Mitophagy in human health, ageing and disease

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Sies, H., & Jones, D. P. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0230-3 · Cited by 5,335

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature · doi:10.1038/nature14893 · Cited by 2,774

Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation

Egan, B., & Zierath, J. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.012 · Cited by 2,084

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0332-9 · Cited by 1,740

Defective repair replication of DNA in xeroderma pigmentosum

CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0176-2 · Cited by 1,556

Autophagy maintains stemness by preventing senescence

García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355

Essential role for Nix in autophagic maturation of erythroid cells

Sandoval, H., Thiagarajan, P., Dasgupta, S. K., Schumacher, A., Prchal, J. T., Chen, M., & Wang, J. (2008) · Nature · doi:10.1038/nature07006 · Cited by 1,185

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

Chu, C. T., Ji, J., Dagda, R. K., Jiang, J. F., Tyurina, Y. Y., Kapralov, A. A., Tyurin, V. A., Yanamala, N., Shrivastava, I. H., Mohammadyani, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2837 · Cited by 1,083

Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

Koliaki, C., Szendroedi, J., Kaul, K., Jelenik, T., Nowotny, P., Jankowiak, F., Herder, C., Carstensen, M., Krausch, M., Knoefel, W. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.004 · Cited by 1,032

Human muscle metabolism during intermittent maximal exercise

Gaitanos, G. C., Williams, C., Boobis, L. H., & Brooks, S. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.712 · Cited by 967

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Gegg, M. E., Cooper, J. M., Chau, K.-Y., Rojo, M., Schapira, A. H. V., & Taanman, J.-W. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq419 · Cited by 910

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790

NAD+ in Brain Aging and Neurodegenerative Disorders

Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770

A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart

Nicolás-Ávila, J. A., Lechuga-Vieco, A. V., Esteban-Martínez, L., Sánchez-Díaz, M., Díaz-García, E., Santiago, D. J., Rubio-Ponce, A., Li, J. L., Balachander, A., Quintana, J. A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.031 · Cited by 762

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

Soubannier, V., McLelland, G., Zunino, R., Braschi, E., Rippstein, P. U., Fon, E. A., & McBride, H. M. (2012) · Current Biology · doi:10.1016/j.cub.2011.11.057 · Cited by 755

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

McLelland, G., Soubannier, V., Chen, C. X., McBride, H. M., & Fon, E. A. (2014) · The EMBO Journal · doi:10.1002/embj.201385902 · Cited by 743

Measuring In Vivo Mitophagy

Sun, N., Yun, J., Liu, J., Malide, D. A., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.009 · Cited by 718

p53 status determines the role of autophagy in pancreatic tumour development

Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature · doi:10.1038/nature12865 · Cited by 713

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711

Transcellular degradation of axonal mitochondria

Davis, C.-H. O., Kim, K.-Y., Bushong, E. A., Mills, E. A., Boassa, D., Shih, T., Kinebuchi, M., Phan, S., Zhou, Y., Bihlmeyer, N. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404651111 · Cited by 673

Glycolysis – a key player in the inflammatory response

Soto‐Heredero, G., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Oller, J., & Mittelbrunn, M. (2020) · FEBS Journal · doi:10.1111/febs.15327 · Cited by 660

Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction

Monzel, A. S., Enrı́quez, J. A., & Picard, M. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00783-1 · Cited by 632

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630

An Autophagy-Enhancing Drug Promotes Degradation of Mutant α 1 -Antitrypsin Z and Reduces Hepatic Fibrosis

Hidvegi, T., Ewing, M., Hale, P. D., Dippold, C. S., Beckett, C. S., Kemp, C., Maurice, N. M., Mukherjee, A., Goldbach, C., Watkins, S. C., et al. (2010) · Science · doi:10.1126/science.1190354 · Cited by 603

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Kim, J., Kim, H., & Chung, J. H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00965-7 · Cited by 594

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.004 · Cited by 575

Autophagy balances inflammation in innate immunity

Deretic, V., & Levine, B. (2018) · Autophagy · doi:10.1080/15548627.2017.1402992 · Cited by 563

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

McWilliams, T. G., Prescott, A. R., Allen, G. F. G., Tamjar, J., Munson, M. J., Thomson, C., Muqit, M. M. K., & Ganley, I. G. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603039 · Cited by 561

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

Laker, R. C., Drake, J. C., Wilson, R. J., Lira, V. A., Lewellen, B. M., Ryall, K. A., Fisher, C. C., Zhang, M., Saucerman, J. J., Goodyear, L. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00520-9 · Cited by 529

The different autophagy degradation pathways and neurodegeneration

Fleming, A., Bourdenx, M., Fujimaki, M., Karabiyik, C., Krause, G. J., Lopez, A., Martín‐Segura, A., Puri, C., Scrivo, A., Skidmore, J., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.017 · Cited by 500

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499

Mitochondrial biogenesis and clearance: a balancing act

Ploumi, C., Daskalaki, I., & Tavernarakis, N. (2016) · FEBS Journal · doi:10.1111/febs.13820 · Cited by 479

Parkin Protein Deficiency Exacerbates Cardiac Injury and Reduces Survival following Myocardial Infarction

