The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer
Open accessAbstract
Metastasis-initiating cells with stem-like properties drive cancer lethality, yet their origins and relationship to primary-tumor-initiating stem cells are not known. We show that L1CAM+ cells in human colorectal cancer (CRC) have metastasis-initiating capacity, and we define their relationship to tissue regeneration. L1CAM is not expressed in the homeostatic intestinal epithelium, but is induced and required for epithelial regeneration following colitis and in CRC organoid growth. By using human tissues and mouse models, we show that L1CAM is dispensable for adenoma initiation but required for orthotopic carcinoma propagation, liver metastatic colonization and chemoresistance. L1CAMhigh cells partially overlap with LGR5high stem-like cells in human CRC organoids. Disruption of intercellular epithelial contacts causes E-cadherin–REST transcriptional derepression of L1CAM, switching chemoresistant CRC progenitors from an L1CAMlow to an L1CAMhigh state. Thus, L1CAM dependency emerges in regenerative intestinal cells when epithelial integrity is lost, a phenotype of wound healing deployed in metastasis-initiating cells. The authors identify a population of L1CAM-positive cells that, following loss of epithelial integrity, promote intestinal tissue regeneration and mediate metastasis initiation and chemoresistance in colorectal cancer.
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Metadata
- Authors
- Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A. M., He, L., Sharma, R., O’Rourke, K. P., Reuter, V. P., Huang, Y.-H., Turkekul, M., Er, E. E., Masilionis, I., Manova-Todorova, K., Weiser, M. R., Saltz, L. B., Garcia-Aguilar, J., Koche, R., Lowe, S. W., Pe’er, D., Shia, J., & Massagué, J.
- Venue
- Nature Cancer
- Published
- 2020-01-13
- Volume
- 1
- Issue
- 1
- Pages
- 28-45
- ISSN
- 2662-1347 (ISSN-L)
- OpenAlex
- W2999168532
- Cited by
- 242
- References
- 16
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Ganesh, K., Basnet, H., Kaygusuz, Y., Laughney, A. M., He, L., Sharma, R., O’Rourke, K. P., Reuter, V. P., Huang, Y.-H., Turkekul, M., Er, E. E., Masilionis, I., Manova-Todorova, K., Weiser, M. R., Saltz, L. B., Garcia-Aguilar, J., Koche, R., Lowe, S. W., Pe’er, D., . . . Massagué, J. (2020). L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer. Nature Cancer. https://doi.org/10.1038/s43018-019-0006-x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
