Mitophagy in human health, ageing and disease

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0332-9 · Cited by 1,740

Defective repair replication of DNA in xeroderma pigmentosum

CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0176-2 · Cited by 1,556

O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy

Dai, S., Wan, X., Xia, L., Xu, L., Xie, C., Wang, G., & Tang, J. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08548-w

Neuronal mitochondrial dynamics: roles in brain disorders and therapeutic potential

Zhang, X., Du, J., Wang, S.-Z., Mo, X., & Zhang, X. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01746-w · Cited by 3

Non-invasive brain stimulation to prevent aging-related diseases: What does photobiomodulation offer compared with other methods

Dole, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.03.001

Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint

Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2026) · eLife · doi:10.7554/elife.109761.1

Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint

Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2026) · eLife · doi:10.7554/elife.109761

MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity

Xing, G., Huang, Y., Liu, X., Li, L., Liu, Z., Wu, Y., Zhou, Y., Ding, Y., Chen, B., Xue, G., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117177

The Theoretical Intersection of Plant-Based Diets, Alzheimer’s, and Cardiovascular Disease

VanCleef, T. R., & Jones, E. J. (2026) · Biological Research For Nursing · doi:10.1177/10998004261439115

Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy

Chen, J., & Pan, X. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.01.007

Mitochondrial Ubiquitination as a Signaling Hub: Balancing Mitophagy, Inflammation, and Cell Death

Kumar, A. P., & Zacharioudakis, E. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00007

Targeting GHSR-1α with silibinin to enhance mitophagy and prevent tubular injury in diabetic kidney disease.

Zhang, N.-N., Chen, C.-A., Chen, L., Chen, Y.-Q., Yu, P.-R., Yu, H., Shi, B., & Feng, B. (2026) · Biochimica et Biophysica Acta - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168255

The therapeutic potential of botanicals: how medicinal plants targeting autophagy can reverse metabolic-associated fatty liver disease

Wang, K., Jiang, B., Huang, X., Zhang, Y., Qi, H., Xu, S., Sun, L., & Liu, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1776868

Curcumin ameliorates hepatic insulin resistance by activating PINK1/Parkin-mediated mitophagy

Guo, Z., Zhang, H., & Kong, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-47924-6 · Cited by 1

VAMP4/STX8 Mediate the Autophagic Secretion of Mitochondria and Promote TAMs Polarization in HNSCC

Shi, J., Liu, C., Wang, X., Li, C., Zhang, Z. H., Yan, M., Guo, H., & Zhang, J. Y. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70276

Biomimetic Human Intestinal Tumor‐on‐a‐Chip with Crypts and Villus‐Like Structures for Chemotherapy Drug Evaluations

Lu, J., Lin, X., Zhao, J., Shang, L., Zhao, Y., & Sun, W. (2026) · Small · doi:10.1002/smll.202514836

A robust workflow for 3D imaging of human mitochondria using cryo-electron tomographyPreprint

Gargey, A., Artemchuk, O., Bobe, D., Ratliff, A., Pavlov, E., & Aydin, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.16.717704

Particulate matter induced cell death: Current understanding of molecular drivers that lead to lung damage

Das, D. N., & Mitroo, D. (2026) · Next research. · doi:10.1016/j.nexres.2026.101769

Lysosomal Alkalinization Selects for Metabolically Plastic, Motile Cancer Cells under Nutrient StressPreprint

Nehri, L. N., Hüsnügil, H. H., Taşkıran, A. E. G., Yilmaz, H. B. C., Acar, A. C., Liv, N., & Banerjee, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.16.718649

Bioenergetic-active hybrid nanovesicles empower tumor associated macrophages phagocytosis for cancer immunotherapy

Lin, R., Wu, X., Wang, Z., Li, G., Ding, W., Huang, W., Deng, S., Chen, X., Wen, M., Lv, J., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103155

Canagliflozin Alleviates Pressure Overload-Induced Cardiac Dysfunction via PINK1 Regulation by Inhibiting Mitophagy-Driven Ferroptosis

Xiong, W., Xiong, N., Wu, Y., Sui, Y., Xiao, M., Qi, X., Gong, S., Peng, X., Zheng, W., & Xiong, J. (2026) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2026.04.015

The role of estrogen and its receptors in the regulation of ferroptosis and autophagy