Kubli, D. A., Zhang, X., Lee, Y., Hanna, R. A., Quinsay, M. N., Nguyen, C. K., Jimenez, R., Petrosyan, S., Murphy, A. N., & Gustafsson, Å. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.411363 · Cited by 476

Mitochondrial Function, Biology, and Role in Disease

Murphy, E., Ardehali, H., Balaban, R. S., Lisa, F. D., Dorn, G. W., Kitsis, R. N., Otsu, K., Ping, P., Rizzuto, R., Sack, M. N., et al. (2016) · Circulation Research · doi:10.1161/res.0000000000000104 · Cited by 476

Mitophagy and Neuroprotection

Lou, G., Palikaras, K., Lautrup, S., Scheibye‐Knudsen, M., Tavernarakis, N., & Fang, E. F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.07.002 · Cited by 455

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Melentijevic, I., Toth, M. L., Arnold, M. L., Guasp, R. J., Harinath, G., Nguyen, K. C., Taub, D., Parker, J. A., Neri, C., Gabel, C. V., et al. (2017) · Nature · doi:10.1038/nature21362 · Cited by 454

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

Palikaras, K., & Tavernarakis, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.021 · Cited by 447

Mitochondrial quality control: a matter of life and death for neurons

Rugarli, E. I., & Langer, T. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.38 · Cited by 423

Impact of the natural compound urolithin a on health, disease, and aging

D’Amico, D., Andreux, P. A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.04.009 · Cited by 419

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

Billia, F., Hauck, L., Konecny, F., Rao, V., Shen, J., & Mak, T. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106291108 · Cited by 414

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

Lee, Y., Lee, H.-Y., Hanna, R. A., & Gustafsson, Å. B. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2011 · Cited by 409

Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts

Sin, J., Andres, A. M., Taylor, D. J. R., Weston, T., Hiraumi, Y., Stotland, A., Kim, B. J., Huang, C., Doran, K. S., & Gottlieb, R. A. (2016) · Autophagy · doi:10.1080/15548627.2015.1115172 · Cited by 385

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

Wu, W., Lin, C., Wu, K., Jiang, L., Wang, X., Li, W., Zhuang, H., Zhang, X., Chen, H. H., Li, S., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593102 · Cited by 370

Mitochondrial dysfunction in ataxia-telangiectasia

Valentin-Vega, Y. A., MacLean, K. H., Tait-Mulder, J., Milasta, S., Steeves, M., Dorsey, F. C., Cleveland, J. L., Green, D. R., & Kastan, M. B. (2012) · Blood · doi:10.1182/blood-2011-08-373639 · Cited by 365

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

Liu, H.-Y., Han, J., Cao, S. Y., Hong, T., Zhuo, D., Shi, J., Liu, Z., & Cao, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033936 · Cited by 352

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

Xie, C., Zhuang, X., Niu, Z., Ai, R., Lautrup, S., Zheng, S., Jiang, Y., Han, R., Gupta, T. S., Cao, S., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00819-5 · Cited by 350

Reconstitution of Mitochondria Derived Vesicle Formation Demonstrates Selective Enrichment of Oxidized Cargo

Soubannier, V., Rippstein, P. U., Kaufman, B. A., Shoubridge, E. A., & McBride, H. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052830 · Cited by 346

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban‐Martínez, L., Sierra‐Filardi, E., McGreal, R., Salazar‐Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D. P., Graña‐Castro, O., Malumbres, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695916 · Cited by 344

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

Wang, B., Nie, J., Wu, L., Hu, Y., Wen, Z., Dong, L., Zou, M.-H., Chen, C., & Wang, D. W. (2018) · Circulation Research · doi:10.1161/circresaha.117.312317 · Cited by 334

DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders

Kahle, P. J., Waak, J., & Gasser, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.08.003 · Cited by 324

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

Sekine, S., & Youle, R. J. (2018) · BMC Biology · doi:10.1186/s12915-017-0470-7 · Cited by 320

Parkin , a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25–q27

Cesari, R., Martin, E. S., Calin, G. A., Pentimalli, F., Bichi, R., McAdams, H., Trapasso, F., Drusco, A., Shimizu, M., Masciullo, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931262100 · Cited by 314

PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer’s disease

Du, F., Yu, Q., Yan, S., Hu, G., Lue, L., Walker, D., Wu, L., Yan, S. F., Tieu, K., & Yan, S. S. (2017) · Brain · doi:10.1093/brain/awx258 · Cited by 308

BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

Zhang, T., Xue, L., Li, L., Tang, C., Wan, Z., Wang, R., Tan, J., Tan, Y., Han, H., Tian, R., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.733410 · Cited by 293

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.014 · Cited by 292

Immunobiography and the heterogeneity of immune responses in the elderly: A focus on inflammaging and trained immunity

Franceschi, C., Salvioli, S., Garagnani, P., de Eguileor, M., Monti, D., & Capri, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00982 · Cited by 290

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13172-8 · Cited by 288

Role and Mechanisms of Mitophagy in Liver Diseases

Ma, X., McKeen, T., Zhang, J., & Ding, W. (2020) · Cells · doi:10.3390/cells9040837 · Cited by 288

