., Fiamoncini, J., Daniel, H., Westphal, S., & Klingenspor, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37464-z · Cited by 25

Farnesoid X Receptor Activation in Brain Alters Brown Adipose Tissue Function via the Sympathetic System

Deckmyn, B., Domenger, D., Blondel, C., Ducastel, S., Nicolas, E., Dorchies, E., Caron, É., Charton, J., Vallez, E., Deprez, B. P., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.808603 · Cited by 23

Differential effects of a 40-hour fast and bile acid supplementation on human GLP-1 and FGF19 responses

van Nierop, F. S., Meessen, E. C. E., Nelissen, K. G. M., Achterbergh, R., Lammers, L. A., Vaz, F. M., Mathôt, R. A. A., Klümpen, H., Damink, S. W. M. O., Schaap, F. G., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00534.2018 · Cited by 21

Genetic determinants of gut microbiota composition and bile acid profiles in micePreprint

Kemis, J. H., Linke, V., Barrett, K. L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/571075 · Cited by 19

Identification of miR-26a as a Target Gene of Bile Acid Receptor GPBAR-1/TGR5

Chen, X., Xu, H., Ding, L., Lou, G., Liu, Y., Yao, Y., Chen, L., Huang, W., & Fu, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131294 · Cited by 16

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY

Yang, H., Liu, H., Jiao, Y., & Qian, J. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200628024500 · Cited by 4

Farnesoid X Receptor activation in brain alters brown adipose tissue function via the sympathetic systemPreprint

Deckmyn, B., Domenger, D., ducatsel, S., et al. (2021) · doi:10.22541/au.162151000.01734906/v1 · Cited by 4

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 993

Gut-liver axis: Pathophysiological concepts and clinical implications

Tilg, H., Adolph, T. E., & Trauner, M. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.017 · Cited by 843

Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway

Nie, Q., Luo, X., Wang, K., Ding, Y., Jia, S., Zhao, Q., Li, M., Zhang, J., Zhuo, Y., Lin, J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.034 · Cited by 356

A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Li, T., Ding, N., Guo, H., Hua, R., Lin, Z., Tian, H., Yu, Y., Fan, D., Yuan, Z., Gonzalez, F. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.015 · Cited by 157

Role of bile acids in the regulation of the metabolic pathways

Taoka, H., Yokoyama, Y., Morimoto, K., Kitamura, N., Tanigaki, T., Takashina, Y., Tsubota, K., & Watanabe, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i13.260 · Cited by 80

Bile acid signaling in health and disease

Fan, Z., He, M., Liang, T., 张必利, Zhao, N., & Li, P. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00603-4

Bile acids signaling pathways and energy homeostasis

Zhao, N. (2009)

Developments in understanding bile acid metabolism

Morimoto, K., Itoh, H., & 渡辺, 光. (2012) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.12.75 · Cited by 3

メタボリックシンドロームに胆汁酸代謝を用いて新規治療アプローチで挑む

渡辺, 光. (2015) · Institutional Repositories DataBase (IRDB) · doi:10.14991/003.00150001-0102