Żabińska, M., Wiśniewska, K., Szulc, A., Olendzka, Z., Tkaczuk, A., Szota, M., Węgrzyn, G., & Pierzynowska, K. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11863-2

Cytochrome P450 1B1 directs pathogenic Th17 cell generation and autoimmune disease by fine-tuning redox homeostasis and mitochondrial integrity

Hu, W., Sun, Y., Sun, J., Liang, Y., Jin, S., Liu, J., & Wu, B. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2527753123

Tetrahydropalmatine may alleviate doxorubicin-induced renal injury by activating the Sirt3-mediated Nrf2/HO-1 pathway

Wang, W. J., Hu, Y., Xu, Y., Ding, N., Wei, J., Li, C., & Chen, Y. (2026) · Biology Direct · doi:10.1186/s13062-026-00773-9

Lysosomes as Regulators of Cancer Stemness and Drug Resistance

Fa-Xiao, Z. H. O. U., Di-Ping, Y. U., Tan, S., Duan, H., & Xiao-Ming, W. U. (2026) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/j.pibb.2025.0553

Mitochondrial dysfunction in equine ageing: Current evidence and clinical implications for geroscience

Puchalska, M., & Witkowska‐Piłaszewicz, O. (2026) · Equine Veterinary Journal · doi:10.1002/evj.70189

Understanding Dysfunctional Autophagy and Mitophagy in Inflammatory Cardiovascular Disease

Kaiser, M., Lewis, T., Malekan, M., Parikh, M. A., Turitto, G., Frishman, W. H., & Peterson, S. J. (2026) · Cardiology in Review · doi:10.1097/crd.0000000000001302

Comprehensive exploration of the role of multimodal programmed cell death- associated lncRNAs in the prognosis and immunity of glioma

Wu, S., Meng, X., Hu, Y., Wang, Q.-X., Yao, Y., Jia, H., Ma, Z., Liu, Y., Sun, Z., Bai, Y., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1765882

Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases

Liu, X., Jia, L., Wu, K., Chen, M., Sun, J., Yang, C., Xu, C., Sun, J., Wang, J., & Dai, L. (2026) · MedComm · doi:10.1002/mco2.70766

ApoE and Brain Aging

Resende, R. R., & Pereira, C. F. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_14

4-N-furfurylcytosine, a novel cytosine-derived modulator of mitochondrial and redox homeostasis to counteract aging: Insights from cellular and mouse models

Fedoruk‐Wyszomirska, A., Pawelczak, P., Orlicka-Płocka, M., Gurda, D., Giel-Pietraszuk, M., Przybył, Ł., Framski, G., Pasternak, K., Chmurzyńska, A., & Wyszko, E. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.312

Unveiling C1QBP: A New Guardian of Dopaminergic Neuron in Parkinson's disease by targeting ULK1 to promote mitophagy and maintain mitochondrial function

Li, J., Wang, Y., Liu, M., Yu, Z., Wang, Y., Wang, P., Guo, C., Wang, M., Shi, R., Peng, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.304

The Trends and Prospects of Research on Caenorhabditis elegans in the Aging Area: a Bibliometric and Visualization Analysis

Song, Y., Qi, J., Liao, Q., Fan, X., Du, H., Li, X., Niu, H., & Liu, G. (2026) · Journal of Visualized Experiments · doi:10.3791/70364

Exercise hormone irisin alleviates rheumatoid arthritis by removing dysfunctional mitochondria

Wu, Y., Fu, T., Teng, Y., Pan, Y., Li, L., Feng, Y., & Lin, J. (2026) · Autophagy · doi:10.1080/15548627.2026.2680560

Activation of GLP-1R ameliorates alcohol withdrawal induced anxiety-like behavior by regulating neuronal mitochondrial quality control

Wang, Z., Zhao, W., Chen, X. M., Zhao, S. P., Li, X., Yang, Q., Zong, F., & Zhang, H. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1820128

CHK1 activates mitophagy to attenuate cardiac aging via inhibiting AHSA1-ubiquitination

Jing, P., Zhou, L.-H., Chen, S.-X., Chen, J.-Y., Gu, L., Yang, T., Wang, S.-B., Du, C., Chen, Y.-X., Wang, Q., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104242

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

Sun, C., Gao, Z., 董恩伏, Ding, L., Feng, S., Chen, J., Kwangwari, P., Shi, Y., Liu, W., Zhang, X., et al. (2026) · Cancer Science · doi:10.1111/cas.70436