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue

Rosina, M., Ceci, V., Turchi, R., Li, C., Borcherding, N. C., Sciarretta, F., Sánchez-Díaz, M., Tortolici, F., Karlinsey, K. S., Chiurchiù, V., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.016 · Cited by 279

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

Leduc-Gaudet, J.-P., Picard, M., Pelletier, F. S.-J., Sgarioto, N., Auger, M.-J., Vallée, J., Robitaille, R., St-Pierre, D. H., & Gouspillou, G. (2015) · Oncotarget · doi:10.18632/oncotarget.4235 · Cited by 273

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Liang, W., Sagar, S., Ravindran, R., Najor, R. H., Quiles, J. M., Chi, L., Diao, R. Y., Woodall, B. P., Leon, L. J., Zumaya, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40680-5 · Cited by 273

The Role of Immunosenescence in the Development of Age-Related Diseases

Fülöp, T., Dupuis, G., Witkowski, J. M., & Larbi, A. (2016) · Revista de investigaci�n Cl�nica · doi:10.1016/s0034-8376(25)00212-8 · Cited by 269

Parkin enhances mitochondrial biogenesis in proliferating cells

Kuroda, Y., Mitsui, T., Kunishige, M., Shono, M., Akaike, M., Azuma, H., & Matsumoto, T. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl006 · Cited by 268

The Effect of Aging on Human Skeletal Muscle Mitochondrial and Intramyocellular Lipid Ultrastructure

Crane, J. D., Devries, M. C., Safdar, A., Hamadeh, M. J., & Tarnopolsky, M. A. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp179 · Cited by 262

Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure

Sweet, M., Cocciolo, A., Slavov, D. B., Jones, K. L., Sweet, J., Graw, S. L., Reece, T. B., Ambardekar, A. V., Bristow, M. R., Mestroni, L., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-5213-9 · Cited by 260

Regulation of PRKN-independent mitophagy

Terešak, P., Lapão, A., Subic, N., Boya, P., Elazar, Z., & Simonsen, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1888244 · Cited by 256

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Singh, A., D’Amico, D., Andreux, P. A., Fouassier, A. M., Blanco-Bose, W., Evans, M., Aebischer, P., Auwerx, J., & Rinsch, C. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100633 · Cited by 256

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1

Malik, N., Ferreira, B. I., Hollstein, P. E., Curtis, S. D., Trefts, E., Novak, S. W., Yu, J., Gilson, R. C., Hellberg, K., Fang, L., et al. (2023) · Science · doi:10.1126/science.abj5559 · Cited by 242

Mitocellular communication: Shaping health and disease

Mottis, A., Herzig, S., & Auwerx, J. H. (2019) · Science · doi:10.1126/science.aax3768 · Cited by 241

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

Poulogiannis, G., McIntyre, R. E., Dimitriadi, M., Apps, J. R., Wilson, C. H., Ichimura, K., Luo, F., Cantley, L. C., Wyllie, A. H., Adams, D. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009941107 · Cited by 239

Early‐onset Parkinson's disease caused by a compound heterozygous DJ‐1 mutation

Hague, S., Rogaeva, E. A., Hernandez, D. G., Gulick, C., Singleton, A., Hanson, M., Johnson, J. O., Weiser, R., Gallardo, M., Ravina, B. M., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10663 · Cited by 237

Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment

Liu, J., Liu, W., Li, R., & Yang, H. (2019) · Cells · doi:10.3390/cells8070712 · Cited by 225

Dietary spermidine improves cognitive function

Schroeder, S., Hofer, S. J., Zimmermann, A., Pechlaner, R., Dammbrueck, C., Pendl, T., Marcello, G. M., Pogatschnigg, V., Bergmann, M., Müller, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108985 · Cited by 225 · cited 1×

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis

Iorio, R., Celenza, G., & Petricca, S. (2021) · Cells · doi:10.3390/cells11010030 · Cited by 222

The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.012 · Cited by 218

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans

Gouspillou, G., Sgarioto, N., Kapchinsky, S., Purves‐Smith, F., Norris, B., Pion, C. H., Barbat‐Artigas, S., Lemieux, F., Taivassalo, T., Morais, J. A., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-242750 · Cited by 217

Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

Hong, X., Isern, J., Campanario, S., Perdiguero, E., Ramírez-Pardo, I., Segalés, J., Hernansanz-Agustín, P., Curtabbi, A., Deryagin, O., Pollán, A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.009 · Cited by 213 · cited 2×

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Zhong, W., Rao, Z., Xu, J., Sun, Y., Hu, H., Wang, P., Xia, Y., Pan, X., Tang, W., Chen, Z., et al. (2022) · Aging Cell · doi:10.1111/acel.13622 · Cited by 212

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Luan, P., D’Amico, D., Andreux, P. A., Laurila, P., Wohlwend, M., Li, H., de Lima, T. I., Place, N., Rinsch, C., Zanou, N., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0319 · Cited by 208

Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury

Zhang, W., Siraj, S., Zhang, R., & Chen, Q. (2017) · Autophagy · doi:10.1080/15548627.2017.1300224 · Cited by 200

