The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas
Open accessPublished version of a preprint
Abstract
Abstract Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to independently activate retinal neurons over a large portion of the subject’s visual field. Reaching such a goal would significantly improve the perception accuracy in retinal implants’ users, along with their spatial cognition, attention, ambient mapping and interaction with the environment. Here we show a wide-field, high-density and high-resolution photovoltaic epiretinal prosthesis for artificial vision (POLYRETINA). The prosthesis embeds 10,498 physically and functionally independent photovoltaic pixels, allowing for wide retinal coverage and high-resolution stimulation. Single-pixel illumination reproducibly induced network-mediated responses from retinal ganglion cells at safe irradiance levels. Furthermore, POLYRETINA allowed response discrimination with a high spatial resolution equivalent to the pixel pitch (120 µm) thanks to the network-mediated stimulation mechanism. This approach could allow mid-peripheral artificial vision in patients with retinitis pigmentosa.
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“POLYRETINA reported ex-vivo a spatial resolution of 120 µm (or 20/480) equivalent to the electrode separation [132].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [132]
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“POLYRETINA is a high-density wide-field epiretinal prosthesis containing 10 498 photovoltaic pixels distributed over an active area of approximately 43 • [38,39,131,132].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [132]
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Cites
Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering
Quiroga, R. Q., Nadasdy, Z., & Ben-Shaul, Y. (2004) · Neural Computation · doi:10.1162/089976604774201631 · Cited by 2,119
The functional diversity of retinal ganglion cells in the mouse
Baden, T., Berens, P., Franke, K., Román Rosón, M., Bethge, M., & Euler, T. (2016) · Nature · doi:10.1038/nature16468 · Cited by 999
Hamel, C. (2006) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-1-40 · Cited by 962
Perceptual grouping and attention in visual search for features and for objects.
Treisman, A. (1982) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.8.2.194 · Cited by 908
Subretinal electronic chips allow blind patients to read letters and combine them to words
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., Besch, D., Bruckmann, A., Gabel, V.-P., Gekeler, F., Greppmaier, U., Harscher, A., Kibbel, S., et al. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1747 · Cited by 819
Interim results from the international trial of Second Sight's visual prosthesis
Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Sahel, J.-A., Stanga, P. E., Cideciyan, A. V., Duncan, J. L., Eliott, D., Filley, E., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.09.028 · Cited by 700
Hot exciton dissociation in polymer solar cells
Grancini, G., Maiuri, M., Fazzi, D., Petrozza, A., Egelhaaf, H., Brida, D., Cerullo, G., & Lanzani, G. (2012) · Nature Materials · doi:10.1038/nmat3502 · Cited by 659
Gargini, C., Tozzini, E. T., Mazzoni, F., & Strettoi, E. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21144 · Cited by 496
Dendritic field size and morphology of midget and parasol ganglion cells of the human retina.
Dacey, D. M., & Petersen, M. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.20.9666 · Cited by 487
Maximum permissible exposures for ocular safety (ANSI 2000), with emphasis on ophthalmic devices
Delori, F. C., Webb, R. H., & Sliney, D. H. (2007) · Journal of the Optical Society of America A · doi:10.1364/josaa.24.001250 · Cited by 484
Research works printed but not linked: 1
- Weiland, J. D. & Humayun, M. S. Retinal prosthetic systems for the treatment of blindness. Bridge 42, 51–57 (2012).
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Metadata
- Authors
- Chenais, N. A. L., Airaghi Leccardi, M. J. I., & Ghezzi, D.
- Affiliations
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Ghezzi, Diego
- Venue
- Communications Materials
- Published
- 2021-03-05
- Volume
- 2
- Issue
- 1
- ISSN
- 2662-4443 (ISSN-L)
- OpenAlex
- W3134642074
- Cited by
- 110
- References
- 107
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 32 · 2023: 17 · 2022: 18 · 2021: 10
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Materials (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Velux Stiftung (1102)
- Gebert Rüf Stiftung (GRS-035/17)
- Fondation Pierre Mercier pour la Science Fondation Pro Visu
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- retinal prosthesis, epiretinal implants, retinitis pigmentosa, retinal ganglion cells, spatial resolution, artificial vision
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