Mitochondria-targeted photodynamic nanoparticles boost antitumor immunity by suppressing mitophagy in osteosarcoma

Deng, Q., (255117), J. L., Tong, Z., Zhang, L., Tang, Y., Liu, J., Wang, D., Zeng, J., Li, Z., Zhang, Y., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.05.028

Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer

Nazam, N., Sadiya, S., Khan, S., Misra, A., Sureka, N., Panwar, K., Sahani, N., & Zaheer, S. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1849057

Selenium nanoparticle-loaded microneedle patches promote diabetic oral ulcer healing by regulating the inflammatory microenvironment through upregulation of SELENBP1-mediated mitophagy

Wang, X., Wan, H., Cui, X., Tan, B., Wang, H., He, J., Yang, Z., Han, X., Xiao, J., Tao, G., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04586-w · Cited by 1

Dietary 3,4-Dihydroxybenzalacetone alleviates LPS-induced intestinal injury in Leizhou black ducks by improving mitochondrial function and suppressing apoptosis

Yang, W., Ma, W., You, Y., Ma, Y., Wu, H., & Chen, Z. (2026) · Poultry Science · doi:10.1016/j.psj.2026.107239

The Role of PINK1/Parkin-Mediated Mitophagy in Cerebral Ischemia-Reperfusion Injury: A Review of Recent Advances

Xing, L., Liu, A., Li, J., Yao, M., Song, J., Duan, P., & Li, H. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05997-4

Sigma-1 receptor protects against renal ischemia-reperfusion injury by enhancing mitophagy via Rac1 regulation

Gong, S., Xiong, Y., Li, W., Leng, Y., Deng, X., Wang, B., Yang, B., Yang, Y., & Li, W. (2026) · Renal Failure · doi:10.1080/0886022x.2026.2728429

Mitochondrial dysfunction in pulmonary fibrosis: from mechanisms to therapeutic opportunities

Jin, X., Sang, L., Zhu, J., Zhong, Z., & Sun, J. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118164

An ROS-responsive, RGC-targeted nanotherapeutic strategy with a TRPV4 antagonist restores autophagic flux and protects RGCs in a rat model of chronic ocular hypertension

Song, J., Zhang, X., Huang, P.-W., Li, H., Liu, W., Wang, L., Wang, R., Ye, Z., Zhang, J.-X., Zhang, Z.-Y., et al. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04661-2

Autophagy/Mitophagy Dysregulation and Neuroimmune Crosstalk in Burn-Induced Skeletal Muscle Dysfunction: Mechanistic Insights and Therapeutic Prospects

Yasuhara, S., You, Z., & Tamura, D. A. A. T. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015862 · Cited by 1

Smart functionalized cartilage repair microspheres: Concepts and applications

Bai, F., Yuan, T., Geng, Z., Liao, Y., Dai, Y., Ma, H., Tu, Z., Li, Y., Wang, X., Su, J., et al. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.103407

Bio-recruiting hydrogel targeting mitochondrial homeostasis under neutrophil extracellular traps for diabetic wound repair

Song, J., Song, B., Zhu, Y., Zhu, Y., Zhang, Y., Song, Y., Wang, T., Shi, Y., Jiao, Y., Yang, G., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.115143

Mitophagy in Hepatic Ischemia–Reperfusion Injury: From Mitochondrial Dysfunction to Therapeutic Targeting

Zou, X., Zhang, T., Wang, N., Li, Y., Jiang, X., & zhong, X. (2026) · Biomolecules · doi:10.3390/biom16070941

Strategies for Targeting Mitochondria in the Treatment of Breast Cancer

Wang, K., Zheng, X., Li, Y., Li, C., Zhang, X., Deng, Q., Yang, H., 帅小翠, Li, J., Guo, L., et al. (2026) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00823

Mitochondrial regulation of inflammation in spinal cord injury: Mechanisms and therapeutic strategies

Li, X., Huang, Y., Zhou, Q., Xu, J., Yang, Y., Li, Y., & Chen, H. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102348

From organ age gaps to precision geromedicine: Multi-omic and imaging frameworks for heterogeneous biological aging

Li, Q.-M., Ge, X.-X., Wen, T.-J., Zhang, L.-W., Liu, H.-Y., Shi, X.-W., Liu, L., Gong, T., Wu, Q., & Gao, S. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103238