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy

Drake, J. C., Wilson, R. J., Laker, R. C., Guan, Y., Spaulding, H. R., Nichenko, A. S., Shen, W., Shang, H., Dorn, M. V., Huang, K. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025932118 · Cited by 198

Function of Autophagy in Nonalcoholic Fatty Liver Disease

Czaja, M. J. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-4025-x · Cited by 195

Quercetin's Influence on Exercise Performance and Muscle Mitochondrial Biogenesis

NIEMAN, D. C., WILLIAMS, A. S., SHANELY, R. A., JIN, F., MCANULTY, S. R., TRIPLETT, N. T., AUSTIN, M. D., & HENSON, D. A. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181b18fa3 · Cited by 194

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 194

Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy

Czajka, A., Ajaz, S., Gnudi, L., Parsade, C. K., Jones, P. M., Reid, F., & Malik, A. N. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.04.002 · Cited by 188

Tomatidine Enhances Lifespan and Healthspan in C. elegans through Mitophagy Induction Via the SKN-1/Nrf2 Pathway

Fang, E. F., Waltz, T. B., Kassahun, H., Lu, Q., Kerr, J. S., Morevati, M., Fivenson, E. M., Wollman, B. N., Marosi, K., Wilson, M. A., et al. (2017) · Scientific Reports · doi:10.1038/srep46208 · Cited by 187

(Patho‐)physiological relevance of PINK1‐dependent ubiquitin phosphorylation

Fiesel, F. C., Ando, M., Hudec, R., Hill, A. R., Castanedes‐Casey, M., Caulfield, T. R., Moussaud‐Lamodière, E. L., Stankowski, J. N., Bauer, P. O., Lorenzo‐Betancor, O., et al. (2015) · The EMBO Reports · doi:10.15252/embr.201540514 · Cited by 185 · cited 2×

Pink1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

Pryde, K. R., Smith, H. L., Chau, K.-Y., & Schapira, A. H. V. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201509003 · Cited by 185

Autophagy and mitophagy in ALS

Evans, C. S., & Holzbaur, E. L. F. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.005 · Cited by 185

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

Seabright, A. P., Fine, N. H. F., Barlow, J. P., Lord, S. O., Musa, I., Gray, A., Bryant, J. A., Banzhaf, M., Lavery, G. G., Hardie, D. G., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201903051r · Cited by 176

Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis

D'Amico, D., Olmer, M., Fouassier, A. M., Valdés, P., Andreux, P. A., Rinsch, C., & Lotz, M. (2022) · Aging Cell · doi:10.1111/acel.13662 · Cited by 171

Mitochondrial control of the NLRP3 inflammasome

Kepp, O., Galluzzi, L., & Kroemer, G. (2011) · Nature Immunology · doi:10.1038/ni0311-199 · Cited by 168 · cited 1×

Miro1 Marks Parkinson’s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson’s Models

Hsieh, C.-H., Li, L., Vanhauwaert, R., Nguyen, K. T., Davis, M. D., Bu, G., Wszołek, Z. K., & Wang, X. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.023 · Cited by 162

Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: A cross-sectional comparison

Drummond, M. J., Addison, O., Brunker, L., Hopkins, P. N., McClain, D. A., LaStayo, P. C., & Marcus, R. L. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu004 · Cited by 161

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie, C. M., Roumans, K. H., Moonen, M. P., Connell, N. J., Havekes, B., Mevenkamp, J., Lindeboom, L., de Wit, V. H., van de Weijer, T., Aarts, S. A., et al. (2020) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa072 · Cited by 160

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D’Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.11.034 · Cited by 159

Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis

Liu, L., Li, Y., Wang, J., Zhang, D., Wu, H., Li, W., Wei, H., Ta, N., Fan, Y., Liu, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202050629 · Cited by 159

Cardiolipin in Immune Signaling and Cell Death

Pizzuto, M., & Pelegrı́n, P. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.004 · Cited by 157

A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

Phadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Denk, D., Petrocelli, V., Conche, C., Drachsler, M. W., Ziegler, P. K., Braun, A., Kress, A., Nicolas, A. M., Mohs, K., Becker, C., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.09.014 · Cited by 153

Effects of Quercetin and EGCG on Mitochondrial Biogenesis and Immunity

Nieman, D. C., Henson, D. A., Maxwell, K. R., Williams, A. S., McAnulty, S. R., Jin, F., Shanely, R. A., & Lines, T. C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318199491f · Cited by 148

Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin‐resistant men

Dollerup, O. L., Chubanava, S., Agerholm, M., Søndergård, S. D., Altıntaş, A., Møller, A. B., Høyer, K. F., Ringgaard, S., Stødkilde‐Jørgensen, H., Lavery, G. G., et al. (2020) · The Journal of Physiology · doi:10.1113/jp278752 · Cited by 145

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

Picca, A., Lezza, A. M. S., Leeuwenburgh, C., Pesce, V., Calvani, R., Bossola, M., Manes-Gravina, E., Landi, F., Bernabei, R., & Marzetti, E. (2018) · Rejuvenation Research · doi:10.1089/rej.2017.1989 · Cited by 144

Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha‐1‐anti‐trypsin deficiency

