Cited by 123Schizophrenia research and treatmentCancer, Stress, Anesthesia, and Immune ResponseInflammatory mediators and NSAID effects

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Cancer risk among users of neuroleptic medication: a population-based cohort study

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Dalton, S O, Johansen, C, Poulsen, A H, Nørgaard, M, Sørensen, H T, McLaughlin, J K, Mortensen, P B, Friis, S·2006·British Journal of Cancer

DOI 10.1038/sj.bjc.6603259PMC PMC2360537

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Abstract

It has been suggested that neuroleptic medication may decrease cancer risk. We compared cancer risks in a population-based cohort study of 25,264 users (>or=2 prescriptions) of neuroleptic medications in the county of North Jutland, Denmark, during 1989-2002, with that of county residents who did not receive such prescriptions. Statistical analyses were based on age-standardisation and Poisson regression analysis, adjusting for age, calendar period, COPD, liver cirrhosis or alcoholism, use of NSAID, and, for breast cancer, additionally for use of hormone therapy, age at first birth, and number of children. Use of neuroleptic medications was associated with a decreased risk for rectal cancer in both women and men (adjusted IRRs of 0.61 (95% confidence interval, 0.41-0.91) and 0.82 (0.56-1.19), respectively) and for colon cancer in female users (0.78; 0.62-0.98). Some risk reduction was seen for prostate cancer (0.87; 0.69-1.08), but breast cancer risk was close to unity (0.93; 0.74-1.17). Overall, treatment with neuroleptic medications was not related to a reduced risk of cancer, but for cancers of the rectum, colon and prostate there were suggestive decreases in risk.

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Authors: Dalton, S. O., Johansen, C., Poulsen, A. H., Nørgaard, M., Sørensen, H. T., McLaughlin, J. K., Mortensen, P. B., & Friis, S.
Affiliations: Danish Cancer Society (DK)
Aarhus University Hospital (DK)
International Epidemiology Institute (US)
Aarhus University (DK)
Corresponding author: Dalton, S O
ORCID: Dalton, S O
Johansen, C
Poulsen, A H
Nørgaard, M
Sørensen, H T
Mortensen, P B
Venue: British Journal of Cancer
Publisher: Springer Science and Business Media LLC
Published: 2006-08-22
Volume: 95
Issue: 7
Pages: 934-939
ISSN: 0007-0920 (ISSN-L)
1532-1827
DOI: 10.1038/sj.bjc.6603259
PMC: PMC2360537
OpenAlex: W2023544789
Cited by: 123
References: 38
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 16 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 6
FWCI: 2.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
www.springer.com/tdm (unspecified)
Locations: British Journal of Cancer (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Kræftens Bekæmpelse
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Keywords: antipsychotic drugs, cancer risk, rectal cancer, colon cancer, prostate cancer, breast cancer, prescription drug use
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neoplasms, Risk Factors, Schizophrenia, Antipsychotic Agents, Cohort Studies, Incidence

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Cancer risk among users of neuroleptic medication: a population-based cohort study

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