Endosymbiotic theory of aging revisited: Age-related leakage of mitochondrial dsDNA/RNA stimulates cytosolic nucleic acid sensors which remodel the immune network and promote the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2026) · Biogerontology · doi:10.1007/s10522-026-10470-9

Mitochondrial homeostasis and aging: Mechanisms, disease associations, and targeted intervention strategies

Bao-Sheng, W. A. N. G., & Ben, Z. H. O. U. (2026) · Shengming kexue · doi:10.3724/cbls.2026103

Targeting mitochondrial dysfunction with traditional Chinese medicine for inflammatory bowel disease: a comprehensive review

Zeng, L., Huang, Y., Ke, J., Han, J., Xie, W., Ding, Z., & Zhou, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1851055

Membrane Potential-Independent Mitochondria-Specific Near-Infrared Fluorescent Probe via Nanoaggregate Formation

Sapkal, G. T., Salam, A., Chandra, S., Garg, R., & Nandi, C. K. (2026) · ACS Applied Nano Materials · doi:10.1021/acsanm.6c01708

Triptolide-induced hepatotoxicity is mediated by NLRP3-dependent pyroptosis and inhibited by mitophagy

Su, Y. C., Li, P., Zhou, K., Chang, Y., Luan, Z., Han, B., Li, H., Ren, J., Zhang, H., & Wei, Y. (2026) · Food and Chemical Toxicology · doi:10.1016/j.fct.2026.116270

Exploring the therapeutic potential of mitochondrial mechanism in metabolic dysfunction associated steatotic liver disease

Selvam, K., Chinnaswamy, S. M., Jawahar, S., & Gunasekaran, V. (2026) · Egyptian Liver Journal · doi:10.1186/s43066-026-00526-3

The embedding of stress: mitophagy as a mechanism for the central nervous system (CNS) programming and lifelong disease vulnerability

Wang, M., Zhang, Z., Sha, Z., Zhang, F., & Bao, K. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1808059

Dual-regulation of mitophagy and cytosolic mtDNA-induced inflammation for the treatment of inflammatory bone loss

Zheng, K., Che, B., Cui, Y., Yang, H., Xiang, Y., Gao, Y., Liu, P., Mu, Z., Wang, J., Xa, Y., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.07.031 · Cited by 1

Calcium-dependent redox signaling connects mitochondrial remodeling with PAD-associated NETosis during respiratory mycoplasma infection

Wang, S., Liu, W., Gu, F., Wang, J., Guo, Y., Guo, L., Li, J., Wang, K., Zhang, J., Yao, Y., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104316

Caffeic Acid Mitigates Behavioral and Biochemical Alterations in Lead-induced Neurotoxicity in Rats With Possible Involvement of TFEB

Gautam, P., Singh, V., Kanwar, N., Singh, T., Singh, M., Singh, T., Grewal, A. K., Singh, R., Ahmad, S. F., & Al‐Mazroua, H. A. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00813-2

In situ monitoring of the handshake between endocytosis and mitophagy via FRET: Up-regulated convergence in cancer cells

Wang, H., Zhan, B., Li, J., Liu, J., Zhang, N., Niu, J., & Tian, M. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.140552

Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline

Gutman, E. G., Muniz‐Santos, R., da Silva, A. M., Costa, G. L. A., da Cunha, C. M. C., de Moraes, B. P. T., & Gonçalves-de-Albuquerque, C. F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1867909

Disrupted Mitochondrial Quality Control in Atherosclerotic Disease

Wilcox, T., Hansen, J. A., Blanker, A., & Widlansky, M. E. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101625

Identification and validation of mitophagy and astrocyte-related molecular signature in the pathogenesis of Alzheimer's disease: evidence from ensemble learning-driven multi-omics and clinical validation

Liu, J., & Chen, W. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1910621 · Cited by 1

Neuroprotective Properties and Molecular Mechanisms of Action of 4H-Pyran-Based Acids.