Pastore, N., Blomenkamp, K., Annunziata, F., Piccolo, P., Mithbaokar, P., Maria Sepe, R., Vetrini, F., Palmer, D., Ng, P., Polishchuk, E., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202046 · Cited by 142

3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus

Faitg, J., Lacefield, C., Davey, T., White, K., Laws, R., Kosmidis, S., Reeve, A. K., Kandel, E. R., Vincent, A. E., & Picard, M. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109509 · Cited by 139

Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay

Lionaki, E., Markaki, M., Palikaras, K., & Tavernarakis, N. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.04.010 · Cited by 137

Mitophagy protects β cells from inflammatory damage in diabetes

Sidarala, V., Pearson, G. L., Parekh, V. S., Thompson, B. M., Christen, L., Gingerich, M. A., Zhu, J., Stromer, T., Ren, J., Reck, E. C., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.141138 · Cited by 137

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Lapatto, H. A. K., Kuusela, M., Heikkinen, A., Muniandy, M., van der Kolk, B. W., Gopalakrishnan, S., Sandvik, M., Schmidt, M. S., Heinonen, S., Saari, S., et al. (2023) · Science Advances · doi:10.1126/sciadv.add5163 · Cited by 136

Muscle strength mediates the relationship between mitochondrial energetics and walking performance

Zane, A. C., Reiter, D. A., Shardell, M., Cameron, D., Simonsick, E. M., Fishbein, K. W., Studenski, S. A., Spencer, R. G., & Ferrucci, L. (2017) · Aging Cell · doi:10.1111/acel.12568 · Cited by 134

The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

Chung, K. W., & Chung, H. Y. (2019) · Nutrients · doi:10.3390/nu11122923 · Cited by 125

Parkin and Parkinsonʼs disease

Mizuno, Y., Hattori, N., Mori, H., Suzuki, T., & Tanaka, K. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200108000-00008 · Cited by 123

Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles

Roberts, R. F., Tang, M. Y. H., Fon, E. A., & Durcan, T. M. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.07.020 · Cited by 121

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116

A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma

Yao, Z., Zhang, X., Zhen, Y., He, X., Zhao, S., Li, X., Yang, B., Gao, F., Guo, F., Fu, L., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0799-z · Cited by 115

Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion

Hao, T., Yu, J., Wu, Z., Jiang, J., Gong, L., Wang, B., Guo, H., Zhao, H., Lü, B., Engelender, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39811-9 · Cited by 115

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy

Tong, M., Saito, T., Zhai, P., Oka, S.-I., Mizushima, W., Nakamura, M., Ikeda, S., Shirakabe, A., & Sadoshima, J. (2021) · Circulation Research · doi:10.1161/circresaha.121.319377 · Cited by 113

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

Castellazzi, M., Patergnani, S., Donadio, M., Giorgi, C., Bonora, M., Bosi, C., Brombo, G., Pugliatti, M., Seripa, D., Zuliani, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56614-5 · Cited by 111

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele, C., Nielsen, A. R., Walden, T. B., Sewell, D. A., Fischer, C. P., Brogan, R. J., Petrovic, N., Larsson, O., Tesch, P. A., Wennmalm, K., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8520com · Cited by 110

Sporadic inclusion-body myositis: A degenerative muscle disease associated with aging, impaired muscle protein homeostasis and abnormal mitophagy

Askanas, V., Engel, W. K., & Nogalska, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.09.005 · Cited by 106

Mitochondrial and inflammatory changes in sporadic inclusion body myositis

Rygiel, K. A., Miller, J. A. L., Grady, J. P., Rocha, M. C., Taylor, R. W., & Turnbull, D. M. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12149 · Cited by 105

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses

Bueno, M., Zank, D. C., Buendía-Roldán, I., Fiedler, K., Mays, B. G., Álvarez, D., Sembrat, J., Kimball, B., Bullock, J., Martin, J. L., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218003 · Cited by 105

Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age

Balan, E., Schwalm, C., Naslain, D., Nielens, H., Francaux, M., & Deldicque, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01088 · Cited by 104

Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress

Qiang, X., Xu, L., Zhang, M., Zhang, P., Wang, Y., Wang, Y., Zhao, Z., Chen, H., Liu, X., & Zhang, Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.019 · Cited by 101

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

Harding, O. J., Evans, C. S., Ye, J., Cheung, J., Maniatis, T., & Holzbaur, E. L. F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025053118 · Cited by 99

Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer

Letessier, A., Garrido‐Urbani, S., Ginestier, C., Fournier, G., Esterni, B., Monville, F., Adélaı̈de, J., Geneix, J., Xerri, L., Dubreuil, P. C., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209772 · Cited by 97

Mitophagy in carcinogenesis, drug resistance and anticancer therapeutics

Guan, Y., Wang, Y., Li, B., Shen, K., Li, Q., Ni, Y.-Y., & Huang, L. H. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02065-w · Cited by 97

Optineurin in amyotrophic lateral sclerosis: Multifunctional adaptor protein at the crossroads of different neuroprotective mechanisms

Markovinović, A., Cimbro, R., Ljutić, T., Križ, J., Rogelj, B., & Munitić, I. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.04.005 · Cited by 95

31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging

Choi, S., Reiter, D. A., Shardell, M., Simonsick, E. M., Studenski, S., Spencer, R. G., Fishbein, K. W., & Ferrucci, L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw059 · Cited by 92

Pink1-Mediated Chondrocytic Mitophagy Contributes to Cartilage Degeneration in Osteoarthritis

Shin, H. J., Park, H., Shin, N., Kwon, H. H., Yin, Y., Hwang, J., Song, H., Kim, J., Kim, D. W., & Beom, J. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111849 · Cited by 91

Genetics of parkin-linked disease

West, A. B., & Maidment, N. T. (2004) · Human Genetics · doi:10.1007/s00439-003-1074-6 · Cited by 90

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

Sun, L., Shen, R., Agnihotri, S. K., Chen, Y., Huang, Z., & Büeler, H. (2018) · Scientific Reports · doi:10.1038/s41598-017-18786-w · Cited by 88

Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study

Bhansali, S., Bhansali, A. K., Dutta, P. R., Walia, R., & Dhawan, V. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14834 · Cited by 82

Calorie restriction-induced weight loss and exercise have differential effects on skeletal muscle mitochondria despite similar effects on insulin sensitivity

Menshikova, E. V., Ritov, V. B., Dube, J. J., Amati, F., Stefanovic-Racic, M., Toledo, F. G. S., Coen, P. M., & Goodpaster, B. H. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw328 · Cited by 80

GAK and PRKCD are positive regulators of PRKN-independent mitophagy

Munson, M. J., Mathai, B. J., Ng, M. Y. W., Trachsel-Moncho, L., de la Ballina, L. R., Schultz, S. W., Aman, Y., Lystad, A. H., Singh, S., Singh, S. K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26331-7 · Cited by 78

Muscle mitochondrial energetics predicts mobility decline in well-functioning older adults: the baltimore longitudinal study of aging

Tian, Q., Mitchell, B. A., Zampino, M., Fishbein, K. W., Spencer, R. G., & Ferrucci, L. (2022) · Aging Cell · doi:10.1111/acel.13552 · Cited by 78

Mitophagy and DNA damage signaling in human aging

Babbar, M., Basu, S., Yang, B., Croteau, D. L., & Bohr, V. A. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111207 · Cited by 77

Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by 31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

Fabbri, E., Chia, C. W., Spencer, R. G., Fishbein, K. W., Reiter, D. A., Cameron, D., Zane, A. C., Moore, Z. A., Gonzalez-Freire, M., Zoli, M., et al. (2017) · Diabetes · doi:10.2337/db16-0754 · Cited by 76

Nrf2/ARE Activators Improve Memory in Aged Mice via Maintaining of Mitochondrial Quality Control of Brain and the Modulation of Gut Microbiome

Sadovnikova, I. S., Gureev, A. P., Ignatyeva, D. A., Vladimirovna, G. M., Chernyshova, E. V., Krutskikh, E. P., Novikova, A. G., & Popov, V. N. (2021) · Pharmaceuticals · doi:10.3390/ph14070607 · Cited by 76

Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis

Undamatla, R., Fagunloye, O. G., Chen, J., Edmunds, L. R., Murali, A., Mills, A. S., Xie, B., Pangburn, M. M., SIPULA, I. J., Gibson, G. A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-34710-x · Cited by 73

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

Hou, X., Watzlawik, J. O., Cook, C. N., Liu, C., Kang, S. S., Lin, W., Deture, M. A., Heckman, M. G., Diehl, N. N., Al‐Shaikh, F. S. H., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12198 · Cited by 72

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Liu, L., Liao, X., Wu, H., Li, Y., Zhu, Y., & Chen, Q. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.8013 · Cited by 69

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

Newman, L. E., & Shadel, G. S. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201808118 · Cited by 68

Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults

Mesquita, P. H. C., Lamb, D. A., Parry, H. A., Moore, J. H., Smith, M. A., Vann, C. G., Osburn, S. C., Fox, C. D., Ruple, B. A., Huggins, K. W., et al. (2020) · Physiological Reports · doi:10.14814/phy2.14526 · Cited by 66

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

Ziviani, E., & Whitworth, A. J. (2010) · Autophagy · doi:10.4161/auto.6.5.12242 · Cited by 64

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Deng, Z., Sheehan, P., Chen, S., & Yue, Z. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0232-6 · Cited by 62

Activation-induced autophagy is preserved in CD4+ T-cells in familial longevity

Raz, Y., Guerrero-Ros, I., Maier, A., Slagboom, P. E., Atzmon, G., Barzilai, N., & Macian, F. (2017) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx020 · Cited by 61

Autolysosomes accumulate during in vitro CD8+ T-lymphocyte aging and may participate in induced death sensitization of senescent cells

Gerland, L., Genestier, L., Peyrol, S., Michallet, M., Hayette, S., Urbanowicz, I., Ffrench, P., Magaud, J., & Ffrench, M. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.013 · Cited by 60

Mitochondrial Dysfunction and Mitophagy in Type 2 Diabetes: Pathophysiology and Therapeutic Targets

Apostolova, N., Vezza, T., Muntané, J., Rocha, M., & Víctor, V. M. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0016 · Cited by 60

Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora’s Box in Health and Disease