Kravtsov, A., Kozin, S., Kondratenko, R., Lyasota, O., Dorohova, A., Leontyeva, O., Hernández-Cáceres, J., & Dzhimak, S. (2026) · Frontiers in Bioscience · doi:10.31083/fbl48552

Tubular injury in diabetic kidney disease: a focus on regulated cell death

Sun, H., Chen, W., Huang, H., Chen, L., He, S., Wang, X., & Xie, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1877238

Epigenetics and the kidney

Wei, Q., & Dong, Z. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34069-7.00008-2

Novel mitophagy activator TJ0113 restricts cytosolic mtDNA to suppress ZBP1-driven inflammation in acute lung injury

Chen, X., Xing, S., Cen, X., Shen, J., Zhu, J., Xu, L., Le, X., Wang, F., Tian, Y., Lai, X., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104337

FUNDC1-mediated mitochondrial quality control protects against immune checkpoint inhibitor–associated cardiac injury

Zhang, N., Zhou, Y., Li, H., & Liu, H. (2026) · Immunologic Research · doi:10.1007/s12026-026-09819-6

A dual-targeted probe of mitochondria and lysosomes based on fluorescence lifetime imaging for visualizing cellular damage and autophagy processes

Yu, H., Cao, M., Huang, J., Gao, X., Liu, Z., Gao, P., & Yu, X. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.140664

Abnormal glucose metabolism and muscle mass decline by bisphenol A or bisphenol S in skeletal muscle of male mice:inhibition of mitophagy by downregulation of the ERα/AMPK/ULK1 pathway

Zhao, M., Song, J., Wang, J., Chen, Y., Zhao, Y., Dong, Y., Zhai, L., & Jia, L. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125392

Characterization of Vlf1 as a regulator of lipophagyPreprint

Fakih, Z., Cavarischia-Rega, C., Glück, B. R., Reichert, S., Dutta, P., Beresh, O., Schuldiner, M., Macek, B., Rapaport, D., & Dimmer, K. (2026) · bioRxiv · doi:10.64898/2026.08.11.744108

Mitophagy-replenishment strategy targeting the aberrant endogenous dsDNA to enhance bone healing quality in the elderly

Ni, Z., Huang, Y., Xi, K., Mao, J., Wang, L., Tang, J., Wang, W., Jiang, X., Jiang, H., Zhou, L., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180559

When more PINK1 is not better

Lin, J.-Y., Tan, H. W. S., & Lu, G. X. (2026) · Aging Research · doi:10.26599/agr.2026.9340080

Autophagy as a mechanistic link between physical exercise and Alzheimer’s disease

Yu, Z., Wang, Y., & Yang, Y. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.08.026

Nanotechnology for targeted modulation of mitophagy: molecular mechanisms, therapeutic applications, and translational perspectives

Bolati, J., Yang, J., Yan, Y., Yu, D., & Yu, C. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae95c8

Exercise as a Programmable Regulator of Mitophagy Sensitivity in Aging Muscle and Age‐Related Disease

Ran, P., & Yang, L. (2026) · IUBMB Life · doi:10.1002/iub.70127

Harnessing autophagy and its transcriptional regulation in tumorigenesis and neurodegeneration: Potential and existing therapeutic strategies

Suri, P., Daartey, A. B., Khan, D. M. I. O., Rayana, N. P., Chilamakuri, R., Godugu, D., Azad, M. G., Reeb, K. L., & Richardson, D. R. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100158

Targeting senescence-associated biomarkers: Emerging strategies for anti-ageing therapy

Qin, Z., Zhang, L., Song, J., Chen, Y., Zhou, Y., Wu, J., Li, X., Chen, L., & Zhou, Z. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103344

MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair

Chen, N., Li, Z., Wang, X., Xu, H., Wang, W., Shang, W., Wang, L., & Tong, C. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117930

The Gut Microbiome as a Mechanistic Link Between the Planetary Health Diet and Healthy Aging

Jarecsny, T., Ceglédi, A., Csípő, T., Fazekas‐Pongor, V., Mózes, N., Csík, B., Zábó, V., Lipécz, Á., Nyáry, D., & Fekete, M. (2026) · Nutrients · doi:10.3390/nu18172864

Tannic acid protects against lapatinib-induced hepatotoxicity by inhibiting cathepsin activity and repairing lysosomal membrane permeabilization

Mu, Y., Pan, Z., Zhao, H., Huang, X., Zhang, N., Xu, Z., Yang, B., He, Q., Yang, X., Luo, P., et al. (2026) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2026.118028

Metabolic Dysfunction-Associated Steatotic Liver Disease and Mitochondrial Quality Control: From Laboratory to Clinical Practice

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