Picca, A., Guerra, F., Calvani, R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., Romanò, R., Bucci, C., & Marzetti, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.601740 · Cited by 58

Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples

Watzlawik, J. O., Hou, X., Fričová, D., Ramnarine, C., Barodia, S. K., Gendron, T. F., Heckman, M. G., Deture, M. A., Siuda, J. S., Wszołek, Z. K., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1834712 · Cited by 56

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

Georgakopoulos, N., Frison, M., Álvarez, M. S., Bertrand, H. C., Wells, G., & Campanella, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-07679-7 · Cited by 54

Parkin Overexpression Attenuates Sepsis-Induced Muscle Wasting

Leduc-Gaudet, J.-P., Mayaki, D., Reynaud, O., Broering, F. E., Chaffer, T. J., Hussain, S. N. A., & Gouspillou, G. (2020) · Cells · doi:10.3390/cells9061454 · Cited by 54

Skeletal muscle autophagy and mitophagy in endurance-trained runners before and after a high-fat meal

Tarpey, M. D., Davy, K. P., McMillan, R. P., Bowser, S. M., Halliday, T. M., Boutagy, N. E., Davy, B. M., Frisard, M. I., & Hulver, M. W. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.10.006 · Cited by 52

Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

Oshima, Y., Cartier, E. A., Boyman, L., Verhoeven, N. A., Polster, B. M., Huang, W., Kane, M. A., Lederer, W. J., & Karbowski, M. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202006043 · Cited by 51

The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle

Gutiérrez-Casado, E., Khraiwesh, H. M., Lopez-Dominguez, J. A., Montero-Guisado, J., López‐Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., González-Reyes, J. A., & Villalba, J. M. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly161 · Cited by 49

Phase II trial of cytarabine and mitoxantrone with devimistat in acute myeloid leukemia

Anderson, R. G., Miller, L. D., Isom, S. P., Chou, J. W., Pladna, K. M., Schramm, N. J., Ellis, L. R., Howard, D. S., Bhave, R. R., Manuel, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29039-4 · Cited by 49

Lack of Activation of Mitophagy during Endurance Exercise in Human

Schwalm, C., Deldicque, L., & Francaux, M. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001256 · Cited by 47

Blood‐based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease

Mahapatra, G., Gao, Z., Bateman, J. R., Lockhart, S. N., Bergstrom, J., DeWitt, A. R., Piloso, J. E., Kramer, P. A., Gonzalez-Armenta, J. L., Amick, K. A., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12731 · Cited by 47

Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease

Ferrucci, L., Candia, J., Ubaida‐Mohien, C., Lyashkov, A. E., Banskota, N., Leeuwenburgh, C., Wohlgemuth, S. E., Guralnik, J. M., Kaileh, M., Zhang, D., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322325 · Cited by 44

Deficient mitophagy pathways in sickle cell disease

Martino, S., Arlet, J., Odièvre, M., Jullien, V., Moras, M., Hattab, C., Lefèbvre, T., Gouya, L., Ostuni, M. A., Lefevre, S. D., et al. (2021) · British Journal of Haematology · doi:10.1111/bjh.17416 · Cited by 43

Targeting mitophagy to promote apoptosis is a potential therapeutic strategy for cancer

Tang, Y., Wang, L., Qin, J., Lü, Y., Shen, H., & Chen, H. (2022) · Autophagy · doi:10.1080/15548627.2022.2112830 · Cited by 43

Pharmacological PINK1 activation ameliorates Pathology in Parkinson’s Disease modelsPreprint

Chin, R., Rakhit, R., Ditsworth, D., Wang, C., Bartholoméüs, J., Liu, S., Mody, A., Laishu, A., Eastes, A., Tai, C., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.14.528378 · Cited by 42

BNIP3 expression in endometrial cancer relates to active hypoxia inducible factor 1α pathway and prognosis

Giatromanolaki, A. N., Koukourakis, M. I., Gatter, K. C., Harris, A. L., & Sivridis, E. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.046680 · Cited by 41

Surface-Binding to Cardiolipin Nanodomains Triggers Cytochrome c Pro-apoptotic Peroxidase Activity via Localized Dynamics

Li, M., Mandal, A., Tyurin, V. A., DeLucia, M., Ahn, J., Kagan, V. E., & van der Wel, P. C. A. (2019) · Structure · doi:10.1016/j.str.2019.02.007 · Cited by 41

The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis

Foster, A. D., & Rea, S. L. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.284977 · Cited by 41

Evaluating mitochondrial autophagy in the mouse heart

Shirakabe, A., Fritzky, L., Saito, T., Zhai, P., Miyamoto, S., Gustafsson, Å. B., Kitsis, R. N., & Sadoshima, J. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.02.007 · Cited by 37

Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases

Lautrup, S., Caponio, D., Cheung, H., Piccoli, C., Stevnsner, T., Chan, W., & Fang, E. F. (2019) · Biogerontology · doi:10.1007/s10522-019-09798-2 · Cited by 37

BAX and BAK at the Gates of Innate Immunity

Galluzzi, L., & Vanpouille-Box, C. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.010 · Cited by 29

RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy

Soh, J. E. C., Shimizu, A., Molla, M. R., Zankov, D. P., Nguyen, L. K. C., Khan, M. R., Tesega, W. W., Chen, S., Tojo, M., Ito, Y., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102993 · Cited by 29

Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure

Mangner, N., Garbade, J., Heyne, E., van den Berg, M., Winzer, E. B., Hommel, J., Sandri, M., Jozwiak‐Nozdrzykowska, J., Meyer, A. L., Lehmann, S., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318060 · Cited by 28

Effects of a resistance-training programme on endoplasmic reticulum unfolded protein response and mitochondrial functions in PBMCs from elderly subjects

Estébanez, B., Moreira, O. C., Almar, M., de Paz, J. A., Gonzalez‐Gallego, J., & Cuevas, M. J. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2018.1561950 · Cited by 26

Expression of Autophagy and Mitophagy Markers in Breast Cancer Tissues

Mustafa, M. F., Saliluddin, S. M., Fakurazi, S., Laim, N. M. S. T., Pauzi, S. H. M., Yahya, N. H. N., Gopal, N. S. R., Abdullah, M. A., & Maniam, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.612009 · Cited by 24

Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults

Picca, A., Triolo, M., Wohlgemuth, S. E., Martenson, M. S., Mankowski, R. T., Anton, S. D., Marzetti, E., Leeuwenburgh, C., & Hood, D. A. (2023) · Cells · doi:10.3390/cells12010183 · Cited by 23

Basal autophagic flux measured in blood correlates positively with age in adults at increased risk of type 2 diabetes

Bensalem, J., Teong, X. T., Hattersley, K. J., Hein, L. K., Fourrier, C., Liu, K., Hutchison, A. T., Heilbronn, L. K., & Sargeant, T. J. (2023) · GeroScience · doi:10.1007/s11357-023-00884-5 · Cited by 21

Exercise Training Attenuates Ubiquitin-Proteasome Pathway and Increases the Genes Related to Autophagy on the Skeletal Muscle of Patients With Inflammatory Myopathies

Borges, I. B. P., de Oliveira, D. S., Marie, S. K. N., Lenario, A. M., Oba‐Shinjo, S. M., & Shinjo, S. K. (2021) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001721 · Cited by 20

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells

McCormick, J., VanDusseldorp, T., Ulrich, C., Lanphere, R., Dokładny, K., Mosely, P., & Mermier, C. (2018) · Physiology International · doi:10.1556/2060.105.2018.3.20 · Cited by 19

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases

Makarov, M., & Korkotian, E. (2023) · Toxins · doi:10.3390/toxins15030202 · Cited by 18

MDVs to the rescue: How autophagy-deficient cancer cells adapt to defective mitophagy

Poillet-Perez, L., & White, E. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.022 · Cited by 17

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

Tufi, R., Clark, E. H., Hoshikawa, T., Tsagkaraki, C., Stanley, J., Takeda, K., Staddon, J. M., & Briston, T. (2023) · SLAS DISCOVERY · doi:10.1016/j.slasd.2022.12.004 · Cited by 16

Increasing whole-body energetic stress does not augment fasting-induced changes in human skeletal muscle

Islam, H., Amato, A., Bonafiglia, J. T., Rahman, F. A., Preobrazenski, N., Ma, A., Simpson, C. A., Quadrilatero, J., & Gurd, B. J. (2021) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02499-7 · Cited by 14

TBK1 variants in Chinese patients with amyotrophic lateral sclerosis

Liu, X., He, J., Chen, L., Zhang, N., Tang, L., Liu, X., Ma, Y., & Fan, D. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.07.028 · Cited by 12

Minimal adaptation of the molecular regulators of mitochondrial dynamics in response to unilateral limb immobilisation and retraining in middle-aged men

Pileggi, C. A., Hedges, C. P., D’Souza, R. F., Durainayagam, B. R., Zeng, N., Figueiredo, V. C., Hickey, A. J., Mitchell, C. J., & Cameron‐Smith, D. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05107-x · Cited by 9

Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances

Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 1,016

Autophagy, aging, and age-related neurodegeneration

Palmer, J. E., Wilson, N., Son, S. M., Obrocki, P., Wróbel, L., Rob, M., Takla, M., Korolchuk, V. I., & Rubinsztein, D. C. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.015 · Cited by 277

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165

The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances

Andersen, J. V. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70029 · Cited by 170

Regulation of the NLRP3 inflammasome by autophagy and mitophagy

Gupta, S., Cassel, S. L., Sutterwala, F. S., & Dagvadorj, J. (2024) · Immunological Reviews · doi:10.1111/imr.13410 · Cited by 116

Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

Chen, G., Kroemer, G., & Kepp, O. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00200 · Cited by 359

Mitophagy, Diseases, and Aging

Bhutia, S. K., Naik, P. P., Panigrahi, D. P., Bhol, C. S., & Mahapatra, K. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-3585-3_9 · Cited by 2

Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications

D'Arcy, M. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01977-y · Cited by 118

The antiaging role of mitophagy

Tsagkari, D., Kounakis, K., Markaki, M., & Tavernarakis, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00014-4

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

Palikaras, K., Daskalaki, I., Markaki, M., & Tavernarakis, N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.04.005 · Cited by 181